PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXG2_LEIMU

TriTrypDb:

LmxM.25.0840

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.485
CLV_NRD_NRD_1	123	125	PF00675	0.566
CLV_NRD_NRD_1	178	180	PF00675	0.636
CLV_NRD_NRD_1	210	212	PF00675	0.644
CLV_NRD_NRD_1	222	224	PF00675	0.684
CLV_NRD_NRD_1	258	260	PF00675	0.558
CLV_NRD_NRD_1	339	341	PF00675	0.714
CLV_NRD_NRD_1	359	361	PF00675	0.718
CLV_NRD_NRD_1	52	54	PF00675	0.421
CLV_NRD_NRD_1	9	11	PF00675	0.555
CLV_PCSK_KEX2_1	125	127	PF00082	0.516
CLV_PCSK_KEX2_1	178	180	PF00082	0.636
CLV_PCSK_KEX2_1	183	185	PF00082	0.617
CLV_PCSK_KEX2_1	210	212	PF00082	0.605
CLV_PCSK_KEX2_1	221	223	PF00082	0.637
CLV_PCSK_KEX2_1	339	341	PF00082	0.714
CLV_PCSK_KEX2_1	51	53	PF00082	0.571
CLV_PCSK_KEX2_1	9	11	PF00082	0.543
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.494
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.585
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.627
CLV_PCSK_PC7_1	179	185	PF00082	0.637
CLV_PCSK_SKI1_1	10	14	PF00082	0.571
CLV_PCSK_SKI1_1	102	106	PF00082	0.706
CLV_PCSK_SKI1_1	126	130	PF00082	0.524
CLV_PCSK_SKI1_1	178	182	PF00082	0.606
CLV_PCSK_SKI1_1	222	226	PF00082	0.660
CLV_PCSK_SKI1_1	339	343	PF00082	0.585
CLV_PCSK_SKI1_1	36	40	PF00082	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DEG_SCF_FBW7_1	372	379	PF00400	0.505
DOC_ANK_TNKS_1	156	163	PF00023	0.436
DOC_CYCLIN_RxL_1	123	134	PF00134	0.518
DOC_CYCLIN_RxL_1	206	218	PF00134	0.613
DOC_MAPK_gen_1	124	131	PF00069	0.489
DOC_MAPK_gen_1	51	59	PF00069	0.519
DOC_USP7_MATH_1	243	247	PF00917	0.580
DOC_USP7_MATH_1	296	300	PF00917	0.719
DOC_USP7_MATH_1	303	307	PF00917	0.742
DOC_USP7_MATH_1	371	375	PF00917	0.636
DOC_USP7_MATH_1	77	81	PF00917	0.617
DOC_USP7_UBL2_3	249	253	PF12436	0.581
DOC_USP7_UBL2_3	357	361	PF12436	0.693
DOC_WW_Pin1_4	132	137	PF00397	0.575
DOC_WW_Pin1_4	267	272	PF00397	0.735
DOC_WW_Pin1_4	309	314	PF00397	0.610
DOC_WW_Pin1_4	372	377	PF00397	0.544
LIG_14-3-3_CanoR_1	132	136	PF00244	0.501
LIG_14-3-3_CanoR_1	178	187	PF00244	0.677
LIG_14-3-3_CanoR_1	222	232	PF00244	0.579
LIG_14-3-3_CanoR_1	259	269	PF00244	0.624
LIG_BRCT_BRCA1_1	262	266	PF00533	0.549
LIG_BRCT_BRCA1_1	337	341	PF00533	0.676
LIG_FHA_1	141	147	PF00498	0.438
LIG_FHA_1	86	92	PF00498	0.581
LIG_FHA_1	96	102	PF00498	0.708
LIG_FHA_2	200	206	PF00498	0.523
LIG_FHA_2	225	231	PF00498	0.511
LIG_FHA_2	313	319	PF00498	0.648
LIG_GBD_Chelix_1	261	269	PF00786	0.559
LIG_LIR_Gen_1	263	274	PF02991	0.651
LIG_LIR_Nem_3	112	118	PF02991	0.433
LIG_LIR_Nem_3	143	148	PF02991	0.567
LIG_LIR_Nem_3	255	261	PF02991	0.519
LIG_LIR_Nem_3	263	269	PF02991	0.587
LIG_LIR_Nem_3	45	49	PF02991	0.633
LIG_Pex14_1	7	11	PF04695	0.654
LIG_Pex14_2	116	120	PF04695	0.413
LIG_Pex14_2	341	345	PF04695	0.473
LIG_SH2_CRK	258	262	PF00017	0.483
LIG_SH2_SRC	195	198	PF00017	0.598
LIG_SH2_STAT5	115	118	PF00017	0.411
LIG_SH2_STAT5	127	130	PF00017	0.477
LIG_SH2_STAT5	139	142	PF00017	0.564
LIG_SH2_STAT5	145	148	PF00017	0.494
