Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXL5_LEIMU

TriTrypDb:

LmxM.25.1360

Length:

965

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.619
CLV_C14_Caspase3-7	495	499	PF00656	0.578
CLV_C14_Caspase3-7	781	785	PF00656	0.528
CLV_C14_Caspase3-7	944	948	PF00656	0.593
CLV_NRD_NRD_1	110	112	PF00675	0.536
CLV_NRD_NRD_1	223	225	PF00675	0.543
CLV_NRD_NRD_1	229	231	PF00675	0.602
CLV_NRD_NRD_1	295	297	PF00675	0.605
CLV_NRD_NRD_1	355	357	PF00675	0.355
CLV_NRD_NRD_1	44	46	PF00675	0.563
CLV_NRD_NRD_1	635	637	PF00675	0.610
CLV_NRD_NRD_1	677	679	PF00675	0.651
CLV_NRD_NRD_1	718	720	PF00675	0.648
CLV_NRD_NRD_1	93	95	PF00675	0.507
CLV_PCSK_FUR_1	108	112	PF00082	0.632
CLV_PCSK_FUR_1	636	640	PF00082	0.640
CLV_PCSK_FUR_1	675	679	PF00082	0.643
CLV_PCSK_KEX2_1	110	112	PF00082	0.580
CLV_PCSK_KEX2_1	222	224	PF00082	0.544
CLV_PCSK_KEX2_1	229	231	PF00082	0.597
CLV_PCSK_KEX2_1	236	238	PF00082	0.595
CLV_PCSK_KEX2_1	295	297	PF00082	0.605
CLV_PCSK_KEX2_1	355	357	PF00082	0.355
CLV_PCSK_KEX2_1	52	54	PF00082	0.548
CLV_PCSK_KEX2_1	635	637	PF00082	0.638
CLV_PCSK_KEX2_1	638	640	PF00082	0.621
CLV_PCSK_KEX2_1	675	677	PF00082	0.632
CLV_PCSK_KEX2_1	718	720	PF00082	0.523
CLV_PCSK_KEX2_1	93	95	PF00082	0.447
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.581
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.709
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.682
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.568
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.678
CLV_PCSK_PC7_1	106	112	PF00082	0.581
CLV_PCSK_SKI1_1	308	312	PF00082	0.409
CLV_PCSK_SKI1_1	356	360	PF00082	0.431
CLV_PCSK_SKI1_1	45	49	PF00082	0.568
CLV_PCSK_SKI1_1	468	472	PF00082	0.343
CLV_PCSK_SKI1_1	491	495	PF00082	0.622
CLV_PCSK_SKI1_1	542	546	PF00082	0.351
CLV_PCSK_SKI1_1	719	723	PF00082	0.640
CLV_PCSK_SKI1_1	817	821	PF00082	0.434
CLV_PCSK_SKI1_1	87	91	PF00082	0.553
CLV_Separin_Metazoa	349	353	PF03568	0.335
DEG_APCC_DBOX_1	166	174	PF00400	0.617
DEG_APCC_DBOX_1	307	315	PF00400	0.450
DEG_APCC_DBOX_1	717	725	PF00400	0.597
DEG_COP1_1	860	868	PF00400	0.669
DEG_Nend_UBRbox_1	1	4	PF02207	0.682
DEG_SPOP_SBC_1	375	379	PF00917	0.500
DEG_SPOP_SBC_1	518	522	PF00917	0.777
DEG_SPOP_SBC_1	951	955	PF00917	0.609
DOC_CKS1_1	96	101	PF01111	0.670
DOC_CYCLIN_RxL_1	352	362	PF00134	0.387
DOC_CYCLIN_RxL_1	465	475	PF00134	0.335
DOC_CYCLIN_RxL_1	638	648	PF00134	0.667
DOC_CYCLIN_yCln2_LP_2	768	771	PF00134	0.359
DOC_MAPK_gen_1	295	305	PF00069	0.582
DOC_MAPK_gen_1	635	644	PF00069	0.582
DOC_MAPK_HePTP_8	293	305	PF00069	0.579
DOC_MAPK_JIP1_4	542	548	PF00069	0.396
DOC_MAPK_MEF2A_6	296	305	PF00069	0.591
