SLBP_RNA_bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone RNA hairpin-binding protein RNA-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXH0_LEIMU

TriTrypDb:

LmxM.25.0920

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071204	histone pre-mRNA 3'end processing complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AXH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXH0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0008152	metabolic process	1	1
GO:0008334	histone mRNA metabolic process	7	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0036002	pre-mRNA binding	5	1
GO:0071207	histone pre-mRNA stem-loop binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.741
CLV_NRD_NRD_1	165	167	PF00675	0.256
CLV_NRD_NRD_1	220	222	PF00675	0.393
CLV_NRD_NRD_1	224	226	PF00675	0.354
CLV_NRD_NRD_1	252	254	PF00675	0.571
CLV_NRD_NRD_1	411	413	PF00675	0.810
CLV_NRD_NRD_1	78	80	PF00675	0.675
CLV_NRD_NRD_1	815	817	PF00675	0.597
CLV_NRD_NRD_1	94	96	PF00675	0.727
CLV_PCSK_FUR_1	76	80	PF00082	0.568
CLV_PCSK_KEX2_1	164	166	PF00082	0.393
CLV_PCSK_KEX2_1	186	188	PF00082	0.393
CLV_PCSK_KEX2_1	213	215	PF00082	0.393
CLV_PCSK_KEX2_1	224	226	PF00082	0.286
CLV_PCSK_KEX2_1	252	254	PF00082	0.571
CLV_PCSK_KEX2_1	411	413	PF00082	0.810
CLV_PCSK_KEX2_1	78	80	PF00082	0.675
CLV_PCSK_KEX2_1	94	96	PF00082	0.727
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.393
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.393
CLV_PCSK_SKI1_1	224	228	PF00082	0.393
CLV_PCSK_SKI1_1	296	300	PF00082	0.676
CLV_PCSK_SKI1_1	816	820	PF00082	0.744
CLV_Separin_Metazoa	262	266	PF03568	0.664
DEG_APCC_DBOX_1	411	419	PF00400	0.536
DEG_COP1_1	376	387	PF00400	0.667
DEG_Nend_UBRbox_1	1	4	PF02207	0.566
DEG_SCF_FBW7_1	541	548	PF00400	0.520
DOC_CKS1_1	656	661	PF01111	0.498
DOC_CKS1_1	846	851	PF01111	0.788
DOC_CYCLIN_RxL_1	486	497	PF00134	0.694
DOC_CYCLIN_RxL_1	813	821	PF00134	0.677
DOC_MAPK_gen_1	164	175	PF00069	0.593
DOC_MAPK_gen_1	210	220	PF00069	0.586
DOC_MAPK_gen_1	265	273	PF00069	0.679
DOC_MAPK_gen_1	411	417	PF00069	0.773
DOC_MAPK_gen_1	802	812	PF00069	0.705
DOC_MAPK_gen_1	852	859	PF00069	0.548
DOC_MAPK_MEF2A_6	265	273	PF00069	0.679
DOC_MAPK_MEF2A_6	852	859	PF00069	0.546
DOC_PP1_RVXF_1	169	176	PF00149	0.593
DOC_PP2B_LxvP_1	203	206	PF13499	0.593
DOC_PP2B_LxvP_1	517	520	PF13499	0.745
DOC_PP2B_LxvP_1	574	577	PF13499	0.728
DOC_PP2B_LxvP_1	657	660	PF13499	0.669
DOC_PP4_FxxP_1	426	429	PF00568	0.534
DOC_PP4_FxxP_1	523	526	PF00568	0.674
DOC_PP4_MxPP_1	621	624	PF00568	0.546
DOC_USP7_MATH_1	134	138	PF00917	0.675
DOC_USP7_MATH_1	284	288	PF00917	0.633
DOC_USP7_MATH_1	473	477	PF00917	0.734
DOC_USP7_MATH_1	563	567	PF00917	0.671
DOC_USP7_MATH_1	633	637	PF00917	0.719
