Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXK5_LEIMU

TriTrypDb:

LmxM.25.1270

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.535
CLV_NRD_NRD_1	135	137	PF00675	0.694
CLV_NRD_NRD_1	184	186	PF00675	0.715
CLV_NRD_NRD_1	253	255	PF00675	0.613
CLV_NRD_NRD_1	388	390	PF00675	0.452
CLV_NRD_NRD_1	62	64	PF00675	0.522
CLV_NRD_NRD_1	99	101	PF00675	0.534
CLV_PCSK_KEX2_1	135	137	PF00082	0.694
CLV_PCSK_KEX2_1	161	163	PF00082	0.365
CLV_PCSK_KEX2_1	184	186	PF00082	0.635
CLV_PCSK_KEX2_1	253	255	PF00082	0.614
CLV_PCSK_KEX2_1	308	310	PF00082	0.576
CLV_PCSK_KEX2_1	387	389	PF00082	0.457
CLV_PCSK_KEX2_1	62	64	PF00082	0.522
CLV_PCSK_KEX2_1	99	101	PF00082	0.534
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.365
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.576
CLV_PCSK_PC7_1	384	390	PF00082	0.545
CLV_PCSK_SKI1_1	238	242	PF00082	0.402
CLV_PCSK_SKI1_1	309	313	PF00082	0.569
CLV_PCSK_SKI1_1	80	84	PF00082	0.450
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DEG_SCF_FBW7_1	278	284	PF00400	0.693
DEG_SCF_FBW7_1	408	414	PF00400	0.605
DEG_SPOP_SBC_1	412	416	PF00917	0.536
DEG_SPOP_SBC_1	481	485	PF00917	0.798
DOC_CKS1_1	120	125	PF01111	0.534
DOC_CKS1_1	278	283	PF01111	0.691
DOC_CKS1_1	408	413	PF01111	0.601
DOC_CKS1_1	442	447	PF01111	0.654
DOC_USP7_MATH_1	15	19	PF00917	0.519
DOC_USP7_MATH_1	173	177	PF00917	0.549
DOC_USP7_MATH_1	214	218	PF00917	0.645
DOC_USP7_MATH_1	262	266	PF00917	0.626
DOC_USP7_MATH_1	279	283	PF00917	0.645
DOC_USP7_MATH_1	324	328	PF00917	0.562
DOC_USP7_MATH_1	411	415	PF00917	0.683
DOC_USP7_MATH_1	450	454	PF00917	0.679
DOC_USP7_MATH_1	481	485	PF00917	0.729
DOC_USP7_MATH_1	91	95	PF00917	0.408
DOC_WW_Pin1_4	115	120	PF00397	0.698
DOC_WW_Pin1_4	129	134	PF00397	0.694
DOC_WW_Pin1_4	200	205	PF00397	0.715
DOC_WW_Pin1_4	215	220	PF00397	0.654
DOC_WW_Pin1_4	221	226	PF00397	0.646
DOC_WW_Pin1_4	248	253	PF00397	0.438
DOC_WW_Pin1_4	268	273	PF00397	0.824
DOC_WW_Pin1_4	277	282	PF00397	0.669
DOC_WW_Pin1_4	407	412	PF00397	0.730
DOC_WW_Pin1_4	413	418	PF00397	0.605
DOC_WW_Pin1_4	441	446	PF00397	0.667
DOC_WW_Pin1_4	459	464	PF00397	0.727
DOC_WW_Pin1_4	87	92	PF00397	0.476
LIG_14-3-3_CanoR_1	135	139	PF00244	0.684
LIG_14-3-3_CanoR_1	162	167	PF00244	0.515
LIG_14-3-3_CanoR_1	174	178	PF00244	0.573
LIG_14-3-3_CanoR_1	213	219	PF00244	0.828
LIG_14-3-3_CanoR_1	227	236	PF00244	0.323
LIG_14-3-3_CanoR_1	242	248	PF00244	0.349
LIG_14-3-3_CanoR_1	290	300	PF00244	0.790
LIG_14-3-3_CanoR_1	309	318	PF00244	0.378
LIG_14-3-3_CanoR_1	457	466	PF00244	0.538
LIG_BRCT_BRCA1_1	19	23	PF00533	0.523