DOC_MAPK_MEF2A_6	635	644	PF00069	0.580
DOC_PP1_RVXF_1	466	473	PF00149	0.441
DOC_PP2B_LxvP_1	768	771	PF13499	0.378
DOC_PP2B_LxvP_1	776	779	PF13499	0.568
DOC_PP4_FxxP_1	657	660	PF00568	0.672
DOC_USP7_MATH_1	177	181	PF00917	0.660
DOC_USP7_MATH_1	186	190	PF00917	0.700
DOC_USP7_MATH_1	375	379	PF00917	0.667
DOC_USP7_MATH_1	421	425	PF00917	0.472
DOC_USP7_MATH_1	516	520	PF00917	0.782
DOC_USP7_MATH_1	651	655	PF00917	0.662
DOC_USP7_MATH_1	787	791	PF00917	0.667
DOC_USP7_MATH_1	808	812	PF00917	0.618
DOC_USP7_MATH_1	897	901	PF00917	0.688
DOC_USP7_MATH_1	92	96	PF00917	0.607
DOC_USP7_MATH_1	951	955	PF00917	0.609
DOC_USP7_UBL2_3	46	50	PF12436	0.538
DOC_WW_Pin1_4	117	122	PF00397	0.606
DOC_WW_Pin1_4	173	178	PF00397	0.685
DOC_WW_Pin1_4	182	187	PF00397	0.707
DOC_WW_Pin1_4	21	26	PF00397	0.609
DOC_WW_Pin1_4	214	219	PF00397	0.674
DOC_WW_Pin1_4	222	227	PF00397	0.637
DOC_WW_Pin1_4	264	269	PF00397	0.489
DOC_WW_Pin1_4	303	308	PF00397	0.513
DOC_WW_Pin1_4	383	388	PF00397	0.648
DOC_WW_Pin1_4	610	615	PF00397	0.541
DOC_WW_Pin1_4	63	68	PF00397	0.526
DOC_WW_Pin1_4	732	737	PF00397	0.491
DOC_WW_Pin1_4	95	100	PF00397	0.553
LIG_14-3-3_CanoR_1	167	177	PF00244	0.624
LIG_14-3-3_CanoR_1	17	23	PF00244	0.537
LIG_14-3-3_CanoR_1	179	185	PF00244	0.778
LIG_14-3-3_CanoR_1	241	245	PF00244	0.621
LIG_14-3-3_CanoR_1	491	497	PF00244	0.596
LIG_14-3-3_CanoR_1	652	660	PF00244	0.599
LIG_14-3-3_CanoR_1	7	16	PF00244	0.736
LIG_14-3-3_CanoR_1	823	833	PF00244	0.417
LIG_14-3-3_CanoR_1	87	92	PF00244	0.613
LIG_14-3-3_CanoR_1	915	921	PF00244	0.607
LIG_14-3-3_CanoR_1	93	97	PF00244	0.553
LIG_Actin_WH2_2	166	181	PF00022	0.428
LIG_AP2alpha_1	433	437	PF02296	0.312
LIG_BIR_III_2	407	411	PF00653	0.411
LIG_BIR_III_4	867	871	PF00653	0.715
LIG_BRCT_BRCA1_1	653	657	PF00533	0.589
LIG_BRCT_BRCA1_1	681	685	PF00533	0.550
LIG_Clathr_ClatBox_1	644	648	PF01394	0.602
LIG_eIF4E_1	465	471	PF01652	0.335
LIG_FHA_1	150	156	PF00498	0.526
LIG_FHA_1	223	229	PF00498	0.675
LIG_FHA_1	300	306	PF00498	0.573
LIG_FHA_1	317	323	PF00498	0.471
LIG_FHA_1	343	349	PF00498	0.403
LIG_FHA_1	371	377	PF00498	0.624
LIG_FHA_1	473	479	PF00498	0.348
LIG_FHA_1	698	704	PF00498	0.587
LIG_FHA_1	74	80	PF00498	0.623
LIG_FHA_1	751	757	PF00498	0.354
LIG_FHA_1	773	779	PF00498	0.447
LIG_FHA_1	852	858	PF00498	0.575
LIG_FHA_2	493	499	PF00498	0.684
LIG_FHA_2	586	592	PF00498	0.534
LIG_FHA_2	906	912	PF00498	0.571
LIG_FHA_2	96	102	PF00498	0.687
LIG_GBD_Chelix_1	309	317	PF00786	0.337
LIG_GBD_Chelix_1	327	335	PF00786	0.481
LIG_LIR_Apic_2	21	25	PF02991	0.615
LIG_LIR_Apic_2	654	660	PF02991	0.711
LIG_LIR_Apic_2	95	99	PF02991	0.654
LIG_LIR_Gen_1	435	445	PF02991	0.371
LIG_LIR_Gen_1	658	668	PF02991	0.642