DOC_USP7_MATH_1	638	642	PF00917	0.695
DOC_USP7_MATH_1	703	707	PF00917	0.713
DOC_USP7_MATH_1	85	89	PF00917	0.564
DOC_WW_Pin1_4	102	107	PF00397	0.805
DOC_WW_Pin1_4	151	156	PF00397	0.606
DOC_WW_Pin1_4	201	206	PF00397	0.593
DOC_WW_Pin1_4	28	33	PF00397	0.761
DOC_WW_Pin1_4	323	328	PF00397	0.690
DOC_WW_Pin1_4	404	409	PF00397	0.771
DOC_WW_Pin1_4	419	424	PF00397	0.566
DOC_WW_Pin1_4	43	48	PF00397	0.562
DOC_WW_Pin1_4	436	441	PF00397	0.513
DOC_WW_Pin1_4	444	449	PF00397	0.598
DOC_WW_Pin1_4	457	462	PF00397	0.644
DOC_WW_Pin1_4	476	481	PF00397	0.498
DOC_WW_Pin1_4	524	529	PF00397	0.770
DOC_WW_Pin1_4	54	59	PF00397	0.648
DOC_WW_Pin1_4	541	546	PF00397	0.521
DOC_WW_Pin1_4	579	584	PF00397	0.580
DOC_WW_Pin1_4	647	652	PF00397	0.730
DOC_WW_Pin1_4	655	660	PF00397	0.625
DOC_WW_Pin1_4	70	75	PF00397	0.574
DOC_WW_Pin1_4	724	729	PF00397	0.700
DOC_WW_Pin1_4	738	743	PF00397	0.572
DOC_WW_Pin1_4	810	815	PF00397	0.748
DOC_WW_Pin1_4	845	850	PF00397	0.750
LIG_14-3-3_CanoR_1	164	173	PF00244	0.547
LIG_14-3-3_CanoR_1	253	263	PF00244	0.626
LIG_14-3-3_CanoR_1	355	360	PF00244	0.619
LIG_14-3-3_CanoR_1	453	458	PF00244	0.581
LIG_14-3-3_CanoR_1	489	494	PF00244	0.777
LIG_14-3-3_CanoR_1	508	517	PF00244	0.499
LIG_14-3-3_CanoR_1	750	757	PF00244	0.597
LIG_14-3-3_CanoR_1	79	85	PF00244	0.568
LIG_Actin_WH2_2	181	198	PF00022	0.593
LIG_Actin_WH2_2	282	298	PF00022	0.683
LIG_BRCT_BRCA1_1	256	260	PF00533	0.619
LIG_BRCT_BRCA1_1	624	628	PF00533	0.595
LIG_BRCT_BRCA1_1	790	794	PF00533	0.637
LIG_CSL_BTD_1	534	537	PF09270	0.673
LIG_CtBP_PxDLS_1	403	407	PF00389	0.707
LIG_EVH1_2	519	523	PF00568	0.727
LIG_FHA_1	488	494	PF00498	0.535
LIG_FHA_1	511	517	PF00498	0.754
LIG_FHA_1	525	531	PF00498	0.590
LIG_FHA_1	647	653	PF00498	0.730
LIG_FHA_1	656	662	PF00498	0.615
LIG_FHA_1	819	825	PF00498	0.686
LIG_FHA_1	854	860	PF00498	0.688
LIG_Integrin_RGD_1	114	116	PF01839	0.743
LIG_LIR_Apic_2	129	134	PF02991	0.512
LIG_LIR_Apic_2	424	429	PF02991	0.534
LIG_LIR_Gen_1	179	190	PF02991	0.593
LIG_LIR_Gen_1	231	239	PF02991	0.669
LIG_LIR_Gen_1	257	267	PF02991	0.629
LIG_LIR_Gen_1	302	313	PF02991	0.652
LIG_LIR_Gen_1	690	700	PF02991	0.736
LIG_LIR_Nem_3	231	235	PF02991	0.624
LIG_LIR_Nem_3	302	308	PF02991	0.657
LIG_Pex14_2	230	234	PF04695	0.667
LIG_PTAP_UEV_1	384	389	PF05743	0.681
LIG_SH2_GRB2like	182	185	PF00017	0.593
LIG_SH2_PTP2	232	235	PF00017	0.603
LIG_SH2_STAP1	757	761	PF00017	0.525
LIG_SH2_STAT5	177	180	PF00017	0.593
LIG_SH2_STAT5	182	185	PF00017	0.544
LIG_SH2_STAT5	232	235	PF00017	0.661
LIG_SH3_2	429	434	PF14604	0.548
LIG_SH3_3	199	205	PF00018	0.593
LIG_SH3_3	382	388	PF00018	0.693
LIG_SH3_3	397	403	PF00018	0.561
LIG_SH3_3	407	413	PF00018	0.749
LIG_SH3_3	426	432	PF00018	0.517
LIG_SH3_3	46	52	PF00018	0.769
LIG_SH3_3	513	519	PF00018	0.733
