RNA_lig_T4_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXK1_LEIMU

TriTrypDb:

LmxM.25.1220

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005846	nuclear cap binding complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0034518	RNA cap binding complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXK1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	373	377	PF00656	0.398
CLV_C14_Caspase3-7	473	477	PF00656	0.492
CLV_NRD_NRD_1	124	126	PF00675	0.475
CLV_NRD_NRD_1	175	177	PF00675	0.375
CLV_NRD_NRD_1	191	193	PF00675	0.184
CLV_NRD_NRD_1	311	313	PF00675	0.427
CLV_NRD_NRD_1	370	372	PF00675	0.397
CLV_NRD_NRD_1	427	429	PF00675	0.389
CLV_NRD_NRD_1	44	46	PF00675	0.402
CLV_NRD_NRD_1	90	92	PF00675	0.447
CLV_PCSK_FUR_1	42	46	PF00082	0.413
CLV_PCSK_KEX2_1	177	179	PF00082	0.346
CLV_PCSK_KEX2_1	311	313	PF00082	0.428
CLV_PCSK_KEX2_1	369	371	PF00082	0.394
CLV_PCSK_KEX2_1	427	429	PF00082	0.407
CLV_PCSK_KEX2_1	44	46	PF00082	0.420
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.336
CLV_PCSK_PC7_1	173	179	PF00082	0.449
CLV_PCSK_PC7_1	365	371	PF00082	0.449
CLV_PCSK_SKI1_1	114	118	PF00082	0.439
CLV_PCSK_SKI1_1	199	203	PF00082	0.363
CLV_PCSK_SKI1_1	209	213	PF00082	0.449
CLV_PCSK_SKI1_1	275	279	PF00082	0.414
CLV_PCSK_SKI1_1	311	315	PF00082	0.449
CLV_PCSK_SKI1_1	352	356	PF00082	0.449
CLV_PCSK_SKI1_1	365	369	PF00082	0.413
CLV_PCSK_SKI1_1	44	48	PF00082	0.318
CLV_PCSK_SKI1_1	440	444	PF00082	0.357
CLV_PCSK_SKI1_1	599	603	PF00082	0.372
DEG_APCC_DBOX_1	351	359	PF00400	0.439
DEG_APCC_DBOX_1	598	606	PF00400	0.385
DEG_Nend_UBRbox_1	1	4	PF02207	0.449
DEG_SPOP_SBC_1	384	388	PF00917	0.470
DOC_CKS1_1	526	531	PF01111	0.475
DOC_CYCLIN_RxL_1	193	206	PF00134	0.449
DOC_CYCLIN_RxL_1	39	51	PF00134	0.346
DOC_MAPK_gen_1	39	48	PF00069	0.449
DOC_MAPK_gen_1	91	98	PF00069	0.475
DOC_MAPK_MEF2A_6	397	405	PF00069	0.423
DOC_MAPK_MEF2A_6	91	100	PF00069	0.359
DOC_PP2B_LxvP_1	409	412	PF13499	0.344
DOC_PP2B_LxvP_1	562	565	PF13499	0.449
DOC_USP7_MATH_1	384	388	PF00917	0.446
DOC_USP7_MATH_1	449	453	PF00917	0.458
DOC_WW_Pin1_4	210	215	PF00397	0.490
DOC_WW_Pin1_4	324	329	PF00397	0.328
DOC_WW_Pin1_4	390	395	PF00397	0.478
DOC_WW_Pin1_4	525	530	PF00397	0.343
DOC_WW_Pin1_4	544	549	PF00397	0.468
DOC_WW_Pin1_4	575	580	PF00397	0.317
DOC_WW_Pin1_4	82	87	PF00397	0.367
LIG_14-3-3_CanoR_1	275	280	PF00244	0.478
LIG_14-3-3_CanoR_1	292	296	PF00244	0.433
LIG_14-3-3_CanoR_1	347	355	PF00244	0.449
LIG_14-3-3_CanoR_1	440	448	PF00244	0.353
LIG_14-3-3_CanoR_1	492	501	PF00244	0.415
LIG_APCC_ABBA_1	56	61	PF00400	0.377
LIG_BRCT_BRCA1_1	285	289	PF00533	0.437
LIG_CtBP_PxDLS_1	134	140	PF00389	0.344
LIG_eIF4E_1	436	442	PF01652	0.449
LIG_FHA_1	130	136	PF00498	0.435
LIG_FHA_1	333	339	PF00498	0.449
LIG_FHA_1	400	406	PF00498	0.409
LIG_FHA_1	417	423	PF00498	0.224
