Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PRP38 family, putative

Species:

Leishmania mexicana

UniProt:

E9AXK8_LEIMU

TriTrypDb:

LmxM.25.1300

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	3
GO:0032991	protein-containing complex	1	3
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	3
GO:1990904	ribonucleoprotein complex	2	3
GO:0071011	precatalytic spliceosome	4	2

Expansion

Sequence features

E9AXK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXK8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0008380	RNA splicing	7	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.482
CLV_C14_Caspase3-7	53	57	PF00656	0.639
CLV_C14_Caspase3-7	618	622	PF00656	0.555
CLV_NRD_NRD_1	115	117	PF00675	0.464
CLV_NRD_NRD_1	123	125	PF00675	0.469
CLV_NRD_NRD_1	367	369	PF00675	0.384
CLV_NRD_NRD_1	539	541	PF00675	0.592
CLV_NRD_NRD_1	631	633	PF00675	0.631
CLV_NRD_NRD_1	647	649	PF00675	0.480
CLV_NRD_NRD_1	651	653	PF00675	0.348
CLV_NRD_NRD_1	97	99	PF00675	0.435
CLV_PCSK_FUR_1	537	541	PF00082	0.425
CLV_PCSK_KEX2_1	115	117	PF00082	0.464
CLV_PCSK_KEX2_1	123	125	PF00082	0.469
CLV_PCSK_KEX2_1	262	264	PF00082	0.495
CLV_PCSK_KEX2_1	367	369	PF00082	0.384
CLV_PCSK_KEX2_1	537	539	PF00082	0.592
CLV_PCSK_KEX2_1	612	614	PF00082	0.593
CLV_PCSK_KEX2_1	631	633	PF00082	0.624
CLV_PCSK_KEX2_1	647	649	PF00082	0.480
CLV_PCSK_KEX2_1	97	99	PF00082	0.435
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.495
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.632
CLV_PCSK_PC7_1	111	117	PF00082	0.313
CLV_PCSK_SKI1_1	130	134	PF00082	0.529
CLV_PCSK_SKI1_1	263	267	PF00082	0.377
CLV_PCSK_SKI1_1	303	307	PF00082	0.582
CLV_PCSK_SKI1_1	316	320	PF00082	0.478
CLV_PCSK_SKI1_1	418	422	PF00082	0.455
CLV_PCSK_SKI1_1	605	609	PF00082	0.803
CLV_PCSK_SKI1_1	648	652	PF00082	0.549
CLV_Separin_Metazoa	264	268	PF03568	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DEG_SPOP_SBC_1	180	184	PF00917	0.681
DEG_SPOP_SBC_1	193	197	PF00917	0.620
DEG_SPOP_SBC_1	200	204	PF00917	0.533
DOC_ANK_TNKS_1	495	502	PF00023	0.605
DOC_CKS1_1	390	395	PF01111	0.394
DOC_CYCLIN_RxL_1	124	136	PF00134	0.335
DOC_CYCLIN_RxL_1	260	268	PF00134	0.442
DOC_CYCLIN_RxL_1	414	425	PF00134	0.468
DOC_CYCLIN_yClb1_LxF_4	603	608	PF00134	0.549
DOC_MAPK_gen_1	367	377	PF00069	0.350
DOC_MAPK_gen_1	631	642	PF00069	0.593
DOC_MAPK_MEF2A_6	368	377	PF00069	0.306
DOC_MAPK_MEF2A_6	635	644	PF00069	0.604
DOC_MAPK_NFAT4_5	635	643	PF00069	0.602
DOC_MAPK_RevD_3	524	540	PF00069	0.598
DOC_PP1_RVXF_1	603	609	PF00149	0.619
DOC_PP2B_LxvP_1	13	16	PF13499	0.335
DOC_PP4_FxxP_1	390	393	PF00568	0.317
DOC_PP4_FxxP_1	6	9	PF00568	0.408
DOC_USP7_MATH_1	178	182	PF00917	0.501
DOC_USP7_MATH_1	187	191	PF00917	0.670
DOC_USP7_MATH_1	192	196	PF00917	0.623
DOC_USP7_MATH_1	201	205	PF00917	0.545
DOC_USP7_MATH_1	35	39	PF00917	0.747
DOC_USP7_MATH_1	40	44	PF00917	0.500
