Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AXJ3_LEIMU

TriTrypDb:

LmxM.25.1140

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	518	522	PF00656	0.801
CLV_NRD_NRD_1	12	14	PF00675	0.541
CLV_NRD_NRD_1	176	178	PF00675	0.718
CLV_PCSK_FUR_1	174	178	PF00082	0.721
CLV_PCSK_KEX2_1	12	14	PF00082	0.541
CLV_PCSK_KEX2_1	176	178	PF00082	0.718
CLV_PCSK_SKI1_1	43	47	PF00082	0.379
CLV_PCSK_SKI1_1	523	527	PF00082	0.800
DEG_SCF_FBW7_1	242	249	PF00400	0.776
DEG_SCF_FBW7_2	345	350	PF00400	0.653
DEG_SPOP_SBC_1	109	113	PF00917	0.721
DEG_SPOP_SBC_1	116	120	PF00917	0.663
DEG_SPOP_SBC_1	139	143	PF00917	0.513
DEG_SPOP_SBC_1	241	245	PF00917	0.541
DEG_SPOP_SBC_1	90	94	PF00917	0.595
DOC_CDC14_PxL_1	182	190	PF14671	0.586
DOC_CKS1_1	53	58	PF01111	0.524
DOC_PP2B_LxvP_1	74	77	PF13499	0.677
DOC_PP2B_PxIxI_1	358	364	PF00149	0.576
DOC_PP4_FxxP_1	212	215	PF00568	0.728
DOC_USP7_MATH_1	103	107	PF00917	0.695
DOC_USP7_MATH_1	138	142	PF00917	0.734
DOC_USP7_MATH_1	150	154	PF00917	0.707
DOC_USP7_MATH_1	220	224	PF00917	0.705
DOC_USP7_MATH_1	234	238	PF00917	0.770
DOC_USP7_MATH_1	246	250	PF00917	0.665
DOC_USP7_MATH_1	269	273	PF00917	0.641
DOC_USP7_MATH_1	326	330	PF00917	0.749
DOC_USP7_MATH_1	337	341	PF00917	0.648
DOC_USP7_MATH_1	406	410	PF00917	0.795
DOC_USP7_MATH_1	528	532	PF00917	0.765
DOC_USP7_MATH_1	8	12	PF00917	0.648
DOC_USP7_UBL2_3	136	140	PF12436	0.765
DOC_WW_Pin1_4	126	131	PF00397	0.715
DOC_WW_Pin1_4	236	241	PF00397	0.745
DOC_WW_Pin1_4	242	247	PF00397	0.763
DOC_WW_Pin1_4	287	292	PF00397	0.600
DOC_WW_Pin1_4	341	346	PF00397	0.802
DOC_WW_Pin1_4	413	418	PF00397	0.769
DOC_WW_Pin1_4	419	424	PF00397	0.672
DOC_WW_Pin1_4	503	508	PF00397	0.714
DOC_WW_Pin1_4	510	515	PF00397	0.735
DOC_WW_Pin1_4	52	57	PF00397	0.528
DOC_WW_Pin1_4	524	529	PF00397	0.660
LIG_14-3-3_CanoR_1	403	411	PF00244	0.524
LIG_14-3-3_CanoR_1	47	53	PF00244	0.605
LIG_14-3-3_CanoR_1	523	528	PF00244	0.716
LIG_Actin_WH2_2	459	477	PF00022	0.627
LIG_BIR_III_2	280	284	PF00653	0.520
LIG_BIR_III_2	390	394	PF00653	0.783
LIG_BRCT_BRCA1_1	407	411	PF00533	0.757
LIG_EVH1_1	212	216	PF00568	0.768
LIG_EVH1_2	426	430	PF00568	0.796
LIG_FHA_1	26	32	PF00498	0.564
LIG_FHA_1	430	436	PF00498	0.417
LIG_FHA_1	483	489	PF00498	0.643
LIG_FHA_1	5	11	PF00498	0.572
