RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXI7_LEIMU

TriTrypDb:

LmxM.25.1080

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXI7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.396
CLV_NRD_NRD_1	294	296	PF00675	0.642
CLV_NRD_NRD_1	300	302	PF00675	0.670
CLV_NRD_NRD_1	439	441	PF00675	0.678
CLV_PCSK_FUR_1	153	157	PF00082	0.533
CLV_PCSK_KEX2_1	155	157	PF00082	0.473
CLV_PCSK_KEX2_1	294	296	PF00082	0.642
CLV_PCSK_KEX2_1	300	302	PF00082	0.670
CLV_PCSK_KEX2_1	439	441	PF00082	0.632
CLV_PCSK_SKI1_1	201	205	PF00082	0.563
CLV_PCSK_SKI1_1	238	242	PF00082	0.697
CLV_PCSK_SKI1_1	49	53	PF00082	0.449
CLV_PCSK_SKI1_1	81	85	PF00082	0.603
DEG_APCC_DBOX_1	226	234	PF00400	0.548
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.400
DOC_MAPK_gen_1	153	161	PF00069	0.387
DOC_MAPK_gen_1	6	15	PF00069	0.507
DOC_MAPK_MEF2A_6	153	161	PF00069	0.481
DOC_PP2B_LxvP_1	88	91	PF13499	0.438
DOC_PP4_FxxP_1	279	282	PF00568	0.531
DOC_USP7_MATH_1	179	183	PF00917	0.655
DOC_USP7_MATH_1	368	372	PF00917	0.765
DOC_USP7_MATH_1	424	428	PF00917	0.589
DOC_USP7_MATH_1	74	78	PF00917	0.633
DOC_USP7_UBL2_3	45	49	PF12436	0.597
DOC_USP7_UBL2_3	7	11	PF12436	0.606
DOC_WW_Pin1_4	246	251	PF00397	0.588
DOC_WW_Pin1_4	258	263	PF00397	0.543
DOC_WW_Pin1_4	304	309	PF00397	0.626
DOC_WW_Pin1_4	373	378	PF00397	0.725
LIG_14-3-3_CanoR_1	100	109	PF00244	0.421
LIG_14-3-3_CanoR_1	300	308	PF00244	0.672
LIG_14-3-3_CanoR_1	406	410	PF00244	0.683
LIG_14-3-3_CanoR_1	9	14	PF00244	0.593
LIG_14-3-3_CterR_2	439	441	PF00244	0.632
LIG_BRCT_BRCA1_1	128	132	PF00533	0.360
LIG_BRCT_BRCA1_1	318	322	PF00533	0.481
LIG_deltaCOP1_diTrp_1	29	35	PF00928	0.657
LIG_EH_1	319	323	PF12763	0.664
LIG_FHA_1	10	16	PF00498	0.509
LIG_FHA_1	117	123	PF00498	0.414
LIG_FHA_1	140	146	PF00498	0.426
LIG_FHA_1	71	77	PF00498	0.673
LIG_FHA_2	101	107	PF00498	0.275
LIG_FHA_2	82	88	PF00498	0.579
LIG_Integrin_isoDGR_2	380	382	PF01839	0.751
LIG_LIR_Apic_2	278	282	PF02991	0.537
LIG_LIR_Gen_1	105	116	PF02991	0.538
LIG_LIR_Gen_1	129	140	PF02991	0.341
LIG_LIR_Gen_1	56	65	PF02991	0.588
LIG_LIR_Nem_3	105	111	PF02991	0.535
LIG_LIR_Nem_3	129	135	PF02991	0.327
LIG_LIR_Nem_3	432	438	PF02991	0.630
LIG_LIR_Nem_3	56	60	PF02991	0.503
LIG_MYND_1	311	315	PF01753	0.606
LIG_PCNA_yPIPBox_3	164	178	PF02747	0.548
LIG_Pex14_2	108	112	PF04695	0.323
LIG_Pex14_2	92	96	PF04695	0.398
LIG_SH2_CRK	57	61	PF00017	0.572
LIG_SH2_NCK_1	57	61	PF00017	0.572
LIG_SH2_PTP2	158	161	PF00017	0.398
LIG_SH2_STAP1	57	61	PF00017	0.506
LIG_SH2_STAT5	158	161	PF00017	0.398
LIG_SH2_STAT5	22	25	PF00017	0.504
LIG_SH3_1	420	426	PF00018	0.642
LIG_SH3_3	210	216	PF00018	0.658
LIG_SH3_3	274	280	PF00018	0.621
LIG_SH3_3	302	308	PF00018	0.660
LIG_SH3_3	309	315	PF00018	0.581
LIG_SH3_3	420	426	PF00018	0.638
