AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXH2_LEIMU

TriTrypDb:

LmxM.25.0940

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.764
CLV_C14_Caspase3-7	218	222	PF00656	0.602
CLV_C14_Caspase3-7	224	228	PF00656	0.614
CLV_C14_Caspase3-7	490	494	PF00656	0.531
CLV_NRD_NRD_1	189	191	PF00675	0.682
CLV_NRD_NRD_1	237	239	PF00675	0.653
CLV_NRD_NRD_1	256	258	PF00675	0.531
CLV_NRD_NRD_1	275	277	PF00675	0.580
CLV_NRD_NRD_1	453	455	PF00675	0.533
CLV_NRD_NRD_1	460	462	PF00675	0.490
CLV_NRD_NRD_1	472	474	PF00675	0.473
CLV_NRD_NRD_1	486	488	PF00675	0.563
CLV_NRD_NRD_1	561	563	PF00675	0.691
CLV_NRD_NRD_1	565	567	PF00675	0.671
CLV_NRD_NRD_1	640	642	PF00675	0.541
CLV_PCSK_FUR_1	557	561	PF00082	0.667
CLV_PCSK_KEX2_1	178	180	PF00082	0.666
CLV_PCSK_KEX2_1	237	239	PF00082	0.694
CLV_PCSK_KEX2_1	256	258	PF00082	0.531
CLV_PCSK_KEX2_1	275	277	PF00082	0.580
CLV_PCSK_KEX2_1	453	455	PF00082	0.533
CLV_PCSK_KEX2_1	462	464	PF00082	0.485
CLV_PCSK_KEX2_1	485	487	PF00082	0.701
CLV_PCSK_KEX2_1	559	561	PF00082	0.675
CLV_PCSK_KEX2_1	565	567	PF00082	0.652
CLV_PCSK_KEX2_1	677	679	PF00082	0.583
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.666
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.569
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.675
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.583
CLV_PCSK_PC7_1	174	180	PF00082	0.659
CLV_PCSK_PC7_1	557	563	PF00082	0.675
CLV_PCSK_PC7_1	673	679	PF00082	0.552
CLV_PCSK_SKI1_1	179	183	PF00082	0.661
CLV_PCSK_SKI1_1	394	398	PF00082	0.595
CLV_Separin_Metazoa	367	371	PF03568	0.522
DEG_APCC_DBOX_1	356	364	PF00400	0.502
DEG_COP1_1	601	608	PF00400	0.667
DEG_SCF_FBW7_1	408	413	PF00400	0.646
DEG_SPOP_SBC_1	577	581	PF00917	0.555
DOC_ANK_TNKS_1	485	492	PF00023	0.654
DOC_CKS1_1	314	319	PF01111	0.664
DOC_CKS1_1	635	640	PF01111	0.551
DOC_CYCLIN_yCln2_LP_2	60	63	PF00134	0.516
DOC_MAPK_gen_1	354	363	PF00069	0.513
DOC_MAPK_HePTP_8	416	428	PF00069	0.489
DOC_MAPK_MEF2A_6	419	428	PF00069	0.532
DOC_PP1_RVXF_1	368	375	PF00149	0.395
DOC_PP1_RVXF_1	671	677	PF00149	0.531
DOC_PP2B_LxvP_1	510	513	PF13499	0.687
DOC_PP2B_LxvP_1	60	63	PF13499	0.497
DOC_USP7_MATH_1	144	148	PF00917	0.693
DOC_USP7_MATH_1	160	164	PF00917	0.585
DOC_USP7_MATH_1	249	253	PF00917	0.550
DOC_USP7_MATH_1	302	306	PF00917	0.626