LIG_FHA_1	526	532	PF00498	0.398
LIG_FHA_1	569	575	PF00498	0.386
LIG_FHA_2	325	331	PF00498	0.328
LIG_Integrin_RGD_1	567	569	PF01839	0.398
LIG_LIR_Gen_1	221	232	PF02991	0.302
LIG_LIR_Gen_1	259	267	PF02991	0.455
LIG_LIR_Gen_1	3	12	PF02991	0.319
LIG_LIR_Gen_1	37	48	PF02991	0.328
LIG_LIR_Gen_1	557	566	PF02991	0.357
LIG_LIR_Nem_3	110	116	PF02991	0.449
LIG_LIR_Nem_3	155	161	PF02991	0.475
LIG_LIR_Nem_3	221	227	PF02991	0.404
LIG_LIR_Nem_3	259	263	PF02991	0.455
LIG_LIR_Nem_3	3	7	PF02991	0.319
LIG_LIR_Nem_3	37	43	PF02991	0.328
LIG_LIR_Nem_3	557	562	PF02991	0.375
LIG_LYPXL_yS_3	93	96	PF13949	0.413
LIG_MYND_3	248	252	PF01753	0.300
LIG_NRBOX	42	48	PF00104	0.344
LIG_PCNA_PIPBox_1	194	203	PF02747	0.398
LIG_PCNA_yPIPBox_3	189	202	PF02747	0.413
LIG_PDZ_Class_3	605	610	PF00595	0.398
LIG_SH2_CRK	260	264	PF00017	0.475
LIG_SH2_CRK	436	440	PF00017	0.449
LIG_SH2_CRK	559	563	PF00017	0.449
LIG_SH2_PTP2	224	227	PF00017	0.363
LIG_SH2_PTP2	593	596	PF00017	0.363
LIG_SH2_STAP1	334	338	PF00017	0.475
LIG_SH2_STAP1	559	563	PF00017	0.407
LIG_SH2_STAP1	65	69	PF00017	0.328
LIG_SH2_STAT5	224	227	PF00017	0.363
LIG_SH2_STAT5	334	337	PF00017	0.434
LIG_SH2_STAT5	410	413	PF00017	0.410
LIG_SH2_STAT5	421	424	PF00017	0.375
LIG_SH2_STAT5	593	596	PF00017	0.344
LIG_SH3_1	103	109	PF00018	0.449
LIG_SH3_2	86	91	PF14604	0.475
LIG_SH3_3	103	109	PF00018	0.367
LIG_SH3_3	523	529	PF00018	0.371
LIG_SH3_3	534	540	PF00018	0.383
LIG_SH3_3	589	595	PF00018	0.433
LIG_SH3_3	83	89	PF00018	0.413
LIG_Sin3_3	451	458	PF02671	0.475
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.385
LIG_SUMO_SIM_par_1	539	545	PF11976	0.403
LIG_SUMO_SIM_par_1	580	585	PF11976	0.184
LIG_TRAF2_1	228	231	PF00917	0.449
LIG_TRAF2_1	478	481	PF00917	0.475
LIG_TRAF2_1	552	555	PF00917	0.354
LIG_TRFH_1	13	17	PF08558	0.344
LIG_TYR_ITIM	38	43	PF00017	0.449
LIG_UBA3_1	14	23	PF00899	0.449
LIG_UBA3_1	55	63	PF00899	0.449
LIG_WRC_WIRS_1	1	6	PF05994	0.385
LIG_WRPW_2	113	116	PF00400	0.398
MOD_CDK_SPxxK_3	324	331	PF00069	0.328
MOD_CDK_SPxxK_3	390	397	PF00069	0.386
MOD_CDK_SPxxK_3	544	551	PF00069	0.475
MOD_CK1_1	304	310	PF00069	0.475
MOD_CK1_1	385	391	PF00069	0.423
MOD_CK1_1	392	398	PF00069	0.385
MOD_CK1_1	493	499	PF00069	0.434
MOD_CK1_1	557	563	PF00069	0.449
MOD_CK2_1	200	206	PF00069	0.475
MOD_CK2_1	225	231	PF00069	0.363
MOD_CK2_1	324	330	PF00069	0.328
MOD_CK2_1	597	603	PF00069	0.460
MOD_CK2_1	69	75	PF00069	0.344
MOD_Cter_Amidation	309	312	PF01082	0.475
MOD_Cter_Amidation	425	428	PF01082	0.449
MOD_Cter_Amidation	89	92	PF01082	0.475
MOD_GlcNHglycan	203	206	PF01048	0.469
MOD_GlcNHglycan	227	230	PF01048	0.487
MOD_GlcNHglycan	349	352	PF01048	0.445
MOD_GlcNHglycan	443	446	PF01048	0.369
MOD_GlcNHglycan	449	452	PF01048	0.363
MOD_GlcNHglycan	472	475	PF01048	0.363
MOD_GlcNHglycan	495	498	PF01048	0.421