LIG_SUMO_SIM_par_1	141	146	PF11976	0.551
LIG_TRAF2_1	103	106	PF00917	0.419
MOD_CK1_1	182	188	PF00069	0.596
MOD_CK1_1	217	223	PF00069	0.749
MOD_CK1_1	249	255	PF00069	0.617
MOD_CK1_1	261	267	PF00069	0.573
MOD_CK1_1	270	276	PF00069	0.675
MOD_CK1_1	288	294	PF00069	0.711
MOD_CK1_1	323	329	PF00069	0.635
MOD_CK1_1	344	350	PF00069	0.706
MOD_CK1_1	375	381	PF00069	0.631
MOD_CK1_1	70	76	PF00069	0.593
MOD_CK2_1	100	106	PF00069	0.408
MOD_Cter_Amidation	153	156	PF01082	0.418
MOD_GlcNHglycan	136	139	PF01048	0.439
MOD_GlcNHglycan	184	187	PF01048	0.630
MOD_GlcNHglycan	242	245	PF01048	0.736
MOD_GlcNHglycan	302	305	PF01048	0.787
MOD_GlcNHglycan	322	325	PF01048	0.495
MOD_GlcNHglycan	341	346	PF01048	0.643
MOD_GlcNHglycan	370	373	PF01048	0.749
MOD_GlcNHglycan	412	416	PF01048	0.634
MOD_GlcNHglycan	419	423	PF01048	0.668
MOD_GlcNHglycan	426	429	PF01048	0.551
MOD_GSK3_1	139	146	PF00069	0.466
MOD_GSK3_1	219	226	PF00069	0.627
MOD_GSK3_1	295	302	PF00069	0.663
MOD_GSK3_1	316	323	PF00069	0.701
MOD_GSK3_1	368	375	PF00069	0.764
MOD_GSK3_1	400	407	PF00069	0.616
MOD_GSK3_1	70	77	PF00069	0.577
MOD_N-GLC_1	100	105	PF02516	0.402
MOD_N-GLC_1	368	373	PF02516	0.814
MOD_N-GLC_1	61	66	PF02516	0.652
MOD_NEK2_1	147	152	PF00069	0.388
MOD_NEK2_1	240	245	PF00069	0.699
MOD_NEK2_1	299	304	PF00069	0.795
MOD_PIKK_1	160	166	PF00454	0.496
MOD_PKA_1	300	306	PF00069	0.738
MOD_PKA_2	172	178	PF00069	0.634
MOD_PKA_2	182	188	PF00069	0.720
MOD_PKA_2	299	305	PF00069	0.708
MOD_PKA_2	405	411	PF00069	0.612
MOD_Plk_1	147	153	PF00069	0.392
MOD_Plk_1	288	294	PF00069	0.614
MOD_Plk_1	341	347	PF00069	0.675
MOD_Plk_1	404	410	PF00069	0.600
MOD_Plk_1	55	61	PF00069	0.592
MOD_Plk_2-3	357	363	PF00069	0.632
MOD_Plk_4	107	113	PF00069	0.552
MOD_ProDKin_1	246	252	PF00069	0.587
MOD_ProDKin_1	258	264	PF00069	0.543
MOD_ProDKin_1	304	310	PF00069	0.621
MOD_ProDKin_1	373	379	PF00069	0.724
MOD_SUMO_for_1	338	341	PF00179	0.657
MOD_SUMO_for_1	358	361	PF00179	0.499
MOD_SUMO_rev_2	351	360	PF00179	0.685
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.382
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.558
TRG_ENDOCYTIC_2	158	161	PF00928	0.398
TRG_ENDOCYTIC_2	57	60	PF00928	0.587
TRG_ER_diArg_1	153	156	PF00400	0.546
TRG_ER_diArg_1	299	301	PF00400	0.678
TRG_ER_diArg_1	438	440	PF00400	0.565
TRG_NLS_MonoExtN_4	4	10	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F7	Leptomonas seymouri	65%	100%
A0A0S4IKR5	Bodo saltans	36%	100%
A0A1X0NLV4	Trypanosomatidae	44%	100%
A0A3R7KUR5	Trypanosoma rangeli	51%	100%
A0A3S7WZ21	Leishmania donovani	95%	98%
A4HE44	Leishmania braziliensis	83%	100%
A4I1F0	Leishmania infantum	95%	98%
C9ZJX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4Q9Y5	Leishmania major	92%	100%
V5BKV0	Trypanosoma cruzi	49%	100%