Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXH3_LEIMU

TriTrypDb:

LmxM.25.0950

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.494
CLV_NRD_NRD_1	120	122	PF00675	0.567
CLV_NRD_NRD_1	217	219	PF00675	0.584
CLV_NRD_NRD_1	354	356	PF00675	0.623
CLV_NRD_NRD_1	39	41	PF00675	0.429
CLV_NRD_NRD_1	396	398	PF00675	0.495
CLV_PCSK_KEX2_1	120	122	PF00082	0.566
CLV_PCSK_KEX2_1	156	158	PF00082	0.538
CLV_PCSK_KEX2_1	217	219	PF00082	0.600
CLV_PCSK_KEX2_1	354	356	PF00082	0.512
CLV_PCSK_KEX2_1	39	41	PF00082	0.429
CLV_PCSK_KEX2_1	396	398	PF00082	0.495
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.398
CLV_PCSK_PC7_1	392	398	PF00082	0.497
CLV_PCSK_SKI1_1	164	168	PF00082	0.378
CLV_PCSK_SKI1_1	282	286	PF00082	0.473
CLV_PCSK_SKI1_1	39	43	PF00082	0.385
CLV_PCSK_SKI1_1	98	102	PF00082	0.386
DOC_CYCLIN_RxL_1	161	171	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.405
DOC_MAPK_gen_1	312	321	PF00069	0.633
DOC_MAPK_gen_1	361	369	PF00069	0.400
DOC_MAPK_MEF2A_6	363	371	PF00069	0.386
DOC_PP1_RVXF_1	96	103	PF00149	0.466
DOC_PP4_FxxP_1	31	34	PF00568	0.394
DOC_USP7_MATH_1	12	16	PF00917	0.549
DOC_USP7_MATH_1	148	152	PF00917	0.475
DOC_USP7_MATH_1	277	281	PF00917	0.568
DOC_USP7_MATH_1	301	305	PF00917	0.659
DOC_WW_Pin1_4	239	244	PF00397	0.570
LIG_14-3-3_CanoR_1	132	139	PF00244	0.468
LIG_14-3-3_CanoR_1	184	191	PF00244	0.405
LIG_14-3-3_CanoR_1	272	276	PF00244	0.699
LIG_14-3-3_CanoR_1	282	290	PF00244	0.488
LIG_14-3-3_CanoR_1	60	65	PF00244	0.373
LIG_Actin_RPEL_3	356	375	PF02755	0.462
LIG_Actin_WH2_2	68	85	PF00022	0.443
LIG_APCC_ABBAyCdc20_2	431	437	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_BIR_III_4	116	120	PF00653	0.437
LIG_DLG_GKlike_1	363	371	PF00625	0.446
LIG_FHA_1	184	190	PF00498	0.384
LIG_FHA_1	210	216	PF00498	0.643
LIG_FHA_1	251	257	PF00498	0.732
LIG_FHA_1	417	423	PF00498	0.377
LIG_FHA_1	65	71	PF00498	0.403
LIG_FHA_2	174	180	PF00498	0.475
LIG_LIR_Apic_2	29	34	PF02991	0.385
LIG_LIR_Gen_1	160	169	PF02991	0.445
LIG_LIR_Gen_1	58	69	PF02991	0.399
LIG_LIR_Nem_3	160	165	PF02991	0.511
LIG_LIR_Nem_3	352	356	PF02991	0.363
LIG_LIR_Nem_3	58	64	PF02991	0.396
LIG_NRBOX	190	196	PF00104	0.495
LIG_NRBOX	280	286	PF00104	0.550
LIG_PCNA_yPIPBox_3	227	236	PF02747	0.528
LIG_SH2_CRK	162	166	PF00017	0.442
LIG_SH2_CRK	353	357	PF00017	0.442
LIG_SH2_SRC	158	161	PF00017	0.518
LIG_SH2_STAP1	418	422	PF00017	0.398
LIG_SH2_STAP1	435	439	PF00017	0.484
LIG_SH2_STAT5	275	278	PF00017	0.450
LIG_SH2_STAT5	345	348	PF00017	0.458
LIG_SH2_STAT5	418	421	PF00017	0.376
LIG_SH2_STAT5	61	64	PF00017	0.361
LIG_SH2_STAT5	80	83	PF00017	0.374
LIG_SH2_STAT5	99	102	PF00017	0.434
LIG_SH3_3	317	323	PF00018	0.779
LIG_SH3_3	53	59	PF00018	0.412
LIG_SUMO_SIM_par_1	18	24	PF11976	0.422
LIG_TRAF2_1	357	360	PF00917	0.500
LIG_WRC_WIRS_1	61	66	PF05994	0.375
MOD_CK1_1	15	21	PF00069	0.552
MOD_CK1_1	209	215	PF00069	0.686
MOD_CK1_1	286	292	PF00069	0.534
MOD_CK1_1	29	35	PF00069	0.367
MOD_CK1_1	304	310	PF00069	0.644
