Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXI6_LEIMU

TriTrypDb:

LmxM.25.1070

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.557
CLV_C14_Caspase3-7	595	599	PF00656	0.522
CLV_NRD_NRD_1	105	107	PF00675	0.752
CLV_NRD_NRD_1	304	306	PF00675	0.492
CLV_NRD_NRD_1	328	330	PF00675	0.619
CLV_NRD_NRD_1	331	333	PF00675	0.591
CLV_NRD_NRD_1	357	359	PF00675	0.641
CLV_NRD_NRD_1	56	58	PF00675	0.689
CLV_NRD_NRD_1	629	631	PF00675	0.694
CLV_NRD_NRD_1	637	639	PF00675	0.539
CLV_NRD_NRD_1	725	727	PF00675	0.601
CLV_NRD_NRD_1	737	739	PF00675	0.480
CLV_NRD_NRD_1	759	761	PF00675	0.458
CLV_PCSK_FUR_1	329	333	PF00082	0.604
CLV_PCSK_FUR_1	380	384	PF00082	0.598
CLV_PCSK_FUR_1	54	58	PF00082	0.689
CLV_PCSK_KEX2_1	105	107	PF00082	0.752
CLV_PCSK_KEX2_1	304	306	PF00082	0.497
CLV_PCSK_KEX2_1	328	330	PF00082	0.619
CLV_PCSK_KEX2_1	331	333	PF00082	0.591
CLV_PCSK_KEX2_1	355	357	PF00082	0.548
CLV_PCSK_KEX2_1	382	384	PF00082	0.692
CLV_PCSK_KEX2_1	416	418	PF00082	0.660
CLV_PCSK_KEX2_1	56	58	PF00082	0.689
CLV_PCSK_KEX2_1	629	631	PF00082	0.694
CLV_PCSK_KEX2_1	637	639	PF00082	0.539
CLV_PCSK_KEX2_1	725	727	PF00082	0.560
CLV_PCSK_KEX2_1	737	739	PF00082	0.461
CLV_PCSK_KEX2_1	759	761	PF00082	0.458
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.548
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.692
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.660
CLV_PCSK_SKI1_1	306	310	PF00082	0.525
CLV_PCSK_SKI1_1	385	389	PF00082	0.760
CLV_PCSK_SKI1_1	403	407	PF00082	0.539
CLV_PCSK_SKI1_1	451	455	PF00082	0.602
CLV_PCSK_SKI1_1	509	513	PF00082	0.560
CLV_PCSK_SKI1_1	615	619	PF00082	0.485
CLV_PCSK_SKI1_1	659	663	PF00082	0.655
CLV_PCSK_SKI1_1	737	741	PF00082	0.434
CLV_PCSK_SKI1_1	747	751	PF00082	0.551
DEG_APCC_DBOX_1	479	487	PF00400	0.509
DEG_Kelch_Keap1_1	768	773	PF01344	0.437
DOC_CKS1_1	386	391	PF01111	0.581
DOC_CKS1_1	459	464	PF01111	0.543
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.523
DOC_MAPK_gen_1	491	500	PF00069	0.564
DOC_MAPK_gen_1	805	815	PF00069	0.605
DOC_MAPK_MEF2A_6	132	140	PF00069	0.660
DOC_MAPK_MEF2A_6	37	46	PF00069	0.544
DOC_MAPK_MEF2A_6	808	817	PF00069	0.637
DOC_PP1_RVXF_1	628	635	PF00149	0.502
DOC_PP2B_LxvP_1	538	541	PF13499	0.649
DOC_USP7_MATH_1	142	146	PF00917	0.597
DOC_USP7_MATH_1	170	174	PF00917	0.614
DOC_USP7_MATH_1	372	376	PF00917	0.739