DOC_USP7_MATH_1	323	327	PF00917	0.810
DOC_USP7_MATH_1	410	414	PF00917	0.553
DOC_USP7_MATH_1	577	581	PF00917	0.629
DOC_USP7_MATH_1	593	597	PF00917	0.639
DOC_USP7_MATH_1	599	603	PF00917	0.618
DOC_USP7_MATH_1	69	73	PF00917	0.523
DOC_USP7_UBL2_3	470	474	PF12436	0.642
DOC_WW_Pin1_4	139	144	PF00397	0.613
DOC_WW_Pin1_4	150	155	PF00397	0.691
DOC_WW_Pin1_4	29	34	PF00397	0.474
DOC_WW_Pin1_4	313	318	PF00397	0.770
DOC_WW_Pin1_4	326	331	PF00397	0.590
DOC_WW_Pin1_4	406	411	PF00397	0.825
DOC_WW_Pin1_4	418	423	PF00397	0.559
DOC_WW_Pin1_4	48	53	PF00397	0.547
DOC_WW_Pin1_4	570	575	PF00397	0.670
DOC_WW_Pin1_4	61	66	PF00397	0.608
DOC_WW_Pin1_4	631	636	PF00397	0.578
DOC_WW_Pin1_4	99	104	PF00397	0.572
LIG_14-3-3_CanoR_1	179	184	PF00244	0.656
LIG_14-3-3_CanoR_1	256	266	PF00244	0.555
LIG_14-3-3_CanoR_1	306	314	PF00244	0.709
LIG_14-3-3_CanoR_1	357	361	PF00244	0.512
LIG_14-3-3_CanoR_1	453	459	PF00244	0.516
LIG_14-3-3_CanoR_1	463	469	PF00244	0.523
LIG_14-3-3_CanoR_1	560	569	PF00244	0.650
LIG_14-3-3_CanoR_1	578	586	PF00244	0.577
LIG_14-3-3_CanoR_1	646	654	PF00244	0.576
LIG_14-3-3_CanoR_1	73	78	PF00244	0.632
LIG_Actin_WH2_2	342	359	PF00022	0.551
LIG_deltaCOP1_diTrp_1	514	524	PF00928	0.686
LIG_EH1_1	54	62	PF00400	0.491
LIG_eIF4E_1	25	31	PF01652	0.475
LIG_FHA_1	180	186	PF00498	0.539
LIG_FHA_1	314	320	PF00498	0.711
LIG_FHA_1	45	51	PF00498	0.567
LIG_FHA_2	216	222	PF00498	0.556
LIG_FHA_2	635	641	PF00498	0.547
LIG_LIR_Apic_2	43	49	PF02991	0.477
LIG_LIR_Gen_1	514	524	PF02991	0.565
LIG_LIR_Gen_1	660	669	PF02991	0.522
LIG_LIR_Nem_3	514	520	PF02991	0.567
LIG_LIR_Nem_3	660	665	PF02991	0.535
LIG_Rb_LxCxE_1	607	622	PF01857	0.614
LIG_SH2_CRK	46	50	PF00017	0.476
LIG_SH2_CRK	662	666	PF00017	0.517
LIG_SH2_SRC	438	441	PF00017	0.496
LIG_SH2_STAP1	446	450	PF00017	0.514
LIG_SH2_STAP1	644	648	PF00017	0.552
LIG_SH2_STAP1	662	666	PF00017	0.350
LIG_SH2_STAT5	438	441	PF00017	0.549
LIG_SH2_STAT5	46	49	PF00017	0.476
LIG_SH2_STAT5	647	650	PF00017	0.550
LIG_SH3_1	397	403	PF00018	0.590
LIG_SH3_1	46	52	PF00018	0.471
LIG_SH3_3	263	269	PF00018	0.580
LIG_SH3_3	3	9	PF00018	0.500
LIG_SH3_3	311	317	PF00018	0.664
LIG_SH3_3	360	366	PF00018	0.489
LIG_SH3_3	397	403	PF00018	0.634
LIG_SH3_3	421	427	PF00018	0.569
LIG_SH3_3	46	52	PF00018	0.487
LIG_SH3_3	515	521	PF00018	0.683
