Prefoldin subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin subunit 4

Gene product:

prefoldin subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AXG0_LEIMU

TriTrypDb:

LmxM.25.0820

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXG0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051082	unfolded protein binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	80	84	PF00656	0.349
CLV_NRD_NRD_1	30	32	PF00675	0.276
CLV_NRD_NRD_1	37	39	PF00675	0.200
CLV_PCSK_KEX2_1	30	32	PF00082	0.268
CLV_PCSK_KEX2_1	37	39	PF00082	0.254
CLV_PCSK_SKI1_1	37	41	PF00082	0.277
CLV_PCSK_SKI1_1	63	67	PF00082	0.306
DOC_CYCLIN_RxL_1	31	45	PF00134	0.534
DOC_MAPK_gen_1	6	14	PF00069	0.550
DOC_MAPK_MEF2A_6	6	14	PF00069	0.607
LIG_14-3-3_CanoR_1	30	36	PF00244	0.545
LIG_FHA_2	13	19	PF00498	0.412
LIG_LIR_Gen_1	68	78	PF02991	0.484
LIG_LIR_Nem_3	68	73	PF02991	0.484
LIG_Pex14_2	66	70	PF04695	0.454
LIG_SH2_STAT5	123	126	PF00017	0.430
LIG_SH2_STAT5	64	67	PF00017	0.454
LIG_SUMO_SIM_par_1	9	15	PF11976	0.534
MOD_CK2_1	88	94	PF00069	0.412
MOD_LATS_1	29	35	PF00433	0.374
MOD_N-GLC_2	21	23	PF02516	0.419
MOD_NEK2_1	1	6	PF00069	0.626
MOD_PIKK_1	117	123	PF00454	0.325
MOD_Plk_1	12	18	PF00069	0.485
MOD_SUMO_rev_2	55	65	PF00179	0.419
MOD_SUMO_rev_2	94	103	PF00179	0.361
TRG_ENDOCYTIC_2	115	118	PF00928	0.307
TRG_ER_diArg_1	30	32	PF00400	0.301
TRG_ER_diArg_1	37	39	PF00400	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU3	Leptomonas seymouri	85%	99%
A0A0S4J0Y8	Bodo saltans	50%	100%
A0A1X0P5G6	Trypanosomatidae	50%	100%
A0A3Q8ID97	Leishmania donovani	95%	100%
A0A3S5IQX3	Trypanosoma rangeli	46%	100%
A4HE17	Leishmania braziliensis	91%	99%
A4I1C4	Leishmania infantum	95%	100%
D0A5L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
P53900	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
Q2TBR6	Bos taurus	30%	95%
Q4QA12	Leishmania major	94%	100%
Q54TB7	Dictyostelium discoideum	33%	96%
Q9M4B5	Arabidopsis thaliana	37%	98%
Q9M4C4	Avena fatua	37%	100%
Q9NQP4	Homo sapiens	30%	95%
Q9VRL3	Drosophila melanogaster	28%	92%