LIG_BRCT_BRCA1_1	5	9	PF00533	0.514
LIG_CaM_IQ_9	376	391	PF13499	0.547
LIG_FHA_1	191	197	PF00498	0.497
LIG_FHA_1	342	348	PF00498	0.579
LIG_FHA_1	68	74	PF00498	0.505
LIG_FHA_2	293	299	PF00498	0.630
LIG_FHA_2	486	492	PF00498	0.709
LIG_FHA_2	495	501	PF00498	0.699
LIG_Integrin_RGD_1	37	39	PF01839	0.603
LIG_LIR_Apic_2	68	74	PF02991	0.446
LIG_LIR_Gen_1	154	163	PF02991	0.462
LIG_LIR_Gen_1	175	183	PF02991	0.504
LIG_LIR_Gen_1	297	307	PF02991	0.628
LIG_LIR_Gen_1	499	509	PF02991	0.583
LIG_LIR_Gen_1	6	16	PF02991	0.491
LIG_LIR_Nem_3	154	158	PF02991	0.472
LIG_LIR_Nem_3	175	181	PF02991	0.498
LIG_LIR_Nem_3	20	26	PF02991	0.562
LIG_LIR_Nem_3	233	239	PF02991	0.353
LIG_LIR_Nem_3	297	303	PF02991	0.649
LIG_LIR_Nem_3	6	12	PF02991	0.484
LIG_Pex14_2	12	16	PF04695	0.511
LIG_Pex14_2	236	240	PF04695	0.309
LIG_REV1ctd_RIR_1	233	242	PF16727	0.358
LIG_SH2_CRK	163	167	PF00017	0.419
LIG_SH2_CRK	71	75	PF00017	0.480
LIG_SH2_SRC	26	29	PF00017	0.513
LIG_SH2_STAT5	239	242	PF00017	0.343
LIG_SH2_STAT5	26	29	PF00017	0.571
LIG_SH2_STAT5	71	74	PF00017	0.395
LIG_SH3_1	71	77	PF00018	0.446
LIG_SH3_3	117	123	PF00018	0.493
LIG_SH3_3	135	141	PF00018	0.711
LIG_SH3_3	213	219	PF00018	0.647
LIG_SH3_3	269	275	PF00018	0.742
LIG_SH3_3	414	420	PF00018	0.646
LIG_SH3_3	439	445	PF00018	0.719
LIG_SH3_3	460	466	PF00018	0.706
LIG_SH3_3	71	77	PF00018	0.484
LIG_TRAF2_1	144	147	PF00917	0.488
LIG_TRAF2_1	496	499	PF00917	0.547
LIG_TYR_ITIM	153	158	PF00017	0.476
MOD_CDC14_SPxK_1	251	254	PF00782	0.403
MOD_CDK_SPK_2	248	253	PF00069	0.365
MOD_CDK_SPxK_1	119	125	PF00069	0.568
MOD_CDK_SPxK_1	129	135	PF00069	0.677
MOD_CDK_SPxK_1	221	227	PF00069	0.712
MOD_CDK_SPxK_1	248	254	PF00069	0.373
MOD_CDK_SPxxK_3	129	136	PF00069	0.678
MOD_CK1_1	217	223	PF00069	0.791
MOD_CK1_1	263	269	PF00069	0.705
MOD_CK1_1	271	277	PF00069	0.724
MOD_CK1_1	291	297	PF00069	0.500
MOD_CK1_1	3	9	PF00069	0.554
MOD_CK1_1	334	340	PF00069	0.662
MOD_CK1_1	427	433	PF00069	0.655
MOD_CK1_1	479	485	PF00069	0.803
MOD_CK1_1	494	500	PF00069	0.540
MOD_CK1_1	90	96	PF00069	0.413
MOD_CK2_1	109	115	PF00069	0.686
MOD_CK2_1	228	234	PF00069	0.464
MOD_CK2_1	292	298	PF00069	0.597
MOD_CK2_1	334	340	PF00069	0.611
MOD_CK2_1	392	398	PF00069	0.381
MOD_CK2_1	504	510	PF00069	0.618
MOD_GlcNHglycan	19	22	PF01048	0.491
MOD_GlcNHglycan	220	223	PF01048	0.773
MOD_GlcNHglycan	262	265	PF01048	0.636
MOD_GlcNHglycan	266	269	PF01048	0.584
MOD_GlcNHglycan	314	317	PF01048	0.495
MOD_GlcNHglycan	336	339	PF01048	0.611
MOD_GlcNHglycan	394	397	PF01048	0.512
MOD_GlcNHglycan	453	456	PF01048	0.756
