MPN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NPL4 family, putative

Species:

Leishmania mexicana

UniProt:

E9AXK7_LEIMU

TriTrypDb:

LmxM.25.1290

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXK7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031625	ubiquitin protein ligase binding	5	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1
GO:0044389	ubiquitin-like protein ligase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.642
CLV_NRD_NRD_1	119	121	PF00675	0.503
CLV_NRD_NRD_1	181	183	PF00675	0.482
CLV_NRD_NRD_1	2	4	PF00675	0.438
CLV_NRD_NRD_1	220	222	PF00675	0.533
CLV_NRD_NRD_1	234	236	PF00675	0.558
CLV_NRD_NRD_1	375	377	PF00675	0.312
CLV_NRD_NRD_1	572	574	PF00675	0.312
CLV_PCSK_KEX2_1	119	121	PF00082	0.503
CLV_PCSK_KEX2_1	181	183	PF00082	0.552
CLV_PCSK_KEX2_1	219	221	PF00082	0.482
CLV_PCSK_KEX2_1	226	228	PF00082	0.492
CLV_PCSK_KEX2_1	375	377	PF00082	0.312
CLV_PCSK_KEX2_1	572	574	PF00082	0.287
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.586
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.312
CLV_PCSK_PC7_1	215	221	PF00082	0.558
CLV_PCSK_SKI1_1	367	371	PF00082	0.399
CLV_PCSK_SKI1_1	396	400	PF00082	0.322
CLV_PCSK_SKI1_1	515	519	PF00082	0.313
CLV_PCSK_SKI1_1	528	532	PF00082	0.246
CLV_PCSK_SKI1_1	545	549	PF00082	0.287
CLV_PCSK_SKI1_1	612	616	PF00082	0.385
DEG_APCC_DBOX_1	294	302	PF00400	0.481
DEG_SPOP_SBC_1	274	278	PF00917	0.616
DOC_CYCLIN_yCln2_LP_2	37	40	PF00134	0.435
DOC_MAPK_DCC_7	100	109	PF00069	0.465
DOC_MAPK_gen_1	3	14	PF00069	0.443
DOC_MAPK_gen_1	364	374	PF00069	0.599
DOC_MAPK_gen_1	569	578	PF00069	0.545
DOC_MAPK_gen_1	98	106	PF00069	0.512
DOC_MAPK_MEF2A_6	100	109	PF00069	0.465
DOC_MAPK_MEF2A_6	30	37	PF00069	0.446
DOC_MAPK_MEF2A_6	386	395	PF00069	0.533
DOC_MAPK_RevD_3	360	376	PF00069	0.533
DOC_PP1_RVXF_1	286	292	PF00149	0.470
DOC_PP2B_LxvP_1	22	25	PF13499	0.433
DOC_PP2B_LxvP_1	37	40	PF13499	0.400
DOC_PP2B_PxIxI_1	104	110	PF00149	0.441
DOC_PP2B_PxIxI_1	451	457	PF00149	0.533
DOC_PP4_FxxP_1	539	542	PF00568	0.550
DOC_PP4_MxPP_1	556	559	PF00568	0.512
DOC_USP7_MATH_1	152	156	PF00917	0.439
DOC_USP7_MATH_1	165	169	PF00917	0.444
DOC_USP7_MATH_1	207	211	PF00917	0.547
DOC_USP7_MATH_1	421	425	PF00917	0.550
DOC_USP7_MATH_1	438	442	PF00917	0.366
DOC_USP7_MATH_1	604	608	PF00917	0.527
DOC_WW_Pin1_4	128	133	PF00397	0.497
DOC_WW_Pin1_4	172	177	PF00397	0.502
DOC_WW_Pin1_4	228	233	PF00397	0.642
DOC_WW_Pin1_4	28	33	PF00397	0.452
DOC_WW_Pin1_4	446	451	PF00397	0.527
DOC_WW_Pin1_4	461	466	PF00397	0.545
DOC_WW_Pin1_4	476	481	PF00397	0.512
DOC_WW_Pin1_4	538	543	PF00397	0.550
LIG_14-3-3_CanoR_1	20	25	PF00244	0.437
LIG_14-3-3_CanoR_1	515	521	PF00244	0.471
LIG_14-3-3_CanoR_1	528	534	PF00244	0.496
LIG_14-3-3_CanoR_1	573	579	PF00244	0.479
LIG_14-3-3_CanoR_1	603	609	PF00244	0.550
LIG_14-3-3_CanoR_1	87	93	PF00244	0.513
