ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies), putative

Species:

Leishmania mexicana

UniProt:

E9AXH1_LEIMU

TriTrypDb:

LmxM.25.0930

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	165	169	PF00082	0.414
DEG_APCC_DBOX_1	238	246	PF00400	0.556
DEG_SPOP_SBC_1	115	119	PF00917	0.544
DOC_CKS1_1	95	100	PF01111	0.498
DOC_CYCLIN_RxL_1	162	170	PF00134	0.388
DOC_PP4_FxxP_1	95	98	PF00568	0.430
DOC_USP7_MATH_1	101	105	PF00917	0.607
DOC_USP7_MATH_1	115	119	PF00917	0.574
DOC_USP7_MATH_1	123	127	PF00917	0.648
DOC_USP7_MATH_1	142	146	PF00917	0.176
DOC_USP7_MATH_1	177	181	PF00917	0.309
DOC_USP7_MATH_1	211	215	PF00917	0.491
DOC_USP7_MATH_1	254	258	PF00917	0.496
DOC_WW_Pin1_4	119	124	PF00397	0.706
DOC_WW_Pin1_4	147	152	PF00397	0.246
DOC_WW_Pin1_4	26	31	PF00397	0.471
DOC_WW_Pin1_4	94	99	PF00397	0.427
LIG_14-3-3_CanoR_1	41	45	PF00244	0.321
LIG_14-3-3_CanoR_1	53	61	PF00244	0.304
LIG_14-3-3_CanoR_1	63	68	PF00244	0.269
LIG_14-3-3_CanoR_1	80	90	PF00244	0.372
LIG_14-3-3_CterR_2	258	262	PF00244	0.393
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_EH1_1	195	203	PF00400	0.366
LIG_FHA_1	11	17	PF00498	0.429
LIG_FHA_1	54	60	PF00498	0.316
LIG_FHA_2	182	188	PF00498	0.318
LIG_LIR_Gen_1	227	237	PF02991	0.527
LIG_LIR_Nem_3	227	232	PF02991	0.524
LIG_PCNA_PIPBox_1	160	169	PF02747	0.274
LIG_SH2_PTP2	229	232	PF00017	0.484
LIG_SH2_SRC	194	197	PF00017	0.141
LIG_SH2_SRC	229	232	PF00017	0.597
LIG_SH2_STAT5	166	169	PF00017	0.274
LIG_SH2_STAT5	194	197	PF00017	0.141
LIG_SH2_STAT5	229	232	PF00017	0.551
LIG_SH2_STAT5	35	38	PF00017	0.440
LIG_TYR_ITIM	164	169	PF00017	0.274
MOD_CK1_1	118	124	PF00069	0.622
MOD_CK1_1	128	134	PF00069	0.453
MOD_GlcNHglycan	104	107	PF01048	0.582
MOD_GlcNHglycan	123	126	PF01048	0.538
MOD_GlcNHglycan	144	147	PF01048	0.358
MOD_GlcNHglycan	157	160	PF01048	0.424
MOD_GlcNHglycan	20	24	PF01048	0.453
MOD_GlcNHglycan	213	216	PF01048	0.619
MOD_GlcNHglycan	224	227	PF01048	0.540
MOD_GlcNHglycan	83	86	PF01048	0.364
MOD_GlcNHglycan	99	102	PF01048	0.449
MOD_GSK3_1	114	121	PF00069	0.637
MOD_GSK3_1	124	131	PF00069	0.601
MOD_GSK3_1	177	184	PF00069	0.353
MOD_GSK3_1	218	225	PF00069	0.519
MOD_GSK3_1	3	10	PF00069	0.554
MOD_GSK3_1	59	66	PF00069	0.394
MOD_GSK3_1	93	100	PF00069	0.357
MOD_N-GLC_1	202	207	PF02516	0.411
MOD_N-GLC_1	26	31	PF02516	0.494
MOD_N-GLC_1	33	38	PF02516	0.488
MOD_NEK2_1	102	107	PF00069	0.474
MOD_NEK2_1	167	172	PF00069	0.344
MOD_NEK2_1	202	207	PF00069	0.388
MOD_NEK2_1	59	64	PF00069	0.360
MOD_PIKK_1	10	16	PF00454	0.366
MOD_PIKK_1	219	225	PF00454	0.612
MOD_PIKK_1	54	60	PF00454	0.444
MOD_PKA_2	177	183	PF00069	0.322
MOD_PKA_2	40	46	PF00069	0.302
MOD_Plk_1	19	25	PF00069	0.490
MOD_Plk_1	202	208	PF00069	0.421
MOD_Plk_1	254	260	PF00069	0.504
MOD_Plk_4	125	131	PF00069	0.626
MOD_Plk_4	40	46	PF00069	0.246
MOD_ProDKin_1	119	125	PF00069	0.702
MOD_ProDKin_1	147	153	PF00069	0.246
MOD_ProDKin_1	26	32	PF00069	0.466
MOD_ProDKin_1	94	100	PF00069	0.437
TRG_ENDOCYTIC_2	166	169	PF00928	0.346
TRG_ENDOCYTIC_2	194	197	PF00928	0.141
TRG_ENDOCYTIC_2	229	232	PF00928	0.531
TRG_NES_CRM1_1	187	199	PF08389	0.322
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I922	Leptomonas seymouri	61%	100%
A0A0S4IRG3	Bodo saltans	31%	100%
A0A1X0NNH1	Trypanosomatidae	37%	100%
A0A3Q8ICG2	Leishmania donovani	94%	100%
A0A422NXA4	Trypanosoma rangeli	35%	100%
A4HE28	Leishmania braziliensis	82%	99%
A4I1D4	Leishmania infantum	93%	100%
C9ZKX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QA01	Leishmania major	92%	100%
Q6P6B7	Homo sapiens	28%	73%
V5BBP8	Trypanosoma cruzi	36%	100%