LIG_SH3_3	59	65	PF00018	0.481
LIG_SH3_3	611	617	PF00018	0.632
LIG_SH3_3	629	635	PF00018	0.450
LIG_Sin3_3	629	636	PF02671	0.605
LIG_TRAF2_1	143	146	PF00917	0.544
LIG_TRAF2_1	196	199	PF00917	0.666
LIG_TRAF2_1	269	272	PF00917	0.549
LIG_TRAF2_1	333	336	PF00917	0.621
LIG_TRAF2_1	637	640	PF00917	0.550
LIG_TRFH_1	29	33	PF08558	0.467
LIG_UBA3_1	425	430	PF00899	0.547
MOD_CDK_SPK_2	29	34	PF00069	0.468
MOD_CDK_SPxxK_3	634	641	PF00069	0.555
MOD_CK1_1	147	153	PF00069	0.622
MOD_CK1_1	155	161	PF00069	0.655
MOD_CK1_1	230	236	PF00069	0.550
MOD_CK1_1	252	258	PF00069	0.546
MOD_CK1_1	304	310	PF00069	0.712
MOD_CK1_1	324	330	PF00069	0.651
MOD_CK1_1	414	420	PF00069	0.554
MOD_CK1_1	478	484	PF00069	0.682
MOD_CK1_1	573	579	PF00069	0.656
MOD_CK1_1	592	598	PF00069	0.572
MOD_CK1_1	634	640	PF00069	0.450
MOD_CK1_1	99	105	PF00069	0.598
MOD_CK2_1	139	145	PF00069	0.705
MOD_CK2_1	219	225	PF00069	0.677
MOD_CK2_1	282	288	PF00069	0.701
MOD_CK2_1	634	640	PF00069	0.566
MOD_CK2_1	88	94	PF00069	0.537
MOD_CMANNOS	550	553	PF00535	0.647
MOD_Cter_Amidation	188	191	PF01082	0.682
MOD_Cter_Amidation	471	474	PF01082	0.644
MOD_GlcNHglycan	107	110	PF01048	0.664
MOD_GlcNHglycan	145	149	PF01048	0.616
MOD_GlcNHglycan	162	165	PF01048	0.618
MOD_GlcNHglycan	209	212	PF01048	0.574
MOD_GlcNHglycan	323	326	PF01048	0.825
MOD_GlcNHglycan	385	388	PF01048	0.579
MOD_GlcNHglycan	477	480	PF01048	0.649
MOD_GlcNHglycan	533	536	PF01048	0.669
MOD_GlcNHglycan	541	544	PF01048	0.574
MOD_GlcNHglycan	575	578	PF01048	0.680
MOD_GlcNHglycan	583	586	PF01048	0.624
MOD_GlcNHglycan	591	594	PF01048	0.554
MOD_GlcNHglycan	601	604	PF01048	0.588
MOD_GlcNHglycan	627	630	PF01048	0.664
MOD_GlcNHglycan	650	653	PF01048	0.589
MOD_GSK3_1	144	151	PF00069	0.702
MOD_GSK3_1	15	22	PF00069	0.500
MOD_GSK3_1	152	159	PF00069	0.657
MOD_GSK3_1	160	167	PF00069	0.605
MOD_GSK3_1	194	201	PF00069	0.651
MOD_GSK3_1	213	220	PF00069	0.589
MOD_GSK3_1	223	230	PF00069	0.629
MOD_GSK3_1	302	309	PF00069	0.805
MOD_GSK3_1	40	47	PF00069	0.521
MOD_GSK3_1	406	413	PF00069	0.664
MOD_GSK3_1	414	421	PF00069	0.553
MOD_GSK3_1	474	481	PF00069	0.624
MOD_GSK3_1	561	568	PF00069	0.692
MOD_GSK3_1	573	580	PF00069	0.604
MOD_GSK3_1	589	596	PF00069	0.668
MOD_GSK3_1	604	611	PF00069	0.527
MOD_GSK3_1	69	76	PF00069	0.502
