LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AXI2_LEIMU
TriTrypDb:
LmxM.25.1030
Length:
873

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXI2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXI2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016740 transferase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 478 482 PF00656 0.560
CLV_C14_Caspase3-7 829 833 PF00656 0.590
CLV_C14_Caspase3-7 94 98 PF00656 0.454
CLV_NRD_NRD_1 136 138 PF00675 0.461
CLV_NRD_NRD_1 224 226 PF00675 0.452
CLV_NRD_NRD_1 295 297 PF00675 0.471
CLV_NRD_NRD_1 577 579 PF00675 0.620
CLV_NRD_NRD_1 671 673 PF00675 0.612
CLV_NRD_NRD_1 802 804 PF00675 0.439
CLV_NRD_NRD_1 84 86 PF00675 0.524
CLV_PCSK_KEX2_1 136 138 PF00082 0.426
CLV_PCSK_KEX2_1 224 226 PF00082 0.452
CLV_PCSK_KEX2_1 295 297 PF00082 0.483
CLV_PCSK_KEX2_1 802 804 PF00082 0.439
CLV_PCSK_KEX2_1 84 86 PF00082 0.524
CLV_PCSK_SKI1_1 802 806 PF00082 0.467
DEG_APCC_DBOX_1 136 144 PF00400 0.394
DEG_APCC_DBOX_1 819 827 PF00400 0.497
DEG_Nend_UBRbox_1 1 4 PF02207 0.462
DEG_SCF_FBW7_1 493 500 PF00400 0.429
DEG_SCF_FBW7_2 610 615 PF00400 0.620
DEG_SIAH_1 773 781 PF03145 0.558
DEG_SPOP_SBC_1 501 505 PF00917 0.612
DOC_CKS1_1 494 499 PF01111 0.426
DOC_CYCLIN_RxL_1 133 144 PF00134 0.427
DOC_CYCLIN_RxL_1 800 810 PF00134 0.459
DOC_CYCLIN_yCln2_LP_2 260 266 PF00134 0.533
DOC_MAPK_FxFP_2 8 11 PF00069 0.453
DOC_MAPK_gen_1 136 145 PF00069 0.401
DOC_MAPK_HePTP_8 133 145 PF00069 0.384
DOC_MAPK_MEF2A_6 12 19 PF00069 0.588
DOC_MAPK_MEF2A_6 136 145 PF00069 0.393
DOC_MAPK_MEF2A_6 355 363 PF00069 0.540
DOC_MAPK_MEF2A_6 422 430 PF00069 0.485
DOC_PP1_RVXF_1 642 648 PF00149 0.551
DOC_PP4_FxxP_1 8 11 PF00568 0.453
DOC_SPAK_OSR1_1 346 350 PF12202 0.569
DOC_USP7_MATH_1 11 15 PF00917 0.442
DOC_USP7_MATH_1 151 155 PF00917 0.537
DOC_USP7_MATH_1 160 164 PF00917 0.371
DOC_USP7_MATH_1 316 320 PF00917 0.623
DOC_USP7_MATH_1 37 41 PF00917 0.513
DOC_USP7_MATH_1 418 422 PF00917 0.615
DOC_USP7_MATH_1 479 483 PF00917 0.559
DOC_USP7_MATH_1 501 505 PF00917 0.567
DOC_USP7_MATH_1 65 69 PF00917 0.581
DOC_USP7_MATH_1 70 74 PF00917 0.593
DOC_USP7_MATH_1 780 784 PF00917 0.623
DOC_WW_Pin1_4 100 105 PF00397 0.456
DOC_WW_Pin1_4 259 264 PF00397 0.399
DOC_WW_Pin1_4 296 301 PF00397 0.555
DOC_WW_Pin1_4 493 498 PF00397 0.441
DOC_WW_Pin1_4 592 597 PF00397 0.644
DOC_WW_Pin1_4 608 613 PF00397 0.641
DOC_WW_Pin1_4 692 697 PF00397 0.493
LIG_14-3-3_CanoR_1 12 16 PF00244 0.433
LIG_14-3-3_CanoR_1 2 6 PF00244 0.462
LIG_14-3-3_CanoR_1 320 325 PF00244 0.692
LIG_14-3-3_CanoR_1 395 399 PF00244 0.503
