Modification methylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

modification methylase-like protein

Species:

Leishmania mexicana

UniProt:

E9AXJ9_LEIMU

TriTrypDb:

LmxM.25.1200

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXJ9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	5	6
GO:0008168	methyltransferase activity	4	7
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0009008	DNA-methyltransferase activity	4	6
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	7
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.644
CLV_C14_Caspase3-7	218	222	PF00656	0.833
CLV_C14_Caspase3-7	61	65	PF00656	0.700
CLV_C14_Caspase3-7	792	796	PF00656	0.808
CLV_NRD_NRD_1	242	244	PF00675	0.625
CLV_NRD_NRD_1	43	45	PF00675	0.626
CLV_NRD_NRD_1	520	522	PF00675	0.294
CLV_NRD_NRD_1	556	558	PF00675	0.341
CLV_NRD_NRD_1	677	679	PF00675	0.346
CLV_PCSK_FUR_1	518	522	PF00082	0.294
CLV_PCSK_KEX2_1	116	118	PF00082	0.718
CLV_PCSK_KEX2_1	242	244	PF00082	0.625
CLV_PCSK_KEX2_1	382	384	PF00082	0.672
CLV_PCSK_KEX2_1	43	45	PF00082	0.724
CLV_PCSK_KEX2_1	520	522	PF00082	0.294
CLV_PCSK_KEX2_1	555	557	PF00082	0.344
CLV_PCSK_KEX2_1	677	679	PF00082	0.346
CLV_PCSK_KEX2_1	845	847	PF00082	0.562
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.640
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.672
CLV_PCSK_SKI1_1	155	159	PF00082	0.706
CLV_PCSK_SKI1_1	204	208	PF00082	0.713
CLV_PCSK_SKI1_1	391	395	PF00082	0.723
CLV_PCSK_SKI1_1	43	47	PF00082	0.642
CLV_PCSK_SKI1_1	49	53	PF00082	0.641
CLV_PCSK_SKI1_1	622	626	PF00082	0.280
CLV_PCSK_SKI1_1	698	702	PF00082	0.306
CLV_Separin_Metazoa	482	486	PF03568	0.546
DEG_APCC_DBOX_1	337	345	PF00400	0.470
DEG_APCC_DBOX_1	90	98	PF00400	0.725
DEG_SCF_FBW7_1	9	14	PF00400	0.519
DEG_SCF_FBW7_2	526	532	PF00400	0.563
DEG_SPOP_SBC_1	139	143	PF00917	0.541
DOC_ANK_TNKS_1	735	742	PF00023	0.411
DOC_CKS1_1	526	531	PF01111	0.540
DOC_CKS1_1	667	672	PF01111	0.492
DOC_CYCLIN_RxL_1	619	629	PF00134	0.480
DOC_CYCLIN_RxL_1	695	703	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	614	620	PF00134	0.563
DOC_MAPK_gen_1	305	313	PF00069	0.519
DOC_MAPK_gen_1	43	53	PF00069	0.623
DOC_MAPK_MEF2A_6	305	313	PF00069	0.519
DOC_PP1_RVXF_1	554	561	PF00149	0.546
DOC_PP2B_LxvP_1	174	177	PF13499	0.665
DOC_PP2B_LxvP_1	376	379	PF13499	0.665
DOC_PP2B_LxvP_1	625	628	PF13499	0.530
DOC_PP4_FxxP_1	354	357	PF00568	0.497
DOC_PP4_FxxP_1	584	587	PF00568	0.520
DOC_PP4_FxxP_1	781	784	PF00568	0.546
DOC_USP7_MATH_1	11	15	PF00917	0.549
DOC_USP7_MATH_1	144	148	PF00917	0.798
DOC_USP7_MATH_1	161	165	PF00917	0.486
DOC_USP7_MATH_1	281	285	PF00917	0.672
DOC_USP7_MATH_1	288	292	PF00917	0.657
DOC_USP7_MATH_1	459	463	PF00917	0.546
DOC_USP7_MATH_1	657	661	PF00917	0.619
DOC_USP7_MATH_1	716	720	PF00917	0.563
