Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AXF6_LEIMU

TriTrypDb:

LmxM.25.0780

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AXF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	214	216	PF00675	0.550
CLV_NRD_NRD_1	57	59	PF00675	0.728
CLV_PCSK_FUR_1	212	216	PF00082	0.510
CLV_PCSK_KEX2_1	211	213	PF00082	0.546
CLV_PCSK_KEX2_1	214	216	PF00082	0.531
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.512
CLV_PCSK_SKI1_1	142	146	PF00082	0.594
CLV_PCSK_SKI1_1	77	81	PF00082	0.692
DEG_SPOP_SBC_1	291	295	PF00917	0.652
DEG_SPOP_SBC_1	87	91	PF00917	0.481
DOC_CKS1_1	69	74	PF01111	0.377
DOC_CYCLIN_yCln2_LP_2	117	120	PF00134	0.395
DOC_MAPK_gen_1	58	65	PF00069	0.489
DOC_MAPK_MEF2A_6	58	67	PF00069	0.403
DOC_PP2B_LxvP_1	117	120	PF13499	0.430
DOC_USP7_MATH_1	120	124	PF00917	0.493
DOC_USP7_MATH_1	204	208	PF00917	0.578
DOC_USP7_MATH_1	22	26	PF00917	0.413
DOC_USP7_MATH_1	291	295	PF00917	0.676
DOC_USP7_MATH_1	47	51	PF00917	0.432
DOC_USP7_MATH_1	87	91	PF00917	0.505
DOC_WW_Pin1_4	237	242	PF00397	0.632
DOC_WW_Pin1_4	292	297	PF00397	0.762
DOC_WW_Pin1_4	65	70	PF00397	0.416
LIG_Actin_WH2_2	126	144	PF00022	0.411
LIG_BRCT_BRCA1_1	179	183	PF00533	0.382
LIG_FHA_1	103	109	PF00498	0.486
LIG_FHA_1	136	142	PF00498	0.423
LIG_FHA_1	33	39	PF00498	0.386
LIG_FHA_1	52	58	PF00498	0.443
LIG_FHA_2	138	144	PF00498	0.380
LIG_FHA_2	93	99	PF00498	0.406
LIG_Integrin_RGD_1	4	6	PF01839	0.614
LIG_LIR_Apic_2	255	259	PF02991	0.745
LIG_LIR_Nem_3	130	135	PF02991	0.439
LIG_SH2_CRK	256	260	PF00017	0.818
LIG_SH2_GRB2like	269	272	PF00017	0.770
LIG_SH2_STAT3	225	228	PF00017	0.753
LIG_SH2_STAT3	272	275	PF00017	0.771
LIG_SH2_STAT3	33	36	PF00017	0.431
LIG_SH3_3	217	223	PF00018	0.711
LIG_SH3_3	226	232	PF00018	0.695
LIG_SH3_3	235	241	PF00018	0.683
LIG_SH3_3	257	263	PF00018	0.737
LIG_SH3_3	278	284	PF00018	0.643
LIG_SH3_3	66	72	PF00018	0.378
LIG_TRAF2_1	53	56	PF00917	0.484
LIG_WW_1	259	262	PF00397	0.695
MOD_CK1_1	68	74	PF00069	0.426
MOD_CK2_1	204	210	PF00069	0.589
MOD_GlcNHglycan	12	15	PF01048	0.725
MOD_GlcNHglycan	146	149	PF01048	0.651
MOD_GlcNHglycan	155	160	PF01048	0.622
MOD_GlcNHglycan	179	182	PF01048	0.583
MOD_GlcNHglycan	201	204	PF01048	0.412
MOD_GlcNHglycan	206	209	PF01048	0.479
MOD_GlcNHglycan	272	275	PF01048	0.549
MOD_GlcNHglycan	43	46	PF01048	0.592
MOD_GlcNHglycan	49	52	PF01048	0.630
MOD_GSK3_1	47	54	PF00069	0.437
MOD_GSK3_1	6	13	PF00069	0.560
MOD_GSK3_1	88	95	PF00069	0.481
MOD_N-GLC_1	270	275	PF02516	0.545
MOD_N-GLC_1	297	302	PF02516	0.484
MOD_NEK2_1	135	140	PF00069	0.426
MOD_NEK2_1	199	204	PF00069	0.412
MOD_NEK2_1	88	93	PF00069	0.467
MOD_PIKK_1	32	38	PF00454	0.386
MOD_PKA_1	214	220	PF00069	0.677
MOD_PKA_2	171	177	PF00069	0.362
MOD_PKA_2	214	220	PF00069	0.702
MOD_PKA_2	92	98	PF00069	0.405
MOD_PKB_1	212	220	PF00069	0.676
MOD_Plk_1	29	35	PF00069	0.496
MOD_Plk_2-3	137	143	PF00069	0.287
MOD_Plk_4	22	28	PF00069	0.377
MOD_ProDKin_1	237	243	PF00069	0.636
MOD_ProDKin_1	292	298	PF00069	0.763
MOD_ProDKin_1	65	71	PF00069	0.414
TRG_DiLeu_BaEn_1	163	168	PF01217	0.378
TRG_DiLeu_BaEn_4	55	61	PF01217	0.413
TRG_ER_diArg_1	212	215	PF00400	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IN96	Leishmania donovani	84%	100%
A4HE13	Leishmania braziliensis	51%	99%
A4I1C0	Leishmania infantum	84%	100%
Q4QA16	Leishmania major	80%	100%