DOC_USP7_MATH_1	401	405	PF00917	0.650
DOC_USP7_MATH_1	429	433	PF00917	0.585
DOC_USP7_MATH_1	823	827	PF00917	0.620
DOC_USP7_MATH_1	833	837	PF00917	0.622
DOC_USP7_MATH_1	842	846	PF00917	0.609
DOC_USP7_UBL2_3	267	271	PF12436	0.540
DOC_USP7_UBL2_3	512	516	PF12436	0.446
DOC_WW_Pin1_4	11	16	PF00397	0.727
DOC_WW_Pin1_4	114	119	PF00397	0.655
DOC_WW_Pin1_4	368	373	PF00397	0.658
DOC_WW_Pin1_4	385	390	PF00397	0.570
DOC_WW_Pin1_4	425	430	PF00397	0.603
DOC_WW_Pin1_4	458	463	PF00397	0.522
DOC_WW_Pin1_4	543	548	PF00397	0.591
DOC_WW_Pin1_4	553	558	PF00397	0.607
DOC_WW_Pin1_4	77	82	PF00397	0.659
DOC_WW_Pin1_4	806	811	PF00397	0.575
DOC_WW_Pin1_4	819	824	PF00397	0.603
DOC_WW_Pin1_4	89	94	PF00397	0.648
LIG_14-3-3_CanoR_1	110	114	PF00244	0.736
LIG_14-3-3_CanoR_1	21	25	PF00244	0.673
LIG_14-3-3_CanoR_1	403	408	PF00244	0.531
LIG_14-3-3_CanoR_1	436	444	PF00244	0.497
LIG_14-3-3_CanoR_1	552	557	PF00244	0.615
LIG_14-3-3_CanoR_1	586	591	PF00244	0.681
LIG_14-3-3_CanoR_1	738	744	PF00244	0.368
LIG_14-3-3_CanoR_1	786	795	PF00244	0.452
LIG_14-3-3_CanoR_1	808	814	PF00244	0.591
LIG_14-3-3_CanoR_1	840	850	PF00244	0.562
LIG_Actin_WH2_2	470	486	PF00022	0.437
LIG_APCC_ABBA_1	281	286	PF00400	0.502
LIG_APCC_ABBA_1	562	567	PF00400	0.621
LIG_BRCT_BRCA1_1	151	155	PF00533	0.642
LIG_BRCT_BRCA1_1	164	168	PF00533	0.632
LIG_BRCT_BRCA1_1	173	177	PF00533	0.610
LIG_BRCT_BRCA1_1	221	225	PF00533	0.631
LIG_FHA_1	125	131	PF00498	0.706
LIG_FHA_1	161	167	PF00498	0.562
LIG_FHA_1	283	289	PF00498	0.499
LIG_FHA_1	556	562	PF00498	0.695
LIG_FHA_1	6	12	PF00498	0.670
LIG_FHA_1	726	732	PF00498	0.455
LIG_FHA_1	80	86	PF00498	0.588
LIG_FHA_1	810	816	PF00498	0.644
LIG_FHA_2	186	192	PF00498	0.562
LIG_FHA_2	29	35	PF00498	0.550
LIG_FHA_2	331	337	PF00498	0.683
LIG_FHA_2	404	410	PF00498	0.633
LIG_FHA_2	459	465	PF00498	0.546
LIG_FHA_2	660	666	PF00498	0.609
LIG_FHA_2	95	101	PF00498	0.552
LIG_LIR_Apic_2	76	81	PF02991	0.613
LIG_LIR_Gen_1	234	244	PF02991	0.496
LIG_LIR_Gen_1	313	320	PF02991	0.488
LIG_LIR_Gen_1	442	452	PF02991	0.602
LIG_LIR_Gen_1	471	477	PF02991	0.415
LIG_LIR_Gen_1	848	856	PF02991	0.615
LIG_LIR_Nem_3	234	239	PF02991	0.491
LIG_LIR_Nem_3	313	318	PF02991	0.539
LIG_LIR_Nem_3	442	447	PF02991	0.607
LIG_LIR_Nem_3	848	854	PF02991	0.579
LIG_NRP_CendR_1	857	858	PF00754	0.570
LIG_SH2_CRK	236	240	PF00017	0.497
LIG_SH2_CRK	315	319	PF00017	0.553
