Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXI3_LEIMU

TriTrypDb:

LmxM.25.1040

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	543	547	PF00656	0.717
CLV_C14_Caspase3-7	574	578	PF00656	0.749
CLV_C14_Caspase3-7	656	660	PF00656	0.750
CLV_C14_Caspase3-7	98	102	PF00656	0.559
CLV_NRD_NRD_1	336	338	PF00675	0.495
CLV_NRD_NRD_1	379	381	PF00675	0.715
CLV_NRD_NRD_1	495	497	PF00675	0.755
CLV_NRD_NRD_1	541	543	PF00675	0.550
CLV_NRD_NRD_1	562	564	PF00675	0.623
CLV_NRD_NRD_1	580	582	PF00675	0.724
CLV_NRD_NRD_1	596	598	PF00675	0.658
CLV_NRD_NRD_1	617	619	PF00675	0.745
CLV_NRD_NRD_1	665	667	PF00675	0.726
CLV_NRD_NRD_1	670	672	PF00675	0.715
CLV_PCSK_FUR_1	524	528	PF00082	0.733
CLV_PCSK_KEX2_1	112	114	PF00082	0.555
CLV_PCSK_KEX2_1	288	290	PF00082	0.551
CLV_PCSK_KEX2_1	336	338	PF00082	0.495
CLV_PCSK_KEX2_1	378	380	PF00082	0.611
CLV_PCSK_KEX2_1	494	496	PF00082	0.749
CLV_PCSK_KEX2_1	526	528	PF00082	0.735
CLV_PCSK_KEX2_1	540	542	PF00082	0.555
CLV_PCSK_KEX2_1	562	564	PF00082	0.623
CLV_PCSK_KEX2_1	580	582	PF00082	0.724
CLV_PCSK_KEX2_1	596	598	PF00082	0.658
CLV_PCSK_KEX2_1	617	619	PF00082	0.745
CLV_PCSK_KEX2_1	665	667	PF00082	0.795
CLV_PCSK_KEX2_1	670	672	PF00082	0.819
CLV_PCSK_KEX2_1	717	719	PF00082	0.823
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.644
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.551
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.731
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.823
CLV_PCSK_PC7_1	576	582	PF00082	0.626
CLV_PCSK_PC7_1	666	672	PF00082	0.742
CLV_PCSK_SKI1_1	134	138	PF00082	0.469
CLV_PCSK_SKI1_1	141	145	PF00082	0.448
CLV_PCSK_SKI1_1	282	286	PF00082	0.541
CLV_PCSK_SKI1_1	288	292	PF00082	0.534
CLV_PCSK_SKI1_1	366	370	PF00082	0.594
CLV_PCSK_SKI1_1	527	531	PF00082	0.693
CLV_PCSK_SKI1_1	568	572	PF00082	0.660
CLV_PCSK_SKI1_1	741	745	PF00082	0.460
DEG_APCC_DBOX_1	526	534	PF00400	0.739
DEG_SPOP_SBC_1	13	17	PF00917	0.748
DEG_SPOP_SBC_1	435	439	PF00917	0.625
DEG_SPOP_SBC_1	587	591	PF00917	0.770
DOC_ANK_TNKS_1	541	548	PF00023	0.763
DOC_CYCLIN_yCln2_LP_2	405	411	PF00134	0.777
DOC_MAPK_gen_1	134	142	PF00069	0.465
DOC_MAPK_gen_1	680	688	PF00069	0.518
DOC_PP2B_LxvP_1	291	294	PF13499	0.744
DOC_PP2B_LxvP_1	4	7	PF13499	0.704
DOC_PP2B_LxvP_1	549	552	PF13499	0.749