LIG_FHA_1	504	510	PF00498	0.804
LIG_FHA_1	511	517	PF00498	0.716
LIG_FHA_1	527	533	PF00498	0.719
LIG_FHA_2	216	222	PF00498	0.798
LIG_FHA_2	516	522	PF00498	0.805
LIG_FHA_2	53	59	PF00498	0.518
LIG_FHA_2	67	73	PF00498	0.599
LIG_LIR_Apic_2	209	215	PF02991	0.708
LIG_LIR_Apic_2	223	229	PF02991	0.725
LIG_LIR_Apic_2	329	333	PF02991	0.737
LIG_LIR_Gen_1	433	444	PF02991	0.505
LIG_LIR_Gen_1	461	470	PF02991	0.619
LIG_LIR_Gen_1	69	78	PF02991	0.668
LIG_LIR_Nem_3	298	303	PF02991	0.620
LIG_LIR_Nem_3	433	439	PF02991	0.492
LIG_LIR_Nem_3	461	466	PF02991	0.497
LIG_LIR_Nem_3	468	473	PF02991	0.457
LIG_LIR_Nem_3	69	74	PF02991	0.646
LIG_NRBOX	58	64	PF00104	0.591
LIG_NRP_CendR_1	537	539	PF00754	0.803
LIG_PTAP_UEV_1	129	134	PF05743	0.801
LIG_SH2_CRK	303	307	PF00017	0.589
LIG_SH2_CRK	330	334	PF00017	0.739
LIG_SH2_CRK	449	453	PF00017	0.516
LIG_SH2_PTP2	356	359	PF00017	0.582
LIG_SH2_SRC	356	359	PF00017	0.582
LIG_SH2_STAT3	61	64	PF00017	0.495
LIG_SH2_STAT5	18	21	PF00017	0.504
LIG_SH2_STAT5	192	195	PF00017	0.669
LIG_SH2_STAT5	198	201	PF00017	0.605
LIG_SH2_STAT5	29	32	PF00017	0.572
LIG_SH2_STAT5	356	359	PF00017	0.582
LIG_SH2_STAT5	436	439	PF00017	0.483
LIG_SH2_STAT5	473	476	PF00017	0.451
LIG_SH2_STAT5	61	64	PF00017	0.495
LIG_SH3_1	307	313	PF00018	0.500
LIG_SH3_1	421	427	PF00018	0.529
LIG_SH3_2	423	428	PF14604	0.808
LIG_SH3_3	127	133	PF00018	0.809
LIG_SH3_3	180	186	PF00018	0.610
LIG_SH3_3	210	216	PF00018	0.760
LIG_SH3_3	245	251	PF00018	0.717
LIG_SH3_3	307	313	PF00018	0.714
LIG_SH3_3	383	389	PF00018	0.758
LIG_SH3_3	420	426	PF00018	0.738
LIG_SH3_3	494	500	PF00018	0.569
LIG_SH3_3	50	56	PF00018	0.542
LIG_SH3_3	509	515	PF00018	0.735
MOD_CDC14_SPxK_1	425	428	PF00782	0.581
MOD_CDK_SPK_2	242	247	PF00069	0.777
MOD_CDK_SPK_2	287	292	PF00069	0.475
MOD_CDK_SPxK_1	422	428	PF00069	0.601
MOD_CK1_1	108	114	PF00069	0.733
MOD_CK1_1	190	196	PF00069	0.619
MOD_CK1_1	250	256	PF00069	0.851
MOD_CK1_1	284	290	PF00069	0.749
MOD_CK1_1	295	301	PF00069	0.433
MOD_CK1_1	340	346	PF00069	0.749
MOD_CK1_1	527	533	PF00069	0.742
MOD_CK2_1	52	58	PF00069	0.509
MOD_CK2_1	66	72	PF00069	0.570
MOD_CK2_1	99	105	PF00069	0.521
MOD_GlcNHglycan	101	104	PF01048	0.591
MOD_GlcNHglycan	105	108	PF01048	0.762
MOD_GlcNHglycan	271	274	PF01048	0.807
MOD_GlcNHglycan	283	286	PF01048	0.563