LIG_SH2_CRK	673	677	PF00017	0.514
LIG_SH2_GRB2like	778	781	PF00017	0.359
LIG_SH2_NCK_1	236	240	PF00017	0.497
LIG_SH2_NCK_1	78	82	PF00017	0.682
LIG_SH2_SRC	778	781	PF00017	0.359
LIG_SH2_STAP1	576	580	PF00017	0.624
LIG_SH2_STAP1	604	608	PF00017	0.567
LIG_SH2_STAP1	673	677	PF00017	0.503
LIG_SH2_STAP1	697	701	PF00017	0.577
LIG_SH2_STAP1	732	736	PF00017	0.462
LIG_SH2_STAP1	778	782	PF00017	0.404
LIG_SH2_STAT3	565	568	PF00017	0.542
LIG_SH2_STAT5	565	568	PF00017	0.570
LIG_SH3_1	544	550	PF00018	0.520
LIG_SH3_1	78	84	PF00018	0.677
LIG_SH3_2	547	552	PF14604	0.526
LIG_SH3_3	395	401	PF00018	0.583
LIG_SH3_3	544	550	PF00018	0.520
LIG_SH3_3	78	84	PF00018	0.640
LIG_SH3_4	252	259	PF00018	0.575
LIG_Sin3_3	792	799	PF02671	0.363
LIG_SUMO_SIM_anti_2	461	469	PF11976	0.622
LIG_SUMO_SIM_par_1	586	595	PF11976	0.585
LIG_TRAF2_1	300	303	PF00917	0.515
LIG_TRAF2_1	742	745	PF00917	0.555
LIG_TRAF2_1	97	100	PF00917	0.551
LIG_TYR_ITSM	232	239	PF00017	0.487
LIG_WW_3	102	106	PF00397	0.741
MOD_CDC14_SPxK_1	549	552	PF00782	0.608
MOD_CDK_SPK_2	114	119	PF00069	0.655
MOD_CDK_SPK_2	543	548	PF00069	0.556
MOD_CDK_SPK_2	819	824	PF00069	0.673
MOD_CDK_SPK_2	89	94	PF00069	0.654
MOD_CDK_SPxK_1	546	552	PF00069	0.596
MOD_CDK_SPxxK_3	427	434	PF00069	0.508
MOD_CDK_SPxxK_3	89	96	PF00069	0.695
MOD_CK1_1	109	115	PF00069	0.675
MOD_CK1_1	149	155	PF00069	0.755
MOD_CK1_1	16	22	PF00069	0.696
MOD_CK1_1	237	243	PF00069	0.639
MOD_CK1_1	334	340	PF00069	0.724
MOD_CK1_1	371	377	PF00069	0.778
MOD_CK1_1	391	397	PF00069	0.820
MOD_CK1_1	40	46	PF00069	0.706
MOD_CK1_1	430	436	PF00069	0.653
MOD_CK1_1	437	443	PF00069	0.649
MOD_CK1_1	543	549	PF00069	0.779
MOD_CK1_1	589	595	PF00069	0.611
MOD_CK1_1	809	815	PF00069	0.789
MOD_CK1_1	826	832	PF00069	0.541
MOD_CK1_1	836	842	PF00069	0.611
MOD_CK2_1	185	191	PF00069	0.645
MOD_CK2_1	330	336	PF00069	0.606
MOD_CK2_1	401	407	PF00069	0.650
MOD_CK2_1	458	464	PF00069	0.556
MOD_CK2_1	499	505	PF00069	0.632
MOD_CK2_1	589	595	PF00069	0.612
MOD_CK2_1	596	602	PF00069	0.474
MOD_CK2_1	659	665	PF00069	0.516
MOD_CK2_1	717	723	PF00069	0.553
MOD_CK2_1	73	79	PF00069	0.633
MOD_CK2_1	739	745	PF00069	0.579
MOD_CK2_1	767	773	PF00069	0.560
MOD_CK2_1	94	100	PF00069	0.567
MOD_DYRK1A_RPxSP_1	819	823	PF00069	0.680
MOD_GlcNHglycan	228	231	PF01048	0.498
MOD_GlcNHglycan	26	29	PF01048	0.826
MOD_GlcNHglycan	336	339	PF01048	0.612