LIG_SH3_3	531	537	PF00018	0.546
LIG_SH3_3	557	563	PF00018	0.529
LIG_SH3_3	595	601	PF00018	0.769
LIG_SH3_3	860	866	PF00018	0.699
LIG_SUMO_SIM_par_1	401	407	PF11976	0.701
LIG_SUMO_SIM_par_1	489	494	PF11976	0.539
LIG_SUMO_SIM_par_1	855	861	PF11976	0.528
LIG_TRAF2_1	290	293	PF00917	0.678
LIG_WRC_WIRS_1	141	146	PF05994	0.518
LIG_WW_2	413	416	PF00397	0.764
MOD_CDC14_SPxK_1	154	157	PF00782	0.521
MOD_CDC14_SPxK_1	409	412	PF00782	0.771
MOD_CDK_SPK_2	406	411	PF00069	0.766
MOD_CDK_SPK_2	444	449	PF00069	0.526
MOD_CDK_SPxK_1	151	157	PF00069	0.522
MOD_CDK_SPxK_1	406	412	PF00069	0.768
MOD_CDK_SPxK_1	436	442	PF00069	0.690
MOD_CDK_SPxK_1	70	76	PF00069	0.741
MOD_CDK_SPxK_1	810	816	PF00069	0.747
MOD_CDK_SPxxK_3	404	411	PF00069	0.770
MOD_CDK_SPxxK_3	457	464	PF00069	0.592
MOD_CDK_SPxxK_3	54	61	PF00069	0.736
MOD_CDK_SPxxK_3	810	817	PF00069	0.604
MOD_CDK_SPxxK_3	845	852	PF00069	0.787
MOD_CK1_1	139	145	PF00069	0.643
MOD_CK1_1	156	162	PF00069	0.532
MOD_CK1_1	307	313	PF00069	0.646
MOD_CK1_1	315	321	PF00069	0.575
MOD_CK1_1	377	383	PF00069	0.519
MOD_CK1_1	419	425	PF00069	0.705
MOD_CK1_1	427	433	PF00069	0.626
MOD_CK1_1	455	461	PF00069	0.602
MOD_CK1_1	476	482	PF00069	0.725
MOD_CK1_1	494	500	PF00069	0.582
MOD_CK1_1	636	642	PF00069	0.692
MOD_CK1_1	677	683	PF00069	0.708
MOD_CK1_1	767	773	PF00069	0.645
MOD_CK2_1	156	162	PF00069	0.704
MOD_CK2_1	164	170	PF00069	0.362
MOD_CK2_1	323	329	PF00069	0.670
MOD_CK2_1	738	744	PF00069	0.707
MOD_DYRK1A_RPxSP_1	43	47	PF00069	0.698
MOD_GlcNHglycan	121	124	PF01048	0.786
MOD_GlcNHglycan	17	22	PF01048	0.553
MOD_GlcNHglycan	196	199	PF01048	0.470
MOD_GlcNHglycan	282	285	PF01048	0.728
MOD_GlcNHglycan	314	317	PF01048	0.672
MOD_GlcNHglycan	338	341	PF01048	0.613
MOD_GlcNHglycan	385	388	PF01048	0.785
MOD_GlcNHglycan	396	399	PF01048	0.622
MOD_GlcNHglycan	483	486	PF01048	0.713
MOD_GlcNHglycan	493	496	PF01048	0.573
MOD_GlcNHglycan	510	513	PF01048	0.519
MOD_GlcNHglycan	58	61	PF01048	0.734
MOD_GlcNHglycan	697	700	PF01048	0.769
MOD_GlcNHglycan	715	718	PF01048	0.529
MOD_GlcNHglycan	751	754	PF01048	0.729
MOD_GlcNHglycan	757	760	PF01048	0.643
MOD_GlcNHglycan	762	765	PF01048	0.608
MOD_GlcNHglycan	766	769	PF01048	0.591
MOD_GlcNHglycan	791	794	PF01048	0.662
MOD_GlcNHglycan	807	810	PF01048	0.633
MOD_GlcNHglycan	849	852	PF01048	0.723
MOD_GSK3_1	136	143	PF00069	0.591
MOD_GSK3_1	176	183	PF00069	0.470
MOD_GSK3_1	280	287	PF00069	0.619
MOD_GSK3_1	379	386	PF00069	0.727
MOD_GSK3_1	39	46	PF00069	0.670
MOD_GSK3_1	417	424	PF00069	0.702
MOD_GSK3_1	452	459	PF00069	0.623
MOD_GSK3_1	469	476	PF00069	0.594
MOD_GSK3_1	483	490	PF00069	0.607
MOD_GSK3_1	50	57	PF00069	0.643
MOD_GSK3_1	537	544	PF00069	0.628
MOD_GSK3_1	550	557	PF00069	0.600
MOD_GSK3_1	575	582	PF00069	0.553
MOD_GSK3_1	691	698	PF00069	0.671