DOC_USP7_MATH_1	790	794	PF00917	0.534
DOC_USP7_MATH_1	837	841	PF00917	0.558
DOC_WW_Pin1_4	319	324	PF00397	0.631
DOC_WW_Pin1_4	525	530	PF00397	0.540
DOC_WW_Pin1_4	548	553	PF00397	0.546
DOC_WW_Pin1_4	613	618	PF00397	0.619
DOC_WW_Pin1_4	634	639	PF00397	0.566
DOC_WW_Pin1_4	666	671	PF00397	0.503
DOC_WW_Pin1_4	7	12	PF00397	0.725
DOC_WW_Pin1_4	731	736	PF00397	0.604
LIG_14-3-3_CanoR_1	347	351	PF00244	0.314
LIG_14-3-3_CanoR_1	49	54	PF00244	0.613
LIG_14-3-3_CanoR_1	520	529	PF00244	0.545
LIG_14-3-3_CanoR_1	564	571	PF00244	0.480
LIG_14-3-3_CanoR_1	573	578	PF00244	0.436
LIG_14-3-3_CanoR_1	639	644	PF00244	0.435
LIG_14-3-3_CanoR_1	677	683	PF00244	0.546
LIG_14-3-3_CanoR_1	69	75	PF00244	0.557
LIG_14-3-3_CanoR_1	696	701	PF00244	0.569
LIG_14-3-3_CanoR_1	705	709	PF00244	0.510
LIG_Actin_WH2_2	32	48	PF00022	0.610
LIG_APCC_ABBAyCdc20_2	476	482	PF00400	0.546
LIG_BIR_III_4	468	472	PF00653	0.619
LIG_BRCT_BRCA1_1	321	325	PF00533	0.563
LIG_BRCT_BRCA1_1	327	331	PF00533	0.415
LIG_BRCT_BRCA1_1	431	435	PF00533	0.606
LIG_BRCT_BRCA1_1	444	448	PF00533	0.446
LIG_Clathr_ClatBox_1	503	507	PF01394	0.619
LIG_deltaCOP1_diTrp_1	475	480	PF00928	0.546
LIG_DLG_GKlike_1	573	581	PF00625	0.536
LIG_EVH1_2	761	765	PF00568	0.546
LIG_FHA_1	263	269	PF00498	0.626
LIG_FHA_1	315	321	PF00498	0.464
LIG_FHA_1	491	497	PF00498	0.546
LIG_FHA_1	521	527	PF00498	0.489
LIG_FHA_1	778	784	PF00498	0.599
LIG_FHA_1	800	806	PF00498	0.494
LIG_FHA_2	110	116	PF00498	0.703
LIG_FHA_2	158	164	PF00498	0.669
LIG_FHA_2	216	222	PF00498	0.833
LIG_FHA_2	324	330	PF00498	0.451
LIG_FHA_2	50	56	PF00498	0.731
LIG_FHA_2	528	534	PF00498	0.619
LIG_FHA_2	720	726	PF00498	0.546
LIG_FHA_2	732	738	PF00498	0.546
LIG_FHA_2	99	105	PF00498	0.689
LIG_GBD_Chelix_1	62	70	PF00786	0.716
LIG_LIR_Apic_2	353	357	PF02991	0.491
LIG_LIR_Apic_2	778	784	PF02991	0.546
LIG_LIR_Gen_1	168	177	PF02991	0.729
LIG_LIR_Gen_1	197	206	PF02991	0.455
LIG_LIR_Gen_1	326	334	PF02991	0.454
LIG_LIR_Gen_1	57	66	PF02991	0.773
LIG_LIR_Nem_3	168	173	PF02991	0.722
LIG_LIR_Nem_3	184	189	PF02991	0.455
LIG_LIR_Nem_3	197	201	PF02991	0.597
LIG_LIR_Nem_3	322	327	PF02991	0.504
LIG_LIR_Nem_3	328	334	PF02991	0.439
LIG_LIR_Nem_3	475	481	PF02991	0.546
LIG_LIR_Nem_3	57	62	PF02991	0.765
LIG_LIR_Nem_3	615	621	PF02991	0.549
LIG_LIR_Nem_3	706	711	PF02991	0.506
LIG_LIR_Nem_3	712	717	PF02991	0.506
LIG_LYPXL_SIV_4	617	625	PF13949	0.619
LIG_MLH1_MIPbox_1	321	325	PF16413	0.565
LIG_MLH1_MIPbox_1	444	448	PF16413	0.563
LIG_NRBOX	202	208	PF00104	0.608
LIG_NRP_CendR_1	845	847	PF00754	0.586
LIG_PCNA_yPIPBox_3	723	736	PF02747	0.604
LIG_Pex14_2	327	331	PF04695	0.437
LIG_Pex14_2	350	354	PF04695	0.475
LIG_REV1ctd_RIR_1	558	568	PF16727	0.546
LIG_REV1ctd_RIR_1	763	773	PF16727	0.546
LIG_SH2_CRK	618	622	PF00017	0.546