LIG_14-3-3_CanoR_1 422 430 PF00244 0.485
LIG_14-3-3_CanoR_1 451 460 PF00244 0.476
LIG_14-3-3_CanoR_1 513 519 PF00244 0.462
LIG_14-3-3_CanoR_1 57 63 PF00244 0.531
LIG_14-3-3_CanoR_1 715 719 PF00244 0.453
LIG_14-3-3_CanoR_1 782 790 PF00244 0.481
LIG_14-3-3_CanoR_1 802 808 PF00244 0.452
LIG_14-3-3_CanoR_1 820 830 PF00244 0.522
LIG_Actin_WH2_2 827 842 PF00022 0.462
LIG_APCC_ABBA_1 610 615 PF00400 0.620
LIG_BRCT_BRCA1_1 555 559 PF00533 0.315
LIG_BRCT_BRCA1_1 686 690 PF00533 0.567
LIG_DLG_GKlike_1 803 811 PF00625 0.448
LIG_eIF4E_1 722 728 PF01652 0.390
LIG_FHA_1 100 106 PF00498 0.478
LIG_FHA_1 212 218 PF00498 0.443
LIG_FHA_1 309 315 PF00498 0.573
LIG_FHA_1 375 381 PF00498 0.617
LIG_FHA_1 50 56 PF00498 0.637
LIG_FHA_1 546 552 PF00498 0.480
LIG_FHA_1 605 611 PF00498 0.668
LIG_FHA_1 731 737 PF00498 0.424
LIG_FHA_1 754 760 PF00498 0.574
LIG_FHA_2 106 112 PF00498 0.303
LIG_FHA_2 273 279 PF00498 0.569
LIG_FHA_2 487 493 PF00498 0.477
LIG_FHA_2 515 521 PF00498 0.438
LIG_FHA_2 656 662 PF00498 0.546
LIG_FHA_2 741 747 PF00498 0.498
LIG_FHA_2 92 98 PF00498 0.595
LIG_GBD_Chelix_1 723 731 PF00786 0.349
LIG_LIR_Apic_2 396 401 PF02991 0.556
LIG_LIR_Apic_2 646 650 PF02991 0.546
LIG_LIR_Apic_2 784 790 PF02991 0.488
LIG_LIR_Gen_1 231 238 PF02991 0.634
LIG_LIR_Gen_1 273 282 PF02991 0.746
LIG_LIR_Gen_1 40 48 PF02991 0.506
LIG_LIR_Gen_1 486 495 PF02991 0.484
LIG_LIR_Gen_1 548 558 PF02991 0.447
LIG_LIR_Gen_1 721 730 PF02991 0.340
LIG_LIR_Nem_3 231 236 PF02991 0.569
LIG_LIR_Nem_3 273 279 PF02991 0.763
LIG_LIR_Nem_3 299 304 PF02991 0.563
LIG_LIR_Nem_3 3 8 PF02991 0.453
LIG_LIR_Nem_3 344 350 PF02991 0.701
LIG_LIR_Nem_3 40 45 PF02991 0.625
LIG_LIR_Nem_3 48 54 PF02991 0.602
LIG_LIR_Nem_3 486 490 PF02991 0.499
LIG_LIR_Nem_3 548 553 PF02991 0.448
LIG_LIR_Nem_3 721 725 PF02991 0.342
LIG_MAD2 302 310 PF02301 0.572
LIG_MYND_1 791 795 PF01753 0.506
LIG_NRBOX 163 169 PF00104 0.420
LIG_NRBOX 489 495 PF00104 0.467
LIG_PDZ_Class_3 868 873 PF00595 0.535
LIG_Pex14_1 301 305 PF04695 0.508
LIG_Pex14_1 647 651 PF04695 0.498
LIG_Rb_LxCxE_1 246 262 PF01857 0.433
LIG_RPA_C_Fungi 704 716 PF08784 0.333
LIG_SH2_CRK 356 360 PF00017 0.538
LIG_SH2_CRK 694 698 PF00017 0.448
LIG_SH2_CRK 738 742 PF00017 0.413
LIG_SH2_CRK 787 791 PF00017 0.515
LIG_SH2_NCK_1 233 237 PF00017 0.535
LIG_SH2_NCK_1 42 46 PF00017 0.523
LIG_SH2_PTP2 487 490 PF00017 0.485
LIG_SH2_PTP2 722 725 PF00017 0.299
LIG_SH2_SRC 42 45 PF00017 0.529
LIG_SH2_SRC 534 537 PF00017 0.359
LIG_SH2_SRC 738 741 PF00017 0.421
LIG_SH2_STAP1 410 414 PF00017 0.586
LIG_SH2_STAT5 24 27 PF00017 0.474