MOD_GlcNHglycan	300	303	PF01048	0.412
MOD_GlcNHglycan	321	324	PF01048	0.780
MOD_GlcNHglycan	383	386	PF01048	0.666
MOD_GlcNHglycan	407	411	PF01048	0.531
MOD_GlcNHglycan	518	521	PF01048	0.727
MOD_GlcNHglycan	83	86	PF01048	0.758
MOD_GlcNHglycan	93	96	PF01048	0.660
MOD_GSK3_1	108	115	PF00069	0.691
MOD_GSK3_1	134	141	PF00069	0.778
MOD_GSK3_1	187	194	PF00069	0.601
MOD_GSK3_1	232	239	PF00069	0.753
MOD_GSK3_1	242	249	PF00069	0.779
MOD_GSK3_1	265	272	PF00069	0.771
MOD_GSK3_1	336	343	PF00069	0.829
MOD_GSK3_1	4	11	PF00069	0.684
MOD_GSK3_1	402	409	PF00069	0.765
MOD_GSK3_1	415	422	PF00069	0.661
MOD_GSK3_1	461	468	PF00069	0.562
MOD_GSK3_1	48	55	PF00069	0.651
MOD_GSK3_1	503	510	PF00069	0.718
MOD_GSK3_1	523	530	PF00069	0.814
MOD_GSK3_1	66	73	PF00069	0.474
MOD_GSK3_1	77	84	PF00069	0.708
MOD_GSK3_1	89	96	PF00069	0.698
MOD_GSK3_1	99	106	PF00069	0.740
MOD_N-GLC_1	66	71	PF02516	0.550
MOD_NEK2_1	158	163	PF00069	0.644
MOD_NEK2_1	188	193	PF00069	0.606
MOD_NEK2_1	373	378	PF00069	0.625
MOD_NEK2_1	430	435	PF00069	0.636
MOD_NEK2_1	48	53	PF00069	0.600
MOD_NEK2_2	70	75	PF00069	0.487
MOD_PIKK_1	158	164	PF00454	0.684
MOD_PIKK_1	232	238	PF00454	0.821
MOD_PK_1	292	298	PF00069	0.386
MOD_PKA_2	381	387	PF00069	0.715
MOD_PKA_2	402	408	PF00069	0.518
MOD_PKA_2	48	54	PF00069	0.597
MOD_Plk_4	295	301	PF00069	0.557
MOD_ProDKin_1	126	132	PF00069	0.714
MOD_ProDKin_1	236	242	PF00069	0.741
MOD_ProDKin_1	247	253	PF00069	0.784
MOD_ProDKin_1	287	293	PF00069	0.593
MOD_ProDKin_1	341	347	PF00069	0.796
MOD_ProDKin_1	413	419	PF00069	0.769
MOD_ProDKin_1	422	428	PF00069	0.604
MOD_ProDKin_1	503	509	PF00069	0.715
MOD_ProDKin_1	510	516	PF00069	0.735
MOD_ProDKin_1	52	58	PF00069	0.523
MOD_ProDKin_1	524	530	PF00069	0.662
MOD_SUMO_rev_2	433	442	PF00179	0.539
TRG_DiLeu_BaEn_1	58	63	PF01217	0.586
TRG_DiLeu_BaEn_2	153	159	PF01217	0.642
TRG_ENDOCYTIC_2	303	306	PF00928	0.610
TRG_ENDOCYTIC_2	436	439	PF00928	0.448
TRG_ENDOCYTIC_2	449	452	PF00928	0.459
TRG_ER_diArg_1	12	14	PF00400	0.541
TRG_ER_diArg_1	173	176	PF00400	0.727
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z7	Leptomonas seymouri	53%	100%
A0A3Q8ID95	Leishmania donovani	89%	99%
A4HE58	Leishmania braziliensis	70%	100%
A4I1F6	Leishmania infantum	89%	99%
Q4Q9X9	Leishmania major	88%	100%