LMBR1-like membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXJ5_LEIMU

TriTrypDb:

LmxM.25.1160

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AXJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	465	467	PF00675	0.417
CLV_PCSK_KEX2_1	465	467	PF00082	0.416
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.465
CLV_PCSK_SKI1_1	304	308	PF00082	0.371
CLV_PCSK_SKI1_1	374	378	PF00082	0.271
DEG_Nend_Nbox_1	1	3	PF02207	0.400
DOC_ANK_TNKS_1	433	440	PF00023	0.333
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.292
DOC_MAPK_gen_1	264	272	PF00069	0.566
DOC_MAPK_gen_1	434	442	PF00069	0.231
DOC_MAPK_gen_1	465	476	PF00069	0.659
DOC_MAPK_HePTP_8	240	252	PF00069	0.498
DOC_MAPK_MEF2A_6	177	186	PF00069	0.277
DOC_MAPK_MEF2A_6	232	241	PF00069	0.522
DOC_MAPK_MEF2A_6	243	252	PF00069	0.434
DOC_MAPK_MEF2A_6	41	50	PF00069	0.331
DOC_MAPK_MEF2A_6	434	442	PF00069	0.231
DOC_PP1_RVXF_1	372	379	PF00149	0.471
DOC_PP2B_LxvP_1	56	59	PF13499	0.292
DOC_USP7_MATH_1	164	168	PF00917	0.291
DOC_USP7_MATH_1	51	55	PF00917	0.451
DOC_USP7_UBL2_3	222	226	PF12436	0.541
DOC_WW_Pin1_4	155	160	PF00397	0.197
DOC_WW_Pin1_4	294	299	PF00397	0.554
DOC_WW_Pin1_4	62	67	PF00397	0.338
LIG_14-3-3_CanoR_1	177	183	PF00244	0.188
LIG_Actin_WH2_2	420	438	PF00022	0.284
LIG_AP2alpha_2	331	333	PF02296	0.333
LIG_BIR_III_2	329	333	PF00653	0.285
LIG_CaM_IQ_9	251	266	PF13499	0.626
LIG_EH1_1	394	402	PF00400	0.397
LIG_FHA_1	125	131	PF00498	0.332
LIG_FHA_1	177	183	PF00498	0.283
LIG_FHA_1	186	192	PF00498	0.234
LIG_FHA_1	334	340	PF00498	0.312
LIG_FHA_2	160	166	PF00498	0.267
LIG_GBD_Chelix_1	7	15	PF00786	0.411
LIG_LIR_Gen_1	21	28	PF02991	0.394
LIG_LIR_Gen_1	33	44	PF02991	0.556
LIG_LIR_Gen_1	361	370	PF02991	0.408
LIG_LIR_Gen_1	403	412	PF02991	0.371
LIG_LIR_Gen_1	417	424	PF02991	0.299
LIG_LIR_Gen_1	446	455	PF02991	0.304
LIG_LIR_Nem_3	149	155	PF02991	0.295
LIG_LIR_Nem_3	21	26	PF02991	0.394
LIG_LIR_Nem_3	297	302	PF02991	0.537
LIG_LIR_Nem_3	33	39	PF02991	0.556
LIG_LIR_Nem_3	361	365	PF02991	0.406
LIG_LIR_Nem_3	403	408	PF02991	0.332
LIG_LIR_Nem_3	414	418	PF02991	0.219
LIG_LIR_Nem_3	446	450	PF02991	0.283
LIG_NRBOX	333	339	PF00104	0.341
LIG_Pex14_1	199	203	PF04695	0.302
LIG_Pex14_2	101	105	PF04695	0.371
LIG_Pex14_2	197	201	PF04695	0.451
LIG_Pex14_2	358	362	PF04695	0.302
LIG_PTB_Apo_2	272	279	PF02174	0.566
LIG_PTB_Phospho_1	272	278	PF10480	0.566
LIG_SH2_CRK	23	27	PF00017	0.373
LIG_SH2_CRK	302	306	PF00017	0.478
LIG_SH2_CRK	353	357	PF00017	0.419
LIG_SH2_CRK	405	409	PF00017	0.397
LIG_SH2_NCK_1	291	295	PF00017	0.575
LIG_SH2_NCK_1	405	409	PF00017	0.429
LIG_SH2_NCK_1	60	64	PF00017	0.285
LIG_SH2_STAP1	187	191	PF00017	0.334
LIG_SH2_STAP1	23	27	PF00017	0.373
LIG_SH2_STAP1	405	409	PF00017	0.429
LIG_SH2_STAP1	74	78	PF00017	0.211
LIG_SH2_STAT3	142	145	PF00017	0.373
LIG_SH2_STAT5	171	174	PF00017	0.346
LIG_SH2_STAT5	187	190	PF00017	0.260
LIG_SH2_STAT5	23	26	PF00017	0.315
LIG_SH2_STAT5	27	30	PF00017	0.447
LIG_SH2_STAT5	278	281	PF00017	0.556
LIG_SH2_STAT5	291	294	PF00017	0.534
LIG_SH2_STAT5	359	362	PF00017	0.302
LIG_SH2_STAT5	409	412	PF00017	0.414
LIG_SH3_3	108	114	PF00018	0.447
LIG_SH3_3	177	183	PF00018	0.148
LIG_SH3_3	208	214	PF00018	0.327
LIG_SH3_3	94	100	PF00018	0.343
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.377
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.331
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.384
