Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AXG5_LEIMU

TriTrypDb:

LmxM.25.0870

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000408	EKC/KEOPS complex	2	1
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXG5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006468	protein phosphorylation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.286
CLV_NRD_NRD_1	287	289	PF00675	0.457
CLV_NRD_NRD_1	68	70	PF00675	0.524
CLV_PCSK_FUR_1	66	70	PF00082	0.554
CLV_PCSK_KEX2_1	289	291	PF00082	0.512
CLV_PCSK_KEX2_1	51	53	PF00082	0.503
CLV_PCSK_KEX2_1	68	70	PF00082	0.427
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.542
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.529
CLV_PCSK_SKI1_1	108	112	PF00082	0.413
CLV_PCSK_SKI1_1	23	27	PF00082	0.475
CLV_PCSK_SKI1_1	48	52	PF00082	0.459
CLV_PCSK_SKI1_1	76	80	PF00082	0.496
DOC_CDC14_PxL_1	38	46	PF14671	0.423
DOC_PP1_RVXF_1	21	27	PF00149	0.473
DOC_USP7_MATH_1	12	16	PF00917	0.618
DOC_USP7_MATH_1	141	145	PF00917	0.723
DOC_USP7_MATH_1	203	207	PF00917	0.703
DOC_USP7_MATH_1	244	248	PF00917	0.363
DOC_USP7_MATH_1	254	258	PF00917	0.373
DOC_WW_Pin1_4	125	130	PF00397	0.568
DOC_WW_Pin1_4	137	142	PF00397	0.738
DOC_WW_Pin1_4	145	150	PF00397	0.534
DOC_WW_Pin1_4	192	197	PF00397	0.574
DOC_WW_Pin1_4	205	210	PF00397	0.542
LIG_14-3-3_CanoR_1	243	252	PF00244	0.365
LIG_14-3-3_CanoR_1	288	293	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.717
LIG_BRCT_BRCA1_1	34	38	PF00533	0.452
LIG_eIF4E_1	92	98	PF01652	0.505
LIG_FHA_1	93	99	PF00498	0.473
LIG_FHA_2	104	110	PF00498	0.402
LIG_FHA_2	211	217	PF00498	0.497
LIG_FHA_2	65	71	PF00498	0.431
LIG_LIR_Gen_1	95	103	PF02991	0.478
LIG_LIR_Nem_3	221	225	PF02991	0.378
LIG_SH2_CRK	39	43	PF00017	0.427
LIG_SH2_GRB2like	92	95	PF00017	0.496
LIG_SH2_STAP1	34	38	PF00017	0.237
LIG_SH2_STAT3	118	121	PF00017	0.529
LIG_SH2_STAT5	239	242	PF00017	0.358
LIG_SH2_STAT5	251	254	PF00017	0.382
LIG_SH2_STAT5	92	95	PF00017	0.461
LIG_SH3_3	206	212	PF00018	0.516
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.392
LIG_SUMO_SIM_par_1	215	221	PF11976	0.359
LIG_TRAF2_1	230	233	PF00917	0.364
LIG_WRC_WIRS_1	93	98	PF05994	0.476
MOD_CK1_1	139	145	PF00069	0.738
MOD_CK2_1	103	109	PF00069	0.447
MOD_CK2_1	227	233	PF00069	0.404
MOD_CK2_1	54	60	PF00069	0.463
MOD_CK2_1	64	70	PF00069	0.381
MOD_Cter_Amidation	286	289	PF01082	0.469
MOD_GlcNHglycan	14	17	PF01048	0.577
MOD_GlcNHglycan	141	144	PF01048	0.682
MOD_GlcNHglycan	252	255	PF01048	0.452
MOD_GlcNHglycan	265	268	PF01048	0.451
MOD_GSK3_1	120	127	PF00069	0.591
MOD_GSK3_1	135	142	PF00069	0.685
MOD_GSK3_1	223	230	PF00069	0.503
MOD_GSK3_1	250	257	PF00069	0.504
MOD_GSK3_1	28	35	PF00069	0.506
MOD_N-GLC_1	145	150	PF02516	0.349
MOD_NEK2_1	1	6	PF00069	0.731
MOD_NEK2_1	156	161	PF00069	0.401
MOD_NEK2_1	177	182	PF00069	0.347
MOD_PIKK_1	61	67	PF00454	0.529
MOD_PKA_1	288	294	PF00069	0.547
MOD_PKB_1	286	294	PF00069	0.520
MOD_PKB_1	52	60	PF00069	0.553
MOD_Plk_4	92	98	PF00069	0.391
MOD_ProDKin_1	125	131	PF00069	0.574
MOD_ProDKin_1	137	143	PF00069	0.734
MOD_ProDKin_1	145	151	PF00069	0.525
MOD_ProDKin_1	192	198	PF00069	0.579
MOD_ProDKin_1	205	211	PF00069	0.526
TRG_DiLeu_BaEn_1	20	25	PF01217	0.482
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.489
TRG_DiLeu_LyEn_5	20	25	PF01217	0.482
TRG_ER_diArg_1	283	286	PF00400	0.446
TRG_ER_diArg_1	66	69	PF00400	0.508
TRG_NLS_Bipartite_1	271	292	PF00514	0.557
TRG_NLS_MonoExtN_4	286	292	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P733	Leptomonas seymouri	63%	96%
A0A0S4J0K1	Bodo saltans	39%	100%
A0A1X0P554	Trypanosomatidae	48%	100%
A0A3R7L6S7	Trypanosoma rangeli	45%	100%
A0A3S7WZ44	Leishmania donovani	91%	100%
A1CLD2	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	37%	100%
A4HE22	Leishmania braziliensis	80%	99%
A4I1C8	Leishmania infantum	91%	100%
D0A5M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
P0CP72	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	32%	100%
P0CP73	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	32%	100%
P53323	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q1EBD3	Coccidioides immitis (strain RS)	36%	100%
Q2HGY8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	35%	100%
Q2U3T8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	100%
Q4HYC1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	31%	100%
Q4QA07	Leishmania major	88%	99%
Q4WYU4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	100%
Q54W07	Dictyostelium discoideum	33%	100%
Q5AGC7	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	99%
Q5BAB7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	100%
Q6BHA8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	28%	100%
Q6C2A3	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	100%
Q6CXB9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q6FTW0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q74Z75	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	33%	100%
Q96S44	Homo sapiens	35%	100%
Q99PW4	Mus musculus	34%	100%
Q9P7N1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q9UYB9	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
V5BXG1	Trypanosoma cruzi	45%	100%