39S ribosomal protein L23, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXG7_LEIMU

TriTrypDb:

LmxM.25.0890

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

E9AXG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXG7

PDB structure(s): 7aih_N , 7am2_N , 7ane_N

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.540
CLV_NRD_NRD_1	112	114	PF00675	0.435
CLV_NRD_NRD_1	131	133	PF00675	0.313
CLV_NRD_NRD_1	202	204	PF00675	0.451
CLV_PCSK_FUR_1	200	204	PF00082	0.421
CLV_PCSK_KEX2_1	131	133	PF00082	0.472
CLV_PCSK_KEX2_1	2	4	PF00082	0.537
CLV_PCSK_KEX2_1	202	204	PF00082	0.449
CLV_PCSK_KEX2_1	43	45	PF00082	0.621
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.668
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.640
CLV_PCSK_SKI1_1	151	155	PF00082	0.416
CLV_PCSK_SKI1_1	164	168	PF00082	0.413
CLV_PCSK_SKI1_1	202	206	PF00082	0.540
CLV_PCSK_SKI1_1	233	237	PF00082	0.502
DEG_APCC_DBOX_1	150	158	PF00400	0.409
DEG_Nend_UBRbox_1	1	4	PF02207	0.686
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.377
DOC_MAPK_MEF2A_6	143	152	PF00069	0.508
DOC_PP4_FxxP_1	167	170	PF00568	0.405
DOC_PP4_FxxP_1	47	50	PF00568	0.515
DOC_PP4_FxxP_1	86	89	PF00568	0.459
DOC_USP7_MATH_1	17	21	PF00917	0.502
DOC_USP7_MATH_1	35	39	PF00917	0.654
DOC_WW_Pin1_4	130	135	PF00397	0.478
DOC_WW_Pin1_4	223	228	PF00397	0.413
DOC_WW_Pin1_4	238	243	PF00397	0.561
LIG_14-3-3_CanoR_1	193	197	PF00244	0.490
LIG_14-3-3_CanoR_1	3	11	PF00244	0.580
LIG_BRCT_BRCA1_1	141	145	PF00533	0.531
LIG_BRCT_BRCA1_1	228	232	PF00533	0.481
LIG_BRCT_BRCA1_1	36	40	PF00533	0.442
LIG_deltaCOP1_diTrp_1	116	120	PF00928	0.428
LIG_FHA_1	161	167	PF00498	0.473
LIG_FHA_1	34	40	PF00498	0.656
LIG_FHA_2	69	75	PF00498	0.506
LIG_LIR_Apic_2	116	121	PF02991	0.414
LIG_LIR_Nem_3	133	139	PF02991	0.388
LIG_LIR_Nem_3	142	148	PF02991	0.425
LIG_LIR_Nem_3	229	235	PF02991	0.495
LIG_LIR_Nem_3	98	104	PF02991	0.426
LIG_MLH1_MIPbox_1	141	145	PF16413	0.510
LIG_Pex14_2	137	141	PF04695	0.381
LIG_REV1ctd_RIR_1	137	145	PF16727	0.382
LIG_SH2_CRK	48	52	PF00017	0.504
LIG_SH2_STAT5	136	139	PF00017	0.402
LIG_SH2_STAT5	144	147	PF00017	0.336
LIG_SH2_STAT5	181	184	PF00017	0.382
LIG_SH2_STAT5	94	97	PF00017	0.415
LIG_SH3_3	77	83	PF00018	0.361
LIG_SUMO_SIM_anti_2	225	232	PF11976	0.515
LIG_SUMO_SIM_par_1	220	226	PF11976	0.349
LIG_TRAF2_1	174	177	PF00917	0.487
MOD_CDK_SPxxK_3	238	245	PF00069	0.563
MOD_CK1_1	20	26	PF00069	0.671
MOD_CK1_1	226	232	PF00069	0.488
MOD_CK1_1	31	37	PF00069	0.670
MOD_CK2_1	171	177	PF00069	0.411
MOD_CK2_1	68	74	PF00069	0.562
MOD_CMANNOS	70	73	PF00535	0.464
MOD_Cter_Amidation	200	203	PF01082	0.414
MOD_GlcNHglycan	15	18	PF01048	0.675
MOD_GSK3_1	13	20	PF00069	0.712
MOD_GSK3_1	29	36	PF00069	0.626
MOD_LATS_1	66	72	PF00433	0.348
MOD_N-GLC_1	159	164	PF02516	0.411
MOD_NEK2_1	139	144	PF00069	0.453
MOD_NEK2_1	58	63	PF00069	0.682
MOD_NEK2_1	95	100	PF00069	0.418
MOD_NEK2_2	35	40	PF00069	0.430
MOD_PKA_1	2	8	PF00069	0.611
MOD_PKA_2	192	198	PF00069	0.444
MOD_PKA_2	2	8	PF00069	0.611
MOD_Plk_2-3	210	216	PF00069	0.517
MOD_Plk_4	153	159	PF00069	0.389
MOD_Plk_4	226	232	PF00069	0.515
MOD_Plk_4	35	41	PF00069	0.598
MOD_ProDKin_1	130	136	PF00069	0.468
MOD_ProDKin_1	223	229	PF00069	0.414
MOD_ProDKin_1	238	244	PF00069	0.566
MOD_SUMO_for_1	204	207	PF00179	0.544
MOD_SUMO_rev_2	207	214	PF00179	0.443
MOD_SUMO_rev_2	239	247	PF00179	0.732
TRG_ENDOCYTIC_2	136	139	PF00928	0.426
TRG_ENDOCYTIC_2	48	51	PF00928	0.507
TRG_ER_diArg_1	130	132	PF00400	0.481
TRG_ER_diArg_1	199	202	PF00400	0.447
TRG_ER_diArg_1	44	47	PF00400	0.526
TRG_ER_diArg_1	59	62	PF00400	0.502
TRG_ER_diArg_1	97	100	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z4	Leptomonas seymouri	80%	98%
A0A0S4J3V0	Bodo saltans	57%	100%
A0A1X0P4M1	Trypanosomatidae	74%	100%
A0A3Q8IGI5	Leishmania donovani	93%	98%
A0A422NTM0	Trypanosoma rangeli	72%	99%
A4HE24	Leishmania braziliensis	87%	100%
A4I1D0	Leishmania infantum	93%	98%
D0A5M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
Q4QA05	Leishmania major	95%	100%