MOD_GSK3_1	718	725	PF00069	0.682
MOD_GSK3_1	760	767	PF00069	0.609
MOD_GSK3_1	826	833	PF00069	0.562
MOD_GSK3_1	841	848	PF00069	0.763
MOD_N-GLC_1	424	429	PF02516	0.534
MOD_NEK2_1	194	199	PF00069	0.486
MOD_NEK2_1	39	44	PF00069	0.764
MOD_NEK2_1	417	422	PF00069	0.540
MOD_NEK2_1	491	496	PF00069	0.743
MOD_NEK2_1	554	559	PF00069	0.567
MOD_NEK2_1	587	592	PF00069	0.534
MOD_NEK2_1	803	808	PF00069	0.768
MOD_NEK2_1	818	823	PF00069	0.548
MOD_NEK2_2	304	309	PF00069	0.656
MOD_NEK2_2	503	508	PF00069	0.523
MOD_PIKK_1	164	170	PF00454	0.406
MOD_PIKK_1	417	423	PF00454	0.531
MOD_PIKK_1	427	433	PF00454	0.518
MOD_PIKK_1	483	489	PF00454	0.776
MOD_PIKK_1	677	683	PF00454	0.788
MOD_PIKK_1	80	86	PF00454	0.558
MOD_PIKK_1	803	809	PF00454	0.769
MOD_PIKK_1	841	847	PF00454	0.612
MOD_PKA_1	164	170	PF00069	0.406
MOD_PKA_2	164	170	PF00069	0.406
MOD_PKA_2	354	360	PF00069	0.620
MOD_PKA_2	452	458	PF00069	0.584
MOD_PKA_2	587	593	PF00069	0.566
MOD_PKA_2	682	688	PF00069	0.718
MOD_PKA_2	713	719	PF00069	0.776
MOD_PKA_2	749	755	PF00069	0.622
MOD_PKA_2	772	778	PF00069	0.549
MOD_PKA_2	85	91	PF00069	0.565
MOD_PKA_2	853	859	PF00069	0.708
MOD_ProDKin_1	102	108	PF00069	0.807
MOD_ProDKin_1	151	157	PF00069	0.607
MOD_ProDKin_1	201	207	PF00069	0.470
MOD_ProDKin_1	28	34	PF00069	0.760
MOD_ProDKin_1	323	329	PF00069	0.689
MOD_ProDKin_1	404	410	PF00069	0.767
MOD_ProDKin_1	419	425	PF00069	0.566
MOD_ProDKin_1	43	49	PF00069	0.560
MOD_ProDKin_1	436	442	PF00069	0.515
MOD_ProDKin_1	444	450	PF00069	0.596
MOD_ProDKin_1	457	463	PF00069	0.633
MOD_ProDKin_1	476	482	PF00069	0.501
MOD_ProDKin_1	524	530	PF00069	0.774
MOD_ProDKin_1	54	60	PF00069	0.649
MOD_ProDKin_1	541	547	PF00069	0.524
MOD_ProDKin_1	579	585	PF00069	0.583
MOD_ProDKin_1	647	653	PF00069	0.730
MOD_ProDKin_1	655	661	PF00069	0.628
MOD_ProDKin_1	70	76	PF00069	0.576
MOD_ProDKin_1	724	730	PF00069	0.700
MOD_ProDKin_1	738	744	PF00069	0.572
MOD_ProDKin_1	810	816	PF00069	0.747
MOD_ProDKin_1	845	851	PF00069	0.750
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.470
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.389
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.529
TRG_ENDOCYTIC_2	182	185	PF00928	0.470
TRG_ENDOCYTIC_2	232	235	PF00928	0.638
TRG_ENDOCYTIC_2	305	308	PF00928	0.673
TRG_ENDOCYTIC_2	584	587	PF00928	0.776
TRG_ENDOCYTIC_2	653	656	PF00928	0.674
TRG_ER_diArg_1	10	13	PF00400	0.574
TRG_ER_diArg_1	164	166	PF00400	0.470
TRG_ER_diArg_1	223	225	PF00400	0.470
TRG_ER_diArg_1	410	412	PF00400	0.803
TRG_ER_diArg_1	76	79	PF00400	0.655
TRG_NLS_MonoExtC_3	220	225	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF88	Leishmania donovani	84%	100%
A4HE27	Leishmania braziliensis	62%	97%
A4I1D3	Leishmania infantum	84%	100%
Q4QA02	Leishmania major	83%	100%