Alpha-tubulin N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXJ4_LEIMU

TriTrypDb:

LmxM.25.1150

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AXJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXJ4

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	12
GO:0006475	internal protein amino acid acetylation	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018205	peptidyl-lysine modification	6	12
GO:0018393	internal peptidyl-lysine acetylation	8	12
GO:0018394	peptidyl-lysine acetylation	7	12
GO:0019538	protein metabolic process	3	12
GO:0032886	regulation of microtubule-based process	4	12
GO:0033043	regulation of organelle organization	5	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043543	protein acylation	5	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051128	regulation of cellular component organization	4	12
GO:0051493	regulation of cytoskeleton organization	6	12
GO:0065007	biological regulation	1	12
GO:0070507	regulation of microtubule cytoskeleton organization	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0071929	alpha-tubulin acetylation	9	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008080	N-acetyltransferase activity	6	12
GO:0016407	acetyltransferase activity	5	12
GO:0016410	N-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019799	tubulin N-acetyltransferase activity	4	12
GO:0034212	peptide N-acetyltransferase activity	7	12
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.216
CLV_NRD_NRD_1	2	4	PF00675	0.579
CLV_NRD_NRD_1	43	45	PF00675	0.516
CLV_NRD_NRD_1	55	57	PF00675	0.286
CLV_PCSK_KEX2_1	2	4	PF00082	0.572
CLV_PCSK_KEX2_1	43	45	PF00082	0.504
CLV_PCSK_PC7_1	39	45	PF00082	0.414
CLV_PCSK_SKI1_1	111	115	PF00082	0.210
DEG_COP1_1	14	27	PF00400	0.516
DEG_Nend_UBRbox_1	1	4	PF02207	0.628
DEG_SPOP_SBC_1	225	229	PF00917	0.611
DOC_MAPK_gen_1	56	64	PF00069	0.499
DOC_MAPK_gen_1	86	95	PF00069	0.336
DOC_MAPK_JIP1_4	161	167	PF00069	0.512
DOC_MAPK_MEF2A_6	101	110	PF00069	0.518
DOC_PP1_RVXF_1	171	178	PF00149	0.410
DOC_PP1_SILK_1	103	108	PF00149	0.420
DOC_USP7_MATH_1	223	227	PF00917	0.609
DOC_USP7_UBL2_3	107	111	PF12436	0.410
DOC_WW_Pin1_4	185	190	PF00397	0.430
DOC_WW_Pin1_4	214	219	PF00397	0.541
DOC_WW_Pin1_4	240	245	PF00397	0.595
LIG_Clathr_ClatBox_1	123	127	PF01394	0.410
LIG_FHA_1	114	120	PF00498	0.518
LIG_FHA_1	186	192	PF00498	0.464
LIG_FHA_1	59	65	PF00498	0.468
LIG_FHA_1	88	94	PF00498	0.468
LIG_FHA_2	203	209	PF00498	0.438
LIG_FHA_2	29	35	PF00498	0.389
LIG_KLC1_Yacidic_2	133	137	PF13176	0.512
LIG_LIR_Nem_3	90	94	PF02991	0.493
LIG_OCRL_FandH_1	176	188	PF00620	0.452
LIG_Pex14_2	197	201	PF04695	0.410
LIG_SH2_CRK	145	149	PF00017	0.360
LIG_SH2_STAP1	150	154	PF00017	0.512
LIG_SH2_STAT3	187	190	PF00017	0.434
LIG_SH2_STAT5	135	138	PF00017	0.477
LIG_SH2_STAT5	187	190	PF00017	0.429
LIG_SH2_STAT5	94	97	PF00017	0.420
LIG_SH3_2	4	9	PF14604	0.436
LIG_SH3_3	1	7	PF00018	0.447
LIG_SH3_3	112	118	PF00018	0.434
LIG_SH3_3	156	162	PF00018	0.464
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.533
LIG_SUMO_SIM_anti_2	61	66	PF11976	0.478
LIG_SUMO_SIM_par_1	122	127	PF11976	0.453
LIG_SUMO_SIM_par_1	163	168	PF11976	0.496
LIG_TRAF2_1	13	16	PF00917	0.462
LIG_UBA3_1	174	180	PF00899	0.512
LIG_WRC_WIRS_1	197	202	PF05994	0.429
MOD_CDC14_SPxK_1	217	220	PF00782	0.634
MOD_CDK_SPxK_1	214	220	PF00069	0.606
MOD_CK1_1	226	232	PF00069	0.628
MOD_CK1_1	28	34	PF00069	0.459
MOD_CK1_1	77	83	PF00069	0.377
MOD_CK2_1	202	208	PF00069	0.459
MOD_DYRK1A_RPxSP_1	214	218	PF00069	0.570
MOD_GlcNHglycan	228	231	PF01048	0.549
MOD_GSK3_1	113	120	PF00069	0.529
MOD_GSK3_1	219	226	PF00069	0.646
MOD_GSK3_1	74	81	PF00069	0.390
MOD_N-GLC_1	240	245	PF02516	0.638
MOD_N-GLC_1	87	92	PF02516	0.299
MOD_NEK2_1	113	118	PF00069	0.463
MOD_NEK2_1	201	206	PF00069	0.475
MOD_PIKK_1	66	72	PF00454	0.459
MOD_PIKK_1	94	100	PF00454	0.464
MOD_PKA_2	168	174	PF00069	0.434
MOD_PKA_2	28	34	PF00069	0.430
MOD_Plk_1	201	207	PF00069	0.359
MOD_Plk_1	87	93	PF00069	0.497
MOD_Plk_2-3	202	208	PF00069	0.476
MOD_Plk_4	196	202	PF00069	0.432
MOD_Plk_4	74	80	PF00069	0.390
MOD_ProDKin_1	185	191	PF00069	0.430
MOD_ProDKin_1	214	220	PF00069	0.550
MOD_SUMO_for_1	154	157	PF00179	0.429
MOD_SUMO_rev_2	53	58	PF00179	0.518
TRG_DiLeu_BaEn_1	208	213	PF01217	0.519
TRG_DiLeu_BaEn_4	15	21	PF01217	0.438
TRG_ENDOCYTIC_2	145	148	PF00928	0.448
TRG_ENDOCYTIC_2	150	153	PF00928	0.457
TRG_ER_diArg_1	1	3	PF00400	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K7	Leptomonas seymouri	64%	100%
A0A0S4IKU1	Bodo saltans	49%	74%
A0A1X0NLY3	Trypanosomatidae	58%	73%
A0A3Q8IBQ9	Leishmania donovani	92%	100%
A0A422P1Z8	Trypanosoma rangeli	60%	77%
A4HE59	Leishmania braziliensis	78%	96%
A4I1F7	Leishmania infantum	92%	100%
A8XKM2	Caenorhabditis briggsae	30%	93%
B3RNE8	Trichoplax adhaerens	40%	100%
C0H559	Plasmodium falciparum (isolate 3D7)	27%	100%
C9ZK12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	73%
Q23192	Caenorhabditis elegans	28%	93%
Q4CQJ5	Trypanosoma cruzi (strain CL Brener)	56%	74%
Q4DTX9	Trypanosoma cruzi (strain CL Brener)	56%	75%
Q4Q9X8	Leishmania major	92%	100%
Q57XX3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	55%	73%
Q58CX6	Bos taurus	44%	100%
Q5DD96	Schistosoma japonicum	42%	92%
Q5TM63	Macaca mulatta	47%	76%
Q6PH17	Danio rerio	45%	82%
Q767K7	Sus scrofa	48%	82%
V5BCX4	Trypanosoma cruzi	57%	74%