LIG_Actin_WH2_2	361	377	PF00022	0.550
LIG_BRCT_BRCA1_1	114	118	PF00533	0.467
LIG_BRCT_BRCA1_1	166	170	PF00533	0.660
LIG_BRCT_BRCA1_1	22	26	PF00533	0.458
LIG_BRCT_BRCA1_1	252	256	PF00533	0.553
LIG_BRCT_BRCA1_1	574	578	PF00533	0.533
LIG_Clathr_ClatBox_1	298	302	PF01394	0.410
LIG_eIF4E_1	57	63	PF01652	0.442
LIG_FHA_1	133	139	PF00498	0.527
LIG_FHA_1	229	235	PF00498	0.638
LIG_FHA_1	269	275	PF00498	0.546
LIG_FHA_1	294	300	PF00498	0.438
LIG_FHA_1	332	338	PF00498	0.518
LIG_FHA_1	451	457	PF00498	0.599
LIG_FHA_1	496	502	PF00498	0.515
LIG_FHA_1	529	535	PF00498	0.502
LIG_FHA_2	504	510	PF00498	0.550
LIG_FHA_2	521	527	PF00498	0.550
LIG_FHA_2	579	585	PF00498	0.604
LIG_FHA_2	595	601	PF00498	0.454
LIG_LIR_Gen_1	253	264	PF02991	0.536
LIG_LIR_Gen_1	531	539	PF02991	0.512
LIG_LIR_Gen_1	584	592	PF02991	0.506
LIG_LIR_Nem_3	17	22	PF02991	0.451
LIG_LIR_Nem_3	23	29	PF02991	0.421
LIG_LIR_Nem_3	253	259	PF02991	0.516
LIG_LIR_Nem_3	351	357	PF02991	0.612
LIG_LIR_Nem_3	527	533	PF02991	0.490
LIG_LIR_Nem_3	55	60	PF02991	0.439
LIG_LIR_Nem_3	584	588	PF02991	0.506
LIG_LYPXL_L_2	56	65	PF13949	0.445
LIG_LYPXL_S_1	56	60	PF13949	0.437
LIG_MYND_1	36	40	PF01753	0.436
LIG_NRBOX	587	593	PF00104	0.599
LIG_Pex14_1	529	533	PF04695	0.512
LIG_Pex14_2	71	75	PF04695	0.451
LIG_Rb_pABgroove_1	324	332	PF01858	0.599
LIG_SH2_CRK	19	23	PF00017	0.446
LIG_SH2_CRK	323	327	PF00017	0.550
LIG_SH2_CRK	621	625	PF00017	0.560
LIG_SH2_NCK_1	330	334	PF00017	0.512
LIG_SH2_PTP2	533	536	PF00017	0.512
LIG_SH2_SRC	330	333	PF00017	0.599
LIG_SH2_SRC	46	49	PF00017	0.477
LIG_SH2_STAP1	245	249	PF00017	0.518
LIG_SH2_STAP1	323	327	PF00017	0.599
LIG_SH2_STAT5	352	355	PF00017	0.558
LIG_SH2_STAT5	533	536	PF00017	0.512
LIG_SH2_STAT5	567	570	PF00017	0.491
LIG_SH2_STAT5	590	593	PF00017	0.550
LIG_SH3_3	148	154	PF00018	0.463
LIG_SH3_3	30	36	PF00018	0.444
LIG_SH3_3	339	345	PF00018	0.497
LIG_SH3_3	37	43	PF00018	0.422
LIG_SH3_3	53	59	PF00018	0.429
LIG_SH3_3	551	557	PF00018	0.550
LIG_SUMO_SIM_par_1	451	457	PF11976	0.599
LIG_TYR_ITSM	529	536	PF00017	0.370
LIG_UBA3_1	187	191	PF00899	0.569
LIG_UBA3_1	255	263	PF00899	0.576
LIG_WRC_WIRS_1	309	314	PF05994	0.409
LIG_WW_1	43	46	PF00397	0.449
LIG_WW_2	40	43	PF00397	0.429
MOD_CDK_SPxxK_3	228	235	PF00069	0.638
MOD_CDK_SPxxK_3	538	545	PF00069	0.424
MOD_CK1_1	168	174	PF00069	0.596
MOD_CK1_1	268	274	PF00069	0.556
MOD_CK1_1	350	356	PF00069	0.399
MOD_CK1_1	424	430	PF00069	0.353
MOD_CK1_1	446	452	PF00069	0.468
MOD_CK1_1	86	92	PF00069	0.507
MOD_CK2_1	574	580	PF00069	0.399
MOD_CK2_1	595	601	PF00069	0.427
MOD_Cter_Amidation	1	4	PF01082	0.444
MOD_Cter_Amidation	179	182	PF01082	0.475
MOD_GlcNHglycan	147	150	PF01048	0.446
MOD_GlcNHglycan	205	208	PF01048	0.563
MOD_GlcNHglycan	252	255	PF01048	0.439
MOD_GlcNHglycan	426	429	PF01048	0.450
MOD_GlcNHglycan	431	434	PF01048	0.463
MOD_GlcNHglycan	445	448	PF01048	0.277