MOD_GlcNHglycan	368	371	PF01048	0.781
MOD_GlcNHglycan	390	393	PF01048	0.580
MOD_GlcNHglycan	402	406	PF01048	0.629
MOD_GlcNHglycan	441	444	PF01048	0.528
MOD_GlcNHglycan	454	457	PF01048	0.507
MOD_GlcNHglycan	651	654	PF01048	0.585
MOD_GlcNHglycan	714	717	PF01048	0.676
MOD_GlcNHglycan	719	722	PF01048	0.628
MOD_GlcNHglycan	768	773	PF01048	0.568
MOD_GlcNHglycan	835	838	PF01048	0.648
MOD_GSK3_1	142	149	PF00069	0.625
MOD_GSK3_1	158	165	PF00069	0.616
MOD_GSK3_1	16	23	PF00069	0.711
MOD_GSK3_1	199	206	PF00069	0.640
MOD_GSK3_1	214	221	PF00069	0.621
MOD_GSK3_1	231	238	PF00069	0.582
MOD_GSK3_1	24	31	PF00069	0.586
MOD_GSK3_1	33	40	PF00069	0.640
MOD_GSK3_1	330	337	PF00069	0.528
MOD_GSK3_1	364	371	PF00069	0.649
MOD_GSK3_1	372	379	PF00069	0.668
MOD_GSK3_1	423	430	PF00069	0.662
MOD_GSK3_1	435	442	PF00069	0.721
MOD_GSK3_1	499	506	PF00069	0.435
MOD_GSK3_1	5	12	PF00069	0.637
MOD_GSK3_1	548	555	PF00069	0.647
MOD_GSK3_1	644	651	PF00069	0.591
MOD_GSK3_1	659	666	PF00069	0.585
MOD_GSK3_1	717	724	PF00069	0.459
MOD_GSK3_1	73	80	PF00069	0.581
MOD_GSK3_1	815	822	PF00069	0.614
MOD_GSK3_1	823	830	PF00069	0.646
MOD_GSK3_1	832	839	PF00069	0.675
MOD_GSK3_1	94	101	PF00069	0.705
MOD_LATS_1	838	844	PF00433	0.669
MOD_N-GLC_1	149	154	PF02516	0.562
MOD_N-GLC_1	177	182	PF02516	0.657
MOD_N-GLC_1	372	377	PF02516	0.728
MOD_N-GLC_1	553	558	PF02516	0.507
MOD_N-GLC_1	827	832	PF02516	0.696
MOD_NEK2_1	199	204	PF00069	0.495
MOD_NEK2_1	411	416	PF00069	0.521
MOD_NEK2_1	452	457	PF00069	0.510
MOD_NEK2_1	703	708	PF00069	0.604
MOD_NEK2_1	767	772	PF00069	0.681
MOD_NEK2_1	815	820	PF00069	0.579
MOD_NEK2_2	73	78	PF00069	0.632
MOD_NEK2_2	732	737	PF00069	0.356
MOD_PIKK_1	16	22	PF00454	0.698
MOD_PIKK_1	160	166	PF00454	0.513
MOD_PIKK_1	203	209	PF00454	0.642
MOD_PIKK_1	503	509	PF00454	0.419
MOD_PIKK_1	645	651	PF00454	0.566
MOD_PIKK_1	98	104	PF00454	0.716
MOD_PK_1	586	592	PF00069	0.679
MOD_PKA_1	331	337	PF00069	0.593
MOD_PKA_1	637	643	PF00069	0.560
MOD_PKA_1	725	731	PF00069	0.394
MOD_PKA_2	109	115	PF00069	0.644
MOD_PKA_2	20	26	PF00069	0.547
MOD_PKA_2	294	300	PF00069	0.471
MOD_PKA_2	330	336	PF00069	0.623
MOD_PKA_2	375	381	PF00069	0.586
MOD_PKA_2	435	441	PF00069	0.505
MOD_PKA_2	637	643	PF00069	0.560
MOD_PKA_2	712	718	PF00069	0.531
MOD_PKA_2	725	731	PF00069	0.459
MOD_PKA_2	823	829	PF00069	0.750
MOD_PKA_2	852	858	PF00069	0.581