LIG_SH2_CRK	819	823	PF00017	0.486
LIG_SH2_NCK_1	257	261	PF00017	0.433
LIG_SH2_STAP1	257	261	PF00017	0.433
LIG_SH2_STAP1	711	715	PF00017	0.504
LIG_SH2_STAT5	237	240	PF00017	0.713
LIG_SH2_STAT5	559	562	PF00017	0.533
LIG_SH2_STAT5	841	844	PF00017	0.495
LIG_SH3_3	14	20	PF00018	0.677
LIG_SH3_3	244	250	PF00018	0.632
LIG_SH3_3	317	323	PF00018	0.550
LIG_SH3_3	732	738	PF00018	0.625
LIG_SH3_3	750	756	PF00018	0.480
LIG_SUMO_SIM_anti_2	168	175	PF11976	0.755
LIG_SUMO_SIM_par_1	501	507	PF11976	0.619
LIG_TRAF2_1	290	293	PF00917	0.505
LIG_TRAF2_1	642	645	PF00917	0.411
LIG_TYR_ITIM	479	484	PF00017	0.546
LIG_WRC_WIRS_1	324	329	PF05994	0.557
LIG_WW_1	16	19	PF00397	0.695
MOD_CDC14_SPxK_1	616	619	PF00782	0.619
MOD_CDK_SPK_2	634	639	PF00069	0.411
MOD_CDK_SPK_2	731	736	PF00069	0.411
MOD_CDK_SPxK_1	613	619	PF00069	0.619
MOD_CDK_SPxK_1	7	13	PF00069	0.523
MOD_CDK_SPxxK_3	548	555	PF00069	0.546
MOD_CDK_SPxxK_3	634	641	PF00069	0.563
MOD_CK1_1	209	215	PF00069	0.754
MOD_CK1_1	217	223	PF00069	0.733
MOD_CK1_1	296	302	PF00069	0.693
MOD_CK1_1	314	320	PF00069	0.544
MOD_CK1_1	408	414	PF00069	0.545
MOD_CK1_1	524	530	PF00069	0.573
MOD_CK1_1	613	619	PF00069	0.555
MOD_CK1_1	633	639	PF00069	0.383
MOD_CK1_1	658	664	PF00069	0.615
MOD_CK1_1	703	709	PF00069	0.504
MOD_CK1_1	719	725	PF00069	0.504
MOD_CK2_1	109	115	PF00069	0.703
MOD_CK2_1	25	31	PF00069	0.620
MOD_CK2_1	287	293	PF00069	0.510
MOD_CK2_1	323	329	PF00069	0.467
MOD_CK2_1	336	342	PF00069	0.458
MOD_CK2_1	639	645	PF00069	0.501
MOD_CK2_1	648	654	PF00069	0.560
MOD_CK2_1	70	76	PF00069	0.734
MOD_CK2_1	719	725	PF00069	0.543
MOD_CK2_1	731	737	PF00069	0.537
MOD_CK2_1	98	104	PF00069	0.679
MOD_GlcNHglycan	120	123	PF01048	0.821
MOD_GlcNHglycan	142	145	PF01048	0.686
MOD_GlcNHglycan	146	149	PF01048	0.662
MOD_GlcNHglycan	212	215	PF01048	0.695
MOD_GlcNHglycan	231	234	PF01048	0.454
MOD_GlcNHglycan	298	301	PF01048	0.768
MOD_GlcNHglycan	338	341	PF01048	0.557
MOD_GlcNHglycan	411	414	PF01048	0.677
MOD_GlcNHglycan	444	447	PF01048	0.363
MOD_GlcNHglycan	523	526	PF01048	0.390
MOD_GlcNHglycan	566	569	PF01048	0.348
MOD_GlcNHglycan	593	597	PF01048	0.322
MOD_GlcNHglycan	654	658	PF01048	0.408
MOD_GlcNHglycan	660	663	PF01048	0.337
MOD_GlcNHglycan	72	75	PF01048	0.786
MOD_GlcNHglycan	792	795	PF01048	0.805
MOD_GlcNHglycan	799	802	PF01048	0.728
MOD_GlcNHglycan	814	817	PF01048	0.522
MOD_GSK3_1	129	136	PF00069	0.753
MOD_GSK3_1	140	147	PF00069	0.649
MOD_GSK3_1	157	164	PF00069	0.683
MOD_GSK3_1	205	212	PF00069	0.703
MOD_GSK3_1	299	306	PF00069	0.747
MOD_GSK3_1	319	326	PF00069	0.565
MOD_GSK3_1	402	409	PF00069	0.678
MOD_GSK3_1	438	445	PF00069	0.530
MOD_GSK3_1	520	527	PF00069	0.557
MOD_GSK3_1	626	633	PF00069	0.586
MOD_GSK3_1	644	651	PF00069	0.449
MOD_GSK3_1	653	660	PF00069	0.587
MOD_GSK3_1	696	703	PF00069	0.546
