BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXH8_LEIMU

TriTrypDb:

LmxM.25.1000

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.772
CLV_NRD_NRD_1	425	427	PF00675	0.858
CLV_NRD_NRD_1	481	483	PF00675	0.817
CLV_NRD_NRD_1	682	684	PF00675	0.575
CLV_PCSK_KEX2_1	425	427	PF00082	0.858
CLV_PCSK_KEX2_1	481	483	PF00082	0.817
CLV_PCSK_KEX2_1	490	492	PF00082	0.678
CLV_PCSK_KEX2_1	675	677	PF00082	0.671
CLV_PCSK_KEX2_1	682	684	PF00082	0.564
CLV_PCSK_KEX2_1	728	730	PF00082	0.693
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.820
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.671
CLV_PCSK_PC1ET2_1	728	730	PF00082	0.746
CLV_PCSK_SKI1_1	574	578	PF00082	0.794
CLV_PCSK_SKI1_1	581	585	PF00082	0.708
CLV_PCSK_SKI1_1	644	648	PF00082	0.568
CLV_PCSK_SKI1_1	740	744	PF00082	0.675
DEG_APCC_DBOX_1	17	25	PF00400	0.791
DEG_Nend_Nbox_1	1	3	PF02207	0.850
DEG_SPOP_SBC_1	622	626	PF00917	0.733
DEG_SPOP_SBC_1	658	662	PF00917	0.614
DOC_PP1_SILK_1	705	710	PF00149	0.657
DOC_USP7_MATH_1	111	115	PF00917	0.618
DOC_USP7_MATH_1	122	126	PF00917	0.690
DOC_USP7_MATH_1	134	138	PF00917	0.667
DOC_USP7_MATH_1	179	183	PF00917	0.847
DOC_USP7_MATH_1	244	248	PF00917	0.747
DOC_USP7_MATH_1	268	272	PF00917	0.648
DOC_USP7_MATH_1	289	293	PF00917	0.618
DOC_USP7_MATH_1	300	304	PF00917	0.692
DOC_USP7_MATH_1	312	316	PF00917	0.663
DOC_USP7_MATH_1	357	361	PF00917	0.836
DOC_USP7_MATH_1	424	428	PF00917	0.851
DOC_USP7_MATH_1	46	50	PF00917	0.864
DOC_USP7_MATH_1	510	514	PF00917	0.729
DOC_USP7_MATH_1	597	601	PF00917	0.794
DOC_USP7_MATH_1	605	609	PF00917	0.673
DOC_USP7_MATH_1	622	626	PF00917	0.528
DOC_USP7_MATH_1	703	707	PF00917	0.649
DOC_USP7_MATH_1	748	752	PF00917	0.610
DOC_USP7_MATH_1	90	94	PF00917	0.767
DOC_USP7_UBL2_3	724	728	PF12436	0.733
DOC_WW_Pin1_4	175	180	PF00397	0.839
DOC_WW_Pin1_4	201	206	PF00397	0.838
DOC_WW_Pin1_4	214	219	PF00397	0.652
DOC_WW_Pin1_4	353	358	PF00397	0.832
DOC_WW_Pin1_4	379	384	PF00397	0.813
DOC_WW_Pin1_4	392	397	PF00397	0.638
DOC_WW_Pin1_4	4	9	PF00397	0.812
DOC_WW_Pin1_4	428	433	PF00397	0.603
DOC_WW_Pin1_4	518	523	PF00397	0.840
LIG_14-3-3_CanoR_1	207	213	PF00244	0.612
LIG_14-3-3_CanoR_1	385	391	PF00244	0.602
LIG_14-3-3_CanoR_1	425	432	PF00244	0.736
LIG_14-3-3_CanoR_1	481	489	PF00244	0.817
LIG_14-3-3_CanoR_1	682	691	PF00244	0.407
LIG_FHA_1	149	155	PF00498	0.844
LIG_FHA_1	327	333	PF00498	0.843
LIG_FHA_1	659	665	PF00498	0.518
LIG_FHA_2	234	240	PF00498	0.842
LIG_FHA_2	412	418	PF00498	0.797
LIG_FHA_2	48	54	PF00498	0.615
LIG_FHA_2	582	588	PF00498	0.817
LIG_FHA_2	627	633	PF00498	0.498
LIG_GBD_Chelix_1	13	21	PF00786	0.779
LIG_LIR_Apic_2	155	159	PF02991	0.711
LIG_LIR_Apic_2	333	337	PF02991	0.706
LIG_LIR_Apic_2	660	666	PF02991	0.757
LIG_LIR_Nem_3	679	684	PF02991	0.665