LIG_SH2_STAT5	149	152	PF00017	0.498
LIG_SH2_STAT5	195	198	PF00017	0.623
LIG_SH2_STAT5	63	66	PF00017	0.555
LIG_SH3_1	340	346	PF00018	0.470
LIG_SH3_2	74	79	PF14604	0.672
LIG_SH3_3	268	274	PF00018	0.610
LIG_SH3_3	340	346	PF00018	0.532
LIG_SH3_3	71	77	PF00018	0.584
LIG_SUMO_SIM_par_1	127	135	PF11976	0.558
LIG_SUMO_SIM_par_1	86	93	PF11976	0.524
LIG_SxIP_EBH_1	39	53	PF03271	0.608
LIG_TRAF2_1	119	122	PF00917	0.469
LIG_TRAF2_1	254	257	PF00917	0.540
LIG_TRFH_1	194	198	PF08558	0.462
MOD_CDK_SPxK_1	372	378	PF00069	0.552
MOD_CK1_1	106	112	PF00069	0.471
MOD_CK1_1	239	245	PF00069	0.617
MOD_CK1_1	276	282	PF00069	0.595
MOD_CK1_1	312	318	PF00069	0.517
MOD_CK1_1	325	331	PF00069	0.656
MOD_CK1_1	97	103	PF00069	0.662
MOD_CK2_1	116	122	PF00069	0.466
MOD_CK2_1	199	205	PF00069	0.525
MOD_CK2_1	251	257	PF00069	0.607
MOD_CK2_1	261	267	PF00069	0.677
MOD_CK2_1	269	275	PF00069	0.733
MOD_CK2_1	325	331	PF00069	0.610
MOD_CK2_1	87	93	PF00069	0.604
MOD_GlcNHglycan	152	156	PF01048	0.509
MOD_GlcNHglycan	243	246	PF01048	0.716
MOD_GlcNHglycan	306	309	PF01048	0.810
MOD_GlcNHglycan	353	356	PF01048	0.664
MOD_GlcNHglycan	66	71	PF01048	0.680
MOD_GSK3_1	102	109	PF00069	0.596
MOD_GSK3_1	183	190	PF00069	0.582
MOD_GSK3_1	239	246	PF00069	0.601
MOD_GSK3_1	269	276	PF00069	0.524
MOD_GSK3_1	312	319	PF00069	0.755
MOD_GSK3_1	325	332	PF00069	0.743
MOD_GSK3_1	367	374	PF00069	0.608
MOD_GSK3_1	83	90	PF00069	0.577
MOD_GSK3_1	93	100	PF00069	0.592
MOD_N-GLC_1	106	111	PF02516	0.521
MOD_NEK2_1	130	135	PF00069	0.555
MOD_NEK2_1	141	146	PF00069	0.462
MOD_NEK2_1	224	229	PF00069	0.522
MOD_NEK2_1	329	334	PF00069	0.698
MOD_PKA_1	178	184	PF00069	0.681
MOD_PKA_2	131	137	PF00069	0.561
MOD_PKA_2	178	184	PF00069	0.681
MOD_PKA_2	329	335	PF00069	0.577
MOD_PKB_1	221	229	PF00069	0.574
MOD_Plk_1	276	282	PF00069	0.737
MOD_Plk_1	285	291	PF00069	0.711
MOD_Plk_2-3	87	93	PF00069	0.558
MOD_Plk_4	109	115	PF00069	0.581
MOD_Plk_4	141	147	PF00069	0.485
MOD_Plk_4	183	189	PF00069	0.617
MOD_Plk_4	261	267	PF00069	0.689
MOD_Plk_4	42	48	PF00069	0.609
MOD_ProDKin_1	132	138	PF00069	0.573
MOD_ProDKin_1	267	273	PF00069	0.733
MOD_ProDKin_1	309	315	PF00069	0.611
MOD_ProDKin_1	372	378	PF00069	0.545
MOD_SUMO_rev_2	279	289	PF00179	0.587
TRG_ENDOCYTIC_2	113	116	PF00928	0.438
TRG_ENDOCYTIC_2	127	130	PF00928	0.465
TRG_ENDOCYTIC_2	145	148	PF00928	0.567
TRG_ENDOCYTIC_2	258	261	PF00928	0.485
TRG_ER_diArg_1	124	127	PF00400	0.587
TRG_ER_diArg_1	178	180	PF00400	0.637
TRG_ER_diArg_1	209	211	PF00400	0.651
TRG_ER_diArg_1	221	223	PF00400	0.686
TRG_ER_diArg_1	339	341	PF00400	0.713
TRG_ER_diArg_1	9	11	PF00400	0.562
TRG_NLS_MonoExtC_3	50	56	PF00514	0.638
TRG_NLS_MonoExtN_4	48	55	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI8	Leptomonas seymouri	58%	93%
A0A1X0P4C2	Trypanosomatidae	29%	100%
A0A3S7WYY8	Leishmania donovani	86%	100%
A0A422MPP3	Trypanosoma rangeli	34%	100%
A4HE19	Leishmania braziliensis	66%	100%
A4I1C6	Leishmania infantum	86%	100%
Q4QA10	Leishmania major	78%	100%
V5BXG5	Trypanosoma cruzi	34%	100%