MOD_PKB_1	329	337	PF00069	0.596
MOD_PKB_1	491	499	PF00069	0.459
MOD_PKB_1	96	104	PF00069	0.694
MOD_Plk_1	149	155	PF00069	0.632
MOD_Plk_1	180	186	PF00069	0.615
MOD_Plk_1	199	205	PF00069	0.582
MOD_Plk_1	231	237	PF00069	0.570
MOD_Plk_1	310	316	PF00069	0.580
MOD_Plk_1	493	499	PF00069	0.586
MOD_Plk_1	697	703	PF00069	0.494
MOD_Plk_1	827	833	PF00069	0.529
MOD_Plk_2-3	594	600	PF00069	0.504
MOD_Plk_4	125	131	PF00069	0.676
MOD_Plk_4	142	148	PF00069	0.513
MOD_Plk_4	162	168	PF00069	0.634
MOD_Plk_4	586	592	PF00069	0.588
MOD_Plk_4	73	79	PF00069	0.621
MOD_ProDKin_1	11	17	PF00069	0.731
MOD_ProDKin_1	114	120	PF00069	0.655
MOD_ProDKin_1	368	374	PF00069	0.663
MOD_ProDKin_1	385	391	PF00069	0.571
MOD_ProDKin_1	425	431	PF00069	0.601
MOD_ProDKin_1	458	464	PF00069	0.517
MOD_ProDKin_1	543	549	PF00069	0.593
MOD_ProDKin_1	553	559	PF00069	0.604
MOD_ProDKin_1	77	83	PF00069	0.657
MOD_ProDKin_1	806	812	PF00069	0.580
MOD_ProDKin_1	819	825	PF00069	0.605
MOD_ProDKin_1	89	95	PF00069	0.649
MOD_SUMO_for_1	275	278	PF00179	0.587
MOD_SUMO_for_1	578	581	PF00179	0.423
MOD_SUMO_rev_2	245	254	PF00179	0.637
MOD_SUMO_rev_2	614	623	PF00179	0.511
MOD_SUMO_rev_2	712	720	PF00179	0.521
TRG_AP2beta_CARGO_1	848	858	PF09066	0.552
TRG_DiLeu_BaEn_1	621	626	PF01217	0.474
TRG_DiLeu_BaEn_1	745	750	PF01217	0.493
TRG_DiLeu_BaEn_2	249	255	PF01217	0.513
TRG_DiLeu_BaEn_2	447	453	PF01217	0.664
TRG_ENDOCYTIC_2	236	239	PF00928	0.500
TRG_ENDOCYTIC_2	315	318	PF00928	0.494
TRG_ENDOCYTIC_2	575	578	PF00928	0.671
TRG_ENDOCYTIC_2	673	676	PF00928	0.516
TRG_ER_diArg_1	104	106	PF00400	0.648
TRG_ER_diArg_1	316	319	PF00400	0.570
TRG_ER_diArg_1	328	331	PF00400	0.588
TRG_ER_diArg_1	356	358	PF00400	0.568
TRG_ER_diArg_1	490	493	PF00400	0.475
TRG_ER_diArg_1	54	57	PF00400	0.688
TRG_ER_diArg_1	541	544	PF00400	0.712
TRG_ER_diArg_1	636	638	PF00400	0.523
TRG_ER_diArg_1	736	738	PF00400	0.406
TRG_ER_diArg_1	93	96	PF00400	0.722
TRG_NLS_MonoExtN_4	380	386	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	527	532	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	630	635	PF00026	0.691
TRG_Pf-PMV_PEXEL_1	737	741	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT63	Leptomonas seymouri	41%	89%
A0A3Q8ICH3	Leishmania donovani	82%	100%
A4HE43	Leishmania braziliensis	59%	100%
A4I1E9	Leishmania infantum	83%	100%
Q4Q9Y6	Leishmania major	79%	100%