LIG_LIR_Nem_3	685	691	PF02991	0.548
LIG_LIR_Nem_3	738	742	PF02991	0.559
LIG_SH2_CRK	156	160	PF00017	0.851
LIG_SH2_CRK	334	338	PF00017	0.846
LIG_SH2_CRK	688	692	PF00017	0.618
LIG_SH2_GRB2like	529	532	PF00017	0.598
LIG_SH2_NCK_1	156	160	PF00017	0.851
LIG_SH2_NCK_1	334	338	PF00017	0.846
LIG_SH2_PTP2	529	532	PF00017	0.598
LIG_SH2_PTP2	663	666	PF00017	0.512
LIG_SH2_SRC	374	377	PF00017	0.577
LIG_SH2_STAP1	196	200	PF00017	0.594
LIG_SH2_STAP1	374	378	PF00017	0.579
LIG_SH2_STAP1	606	610	PF00017	0.663
LIG_SH2_STAP1	684	688	PF00017	0.651
LIG_SH2_STAT5	529	532	PF00017	0.829
LIG_SH2_STAT5	663	666	PF00017	0.652
LIG_SH3_3	210	216	PF00018	0.614
LIG_SH3_3	248	254	PF00018	0.858
LIG_SH3_3	388	394	PF00018	0.614
LIG_SH3_3	521	527	PF00018	0.767
LIG_SH3_3	59	65	PF00018	0.609
LIG_SH3_3	70	76	PF00018	0.721
LIG_SH3_4	724	731	PF00018	0.733
LIG_SH3_5	432	436	PF00018	0.596
LIG_WW_3	217	221	PF00397	0.614
LIG_WW_3	395	399	PF00397	0.596
MOD_CDK_SPxK_1	201	207	PF00069	0.841
MOD_CDK_SPxK_1	214	220	PF00069	0.653
MOD_CDK_SPxK_1	379	385	PF00069	0.816
MOD_CDK_SPxK_1	392	398	PF00069	0.641
MOD_CK1_1	175	181	PF00069	0.841
MOD_CK1_1	191	197	PF00069	0.579
MOD_CK1_1	3	9	PF00069	0.816
MOD_CK1_1	353	359	PF00069	0.833
MOD_CK1_1	369	375	PF00069	0.561
MOD_CK1_1	463	469	PF00069	0.571
MOD_CK1_1	47	53	PF00069	0.861
MOD_CK1_1	494	500	PF00069	0.577
MOD_CK1_1	535	541	PF00069	0.612
MOD_CK1_1	608	614	PF00069	0.737
MOD_CK1_1	751	757	PF00069	0.724
MOD_CK2_1	139	145	PF00069	0.675
MOD_CK2_1	233	239	PF00069	0.843
MOD_CK2_1	317	323	PF00069	0.646
MOD_CK2_1	411	417	PF00069	0.808
MOD_CK2_1	424	430	PF00069	0.672
MOD_CK2_1	47	53	PF00069	0.616
MOD_CK2_1	535	541	PF00069	0.749
MOD_CK2_1	581	587	PF00069	0.818
MOD_CK2_1	626	632	PF00069	0.506
MOD_GlcNHglycan	113	116	PF01048	0.864
MOD_GlcNHglycan	136	139	PF01048	0.653
MOD_GlcNHglycan	159	162	PF01048	0.742
MOD_GlcNHglycan	174	177	PF01048	0.604
MOD_GlcNHglycan	188	191	PF01048	0.621
MOD_GlcNHglycan	222	225	PF01048	0.784
MOD_GlcNHglycan	270	273	PF01048	0.645
MOD_GlcNHglycan	291	294	PF01048	0.867
MOD_GlcNHglycan	314	317	PF01048	0.641
MOD_GlcNHglycan	337	340	PF01048	0.739
MOD_GlcNHglycan	352	355	PF01048	0.601
MOD_GlcNHglycan	366	369	PF01048	0.609
MOD_GlcNHglycan	400	403	PF01048	0.775
MOD_GlcNHglycan	458	461	PF01048	0.769
MOD_GlcNHglycan	46	49	PF01048	0.621
MOD_GlcNHglycan	463	466	PF01048	0.805
MOD_GlcNHglycan	476	479	PF01048	0.566
MOD_GlcNHglycan	493	496	PF01048	0.546
MOD_GlcNHglycan	512	515	PF01048	0.539
MOD_GlcNHglycan	634	637	PF01048	0.735
MOD_GlcNHglycan	666	669	PF01048	0.727
MOD_GlcNHglycan	693	697	PF01048	0.630
MOD_GlcNHglycan	92	95	PF01048	0.754
MOD_GSK3_1	148	155	PF00069	0.657
MOD_GSK3_1	171	178	PF00069	0.842
MOD_GSK3_1	179	186	PF00069	0.726
MOD_GSK3_1	188	195	PF00069	0.568
