LeishMANIAdb
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MGT2 magnesium transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MGT2 magnesium transporter
Gene product:
magnesium transporter protein 2
Species:
Leishmania mexicana
UniProt:
E9AXI8_LEIMU
TriTrypDb:
LmxM.25.1090
Length:
412

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AXI8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXI8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 6
GO:0006811 monoatomic ion transport 4 6
GO:0006812 monoatomic cation transport 5 6
GO:0051179 localization 1 6
GO:0051234 establishment of localization 2 6
GO:0015693 magnesium ion transport 7 5
GO:0030001 metal ion transport 6 5
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 15
GO:0008324 monoatomic cation transmembrane transporter activity 4 15
GO:0015075 monoatomic ion transmembrane transporter activity 3 15
GO:0015095 magnesium ion transmembrane transporter activity 6 10
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 15
GO:0022857 transmembrane transporter activity 2 15
GO:0022890 inorganic cation transmembrane transporter activity 4 15
GO:0046873 metal ion transmembrane transporter activity 5 15
GO:0015562 efflux transmembrane transporter activity 3 1
GO:0046583 monoatomic cation efflux transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 243 245 PF00675 0.269
CLV_NRD_NRD_1 250 252 PF00675 0.269
CLV_NRD_NRD_1 41 43 PF00675 0.446
CLV_NRD_NRD_1 70 72 PF00675 0.343
CLV_PCSK_KEX2_1 164 166 PF00082 0.428
CLV_PCSK_KEX2_1 243 245 PF00082 0.274
CLV_PCSK_KEX2_1 249 251 PF00082 0.276
CLV_PCSK_KEX2_1 70 72 PF00082 0.326
CLV_PCSK_PC1ET2_1 164 166 PF00082 0.316
CLV_PCSK_SKI1_1 164 168 PF00082 0.336
CLV_PCSK_SKI1_1 244 248 PF00082 0.315
CLV_PCSK_SKI1_1 256 260 PF00082 0.306
CLV_PCSK_SKI1_1 27 31 PF00082 0.379
CLV_PCSK_SKI1_1 291 295 PF00082 0.298
CLV_PCSK_SKI1_1 308 312 PF00082 0.295
CLV_PCSK_SKI1_1 396 400 PF00082 0.426
CLV_PCSK_SKI1_1 71 75 PF00082 0.276
CLV_Separin_Metazoa 171 175 PF03568 0.525
DEG_APCC_DBOX_1 2 10 PF00400 0.651
DEG_APCC_DBOX_1 70 78 PF00400 0.483
DOC_CKS1_1 192 197 PF01111 0.484
DOC_CKS1_1 269 274 PF01111 0.593
DOC_PP2B_LxvP_1 230 233 PF13499 0.512
DOC_USP7_MATH_1 204 208 PF00917 0.586
DOC_USP7_MATH_1 94 98 PF00917 0.581
DOC_WW_Pin1_4 17 22 PF00397 0.733
DOC_WW_Pin1_4 191 196 PF00397 0.575
DOC_WW_Pin1_4 268 273 PF00397 0.564
DOC_WW_Pin1_4 63 68 PF00397 0.607
DOC_WW_Pin1_4 7 12 PF00397 0.738
LIG_14-3-3_CanoR_1 249 259 PF00244 0.498
LIG_14-3-3_CanoR_1 27 32 PF00244 0.611
LIG_14-3-3_CanoR_1 325 335 PF00244 0.525
LIG_14-3-3_CanoR_1 33 39 PF00244 0.546
LIG_Actin_WH2_2 34 50 PF00022 0.463
LIG_APCC_ABBA_1 287 292 PF00400 0.593
LIG_BRCT_BRCA1_1 142 146 PF00533 0.522
LIG_BRCT_BRCA1_1 195 199 PF00533 0.484
LIG_BRCT_BRCA1_1 331 335 PF00533 0.485
LIG_BRCT_BRCA1_1 36 40 PF00533 0.642
LIG_DLG_GKlike_1 251 258 PF00625 0.593
LIG_eIF4E_1 260 266 PF01652 0.512
LIG_FHA_1 152 158 PF00498 0.575
LIG_FHA_1 183 189 PF00498 0.516
LIG_FHA_1 192 198 PF00498 0.602
LIG_FHA_1 213 219 PF00498 0.494
LIG_FHA_1 55 61 PF00498 0.587
LIG_FHA_1 8 14 PF00498 0.775
LIG_FHA_2 158 164 PF00498 0.593
LIG_FHA_2 64 70 PF00498 0.563
LIG_FHA_2 93 99 PF00498 0.547
LIG_LIR_Gen_1 196 205 PF02991 0.484
LIG_LIR_Gen_1 56 67 PF02991 0.542
LIG_LIR_Nem_3 163 169 PF02991 0.529
LIG_LIR_Nem_3 196 202 PF02991 0.603
LIG_LIR_Nem_3 253 258 PF02991 0.596
LIG_LIR_Nem_3 36 41 PF02991 0.606
LIG_LIR_Nem_3 368 373 PF02991 0.283
LIG_LIR_Nem_3 56 62 PF02991 0.504
LIG_LYPXL_yS_3 370 373 PF13949 0.322