LIG_LIR_Gen_1	725	736	PF02991	0.456
LIG_LIR_Gen_1	81	89	PF02991	0.497
LIG_LIR_Gen_1	834	845	PF02991	0.386
LIG_LIR_Nem_3	243	249	PF02991	0.641
LIG_LIR_Nem_3	337	342	PF02991	0.404
LIG_LIR_Nem_3	435	439	PF02991	0.364
LIG_LIR_Nem_3	538	544	PF02991	0.467
LIG_LIR_Nem_3	648	653	PF02991	0.534
LIG_LIR_Nem_3	658	664	PF02991	0.548
LIG_LIR_Nem_3	725	731	PF02991	0.461
LIG_LIR_Nem_3	81	86	PF02991	0.485
LIG_LIR_Nem_3	834	840	PF02991	0.373
LIG_LIR_Nem_3	846	852	PF02991	0.445
LIG_NRBOX	308	314	PF00104	0.421
LIG_PCNA_yPIPBox_3	924	938	PF02747	0.421
LIG_PDZ_Class_3	960	965	PF00595	0.625
LIG_Pex14_2	18	22	PF04695	0.685
LIG_Pex14_2	433	437	PF04695	0.312
LIG_Pex14_2	55	59	PF04695	0.520
LIG_Pex14_2	657	661	PF04695	0.624
LIG_PTAP_UEV_1	267	272	PF05743	0.556
LIG_PTB_Apo_2	426	433	PF02174	0.418
LIG_PTB_Apo_2	623	630	PF02174	0.698
LIG_PTB_Apo_2	731	738	PF02174	0.309
LIG_PTB_Phospho_1	426	432	PF10480	0.422
LIG_PTB_Phospho_1	623	629	PF10480	0.700
LIG_SH2_CRK	541	545	PF00017	0.434
LIG_SH2_CRK	822	826	PF00017	0.473
LIG_SH2_NCK_1	391	395	PF00017	0.502
LIG_SH2_STAP1	391	395	PF00017	0.481
LIG_SH2_STAP1	465	469	PF00017	0.340
LIG_SH2_STAP1	698	702	PF00017	0.557
LIG_SH2_STAT5	169	172	PF00017	0.624
LIG_SH2_STAT5	391	394	PF00017	0.474
LIG_SH2_STAT5	404	407	PF00017	0.357
LIG_SH2_STAT5	432	435	PF00017	0.450
LIG_SH2_STAT5	469	472	PF00017	0.319
LIG_SH2_STAT5	474	477	PF00017	0.354
LIG_SH2_STAT5	58	61	PF00017	0.504
LIG_SH3_1	764	770	PF00018	0.388
LIG_SH3_3	113	119	PF00018	0.607
LIG_SH3_3	232	238	PF00018	0.702
LIG_SH3_3	265	271	PF00018	0.530
LIG_SH3_3	319	325	PF00018	0.482
LIG_SH3_3	363	369	PF00018	0.473
LIG_SH3_3	537	543	PF00018	0.466
LIG_SH3_3	764	770	PF00018	0.470
LIG_SUMO_SIM_anti_2	343	352	PF11976	0.386
LIG_SUMO_SIM_par_1	210	215	PF11976	0.588
LIG_SUMO_SIM_par_1	254	260	PF11976	0.486
LIG_SUMO_SIM_par_1	318	324	PF11976	0.563
LIG_SUMO_SIM_par_1	772	777	PF11976	0.481
LIG_TRAF2_1	859	862	PF00917	0.741
LIG_TRAF2_2	121	126	PF00917	0.597
LIG_TRFH_1	63	67	PF08558	0.582
LIG_TYR_ITIM	820	825	PF00017	0.472
LIG_UBA3_1	272	278	PF00899	0.662
LIG_UBA3_1	311	315	PF00899	0.450
LIG_WRC_WIRS_1	80	85	PF05994	0.452
MOD_CDC14_SPxK_1	176	179	PF00782	0.524
MOD_CDK_SPK_2	182	187	PF00069	0.625
MOD_CDK_SPK_2	303	308	PF00069	0.513
MOD_CDK_SPxK_1	173	179	PF00069	0.519
MOD_CDK_SPxxK_3	222	229	PF00069	0.674
MOD_CDK_SPxxK_3	63	70	PF00069	0.619
MOD_CDK_SPxxK_3	95	102	PF00069	0.671
MOD_CK1_1	180	186	PF00069	0.630
MOD_CK1_1	21	27	PF00069	0.610
MOD_CK1_1	286	292	PF00069	0.691
MOD_CK1_1	374	380	PF00069	0.691
MOD_CK1_1	519	525	PF00069	0.721
MOD_CK1_1	777	783	PF00069	0.681
MOD_CK1_1	9	15	PF00069	0.538
MOD_CK1_1	900	906	PF00069	0.665