MOD_GSK3_1	326	333	PF00069	0.657
MOD_GSK3_1	349	356	PF00069	0.839
MOD_GSK3_1	357	364	PF00069	0.716
MOD_GSK3_1	366	373	PF00069	0.551
MOD_GSK3_1	40	47	PF00069	0.615
MOD_GSK3_1	424	431	PF00069	0.607
MOD_GSK3_1	456	463	PF00069	0.618
MOD_GSK3_1	510	517	PF00069	0.608
MOD_GSK3_1	597	604	PF00069	0.745
MOD_GSK3_1	605	612	PF00069	0.622
MOD_GSK3_1	622	629	PF00069	0.523
MOD_GSK3_1	703	710	PF00069	0.653
MOD_N-GLC_1	186	191	PF02516	0.847
MOD_N-GLC_1	364	369	PF02516	0.837
MOD_N-GLC_1	428	433	PF02516	0.603
MOD_N-GLC_1	751	756	PF02516	0.485
MOD_NEK2_1	1	6	PF00069	0.593
MOD_NEK2_1	172	177	PF00069	0.843
MOD_NEK2_1	183	188	PF00069	0.684
MOD_NEK2_1	350	355	PF00069	0.840
MOD_NEK2_1	361	366	PF00069	0.674
MOD_NEK2_1	532	537	PF00069	0.697
MOD_NEK2_1	564	569	PF00069	0.742
MOD_NEK2_1	623	628	PF00069	0.785
MOD_NEK2_1	631	636	PF00069	0.594
MOD_NEK2_2	179	184	PF00069	0.849
MOD_NEK2_2	357	362	PF00069	0.838
MOD_PIKK_1	109	115	PF00454	0.854
MOD_PIKK_1	128	134	PF00454	0.553
MOD_PIKK_1	188	194	PF00454	0.839
MOD_PIKK_1	287	293	PF00454	0.857
MOD_PIKK_1	306	312	PF00454	0.555
MOD_PIKK_1	366	372	PF00454	0.821
MOD_PKA_1	481	487	PF00069	0.816
MOD_PKA_1	682	688	PF00069	0.566
MOD_PKA_2	206	212	PF00069	0.859
MOD_PKA_2	384	390	PF00069	0.850
MOD_PKA_2	424	430	PF00069	0.839
MOD_PKA_2	481	487	PF00069	0.816
MOD_PKA_2	510	516	PF00069	0.602
MOD_PKA_2	682	688	PF00069	0.661
MOD_Plk_1	179	185	PF00069	0.850
MOD_Plk_1	357	363	PF00069	0.841
MOD_Plk_1	676	682	PF00069	0.660
MOD_Plk_1	692	698	PF00069	0.376
MOD_Plk_2-3	552	558	PF00069	0.545
MOD_Plk_4	139	145	PF00069	0.613
MOD_Plk_4	317	323	PF00069	0.604
MOD_Plk_4	552	558	PF00069	0.631
MOD_Plk_4	565	571	PF00069	0.704
MOD_Plk_4	659	665	PF00069	0.554
MOD_Plk_4	676	682	PF00069	0.601
MOD_Plk_4	703	709	PF00069	0.650
MOD_ProDKin_1	175	181	PF00069	0.841
MOD_ProDKin_1	201	207	PF00069	0.841
MOD_ProDKin_1	214	220	PF00069	0.653
MOD_ProDKin_1	353	359	PF00069	0.833
MOD_ProDKin_1	379	385	PF00069	0.816
MOD_ProDKin_1	392	398	PF00069	0.641
MOD_ProDKin_1	4	10	PF00069	0.812
MOD_ProDKin_1	428	434	PF00069	0.603
MOD_ProDKin_1	518	524	PF00069	0.836
MOD_SUMO_rev_2	719	726	PF00179	0.730
MOD_SUMO_rev_2	733	742	PF00179	0.474
TRG_DiLeu_BaEn_2	559	565	PF01217	0.752
TRG_ENDOCYTIC_2	529	532	PF00928	0.703
TRG_ENDOCYTIC_2	688	691	PF00928	0.628
TRG_ER_diArg_1	424	426	PF00400	0.855
TRG_ER_diArg_1	481	483	PF00400	0.817
TRG_ER_diArg_1	681	683	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.815
TRG_Pf-PMV_PEXEL_1	548	552	PF00026	0.817
TRG_Pf-PMV_PEXEL_1	574	578	PF00026	0.696
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	741	745	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZ10	Leishmania donovani	72%	78%
A4I1E1	Leishmania infantum	71%	98%
Q4Q9Z4	Leishmania major	70%	100%