LIG_PTB_Apo_2 116 123 PF02174 0.583
LIG_PTB_Phospho_1 116 122 PF10480 0.583
LIG_SH2_SRC 109 112 PF00017 0.500
LIG_SH2_STAP1 205 209 PF00017 0.564
LIG_SH2_STAT5 28 31 PF00017 0.556
LIG_SH3_3 189 195 PF00018 0.613
LIG_SH3_3 78 84 PF00018 0.564
LIG_SH3_3 88 94 PF00018 0.512
LIG_SUMO_SIM_anti_2 225 232 PF11976 0.496
LIG_SUMO_SIM_anti_2 341 347 PF11976 0.369
LIG_SUMO_SIM_par_1 154 160 PF11976 0.506
LIG_TRAF2_1 66 69 PF00917 0.558
LIG_UBA3_1 157 164 PF00899 0.567
LIG_UBA3_1 258 264 PF00899 0.516
LIG_WRC_WIRS_1 252 257 PF05994 0.564
MOD_CDK_SPxxK_3 268 275 PF00069 0.564
MOD_CDK_SPxxK_3 63 70 PF00069 0.516
MOD_CK1_1 187 193 PF00069 0.456
MOD_CK1_1 20 26 PF00069 0.634
MOD_CK1_1 327 333 PF00069 0.531
MOD_CK1_1 34 40 PF00069 0.613
MOD_CK1_1 391 397 PF00069 0.495
MOD_CK1_1 53 59 PF00069 0.440
MOD_CK2_1 63 69 PF00069 0.524
MOD_GlcNHglycan 135 138 PF01048 0.387
MOD_GlcNHglycan 329 332 PF01048 0.295
MOD_GlcNHglycan 33 36 PF01048 0.400
MOD_GlcNHglycan 84 87 PF01048 0.405
MOD_GSK3_1 13 20 PF00069 0.752
MOD_GSK3_1 147 154 PF00069 0.483
MOD_GSK3_1 183 190 PF00069 0.534
MOD_GSK3_1 212 219 PF00069 0.517
MOD_GSK3_1 27 34 PF00069 0.652
MOD_GSK3_1 270 277 PF00069 0.532
MOD_GSK3_1 320 327 PF00069 0.550
MOD_GSK3_1 50 57 PF00069 0.646
MOD_N-GLC_1 133 138 PF02516 0.419
MOD_N-GLC_1 31 36 PF02516 0.448
MOD_NEK2_1 1 6 PF00069 0.784
MOD_NEK2_1 140 145 PF00069 0.532
MOD_NEK2_1 157 162 PF00069 0.494
MOD_NEK2_1 183 188 PF00069 0.594
MOD_NEK2_1 274 279 PF00069 0.485
MOD_NEK2_1 324 329 PF00069 0.510
MOD_NEK2_1 352 357 PF00069 0.349
MOD_NEK2_1 388 393 PF00069 0.457
MOD_PIKK_1 295 301 PF00454 0.512
MOD_PIKK_1 324 330 PF00454 0.512
MOD_PIKK_1 338 344 PF00454 0.564
MOD_PIKK_1 50 56 PF00454 0.669
MOD_PKA_1 250 256 PF00069 0.508
MOD_PKA_2 250 256 PF00069 0.489
MOD_PKA_2 274 280 PF00069 0.483
MOD_PKA_2 324 330 PF00069 0.512
MOD_PKA_2 92 98 PF00069 0.553
MOD_PKB_1 249 257 PF00069 0.543
MOD_PKB_1 25 33 PF00069 0.653
MOD_Plk_1 183 189 PF00069 0.595
MOD_Plk_1 54 60 PF00069 0.571
MOD_Plk_4 147 153 PF00069 0.489
MOD_Plk_4 188 194 PF00069 0.569
MOD_Plk_4 198 204 PF00069 0.491
MOD_Plk_4 213 219 PF00069 0.436
MOD_Plk_4 274 280 PF00069 0.480
MOD_Plk_4 34 40 PF00069 0.634
MOD_Plk_4 352 358 PF00069 0.362
MOD_Plk_4 54 60 PF00069 0.504
MOD_ProDKin_1 17 23 PF00069 0.731
MOD_ProDKin_1 191 197 PF00069 0.575
MOD_ProDKin_1 268 274 PF00069 0.564
MOD_ProDKin_1 63 69 PF00069 0.607
MOD_ProDKin_1 7 13 PF00069 0.739
MOD_SUMO_rev_2 329 337 PF00179 0.514
TRG_DiLeu_BaEn_1 226 231 PF01217 0.480
TRG_DiLeu_BaEn_3 68 74 PF01217 0.595
TRG_ENDOCYTIC_2 28 31 PF00928 0.556
TRG_ENDOCYTIC_2 370 373 PF00928 0.284
TRG_ER_diArg_1 242 244 PF00400 0.469
TRG_ER_diArg_1 248 251 PF00400 0.469
TRG_ER_diArg_1 25 28 PF00400 0.692
TRG_Pf-PMV_PEXEL_1 165 170 PF00026 0.316
TRG_Pf-PMV_PEXEL_1 264 268 PF00026 0.319

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3I5 Leptomonas seymouri 73% 100%
A0A1X0NLW5 Trypanosomatidae 43% 95%
A0A1X0NUD3 Trypanosomatidae 30% 100%
A0A3Q8IND2 Leishmania donovani 94% 100%
A0A3R7KXL6 Trypanosoma rangeli 37% 100%
A0A3R7R8A9 Trypanosoma rangeli 44% 97%
A4HE45 Leishmania braziliensis 84% 100%
A4I1F1 Leishmania infantum 94% 100%
C9ZK17 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZK26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 96%
C9ZXP3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
Q4Q9Y4 Leishmania major 93% 100%
V5B7S4 Trypanosoma cruzi 42% 100%
V5D3L0 Trypanosoma cruzi 43% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS