Ferroxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ferroxidase

Gene product:

frataxin-like protein

Species:

Leishmania mexicana

UniProt:

E9AXI4_LEIMU

TriTrypDb:

LmxM.25.1050

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AXI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXI4

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006778	porphyrin-containing compound metabolic process	5	8
GO:0006779	porphyrin-containing compound biosynthetic process	6	8
GO:0006783	heme biosynthetic process	4	8
GO:0006790	sulfur compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006810	transport	3	8
GO:0006811	monoatomic ion transport	4	8
GO:0006873	intracellular monoatomic ion homeostasis	4	8
GO:0006875	obsolete intracellular metal ion homeostasis	6	8
GO:0006879	intracellular iron ion homeostasis	8	8
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0016226	iron-sulfur cluster assembly	4	9
GO:0018130	heterocycle biosynthetic process	4	8
GO:0019438	aromatic compound biosynthetic process	4	8
GO:0019725	cellular homeostasis	2	8
GO:0022607	cellular component assembly	4	9
GO:0030003	intracellular monoatomic cation homeostasis	5	8
GO:0031163	metallo-sulfur cluster assembly	5	9
GO:0033013	tetrapyrrole metabolic process	4	8
GO:0033014	tetrapyrrole biosynthetic process	5	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0042168	heme metabolic process	3	8
GO:0042440	pigment metabolic process	2	8
GO:0042592	homeostatic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0046148	pigment biosynthetic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	8
GO:0048878	chemical homeostasis	4	9
GO:0050801	monoatomic ion homeostasis	5	9
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0055065	obsolete metal ion homeostasis	7	9
GO:0055072	obsolete iron ion homeostasis	9	9
GO:0055076	obsolete transition metal ion homeostasis	8	9
GO:0055080	monoatomic cation homeostasis	6	9
GO:0055082	intracellular chemical homeostasis	3	8
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0071704	organic substance metabolic process	2	8
GO:0071840	cellular component organization or biogenesis	2	9
GO:0098771	inorganic ion homeostasis	6	9
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901362	organic cyclic compound biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8
GO:0018282	metal incorporation into metallo-sulfur cluster	5	1
GO:0018283	iron incorporation into metallo-sulfur cluster	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004322	ferroxidase activity	5	8
GO:0005488	binding	1	9
GO:0005506	iron ion binding	6	9
GO:0008199	ferric iron binding	7	9
GO:0016491	oxidoreductase activity	2	8
GO:0016722	oxidoreductase activity, acting on metal ions	3	8
GO:0016724	oxidoreductase activity, acting on metal ions, oxygen as acceptor	4	8
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0008198	ferrous iron binding	7	1
GO:0016530	metallochaperone activity	2	1
GO:0034986	iron chaperone activity	3	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1