MOD_GSK3_1	7	14	PF00069	0.680
MOD_GSK3_1	715	722	PF00069	0.546
MOD_GSK3_1	784	791	PF00069	0.616
MOD_GSK3_1	795	802	PF00069	0.611
MOD_LATS_1	96	102	PF00433	0.725
MOD_N-GLC_1	49	54	PF02516	0.635
MOD_NEK2_1	108	113	PF00069	0.707
MOD_NEK2_1	134	139	PF00069	0.596
MOD_NEK2_1	2	7	PF00069	0.519
MOD_NEK2_1	228	233	PF00069	0.758
MOD_NEK2_1	262	267	PF00069	0.599
MOD_NEK2_1	303	308	PF00069	0.739
MOD_NEK2_1	336	341	PF00069	0.552
MOD_NEK2_1	487	492	PF00069	0.530
MOD_NEK2_1	700	705	PF00069	0.506
MOD_NEK2_1	90	95	PF00069	0.712
MOD_NEK2_2	161	166	PF00069	0.467
MOD_PIKK_1	109	115	PF00454	0.805
MOD_PIKK_1	288	294	PF00454	0.510
MOD_PIKK_1	392	398	PF00454	0.714
MOD_PIKK_1	719	725	PF00454	0.619
MOD_PIKK_1	785	791	PF00454	0.558
MOD_PKA_1	520	526	PF00069	0.411
MOD_PKA_2	123	129	PF00069	0.572
MOD_PKA_2	132	138	PF00069	0.585
MOD_PKA_2	144	150	PF00069	0.699
MOD_PKA_2	161	167	PF00069	0.665
MOD_PKA_2	2	8	PF00069	0.520
MOD_PKA_2	262	268	PF00069	0.600
MOD_PKA_2	314	320	PF00069	0.559
MOD_PKA_2	346	352	PF00069	0.310
MOD_PKA_2	490	496	PF00069	0.563
MOD_PKA_2	520	526	PF00069	0.411
MOD_PKA_2	676	682	PF00069	0.546
MOD_PKA_2	704	710	PF00069	0.546
MOD_PKA_2	90	96	PF00069	0.815
MOD_PKA_2	97	103	PF00069	0.684
MOD_PKB_1	518	526	PF00069	0.466
MOD_Plk_1	49	55	PF00069	0.612
MOD_Plk_1	777	783	PF00069	0.597
MOD_Plk_4	169	175	PF00069	0.753
MOD_Plk_4	49	55	PF00069	0.612
MOD_Plk_4	627	633	PF00069	0.489
MOD_Plk_4	777	783	PF00069	0.563
MOD_Plk_4	837	843	PF00069	0.567
MOD_Plk_4	90	96	PF00069	0.815
MOD_ProDKin_1	319	325	PF00069	0.610
MOD_ProDKin_1	525	531	PF00069	0.540
MOD_ProDKin_1	548	554	PF00069	0.546
MOD_ProDKin_1	613	619	PF00069	0.619
MOD_ProDKin_1	634	640	PF00069	0.566
MOD_ProDKin_1	666	672	PF00069	0.503
MOD_ProDKin_1	7	13	PF00069	0.725
MOD_ProDKin_1	731	737	PF00069	0.604
MOD_SUMO_for_1	165	168	PF00179	0.458
MOD_SUMO_for_1	381	384	PF00179	0.742
TRG_DiLeu_BaEn_1	104	109	PF01217	0.722
TRG_DiLeu_BaEn_1	154	159	PF01217	0.663
TRG_DiLeu_BaEn_1	169	174	PF01217	0.686
TRG_DiLeu_BaEn_1	202	207	PF01217	0.604
TRG_DiLeu_BaEn_1	224	229	PF01217	0.527
TRG_DiLeu_BaEn_1	778	783	PF01217	0.619
TRG_ENDOCYTIC_2	481	484	PF00928	0.546
TRG_ENDOCYTIC_2	618	621	PF00928	0.546
TRG_ENDOCYTIC_2	711	714	PF00928	0.546
TRG_ENDOCYTIC_2	819	822	PF00928	0.488
TRG_ER_diArg_1	241	243	PF00400	0.611
TRG_ER_diArg_1	43	45	PF00400	0.724
TRG_ER_diArg_1	518	521	PF00400	0.500
TRG_ER_diArg_1	555	557	PF00400	0.546
TRG_ER_diArg_1	638	641	PF00400	0.411
TRG_ER_diArg_1	676	678	PF00400	0.546
TRG_ER_diArg_1	845	847	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHE0	Leptomonas seymouri	47%	100%
A0A3S5H7E7	Leishmania donovani	88%	100%
A4HE63	Leishmania braziliensis	73%	100%
A4I1G3	Leishmania infantum	88%	100%
Q4Q9X3	Leishmania major	88%	100%