MOD_GlcNHglycan	509	513	PF01048	0.393
MOD_GlcNHglycan	83	86	PF01048	0.482
MOD_GSK3_1	108	115	PF00069	0.444
MOD_GSK3_1	128	135	PF00069	0.423
MOD_GSK3_1	154	161	PF00069	0.559
MOD_GSK3_1	164	171	PF00069	0.571
MOD_GSK3_1	191	198	PF00069	0.607
MOD_GSK3_1	203	210	PF00069	0.581
MOD_GSK3_1	265	272	PF00069	0.475
MOD_GSK3_1	424	431	PF00069	0.405
MOD_GSK3_1	446	453	PF00069	0.399
MOD_GSK3_1	48	55	PF00069	0.734
MOD_GSK3_1	515	522	PF00069	0.368
MOD_GSK3_1	524	531	PF00069	0.335
MOD_GSK3_1	574	581	PF00069	0.401
MOD_GSK3_1	590	597	PF00069	0.391
MOD_GSK3_1	604	611	PF00069	0.314
MOD_GSK3_1	81	88	PF00069	0.492
MOD_LATS_1	513	519	PF00433	0.424
MOD_N-GLC_1	203	208	PF02516	0.543
MOD_N-GLC_2	248	250	PF02516	0.524
MOD_NEK2_1	516	521	PF00069	0.213
MOD_NEK2_1	549	554	PF00069	0.384
MOD_NEK2_1	578	583	PF00069	0.399
MOD_NEK2_2	105	110	PF00069	0.436
MOD_NEK2_2	154	159	PF00069	0.544
MOD_NEK2_2	165	170	PF00069	0.699
MOD_NEK2_2	66	71	PF00069	0.476
MOD_OFUCOSY	11	18	PF10250	0.452
MOD_OFUCOSY	153	158	PF10250	0.448
MOD_PIKK_1	126	132	PF00454	0.503
MOD_PIKK_1	293	299	PF00454	0.498
MOD_PIKK_1	590	596	PF00454	0.424
MOD_PKA_1	572	578	PF00069	0.399
MOD_PKA_2	138	144	PF00069	0.552
MOD_PKA_2	165	171	PF00069	0.749
MOD_PKA_2	549	555	PF00069	0.370
MOD_PKA_2	572	578	PF00069	0.403
MOD_PKA_2	81	87	PF00069	0.485
MOD_PKB_1	110	118	PF00069	0.435
MOD_Plk_1	284	290	PF00069	0.476
MOD_Plk_1	403	409	PF00069	0.360
MOD_Plk_4	165	171	PF00069	0.646
MOD_Plk_4	265	271	PF00069	0.480
MOD_Plk_4	308	314	PF00069	0.411
MOD_Plk_4	450	456	PF00069	0.427
MOD_Plk_4	529	535	PF00069	0.356
MOD_Plk_4	66	72	PF00069	0.476
MOD_ProDKin_1	128	134	PF00069	0.495
MOD_ProDKin_1	172	178	PF00069	0.501
MOD_ProDKin_1	228	234	PF00069	0.638
MOD_ProDKin_1	28	34	PF00069	0.452
MOD_ProDKin_1	446	452	PF00069	0.392
MOD_ProDKin_1	461	467	PF00069	0.416
MOD_ProDKin_1	476	482	PF00069	0.370
MOD_ProDKin_1	538	544	PF00069	0.424
MOD_SUMO_rev_2	258	264	PF00179	0.475
TRG_DiLeu_BaEn_3	101	107	PF01217	0.478
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.602
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.458
TRG_ENDOCYTIC_2	19	22	PF00928	0.450
TRG_ENDOCYTIC_2	323	326	PF00928	0.424
TRG_ENDOCYTIC_2	533	536	PF00928	0.370
TRG_ENDOCYTIC_2	57	60	PF00928	0.435
TRG_ENDOCYTIC_2	621	624	PF00928	0.483
TRG_ER_diArg_1	109	112	PF00400	0.417
TRG_ER_diArg_1	118	120	PF00400	0.468
TRG_ER_diArg_1	181	183	PF00400	0.482
TRG_ER_diArg_1	219	221	PF00400	0.517
TRG_ER_diArg_1	374	376	PF00400	0.370
TRG_ER_diArg_1	7	10	PF00400	0.449
TRG_NES_CRM1_1	389	404	PF08389	0.399
TRG_NES_CRM1_1	580	594	PF08389	0.424
TRG_NLS_MonoExtN_4	569	576	PF00514	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H2	Leptomonas seymouri	72%	100%
A0A3S7WZ51	Leishmania donovani	94%	100%
A4HE71	Leishmania braziliensis	87%	100%
C9ZK00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q9W4	Leishmania major	82%	100%