MOD_GSK3_1	84	91	PF00069	0.700
MOD_LATS_1	71	77	PF00433	0.504
MOD_NEK2_1	126	131	PF00069	0.523
MOD_NEK2_1	356	361	PF00069	0.554
MOD_NEK2_1	664	669	PF00069	0.515
MOD_PIKK_1	219	225	PF00454	0.611
MOD_PIKK_1	398	404	PF00454	0.688
MOD_PIKK_1	452	458	PF00454	0.493
MOD_PKA_1	473	479	PF00069	0.616
MOD_PKA_1	560	566	PF00069	0.691
MOD_PKA_2	302	308	PF00069	0.725
MOD_PKA_2	356	362	PF00069	0.512
MOD_PKA_2	452	458	PF00069	0.560
MOD_PKA_2	464	470	PF00069	0.518
MOD_PKA_2	560	566	PF00069	0.691
MOD_PKA_2	577	583	PF00069	0.546
MOD_PKA_2	96	102	PF00069	0.635
MOD_PKB_1	306	314	PF00069	0.709
MOD_Plk_1	126	132	PF00069	0.515
MOD_Plk_1	197	203	PF00069	0.717
MOD_Plk_1	69	75	PF00069	0.502
MOD_Plk_1	82	88	PF00069	0.526
MOD_Plk_4	198	204	PF00069	0.716
MOD_Plk_4	249	255	PF00069	0.551
MOD_Plk_4	315	321	PF00069	0.673
MOD_Plk_4	356	362	PF00069	0.556
MOD_ProDKin_1	139	145	PF00069	0.615
MOD_ProDKin_1	150	156	PF00069	0.693
MOD_ProDKin_1	29	35	PF00069	0.472
MOD_ProDKin_1	313	319	PF00069	0.771
MOD_ProDKin_1	326	332	PF00069	0.584
MOD_ProDKin_1	406	412	PF00069	0.823
MOD_ProDKin_1	418	424	PF00069	0.549
MOD_ProDKin_1	48	54	PF00069	0.547
MOD_ProDKin_1	570	576	PF00069	0.669
MOD_ProDKin_1	61	67	PF00069	0.607
MOD_ProDKin_1	631	637	PF00069	0.571
MOD_ProDKin_1	99	105	PF00069	0.569
MOD_SUMO_for_1	258	261	PF00179	0.580
MOD_SUMO_for_1	333	336	PF00179	0.566
MOD_SUMO_rev_2	495	505	PF00179	0.627
TRG_DiLeu_BaEn_1	198	203	PF01217	0.716
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.567
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.513
TRG_ENDOCYTIC_2	662	665	PF00928	0.520
TRG_ER_diArg_1	256	258	PF00400	0.548
TRG_ER_diArg_1	274	276	PF00400	0.574
TRG_ER_diArg_1	452	454	PF00400	0.539
TRG_ER_diArg_1	463	466	PF00400	0.479
TRG_ER_diArg_1	485	487	PF00400	0.660
TRG_ER_diArg_1	560	562	PF00400	0.681
TRG_ER_diArg_1	565	567	PF00400	0.661
TRG_NLS_Bipartite_1	176	194	PF00514	0.668
TRG_NLS_MonoCore_2	175	180	PF00514	0.660
TRG_NLS_MonoExtC_3	189	194	PF00514	0.679
TRG_NLS_MonoExtC_3	460	465	PF00514	0.566
TRG_NLS_MonoExtN_4	174	181	PF00514	0.658
TRG_NLS_MonoExtN_4	461	466	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8INB5	Leishmania donovani	81%	100%
A4HE29	Leishmania braziliensis	69%	99%
A4I1D5	Leishmania infantum	81%	100%
Q4QA00	Leishmania major	79%	100%