MOD_CK1_1	311	317	PF00069	0.590
MOD_CK1_1	379	385	PF00069	0.425
MOD_CK1_1	65	71	PF00069	0.426
MOD_CK2_1	101	107	PF00069	0.617
MOD_CK2_1	143	149	PF00069	0.591
MOD_CK2_1	173	179	PF00069	0.500
MOD_CK2_1	286	292	PF00069	0.465
MOD_CK2_1	354	360	PF00069	0.494
MOD_Cter_Amidation	118	121	PF01082	0.436
MOD_GlcNHglycan	13	17	PF01048	0.516
MOD_GlcNHglycan	149	153	PF01048	0.557
MOD_GlcNHglycan	170	173	PF01048	0.679
MOD_GlcNHglycan	2	5	PF01048	0.549
MOD_GlcNHglycan	256	259	PF01048	0.539
MOD_GlcNHglycan	28	31	PF01048	0.397
MOD_GlcNHglycan	298	301	PF01048	0.546
MOD_GlcNHglycan	303	306	PF01048	0.654
MOD_GlcNHglycan	325	328	PF01048	0.539
MOD_GlcNHglycan	64	67	PF01048	0.421
MOD_GlcNHglycan	8	11	PF01048	0.524
MOD_GSK3_1	101	108	PF00069	0.553
MOD_GSK3_1	138	145	PF00069	0.412
MOD_GSK3_1	148	155	PF00069	0.506
MOD_GSK3_1	205	212	PF00069	0.660
MOD_GSK3_1	238	245	PF00069	0.684
MOD_GSK3_1	250	257	PF00069	0.518
MOD_GSK3_1	301	308	PF00069	0.572
MOD_GSK3_1	345	352	PF00069	0.527
MOD_GSK3_1	363	370	PF00069	0.377
MOD_GSK3_1	60	67	PF00069	0.430
MOD_GSK3_1	8	15	PF00069	0.708
MOD_LATS_1	109	115	PF00433	0.466
MOD_NEK2_1	105	110	PF00069	0.432
MOD_NEK2_1	168	173	PF00069	0.668
MOD_NEK2_1	21	26	PF00069	0.598
MOD_NEK2_1	296	301	PF00069	0.534
MOD_NEK2_1	325	330	PF00069	0.431
MOD_NEK2_1	346	351	PF00069	0.399
MOD_NEK2_1	367	372	PF00069	0.432
MOD_NEK2_1	64	69	PF00069	0.413
MOD_NEK2_1	88	93	PF00069	0.421
MOD_NEK2_2	277	282	PF00069	0.510
MOD_PIKK_1	206	212	PF00454	0.651
MOD_PIKK_1	258	264	PF00454	0.603
MOD_PIKK_1	354	360	PF00454	0.425
MOD_PKA_1	354	360	PF00069	0.450
MOD_PKA_1	416	422	PF00069	0.378
MOD_PKA_2	131	137	PF00069	0.370
MOD_PKA_2	183	189	PF00069	0.471
MOD_PKA_2	271	277	PF00069	0.571
MOD_PKA_2	311	317	PF00069	0.638
MOD_PKA_2	354	360	PF00069	0.422
MOD_PKA_2	59	65	PF00069	0.312
MOD_PKB_1	361	369	PF00069	0.400
MOD_Plk_1	143	149	PF00069	0.525
MOD_Plk_1	277	283	PF00069	0.530
MOD_Plk_4	138	144	PF00069	0.463
MOD_Plk_4	271	277	PF00069	0.466
MOD_Plk_4	363	369	PF00069	0.392
MOD_ProDKin_1	239	245	PF00069	0.570
MOD_SUMO_rev_2	421	428	PF00179	0.453
TRG_DiLeu_BaEn_1	394	399	PF01217	0.481
TRG_DiLeu_BaEn_1	423	428	PF01217	0.469
TRG_DiLeu_BaEn_2	230	236	PF01217	0.534
TRG_DiLeu_BaEn_4	423	429	PF01217	0.470
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.401
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.423
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.341
TRG_ENDOCYTIC_2	162	165	PF00928	0.513
TRG_ENDOCYTIC_2	353	356	PF00928	0.442
TRG_ENDOCYTIC_2	435	438	PF00928	0.431
TRG_ENDOCYTIC_2	61	64	PF00928	0.373
TRG_ENDOCYTIC_2	99	102	PF00928	0.434
TRG_ER_diArg_1	120	123	PF00400	0.568
TRG_ER_diArg_1	216	218	PF00400	0.616
TRG_ER_diArg_1	333	336	PF00400	0.508
TRG_ER_diArg_1	353	355	PF00400	0.401
TRG_ER_diArg_1	38	40	PF00400	0.381
TRG_ER_diArg_1	396	398	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU1	Leptomonas seymouri	42%	100%
A4HE30	Leishmania braziliensis	68%	100%
Q4Q9Z9	Leishmania major	86%	100%