MOD_CK1_1	95	101	PF00069	0.605
MOD_CK1_1	953	959	PF00069	0.607
MOD_CK2_1	182	188	PF00069	0.809
MOD_CK2_1	201	207	PF00069	0.616
MOD_CK2_1	340	346	PF00069	0.411
MOD_CK2_1	585	591	PF00069	0.525
MOD_CK2_1	844	850	PF00069	0.548
MOD_CK2_1	905	911	PF00069	0.572
MOD_Cter_Amidation	43	46	PF01082	0.671
MOD_GlcNHglycan	188	191	PF01048	0.611
MOD_GlcNHglycan	231	234	PF01048	0.695
MOD_GlcNHglycan	246	249	PF01048	0.499
MOD_GlcNHglycan	268	271	PF01048	0.724
MOD_GlcNHglycan	285	288	PF01048	0.515
MOD_GlcNHglycan	372	376	PF01048	0.687
MOD_GlcNHglycan	379	382	PF01048	0.633
MOD_GlcNHglycan	446	449	PF01048	0.419
MOD_GlcNHglycan	523	526	PF01048	0.688
MOD_GlcNHglycan	605	608	PF01048	0.699
MOD_GlcNHglycan	76	79	PF01048	0.583
MOD_GlcNHglycan	793	796	PF01048	0.690
MOD_GlcNHglycan	810	813	PF01048	0.623
MOD_GlcNHglycan	846	849	PF01048	0.470
MOD_GlcNHglycan	904	907	PF01048	0.653
MOD_GSK3_1	102	109	PF00069	0.684
MOD_GSK3_1	155	162	PF00069	0.588
MOD_GSK3_1	173	180	PF00069	0.554
MOD_GSK3_1	182	189	PF00069	0.679
MOD_GSK3_1	21	28	PF00069	0.674
MOD_GSK3_1	240	247	PF00069	0.573
MOD_GSK3_1	299	306	PF00069	0.642
MOD_GSK3_1	338	345	PF00069	0.287
MOD_GSK3_1	370	377	PF00069	0.678
MOD_GSK3_1	492	499	PF00069	0.588
MOD_GSK3_1	514	521	PF00069	0.648
MOD_GSK3_1	605	612	PF00069	0.660
MOD_GSK3_1	651	658	PF00069	0.632
MOD_GSK3_1	679	686	PF00069	0.486
MOD_GSK3_1	705	712	PF00069	0.770
MOD_GSK3_1	723	730	PF00069	0.445
MOD_GSK3_1	74	81	PF00069	0.530
MOD_GSK3_1	787	794	PF00069	0.641
MOD_LATS_1	489	495	PF00433	0.469
MOD_N-GLC_1	202	207	PF02516	0.611
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	150	155	PF00069	0.510
MOD_NEK2_1	159	164	PF00069	0.454
MOD_NEK2_1	178	183	PF00069	0.481
MOD_NEK2_1	18	23	PF00069	0.538
MOD_NEK2_1	244	249	PF00069	0.538
MOD_NEK2_1	257	262	PF00069	0.441
MOD_NEK2_1	327	332	PF00069	0.495
MOD_NEK2_1	376	381	PF00069	0.547
MOD_NEK2_1	472	477	PF00069	0.343
MOD_NEK2_1	48	53	PF00069	0.567
MOD_NEK2_1	496	501	PF00069	0.745
MOD_NEK2_1	685	690	PF00069	0.573
MOD_NEK2_1	749	754	PF00069	0.455
MOD_NEK2_1	774	779	PF00069	0.690
MOD_NEK2_1	791	796	PF00069	0.483
MOD_NEK2_1	824	829	PF00069	0.397
MOD_NEK2_2	271	276	PF00069	0.671
MOD_NEK2_2	787	792	PF00069	0.468
MOD_PIKK_1	119	125	PF00454	0.762
MOD_PIKK_1	585	591	PF00454	0.525
MOD_PIKK_1	651	657	PF00454	0.588
MOD_PIKK_1	679	685	PF00454	0.567
MOD_PKA_1	229	235	PF00069	0.694
MOD_PKA_2	178	184	PF00069	0.591
MOD_PKA_2	18	24	PF00069	0.547
MOD_PKA_2	186	192	PF00069	0.661
MOD_PKA_2	194	200	PF00069	0.590
MOD_PKA_2	229	235	PF00069	0.722
MOD_PKA_2	240	246	PF00069	0.679
MOD_PKA_2	6	12	PF00069	0.738
MOD_PKA_2	651	657	PF00069	0.556