DOC_USP7_MATH_1	432	436	PF00917	0.265
DOC_USP7_MATH_1	458	462	PF00917	0.604
DOC_USP7_MATH_1	469	473	PF00917	0.701
DOC_USP7_MATH_1	477	481	PF00917	0.676
DOC_USP7_MATH_1	607	611	PF00917	0.569
DOC_USP7_MATH_2	165	171	PF00917	0.416
DOC_WW_Pin1_4	194	199	PF00397	0.642
DOC_WW_Pin1_4	336	341	PF00397	0.378
DOC_WW_Pin1_4	389	394	PF00397	0.395
LIG_14-3-3_CanoR_1	283	289	PF00244	0.568
LIG_14-3-3_CanoR_1	350	356	PF00244	0.401
LIG_14-3-3_CanoR_1	379	383	PF00244	0.314
LIG_14-3-3_CanoR_1	647	651	PF00244	0.554
LIG_Actin_WH2_2	216	231	PF00022	0.406
LIG_APCC_ABBA_1	574	579	PF00400	0.678
LIG_BRCT_BRCA1_1	201	205	PF00533	0.425
LIG_BRCT_BRCA1_1	479	483	PF00533	0.616
LIG_Clathr_ClatBox_1	575	579	PF01394	0.641
LIG_CSL_BTD_1	429	432	PF09270	0.362
LIG_FHA_1	158	164	PF00498	0.540
LIG_FHA_1	206	212	PF00498	0.416
LIG_FHA_1	283	289	PF00498	0.491
LIG_FHA_1	390	396	PF00498	0.315
LIG_FHA_1	639	645	PF00498	0.560
LIG_FHA_1	91	97	PF00498	0.421
LIG_FHA_2	304	310	PF00498	0.548
LIG_FHA_2	352	358	PF00498	0.329
LIG_FHA_2	420	426	PF00498	0.471
LIG_FHA_2	46	52	PF00498	0.763
LIG_GBD_Chelix_1	343	351	PF00786	0.426
LIG_GBD_Chelix_1	369	377	PF00786	0.329
LIG_LIR_Gen_1	151	162	PF02991	0.514
LIG_LIR_Gen_1	208	214	PF02991	0.445
LIG_LIR_Gen_1	275	284	PF02991	0.274
LIG_LIR_Gen_1	385	395	PF02991	0.450
LIG_LIR_Gen_1	655	661	PF02991	0.515
LIG_LIR_Nem_3	151	157	PF02991	0.531
LIG_LIR_Nem_3	208	212	PF02991	0.449
LIG_LIR_Nem_3	275	280	PF02991	0.356
LIG_LIR_Nem_3	385	390	PF02991	0.446
LIG_LIR_Nem_3	428	433	PF02991	0.464
LIG_LIR_Nem_3	507	513	PF02991	0.615
LIG_LIR_Nem_3	655	661	PF02991	0.630
LIG_PCNA_PIPBox_1	355	364	PF02747	0.452
LIG_PCNA_yPIPBox_3	418	431	PF02747	0.449
LIG_PDZ_Class_2	656	661	PF00595	0.516
LIG_PTAP_UEV_1	197	202	PF05743	0.581
LIG_PTB_Apo_2	83	90	PF02174	0.431
LIG_PTB_Phospho_1	83	89	PF10480	0.425
LIG_Rb_LxCxE_1	397	417	PF01857	0.417
LIG_SH2_CRK	328	332	PF00017	0.446
LIG_SH2_NCK_1	380	384	PF00017	0.309
LIG_SH2_PTP2	232	235	PF00017	0.436
LIG_SH2_STAT3	321	324	PF00017	0.375
LIG_SH2_STAT5	209	212	PF00017	0.432
LIG_SH2_STAT5	22	25	PF00017	0.475
LIG_SH2_STAT5	232	235	PF00017	0.474
LIG_SH2_STAT5	245	248	PF00017	0.426
LIG_SH2_STAT5	321	324	PF00017	0.366
LIG_SH2_STAT5	376	379	PF00017	0.332
LIG_SH2_STAT5	380	383	PF00017	0.315
LIG_SH2_STAT5	387	390	PF00017	0.347
LIG_SH2_STAT5	658	661	PF00017	0.548
LIG_SH3_3	142	148	PF00018	0.469
LIG_SH3_3	195	201	PF00018	0.579
LIG_SH3_3	439	445	PF00018	0.473
LIG_SH3_3	523	529	PF00018	0.525
LIG_SH3_3	623	629	PF00018	0.589
LIG_SUMO_SIM_anti_2	557	568	PF11976	0.630
LIG_SUMO_SIM_anti_2	641	646	PF11976	0.550
LIG_TRAF2_1	26	29	PF00917	0.508
LIG_TRFH_1	380	384	PF08558	0.425
LIG_TYR_ITIM	326	331	PF00017	0.356
MOD_CK1_1	136	142	PF00069	0.612
MOD_CK1_1	181	187	PF00069	0.558
MOD_CK1_1	196	202	PF00069	0.591
MOD_CK1_1	282	288	PF00069	0.495
MOD_CK1_1	531	537	PF00069	0.552
