LeishMANIAdb
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Putative dynein heavy chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative dynein heavy chain
Gene product:
dynein heavy chain, putative
Species:
Leishmania mexicana
UniProt:
E9AXH6_LEIMU
TriTrypDb:
LmxM.25.0980
Length:
4702

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 10
GO:0005858 axonemal dynein complex 4 1
GO:0005874 microtubule 6 11
GO:0005875 microtubule associated complex 2 12
GO:0005930 axoneme 2 1
GO:0030286 dynein complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0036157 outer dynein arm 5 1
GO:0099080 supramolecular complex 2 11
GO:0099081 supramolecular polymer 3 11
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Expansion

Sequence features

E9AXH6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
TermNameLevelCount
GO:0007017 microtubule-based process 2 12
GO:0007018 microtubule-based movement 3 12
GO:0007165 signal transduction 2 2
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0036158 outer dynein arm assembly 7 1
GO:0043933 protein-containing complex organization 4 1
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003774 cytoskeletal motor activity 1 12
GO:0003777 microtubule motor activity 2 12
GO:0003824 catalytic activity 1 1
GO:0005488 binding 1 12
GO:0005515 protein binding 2 1
GO:0005524 ATP binding 5 12
GO:0008569 minus-end-directed microtubule motor activity 3 12
GO:0016787 hydrolase activity 2 1
GO:0017076 purine nucleotide binding 4 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1439 1443 PF00656 0.575
CLV_C14_Caspase3-7 1486 1490 PF00656 0.575
CLV_C14_Caspase3-7 1918 1922 PF00656 0.401
CLV_C14_Caspase3-7 2835 2839 PF00656 0.521
CLV_C14_Caspase3-7 3068 3072 PF00656 0.481
CLV_C14_Caspase3-7 3820 3824 PF00656 0.478
CLV_C14_Caspase3-7 41 45 PF00656 0.576
CLV_C14_Caspase3-7 590 594 PF00656 0.489
CLV_MEL_PAP_1 998 1004 PF00089 0.354
CLV_NRD_NRD_1 1106 1108 PF00675 0.341
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P5Z1 Leptomonas seymouri 30% 100%
A0A0N0P6T2 Leptomonas seymouri 29% 100%
A0A0N0P8F1 Leptomonas seymouri 30% 100%
A0A0N1HVV7 Leptomonas seymouri 28% 100%
A0A0N1I0K3 Leptomonas seymouri 30% 100%
A0A0N1I4F9 Leptomonas seymouri 31% 100%
A0A0N1PBB8 Leptomonas seymouri 31% 100%
A0A0N1PCN0 Leptomonas seymouri 31% 98%
A0A0N1PCS5 Leptomonas seymouri 28% 100%
A0A0N1PF93 Leptomonas seymouri 90% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS