Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AXG8_LEIMU

TriTrypDb:

LmxM.25.0900

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AXG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.711
CLV_NRD_NRD_1	252	254	PF00675	0.269
CLV_PCSK_KEX2_1	138	140	PF00082	0.681
CLV_PCSK_KEX2_1	252	254	PF00082	0.304
DEG_APCC_DBOX_1	252	260	PF00400	0.472
DEG_SCF_FBW7_1	237	244	PF00400	0.676
DEG_SPOP_SBC_1	285	289	PF00917	0.454
DOC_ANK_TNKS_1	233	240	PF00023	0.686
DOC_MAPK_gen_1	252	259	PF00069	0.469
DOC_MAPK_MEF2A_6	252	261	PF00069	0.525
DOC_USP7_MATH_1	241	245	PF00917	0.670
DOC_USP7_MATH_1	290	294	PF00917	0.506
DOC_USP7_MATH_1	313	317	PF00917	0.467
DOC_USP7_UBL2_3	89	93	PF12436	0.644
DOC_WW_Pin1_4	223	228	PF00397	0.708
DOC_WW_Pin1_4	237	242	PF00397	0.613
DOC_WW_Pin1_4	243	248	PF00397	0.650
DOC_WW_Pin1_4	274	279	PF00397	0.426
DOC_WW_Pin1_4	329	334	PF00397	0.459
LIG_14-3-3_CanoR_1	252	257	PF00244	0.455
LIG_14-3-3_CanoR_1	312	322	PF00244	0.505
LIG_14-3-3_CanoR_1	9	15	PF00244	0.516
LIG_APCC_ABBA_1	233	238	PF00400	0.691
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_DLG_GKlike_1	252	259	PF00625	0.484
LIG_eIF4E_1	15	21	PF01652	0.205
LIG_eIF4E_1	67	73	PF01652	0.325
LIG_FHA_1	186	192	PF00498	0.504
LIG_FHA_1	329	335	PF00498	0.406
LIG_FHA_1	80	86	PF00498	0.308
LIG_FHA_2	48	54	PF00498	0.365
LIG_LIR_Gen_1	13	22	PF02991	0.363
LIG_LIR_Gen_1	201	210	PF02991	0.268
LIG_LIR_Gen_1	36	41	PF02991	0.445
LIG_LIR_Nem_3	13	18	PF02991	0.363
LIG_LIR_Nem_3	201	205	PF02991	0.422
LIG_LIR_Nem_3	245	251	PF02991	0.661
LIG_LIR_Nem_3	36	40	PF02991	0.444
LIG_LIR_Nem_3	66	70	PF02991	0.269
LIG_SH2_CRK	15	19	PF00017	0.253
LIG_SH2_PTP2	108	111	PF00017	0.325
LIG_SH2_PTP2	202	205	PF00017	0.392
LIG_SH2_PTP2	67	70	PF00017	0.325
LIG_SH2_STAP1	15	19	PF00017	0.304
LIG_SH2_STAP1	152	156	PF00017	0.458
LIG_SH2_STAT5	108	111	PF00017	0.304
LIG_SH2_STAT5	152	155	PF00017	0.458
LIG_SH2_STAT5	202	205	PF00017	0.392
LIG_SH2_STAT5	26	29	PF00017	0.372
LIG_SH2_STAT5	67	70	PF00017	0.284
LIG_SH3_3	221	227	PF00018	0.569
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.270
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.300
LIG_SUMO_SIM_anti_2	36	45	PF11976	0.319
LIG_SUMO_SIM_par_1	18	23	PF11976	0.311
LIG_TYR_ITIM	200	205	PF00017	0.462
LIG_WW_3	164	168	PF00397	0.402
MOD_CK1_1	243	249	PF00069	0.588
MOD_CK1_1	277	283	PF00069	0.496
MOD_CK2_1	198	204	PF00069	0.460
MOD_CK2_1	329	335	PF00069	0.406
MOD_CMANNOS	28	31	PF00535	0.493
MOD_GlcNHglycan	126	129	PF01048	0.611
MOD_GlcNHglycan	15	18	PF01048	0.325
MOD_GlcNHglycan	154	157	PF01048	0.674
MOD_GlcNHglycan	192	195	PF01048	0.634
MOD_GlcNHglycan	279	282	PF01048	0.713
MOD_GlcNHglycan	288	291	PF01048	0.651
MOD_GlcNHglycan	292	295	PF01048	0.734
MOD_GlcNHglycan	309	312	PF01048	0.624
MOD_GlcNHglycan	313	316	PF01048	0.722
MOD_GlcNHglycan	49	53	PF01048	0.631
MOD_GlcNHglycan	61	64	PF01048	0.632
MOD_GlcNHglycan	89	92	PF01048	0.444
MOD_GSK3_1	237	244	PF00069	0.676
MOD_GSK3_1	286	293	PF00069	0.565
MOD_GSK3_1	307	314	PF00069	0.592
MOD_N-GLC_1	259	264	PF02516	0.205
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	20	25	PF00069	0.183
MOD_NEK2_1	259	264	PF00069	0.339
MOD_NEK2_1	286	291	PF00069	0.463
MOD_NEK2_1	41	46	PF00069	0.526
MOD_NEK2_1	59	64	PF00069	0.361
MOD_NEK2_2	10	15	PF00069	0.248
MOD_OFUCOSY	184	189	PF10250	0.589
MOD_PIKK_1	140	146	PF00454	0.494
MOD_PKA_1	252	258	PF00069	0.455
MOD_PKA_2	252	258	PF00069	0.458
MOD_PKA_2	311	317	PF00069	0.474
MOD_PKA_2	47	53	PF00069	0.449
MOD_PKB_1	46	54	PF00069	0.361
MOD_Plk_2-3	198	204	PF00069	0.411
MOD_Plk_4	10	16	PF00069	0.302
MOD_Plk_4	198	204	PF00069	0.428
MOD_Plk_4	252	258	PF00069	0.455
MOD_Plk_4	264	270	PF00069	0.350
MOD_Plk_4	79	85	PF00069	0.299
MOD_ProDKin_1	223	229	PF00069	0.711
MOD_ProDKin_1	237	243	PF00069	0.614
MOD_ProDKin_1	274	280	PF00069	0.427
MOD_ProDKin_1	329	335	PF00069	0.459
TRG_ENDOCYTIC_2	108	111	PF00928	0.304
TRG_ENDOCYTIC_2	112	115	PF00928	0.304
TRG_ENDOCYTIC_2	15	18	PF00928	0.304
TRG_ENDOCYTIC_2	202	205	PF00928	0.419
TRG_ENDOCYTIC_2	67	70	PF00928	0.304
TRG_ER_diArg_1	137	139	PF00400	0.419
TRG_ER_diArg_1	251	253	PF00400	0.669
TRG_ER_diLys_1	337	340	PF00400	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE40	Leptomonas seymouri	42%	100%
A0A3Q8ICA7	Leishmania donovani	84%	100%
A4HE25	Leishmania braziliensis	58%	100%
A4I1D1	Leishmania infantum	84%	100%
Q4QA04	Leishmania major	81%	100%