LIG_SH2_STAT5 410 413 PF00017 0.617
LIG_SH2_STAT5 466 469 PF00017 0.584
LIG_SH2_STAT5 487 490 PF00017 0.582
LIG_SH2_STAT5 534 537 PF00017 0.513
LIG_SH2_STAT5 667 670 PF00017 0.732
LIG_SH2_STAT5 722 725 PF00017 0.304
LIG_SH2_STAT5 740 743 PF00017 0.376
LIG_SH3_1 788 794 PF00018 0.505
LIG_SH3_3 195 201 PF00018 0.542
LIG_SH3_3 71 77 PF00018 0.671
LIG_SH3_3 788 794 PF00018 0.528
LIG_SUMO_SIM_par_1 101 108 PF11976 0.489
LIG_SUMO_SIM_par_1 139 144 PF11976 0.403
LIG_SUMO_SIM_par_1 466 472 PF11976 0.588
LIG_TRAF2_1 275 278 PF00917 0.634
LIG_TRAF2_1 376 379 PF00917 0.437
LIG_TRAF2_1 434 437 PF00917 0.644
LIG_TRAF2_1 618 621 PF00917 0.628
LIG_TRAF2_1 857 860 PF00917 0.683
LIG_TYR_ITIM 303 308 PF00017 0.568
LIG_TYR_ITIM 485 490 PF00017 0.349
LIG_TYR_ITIM 736 741 PF00017 0.412
MOD_CDC14_SPxK_1 299 302 PF00782 0.565
MOD_CDK_SPxK_1 296 302 PF00069 0.556
MOD_CDK_SPxxK_3 692 699 PF00069 0.476
MOD_CK1_1 22 28 PF00069 0.470
MOD_CK1_1 231 237 PF00069 0.542
MOD_CK1_1 421 427 PF00069 0.597
MOD_CK1_1 454 460 PF00069 0.730
MOD_CK1_1 486 492 PF00069 0.543
MOD_CK1_1 500 506 PF00069 0.545
MOD_CK1_1 58 64 PF00069 0.504
MOD_CK1_1 595 601 PF00069 0.739
MOD_CK1_1 781 787 PF00069 0.545
MOD_CK1_1 863 869 PF00069 0.655
MOD_CK2_1 177 183 PF00069 0.544
MOD_CK2_1 264 270 PF00069 0.609
MOD_CK2_1 272 278 PF00069 0.570
MOD_CK2_1 500 506 PF00069 0.622
MOD_CK2_1 514 520 PF00069 0.368
MOD_CK2_1 615 621 PF00069 0.695
MOD_CK2_1 655 661 PF00069 0.662
MOD_CK2_1 740 746 PF00069 0.510
MOD_CMANNOS 227 230 PF00535 0.444
MOD_Cter_Amidation 670 673 PF01082 0.609
MOD_GlcNHglycan 266 269 PF01048 0.737
MOD_GlcNHglycan 322 325 PF01048 0.670
MOD_GlcNHglycan 326 329 PF01048 0.645
MOD_GlcNHglycan 423 426 PF01048 0.545
MOD_GlcNHglycan 440 443 PF01048 0.620
MOD_GlcNHglycan 453 456 PF01048 0.479
MOD_GlcNHglycan 471 474 PF01048 0.606
MOD_GlcNHglycan 477 480 PF01048 0.546
MOD_GlcNHglycan 481 484 PF01048 0.674
MOD_GlcNHglycan 584 587 PF01048 0.813
MOD_GlcNHglycan 602 605 PF01048 0.568
MOD_GlcNHglycan 66 70 PF01048 0.633
MOD_GlcNHglycan 677 680 PF01048 0.560
MOD_GlcNHglycan 762 765 PF01048 0.672
MOD_GlcNHglycan 865 868 PF01048 0.676
MOD_GSK3_1 156 163 PF00069 0.389
MOD_GSK3_1 177 184 PF00069 0.537
MOD_GSK3_1 25 32 PF00069 0.491
MOD_GSK3_1 316 323 PF00069 0.675
MOD_GSK3_1 417 424 PF00069 0.654
MOD_GSK3_1 475 482 PF00069 0.598
MOD_GSK3_1 493 500 PF00069 0.501
MOD_GSK3_1 536 543 PF00069 0.587
MOD_GSK3_1 591 598 PF00069 0.780
MOD_GSK3_1 600 607 PF00069 0.741
MOD_GSK3_1 65 72 PF00069 0.697
MOD_GSK3_1 657 664 PF00069 0.686
MOD_GSK3_1 675 682 PF00069 0.520
MOD_GSK3_1 714 721 PF00069 0.394
MOD_GSK3_1 760 767 PF00069 0.755
MOD_GSK3_1 803 810 PF00069 0.515
MOD_GSK3_1 822 829 PF00069 0.513
MOD_LATS_1 589 595 PF00433 0.639
MOD_N-GLC_1 760 765 PF02516 0.613
MOD_N-GLC_2 799 801 PF02516 0.451
MOD_NEK2_1 1 6 PF00069 0.462
MOD_NEK2_1 475 480 PF00069 0.627
MOD_NEK2_1 759 764 PF00069 0.665
MOD_NEK2_1 807 812 PF00069 0.505
MOD_NEK2_1 819 824 PF00069 0.361
MOD_NEK2_2 228 233 PF00069 0.492
MOD_NEK2_2 37 42 PF00069 0.513
MOD_NEK2_2 679 684 PF00069 0.562
MOD_OFUCOSY 399 406 PF10250 0.558
MOD_PIKK_1 151 157 PF00454 0.489
MOD_PIKK_1 212 218 PF00454 0.468
MOD_PIKK_1 374 380 PF00454 0.555
MOD_PIKK_1 655 661 PF00454 0.581
MOD_PIKK_1 781 787 PF00454 0.588
MOD_PIKK_1 807 813 PF00454 0.564
MOD_PIKK_1 855 861 PF00454 0.520
MOD_PKA_2 1 7 PF00069 0.457
MOD_PKA_2 11 17 PF00069 0.433
MOD_PKA_2 394 400 PF00069 0.505
MOD_PKA_2 421 427 PF00069 0.476
MOD_PKA_2 590 596 PF00069 0.734
MOD_PKA_2 714 720 PF00069 0.457
MOD_PKA_2 781 787 PF00069 0.515
MOD_PKA_2 819 825 PF00069 0.459
MOD_Plk_1 645 651 PF00069 0.668
MOD_Plk_1 679 685 PF00069 0.556
MOD_Plk_2-3 272 278 PF00069 0.472
MOD_Plk_4 19 25 PF00069 0.460
MOD_Plk_4 37 43 PF00069 0.490
MOD_Plk_4 483 489 PF00069 0.645
MOD_Plk_4 718 724 PF00069 0.394
MOD_ProDKin_1 100 106 PF00069 0.450
MOD_ProDKin_1 259 265 PF00069 0.406
MOD_ProDKin_1 296 302 PF00069 0.556
MOD_ProDKin_1 493 499 PF00069 0.456
MOD_ProDKin_1 592 598 PF00069 0.642
MOD_ProDKin_1 608 614 PF00069 0.639
MOD_ProDKin_1 692 698 PF00069 0.504
TRG_DiLeu_BaEn_4 620 626 PF01217 0.514
TRG_DiLeu_BaLyEn_6 136 141 PF01217 0.552
TRG_DiLeu_BaLyEn_6 471 476 PF01217 0.560
TRG_ENDOCYTIC_2 210 213 PF00928 0.605
TRG_ENDOCYTIC_2 223 226 PF00928 0.345
TRG_ENDOCYTIC_2 233 236 PF00928 0.531
TRG_ENDOCYTIC_2 305 308 PF00928 0.564
TRG_ENDOCYTIC_2 356 359 PF00928 0.532
TRG_ENDOCYTIC_2 42 45 PF00928 0.647
TRG_ENDOCYTIC_2 487 490 PF00928 0.479
TRG_ENDOCYTIC_2 722 725 PF00928 0.376
TRG_ENDOCYTIC_2 738 741 PF00928 0.332
TRG_ER_diArg_1 135 137 PF00400 0.430
TRG_ER_diArg_1 223 225 PF00400 0.450
TRG_ER_diArg_1 683 686 PF00400 0.607
TRG_ER_diArg_1 84 86 PF00400 0.524
TRG_Pf-PMV_PEXEL_1 302 306 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 803 808 PF00026 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUQ4 Leptomonas seymouri 39% 100%
A0A3R7LA44 Trypanosoma rangeli 24% 100%
A0A3S7WZ43 Leishmania donovani 88% 100%
A4HE39 Leishmania braziliensis 64% 100%
A4I1E5 Leishmania infantum 87% 100%
Q4Q9Z0 Leishmania major 86% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS