Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXK9_LEIMU

TriTrypDb:

LmxM.25.1310

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.444
CLV_NRD_NRD_1	239	241	PF00675	0.443
CLV_NRD_NRD_1	3	5	PF00675	0.619
CLV_PCSK_KEX2_1	239	241	PF00082	0.443
CLV_PCSK_SKI1_1	240	244	PF00082	0.394
CLV_PCSK_SKI1_1	60	64	PF00082	0.441
DOC_CDC14_PxL_1	91	99	PF14671	0.443
DOC_USP7_MATH_1	122	126	PF00917	0.523
DOC_USP7_MATH_1	150	154	PF00917	0.565
DOC_USP7_MATH_1	168	172	PF00917	0.700
DOC_USP7_MATH_1	3	7	PF00917	0.627
DOC_USP7_MATH_1	35	39	PF00917	0.610
DOC_USP7_MATH_1	8	12	PF00917	0.588
DOC_WW_Pin1_4	174	179	PF00397	0.629
LIG_BRCT_BRCA1_1	5	9	PF00533	0.631
LIG_FHA_1	49	55	PF00498	0.519
LIG_FHA_1	99	105	PF00498	0.366
LIG_FHA_2	113	119	PF00498	0.493
LIG_FHA_2	220	226	PF00498	0.489
LIG_FHA_2	48	54	PF00498	0.488
LIG_Integrin_RGD_1	230	232	PF01839	0.464
LIG_LIR_Gen_1	80	88	PF02991	0.535
LIG_LIR_Nem_3	245	249	PF02991	0.488
LIG_LIR_Nem_3	88	94	PF02991	0.424
LIG_LYPXL_yS_3	246	249	PF13949	0.496
LIG_PALB2_WD40_1	86	94	PF16756	0.430
LIG_PDZ_Class_3	250	255	PF00595	0.584
LIG_SH2_GRB2like	55	58	PF00017	0.475
LIG_SH2_SRC	192	195	PF00017	0.429
LIG_SH2_STAT5	192	195	PF00017	0.404
LIG_SH2_STAT5	55	58	PF00017	0.411
LIG_SH3_3	241	247	PF00018	0.412
LIG_TRAF2_1	115	118	PF00917	0.349
LIG_TRAF2_1	56	59	PF00917	0.468
LIG_TYR_ITIM	244	249	PF00017	0.545
MOD_CK1_1	134	140	PF00069	0.674
MOD_CK1_1	148	154	PF00069	0.628
MOD_CK1_1	33	39	PF00069	0.598
MOD_CK1_1	77	83	PF00069	0.618
MOD_CK2_1	112	118	PF00069	0.483
MOD_CK2_1	53	59	PF00069	0.410
MOD_CK2_1	96	102	PF00069	0.400
MOD_GlcNHglycan	10	13	PF01048	0.677
MOD_GlcNHglycan	139	143	PF01048	0.732
MOD_GlcNHglycan	33	36	PF01048	0.625
MOD_GlcNHglycan	37	40	PF01048	0.613
MOD_GlcNHglycan	71	74	PF01048	0.644
MOD_GlcNHglycan	76	79	PF01048	0.541
MOD_GlcNHglycan	98	101	PF01048	0.411
MOD_GSK3_1	131	138	PF00069	0.629
MOD_GSK3_1	145	152	PF00069	0.706
MOD_GSK3_1	31	38	PF00069	0.613
MOD_N-GLC_2	156	158	PF02516	0.641
MOD_NEK2_1	62	67	PF00069	0.387
MOD_NEK2_1	69	74	PF00069	0.481
MOD_PIKK_1	62	68	PF00454	0.392
MOD_PKA_2	3	9	PF00069	0.629
MOD_PKA_2	83	89	PF00069	0.519
MOD_Plk_4	93	99	PF00069	0.497
MOD_ProDKin_1	174	180	PF00069	0.618
TRG_DiLeu_BaEn_2	57	63	PF01217	0.450
TRG_DiLeu_BaEn_3	188	194	PF01217	0.383
TRG_DiLeu_BaEn_4	58	64	PF01217	0.448
TRG_ENDOCYTIC_2	246	249	PF00928	0.556
TRG_ER_diArg_1	238	240	PF00400	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL9	Leptomonas seymouri	53%	95%
A0A1X0NMN4	Trypanosomatidae	31%	100%
A0A3Q8IBS1	Leishmania donovani	95%	100%
A4HE73	Leishmania braziliensis	77%	100%
A4I1H5	Leishmania infantum	94%	100%
Q4Q9W2	Leishmania major	93%	100%