MOD_CK1_1	60	66	PF00069	0.611
MOD_CK2_1	23	29	PF00069	0.602
MOD_CK2_1	275	281	PF00069	0.314
MOD_CK2_1	303	309	PF00069	0.506
MOD_CK2_1	45	51	PF00069	0.749
MOD_CK2_1	509	515	PF00069	0.677
MOD_Cter_Amidation	645	648	PF01082	0.615
MOD_GlcNHglycan	140	143	PF01048	0.665
MOD_GlcNHglycan	183	186	PF01048	0.565
MOD_GlcNHglycan	189	192	PF01048	0.571
MOD_GlcNHglycan	198	201	PF01048	0.487
MOD_GlcNHglycan	25	28	PF01048	0.611
MOD_GlcNHglycan	294	297	PF01048	0.520
MOD_GlcNHglycan	37	40	PF01048	0.627
MOD_GlcNHglycan	42	46	PF01048	0.646
MOD_GlcNHglycan	460	463	PF01048	0.460
MOD_GlcNHglycan	590	594	PF01048	0.694
MOD_GlcNHglycan	621	625	PF01048	0.657
MOD_GlcNHglycan	63	66	PF01048	0.637
MOD_GlcNHglycan	78	81	PF01048	0.516
MOD_GSK3_1	133	140	PF00069	0.624
MOD_GSK3_1	167	174	PF00069	0.495
MOD_GSK3_1	179	186	PF00069	0.592
MOD_GSK3_1	192	199	PF00069	0.710
MOD_GSK3_1	201	208	PF00069	0.551
MOD_GSK3_1	275	282	PF00069	0.387
MOD_GSK3_1	41	48	PF00069	0.735
MOD_GSK3_1	465	472	PF00069	0.621
MOD_GSK3_1	473	480	PF00069	0.626
MOD_GSK3_1	56	63	PF00069	0.668
MOD_N-GLC_1	56	61	PF02516	0.722
MOD_NEK2_1	171	176	PF00069	0.463
MOD_NEK2_1	205	210	PF00069	0.291
MOD_NEK2_1	265	270	PF00069	0.426
MOD_NEK2_1	41	46	PF00069	0.484
MOD_NEK2_1	449	454	PF00069	0.426
MOD_NEK2_1	638	643	PF00069	0.545
MOD_NEK2_2	646	651	PF00069	0.506
MOD_PIKK_1	254	260	PF00454	0.497
MOD_PIKK_1	469	475	PF00454	0.611
MOD_PIKK_1	477	483	PF00454	0.553
MOD_PKA_2	282	288	PF00069	0.411
MOD_PKA_2	292	298	PF00069	0.414
MOD_PKA_2	378	384	PF00069	0.369
MOD_PKA_2	646	652	PF00069	0.612
MOD_Plk_1	150	156	PF00069	0.411
MOD_Plk_2-3	275	281	PF00069	0.253
MOD_Plk_4	150	156	PF00069	0.540
MOD_Plk_4	205	211	PF00069	0.497
MOD_Plk_4	531	537	PF00069	0.545
MOD_Plk_4	640	646	PF00069	0.549
MOD_ProDKin_1	194	200	PF00069	0.640
MOD_ProDKin_1	336	342	PF00069	0.372
MOD_ProDKin_1	389	395	PF00069	0.393
TRG_DiLeu_BaEn_3	336	342	PF01217	0.449
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.459
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.504
TRG_ENDOCYTIC_2	209	212	PF00928	0.459
TRG_ENDOCYTIC_2	232	235	PF00928	0.436
TRG_ENDOCYTIC_2	328	331	PF00928	0.359
TRG_ENDOCYTIC_2	387	390	PF00928	0.421
TRG_ENDOCYTIC_2	658	661	PF00928	0.671
TRG_ER_diArg_1	114	116	PF00400	0.473
TRG_ER_diArg_1	123	125	PF00400	0.462
TRG_ER_diArg_1	366	368	PF00400	0.396
TRG_ER_diArg_1	536	539	PF00400	0.636
TRG_ER_diArg_1	631	633	PF00400	0.624
TRG_ER_diArg_1	96	98	PF00400	0.435
TRG_NLS_MonoExtN_4	609	616	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP9	Leptomonas seymouri	60%	100%
A0A1X0NM33	Trypanosomatidae	33%	100%
A0A3Q8IDC3	Leishmania donovani	92%	100%
A0A422P1Y9	Trypanosoma rangeli	33%	100%
A4HE72	Leishmania braziliensis	82%	100%
A4I1H4	Leishmania infantum	91%	100%
C9ZJZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q9W3	Leishmania major	91%	100%