MOD_GlcNHglycan	459	462	PF01048	0.656
MOD_GlcNHglycan	488	491	PF01048	0.724
MOD_GlcNHglycan	493	496	PF01048	0.660
MOD_GlcNHglycan	93	96	PF01048	0.442
MOD_GSK3_1	107	114	PF00069	0.676
MOD_GSK3_1	115	122	PF00069	0.782
MOD_GSK3_1	173	180	PF00069	0.566
MOD_GSK3_1	214	221	PF00069	0.675
MOD_GSK3_1	260	267	PF00069	0.693
MOD_GSK3_1	273	280	PF00069	0.733
MOD_GSK3_1	288	295	PF00069	0.772
MOD_GSK3_1	3	10	PF00069	0.498
MOD_GSK3_1	341	348	PF00069	0.750
MOD_GSK3_1	407	414	PF00069	0.729
MOD_GSK3_1	476	483	PF00069	0.740
MOD_GSK3_1	494	501	PF00069	0.594
MOD_GSK3_1	87	94	PF00069	0.426
MOD_NEK2_1	241	246	PF00069	0.384
MOD_PIKK_1	241	247	PF00454	0.444
MOD_PIKK_1	3	9	PF00454	0.522
MOD_PKA_2	134	140	PF00069	0.680
MOD_PKA_2	173	179	PF00069	0.591
MOD_PKA_2	228	234	PF00069	0.443
MOD_PKA_2	241	247	PF00069	0.338
MOD_PKA_2	291	297	PF00069	0.763
MOD_PKA_2	334	340	PF00069	0.584
MOD_PKA_2	435	441	PF00069	0.638
MOD_PKB_1	290	298	PF00069	0.724
MOD_Plk_1	424	430	PF00069	0.681
MOD_Plk_1	498	504	PF00069	0.625
MOD_Plk_1	67	73	PF00069	0.569
MOD_Plk_2-3	345	351	PF00069	0.617
MOD_Plk_4	162	168	PF00069	0.495
MOD_Plk_4	173	179	PF00069	0.672
MOD_Plk_4	324	330	PF00069	0.546
MOD_Plk_4	371	377	PF00069	0.422
MOD_Plk_4	498	504	PF00069	0.730
MOD_ProDKin_1	115	121	PF00069	0.697
MOD_ProDKin_1	129	135	PF00069	0.694
MOD_ProDKin_1	200	206	PF00069	0.713
MOD_ProDKin_1	215	221	PF00069	0.655
MOD_ProDKin_1	248	254	PF00069	0.446
MOD_ProDKin_1	268	274	PF00069	0.825
MOD_ProDKin_1	277	283	PF00069	0.671
MOD_ProDKin_1	407	413	PF00069	0.734
MOD_ProDKin_1	441	447	PF00069	0.669
MOD_ProDKin_1	459	465	PF00069	0.728
MOD_ProDKin_1	87	93	PF00069	0.469
MOD_SUMO_for_1	16	19	PF00179	0.521
MOD_SUMO_rev_2	349	359	PF00179	0.692
MOD_SUMO_rev_2	395	402	PF00179	0.345
TRG_AP2beta_CARGO_1	237	247	PF09066	0.330
TRG_DiLeu_BaEn_2	18	24	PF01217	0.524
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.393
TRG_ENDOCYTIC_2	155	158	PF00928	0.506
TRG_ENDOCYTIC_2	163	166	PF00928	0.392
TRG_ER_diArg_1	149	152	PF00400	0.370
TRG_ER_diArg_1	184	186	PF00400	0.639
TRG_ER_diArg_1	227	230	PF00400	0.515
TRG_ER_diArg_1	252	254	PF00400	0.606
TRG_ER_diArg_1	387	389	PF00400	0.497
TRG_ER_diArg_1	61	63	PF00400	0.522
TRG_ER_diArg_1	98	100	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC05	Leptomonas seymouri	47%	94%
A0A1X0NLY0	Trypanosomatidae	27%	100%
A0A3R7NU60	Trypanosoma rangeli	28%	100%
A0A3S7WZ41	Leishmania donovani	89%	100%
A4HE69	Leishmania braziliensis	66%	98%
A4I1H1	Leishmania infantum	89%	100%
Q4Q9W6	Leishmania major	90%	100%