GO:0140104	molecular carrier activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.492
CLV_NRD_NRD_1	48	50	PF00675	0.624
CLV_PCSK_KEX2_1	48	50	PF00082	0.624
CLV_PCSK_SKI1_1	177	181	PF00082	0.224
CLV_PCSK_SKI1_1	29	33	PF00082	0.517
DEG_APCC_DBOX_1	8	16	PF00400	0.680
DEG_SPOP_SBC_1	16	20	PF00917	0.582
DOC_MAPK_HePTP_8	125	137	PF00069	0.471
DOC_MAPK_MEF2A_6	128	137	PF00069	0.471
DOC_PP1_RVXF_1	157	163	PF00149	0.567
DOC_USP7_MATH_1	27	31	PF00917	0.627
DOC_USP7_MATH_1	34	38	PF00917	0.623
DOC_USP7_MATH_1	98	102	PF00917	0.529
DOC_USP7_UBL2_3	159	163	PF12436	0.512
DOC_USP7_UBL2_3	173	177	PF12436	0.358
DOC_WW_Pin1_4	136	141	PF00397	0.460
DOC_WW_Pin1_4	59	64	PF00397	0.686
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_BRCT_BRCA1_1	27	31	PF00533	0.623
LIG_EH1_1	146	154	PF00400	0.491
LIG_FHA_1	121	127	PF00498	0.454
LIG_FHA_1	178	184	PF00498	0.479
LIG_FHA_1	60	66	PF00498	0.629
LIG_FHA_2	30	36	PF00498	0.515
LIG_FHA_2	81	87	PF00498	0.471
LIG_FHA_2	92	98	PF00498	0.471
LIG_GBD_Chelix_1	171	179	PF00786	0.367
LIG_LIR_Gen_1	74	84	PF02991	0.314
LIG_LIR_Nem_3	19	25	PF02991	0.622
LIG_LIR_Nem_3	74	79	PF02991	0.419
LIG_LYPXL_yS_3	22	25	PF13949	0.604
LIG_MYND_1	23	27	PF01753	0.508
LIG_PDZ_Class_2	184	189	PF00595	0.549
LIG_SH2_CRK	147	151	PF00017	0.471
LIG_SH2_CRK	68	72	PF00017	0.571
LIG_SH2_NCK_1	147	151	PF00017	0.529
LIG_SUMO_SIM_anti_2	86	94	PF11976	0.567
LIG_SUMO_SIM_par_1	112	120	PF11976	0.473
LIG_SUMO_SIM_par_1	86	94	PF11976	0.567
LIG_TYR_ITIM	66	71	PF00017	0.596
LIG_UBA3_1	88	95	PF00899	0.462
MOD_CK1_1	139	145	PF00069	0.384
MOD_CK1_1	161	167	PF00069	0.417
MOD_CK1_1	37	43	PF00069	0.571
MOD_CK1_1	57	63	PF00069	0.667
MOD_GlcNHglycan	100	103	PF01048	0.370
MOD_GlcNHglycan	141	144	PF01048	0.326
MOD_GlcNHglycan	41	44	PF01048	0.699
MOD_GlcNHglycan	56	59	PF01048	0.557
MOD_GSK3_1	112	119	PF00069	0.347
MOD_GSK3_1	135	142	PF00069	0.358
MOD_GSK3_1	25	32	PF00069	0.600
MOD_GSK3_1	33	40	PF00069	0.653
MOD_GSK3_1	54	61	PF00069	0.626
MOD_NEK2_1	135	140	PF00069	0.326
MOD_NEK2_1	17	22	PF00069	0.654
MOD_NEK2_1	39	44	PF00069	0.604
MOD_NEK2_1	91	96	PF00069	0.455
MOD_PKA_2	120	126	PF00069	0.338
MOD_Plk_1	34	40	PF00069	0.412
MOD_Plk_4	120	126	PF00069	0.303
MOD_Plk_4	148	154	PF00069	0.315
MOD_Plk_4	34	40	PF00069	0.617
MOD_ProDKin_1	136	142	PF00069	0.312
MOD_ProDKin_1	59	65	PF00069	0.684
MOD_SUMO_rev_2	181	189	PF00179	0.357
MOD_SUMO_rev_2	74	81	PF00179	0.452
MOD_SUMO_rev_2	87	96	PF00179	0.330
TRG_DiLeu_BaEn_1	87	92	PF01217	0.462
TRG_ENDOCYTIC_2	147	150	PF00928	0.326
TRG_ENDOCYTIC_2	22	25	PF00928	0.657
TRG_ENDOCYTIC_2	68	71	PF00928	0.581
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I091	Leptomonas seymouri	63%	96%
A0A1X0NLP7	Trypanosomatidae	49%	100%
A0A422NXL2	Trypanosoma rangeli	55%	100%
A4HE41	Leishmania braziliensis	76%	99%
A4I1E7	Leishmania infantum	89%	100%
I7HD01	Leishmania donovani	89%	100%
O74831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4Q9Y8	Leishmania major	87%	100%