LIG_SUMO_SIM_par_1	134	139	PF11976	0.256
LIG_SUMO_SIM_par_1	181	188	PF11976	0.325
LIG_SUMO_SIM_par_1	398	404	PF11976	0.349
LIG_TYR_ITIM	300	305	PF00017	0.484
LIG_TYR_ITIM	407	412	PF00017	0.448
LIG_TYR_ITSM	19	26	PF00017	0.429
LIG_TYR_ITSM	401	408	PF00017	0.429
LIG_UBA3_1	457	465	PF00899	0.408
LIG_WRC_WIRS_1	22	27	PF05994	0.276
LIG_WRC_WIRS_1	325	330	PF05994	0.318
LIG_WRC_WIRS_1	412	417	PF05994	0.329
MOD_CK1_1	115	121	PF00069	0.501
MOD_CK1_1	167	173	PF00069	0.296
MOD_CK1_1	175	181	PF00069	0.214
MOD_CK1_1	185	191	PF00069	0.242
MOD_CK1_1	258	264	PF00069	0.618
MOD_CK1_1	453	459	PF00069	0.380
MOD_CK2_1	159	165	PF00069	0.223
MOD_GlcNHglycan	165	169	PF01048	0.452
MOD_GlcNHglycan	228	231	PF01048	0.213
MOD_GSK3_1	155	162	PF00069	0.288
MOD_GSK3_1	163	170	PF00069	0.277
MOD_GSK3_1	172	179	PF00069	0.238
MOD_GSK3_1	258	265	PF00069	0.581
MOD_GSK3_1	27	34	PF00069	0.556
MOD_GSK3_1	465	472	PF00069	0.657
MOD_GSK3_1	62	69	PF00069	0.325
MOD_N-GLC_1	155	160	PF02516	0.463
MOD_N-GLC_1	395	400	PF02516	0.371
MOD_NEK2_1	136	141	PF00069	0.245
MOD_NEK2_1	176	181	PF00069	0.222
MOD_NEK2_1	333	338	PF00069	0.305
MOD_NEK2_1	358	363	PF00069	0.393
MOD_NEK2_1	395	400	PF00069	0.366
MOD_NEK2_1	401	406	PF00069	0.318
MOD_NEK2_1	450	455	PF00069	0.371
MOD_PIKK_1	115	121	PF00454	0.538
MOD_PIKK_1	77	83	PF00454	0.333
MOD_PKA_1	465	471	PF00069	0.656
MOD_PKA_2	176	182	PF00069	0.260
MOD_PKA_2	258	264	PF00069	0.601
MOD_PKA_2	465	471	PF00069	0.656
MOD_Plk_1	164	170	PF00069	0.283
MOD_Plk_1	395	401	PF00069	0.366
MOD_Plk_4	124	130	PF00069	0.341
MOD_Plk_4	18	24	PF00069	0.380
MOD_Plk_4	182	188	PF00069	0.251
MOD_Plk_4	213	219	PF00069	0.371
MOD_Plk_4	333	339	PF00069	0.299
MOD_Plk_4	385	391	PF00069	0.458
MOD_Plk_4	395	401	PF00069	0.284
MOD_Plk_4	450	456	PF00069	0.331
MOD_Plk_4	51	57	PF00069	0.424
MOD_ProDKin_1	155	161	PF00069	0.197
MOD_ProDKin_1	294	300	PF00069	0.553
MOD_ProDKin_1	62	68	PF00069	0.338
TRG_DiLeu_BaEn_3	235	241	PF01217	0.501
TRG_ENDOCYTIC_2	23	26	PF00928	0.330
TRG_ENDOCYTIC_2	302	305	PF00928	0.476
TRG_ENDOCYTIC_2	325	328	PF00928	0.284
TRG_ENDOCYTIC_2	353	356	PF00928	0.302
TRG_ENDOCYTIC_2	405	408	PF00928	0.397
TRG_ENDOCYTIC_2	409	412	PF00928	0.397
TRG_ENDOCYTIC_2	418	421	PF00928	0.318
TRG_NLS_MonoExtC_3	464	469	PF00514	0.685
TRG_NLS_MonoExtN_4	464	469	PF00514	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRR8	Leptomonas seymouri	73%	100%
A0A0N1I533	Leptomonas seymouri	23%	100%
A0A0S4IQ17	Bodo saltans	46%	100%
A0A0S4JTI8	Bodo saltans	34%	94%
A0A1X0NKT2	Trypanosomatidae	34%	100%
A0A1X0NM00	Trypanosomatidae	56%	100%
A0A3Q8IGK4	Leishmania donovani	94%	100%
A0A3S5H7Y2	Leishmania donovani	23%	100%
A0A422P212	Trypanosoma rangeli	55%	100%
A4HE60	Leishmania braziliensis	79%	100%
A4HM51	Leishmania braziliensis	24%	97%
A4I1F8	Leishmania infantum	94%	100%
A4IAR3	Leishmania infantum	23%	100%
A7RM45	Nematostella vectensis	21%	88%
C9ZK11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A2E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D8TFA8	Selaginella moellendorffii	27%	100%
E9AEI9	Leishmania major	24%	96%
E9B5Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q9X7	Leishmania major	93%	100%
Q54BI3	Dictyostelium discoideum	31%	95%
Q54QP7	Dictyostelium discoideum	32%	95%
Q658I5	Oryza sativa subsp. japonica	29%	94%
Q9M028	Arabidopsis thaliana	30%	94%
Q9SR93	Arabidopsis thaliana	30%	94%