DOC_USP7_MATH_1	317	321	PF00917	0.743
DOC_USP7_MATH_1	436	440	PF00917	0.625
DOC_USP7_MATH_1	480	484	PF00917	0.620
DOC_USP7_MATH_1	502	506	PF00917	0.797
DOC_USP7_MATH_1	532	536	PF00917	0.780
DOC_USP7_MATH_1	587	591	PF00917	0.770
DOC_USP7_MATH_1	632	636	PF00917	0.732
DOC_USP7_MATH_1	664	668	PF00917	0.644
DOC_USP7_MATH_1	721	725	PF00917	0.655
DOC_WW_Pin1_4	246	251	PF00397	0.660
DOC_WW_Pin1_4	258	263	PF00397	0.745
DOC_WW_Pin1_4	289	294	PF00397	0.751
DOC_WW_Pin1_4	404	409	PF00397	0.733
DOC_WW_Pin1_4	437	442	PF00397	0.775
DOC_WW_Pin1_4	47	52	PF00397	0.711
DOC_WW_Pin1_4	553	558	PF00397	0.681
LIG_14-3-3_CanoR_1	105	114	PF00244	0.539
LIG_14-3-3_CanoR_1	206	211	PF00244	0.656
LIG_14-3-3_CanoR_1	282	291	PF00244	0.839
LIG_14-3-3_CanoR_1	449	458	PF00244	0.655
LIG_14-3-3_CanoR_1	617	621	PF00244	0.719
LIG_14-3-3_CanoR_1	651	656	PF00244	0.764
LIG_14-3-3_CanoR_1	665	672	PF00244	0.674
LIG_14-3-3_CanoR_1	710	716	PF00244	0.691
LIG_14-3-3_CanoR_1	720	730	PF00244	0.807
LIG_14-3-3_CanoR_1	89	94	PF00244	0.516
LIG_BIR_III_2	433	437	PF00653	0.559
LIG_BRCT_BRCA1_1	150	154	PF00533	0.527
LIG_DLG_GKlike_1	175	182	PF00625	0.462
LIG_FHA_1	178	184	PF00498	0.624
LIG_FHA_1	404	410	PF00498	0.520
LIG_FHA_1	440	446	PF00498	0.560
LIG_FHA_1	480	486	PF00498	0.598
LIG_FHA_1	611	617	PF00498	0.703
LIG_FHA_2	367	373	PF00498	0.640
LIG_FHA_2	541	547	PF00498	0.764
LIG_FHA_2	75	81	PF00498	0.550
LIG_HCF-1_HBM_1	420	423	PF13415	0.701
LIG_Integrin_isoDGR_2	643	645	PF01839	0.553
LIG_LIR_Apic_2	420	426	PF02991	0.794
LIG_LIR_Gen_1	177	187	PF02991	0.642
LIG_LIR_Gen_1	242	253	PF02991	0.678
LIG_LIR_Gen_1	619	626	PF02991	0.622
LIG_LIR_Nem_3	177	182	PF02991	0.627
LIG_LIR_Nem_3	242	247	PF02991	0.641
LIG_LIR_Nem_3	619	625	PF02991	0.624
LIG_LYPXL_SIV_4	323	331	PF13949	0.570
LIG_NRBOX	168	174	PF00104	0.393
LIG_NRBOX	413	419	PF00104	0.623
LIG_NRBOX	692	698	PF00104	0.622
LIG_PDZ_Class_1	744	749	PF00595	0.539
LIG_Rb_pABgroove_1	91	99	PF01858	0.534
LIG_RPA_C_Fungi	613	625	PF08784	0.595
LIG_SH2_CRK	130	134	PF00017	0.625
LIG_SH2_CRK	179	183	PF00017	0.638
LIG_SH2_CRK	423	427	PF00017	0.815
LIG_SH2_GRB2like	352	355	PF00017	0.685
LIG_SH2_PTP2	146	149	PF00017	0.515
LIG_SH2_SRC	639	642	PF00017	0.546
LIG_SH2_STAP1	179	183	PF00017	0.638
LIG_SH2_STAP1	239	243	PF00017	0.681
LIG_SH2_STAP1	352	356	PF00017	0.582
LIG_SH2_STAP1	622	626	PF00017	0.679
LIG_SH2_STAP1	71	75	PF00017	0.539
LIG_SH2_STAP1	711	715	PF00017	0.521
LIG_SH2_STAT5	146	149	PF00017	0.515
LIG_SH2_STAT5	179	182	PF00017	0.633
LIG_SH3_1	429	435	PF00018	0.776
LIG_SH3_2	661	666	PF14604	0.742
LIG_SH3_3	244	250	PF00018	0.663
LIG_SH3_3	259	265	PF00018	0.646
LIG_SH3_3	429	435	PF00018	0.776
LIG_SH3_3	442	448	PF00018	0.604
LIG_SH3_3	453	459	PF00018	0.690
LIG_SH3_3	515	521	PF00018	0.563
LIG_SH3_3	658	664	PF00018	0.746
LIG_SH3_3	710	716	PF00018	0.667
LIG_SUMO_SIM_par_1	337	342	PF11976	0.560
LIG_TYR_ITIM	620	625	PF00017	0.646
LIG_WW_3	446	450	PF00397	0.650
MOD_CK1_1	12	18	PF00069	0.723
MOD_CK1_1	152	158	PF00069	0.532
MOD_CK1_1	178	184	PF00069	0.499
MOD_CK1_1	310	316	PF00069	0.512
MOD_CK1_1	38	44	PF00069	0.794
MOD_CK1_1	439	445	PF00069	0.747
MOD_CK1_1	479	485	PF00069	0.833
MOD_CK1_1	50	56	PF00069	0.732
MOD_CK1_1	535	541	PF00069	0.754
MOD_CK1_1	589	595	PF00069	0.838
MOD_CK2_1	310	316	PF00069	0.687
MOD_CK2_1	366	372	PF00069	0.667
MOD_CK2_1	74	80	PF00069	0.550
MOD_Cter_Amidation	538	541	PF01082	0.546
MOD_DYRK1A_RPxSP_1	289	293	PF00069	0.541
MOD_GlcNHglycan	11	14	PF01048	0.725
MOD_GlcNHglycan	203	206	PF01048	0.629
MOD_GlcNHglycan	256	259	PF01048	0.734
MOD_GlcNHglycan	277	280	PF01048	0.553
MOD_GlcNHglycan	313	316	PF01048	0.718
MOD_GlcNHglycan	478	481	PF01048	0.772
MOD_GlcNHglycan	482	485	PF01048	0.719
MOD_GlcNHglycan	504	507	PF01048	0.752
MOD_GlcNHglycan	537	540	PF01048	0.832
MOD_GlcNHglycan	592	595	PF01048	0.787
MOD_GSK3_1	148	155	PF00069	0.487
MOD_GSK3_1	233	240	PF00069	0.774
MOD_GSK3_1	254	261	PF00069	0.741
MOD_GSK3_1	297	304	PF00069	0.791
MOD_GSK3_1	307	314	PF00069	0.628
MOD_GSK3_1	435	442	PF00069	0.742
MOD_GSK3_1	472	479	PF00069	0.807
MOD_GSK3_1	500	507	PF00069	0.683
MOD_GSK3_1	586	593	PF00069	0.731
MOD_GSK3_1	608	615	PF00069	0.829
MOD_GSK3_1	626	633	PF00069	0.593
MOD_GSK3_1	651	658	PF00069	0.732
MOD_GSK3_1	70	77	PF00069	0.562
MOD_GSK3_1	9	16	PF00069	0.712
MOD_LATS_1	628	634	PF00433	0.735
MOD_N-GLC_1	103	108	PF02516	0.639
MOD_N-GLC_1	152	157	PF02516	0.414
MOD_N-GLC_1	307	312	PF02516	0.525
MOD_N-GLC_1	486	491	PF02516	0.716
MOD_NEK2_1	129	134	PF00069	0.626
MOD_NEK2_1	149	154	PF00069	0.607
MOD_NEK2_1	522	527	PF00069	0.578
MOD_NEK2_1	626	631	PF00069	0.770
MOD_NEK2_1	692	697	PF00069	0.625
MOD_PIKK_1	15	21	PF00454	0.756
MOD_PIKK_1	233	239	PF00454	0.777
MOD_PIKK_1	308	314	PF00454	0.522
MOD_PIKK_1	721	727	PF00454	0.754
MOD_PKA_1	540	546	PF00069	0.553
MOD_PKA_2	196	202	PF00069	0.641
MOD_PKA_2	342	348	PF00069	0.391
MOD_PKA_2	540	546	PF00069	0.578
MOD_PKA_2	616	622	PF00069	0.723
MOD_PKA_2	664	670	PF00069	0.745
MOD_PKB_1	113	121	PF00069	0.551
MOD_PKB_1	280	288	PF00069	0.661
MOD_PKB_1	649	657	PF00069	0.770
MOD_Plk_1	103	109	PF00069	0.639
MOD_Plk_1	366	372	PF00069	0.560
MOD_Plk_1	480	486	PF00069	0.545
MOD_Plk_4	178	184	PF00069	0.666
MOD_Plk_4	692	698	PF00069	0.488
MOD_ProDKin_1	246	252	PF00069	0.664
MOD_ProDKin_1	258	264	PF00069	0.744
MOD_ProDKin_1	289	295	PF00069	0.753
MOD_ProDKin_1	404	410	PF00069	0.722
MOD_ProDKin_1	437	443	PF00069	0.775
MOD_ProDKin_1	47	53	PF00069	0.707
MOD_ProDKin_1	553	559	PF00069	0.674
MOD_SUMO_for_1	136	139	PF00179	0.512
MOD_SUMO_for_1	370	373	PF00179	0.684
MOD_SUMO_rev_2	109	114	PF00179	0.640
MOD_SUMO_rev_2	724	730	PF00179	0.714
TRG_DiLeu_BaEn_1	168	173	PF01217	0.584
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.324
TRG_ENDOCYTIC_2	130	133	PF00928	0.521
TRG_ENDOCYTIC_2	146	149	PF00928	0.487
TRG_ENDOCYTIC_2	179	182	PF00928	0.633
TRG_ENDOCYTIC_2	324	327	PF00928	0.584
TRG_ENDOCYTIC_2	622	625	PF00928	0.631
TRG_ENDOCYTIC_2	97	100	PF00928	0.507
TRG_ER_diArg_1	336	338	PF00400	0.591
TRG_ER_diArg_1	378	380	PF00400	0.709
TRG_ER_diArg_1	493	496	PF00400	0.736
TRG_ER_diArg_1	540	542	PF00400	0.555
TRG_ER_diArg_1	562	564	PF00400	0.669
TRG_ER_diArg_1	596	599	PF00400	0.751
TRG_ER_diArg_1	616	618	PF00400	0.485
TRG_ER_diArg_1	649	652	PF00400	0.817
TRG_ER_diArg_1	664	666	PF00400	0.640
TRG_ER_diArg_1	670	672	PF00400	0.707
TRG_ER_diArg_1	718	721	PF00400	0.741
TRG_NES_CRM1_1	148	163	PF08389	0.589
TRG_NES_CRM1_1	694	706	PF08389	0.469
TRG_NLS_MonoExtC_3	716	721	PF00514	0.741
TRG_NLS_MonoExtN_4	716	721	PF00514	0.720
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	618	623	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	741	745	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T6	Leptomonas seymouri	39%	94%
A0A3Q8ICB6	Leishmania donovani	81%	100%
A4HE40	Leishmania braziliensis	60%	100%
A4I1E6	Leishmania infantum	80%	77%
Q4Q9Y9	Leishmania major	80%	98%