MOD_PKA_2	74	80	PF00069	0.573
MOD_PKA_2	791	797	PF00069	0.762
MOD_PKA_2	825	831	PF00069	0.547
MOD_PKA_2	916	922	PF00069	0.586
MOD_PKA_2	92	98	PF00069	0.433
MOD_Plk_1	125	131	PF00069	0.549
MOD_Plk_1	371	377	PF00069	0.614
MOD_Plk_1	497	503	PF00069	0.697
MOD_Plk_1	590	596	PF00069	0.653
MOD_Plk_1	724	730	PF00069	0.551
MOD_Plk_1	941	947	PF00069	0.508
MOD_Plk_4	150	156	PF00069	0.434
MOD_Plk_4	18	24	PF00069	0.622
MOD_Plk_4	251	257	PF00069	0.420
MOD_Plk_4	590	596	PF00069	0.553
MOD_Plk_4	727	733	PF00069	0.475
MOD_Plk_4	750	756	PF00069	0.432
MOD_ProDKin_1	117	123	PF00069	0.604
MOD_ProDKin_1	173	179	PF00069	0.690
MOD_ProDKin_1	182	188	PF00069	0.708
MOD_ProDKin_1	21	27	PF00069	0.603
MOD_ProDKin_1	214	220	PF00069	0.673
MOD_ProDKin_1	222	228	PF00069	0.640
MOD_ProDKin_1	264	270	PF00069	0.499
MOD_ProDKin_1	303	309	PF00069	0.510
MOD_ProDKin_1	383	389	PF00069	0.638
MOD_ProDKin_1	610	616	PF00069	0.542
MOD_ProDKin_1	63	69	PF00069	0.524
MOD_ProDKin_1	732	738	PF00069	0.482
MOD_ProDKin_1	95	101	PF00069	0.555
MOD_SUMO_for_1	536	539	PF00179	0.564
MOD_SUMO_for_1	59	62	PF00179	0.570
TRG_DiLeu_BaEn_1	346	351	PF01217	0.398
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.489
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.417
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.379
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.651
TRG_ENDOCYTIC_2	469	472	PF00928	0.319
TRG_ENDOCYTIC_2	541	544	PF00928	0.368
TRG_ENDOCYTIC_2	621	624	PF00928	0.605
TRG_ENDOCYTIC_2	629	632	PF00928	0.547
TRG_ENDOCYTIC_2	822	825	PF00928	0.471
TRG_ER_diArg_1	107	110	PF00400	0.617
TRG_ER_diArg_1	13	16	PF00400	0.586
TRG_ER_diArg_1	228	230	PF00400	0.621
TRG_ER_diArg_1	294	296	PF00400	0.624
TRG_ER_diArg_1	354	356	PF00400	0.344
TRG_ER_diArg_1	635	637	PF00400	0.602
TRG_ER_diArg_1	639	642	PF00400	0.565
TRG_ER_diArg_1	675	678	PF00400	0.715
TRG_ER_diArg_1	718	720	PF00400	0.555
TRG_ER_diArg_1	92	94	PF00400	0.476
TRG_NES_CRM1_1	349	362	PF08389	0.382
TRG_NES_CRM1_1	921	936	PF08389	0.470
TRG_NLS_MonoExtC_3	221	226	PF00514	0.492
TRG_NLS_MonoExtC_3	48	53	PF00514	0.534
TRG_NLS_MonoExtN_4	46	53	PF00514	0.536
TRG_NLS_MonoExtN_4	635	642	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	643	648	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	719	723	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ93	Leptomonas seymouri	61%	100%
A0A1X0NM18	Trypanosomatidae	41%	100%
A0A3Q8IFB6	Leishmania donovani	91%	100%
A0A422P200	Trypanosoma rangeli	39%	100%
A4HE52	Leishmania braziliensis	80%	100%
A4I1I0	Leishmania infantum	91%	100%
C9ZJY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q9V7	Leishmania major	91%	100%