MOD_GlcNHglycan	508	511	PF01048	0.397
MOD_GlcNHglycan	51	54	PF01048	0.336
MOD_GlcNHglycan	544	547	PF01048	0.445
MOD_GSK3_1	379	386	PF00069	0.459
MOD_GSK3_1	388	395	PF00069	0.279
MOD_GSK3_1	443	450	PF00069	0.482
MOD_GSK3_1	504	511	PF00069	0.475
MOD_GSK3_1	554	561	PF00069	0.413
MOD_N-GLC_2	346	348	PF02516	0.449
MOD_NEK2_1	129	134	PF00069	0.344
MOD_NEK2_1	159	164	PF00069	0.374
MOD_NEK2_1	244	249	PF00069	0.397
MOD_NEK2_1	358	363	PF00069	0.449
MOD_NEK2_1	441	446	PF00069	0.377
MOD_NEK2_1	447	452	PF00069	0.384
MOD_NEK2_1	490	495	PF00069	0.482
MOD_NEK2_1	558	563	PF00069	0.453
MOD_NEK2_1	574	579	PF00069	0.210
MOD_NEK2_1	597	602	PF00069	0.481
MOD_OFUCOSY	157	163	PF10250	0.385
MOD_PIKK_1	233	239	PF00454	0.458
MOD_PIKK_1	332	338	PF00454	0.449
MOD_PIKK_1	585	591	PF00454	0.449
MOD_PKA_1	369	375	PF00069	0.451
MOD_PKA_2	188	194	PF00069	0.437
MOD_PKA_2	291	297	PF00069	0.437
MOD_PKA_2	369	375	PF00069	0.415
MOD_Plk_1	220	226	PF00069	0.367
MOD_Plk_1	301	307	PF00069	0.332
MOD_Plk_1	416	422	PF00069	0.357
MOD_Plk_1	554	560	PF00069	0.364
MOD_Plk_1	582	588	PF00069	0.413
MOD_Plk_4	220	226	PF00069	0.435
MOD_Plk_4	443	449	PF00069	0.449
MOD_Plk_4	554	560	PF00069	0.399
MOD_ProDKin_1	210	216	PF00069	0.490
MOD_ProDKin_1	324	330	PF00069	0.328
MOD_ProDKin_1	390	396	PF00069	0.478
MOD_ProDKin_1	525	531	PF00069	0.343
MOD_ProDKin_1	544	550	PF00069	0.468
MOD_ProDKin_1	575	581	PF00069	0.317
MOD_ProDKin_1	82	88	PF00069	0.367
TRG_DiLeu_BaEn_1	230	235	PF01217	0.344
TRG_DiLeu_BaEn_4	230	236	PF01217	0.475
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.437
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.413
TRG_ENDOCYTIC_2	113	116	PF00928	0.145
TRG_ENDOCYTIC_2	224	227	PF00928	0.377
TRG_ENDOCYTIC_2	260	263	PF00928	0.475
TRG_ENDOCYTIC_2	40	43	PF00928	0.315
TRG_ENDOCYTIC_2	436	439	PF00928	0.430
TRG_ENDOCYTIC_2	468	471	PF00928	0.410
TRG_ENDOCYTIC_2	559	562	PF00928	0.449
TRG_ENDOCYTIC_2	593	596	PF00928	0.330
TRG_ENDOCYTIC_2	93	96	PF00928	0.385
TRG_ER_diArg_1	139	142	PF00400	0.344
TRG_ER_diArg_1	175	178	PF00400	0.342
TRG_ER_diArg_1	311	313	PF00400	0.374
TRG_ER_diArg_1	368	371	PF00400	0.393
TRG_ER_diArg_1	42	45	PF00400	0.400
TRG_ER_diArg_1	427	430	PF00400	0.449
TRG_ER_diArg_1	96	99	PF00400	0.382
TRG_NLS_MonoCore_2	176	181	PF00514	0.344
TRG_NLS_MonoExtC_3	175	180	PF00514	0.364
TRG_NLS_MonoExtN_4	173	180	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II50	Leptomonas seymouri	57%	93%
A0A0S4J8F6	Bodo saltans	33%	100%
A0A1X0NNM1	Trypanosomatidae	38%	97%
A0A3Q8IDG9	Leishmania donovani	93%	100%
A0A422P1X4	Trypanosoma rangeli	42%	100%
A4HE65	Leishmania braziliensis	81%	100%
A4I1G5	Leishmania infantum	93%	100%
C9ZK06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q9X1	Leishmania major	92%	100%
V5D8Y9	Trypanosoma cruzi	43%	100%