Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AXF5_LEIMU

TriTrypDb:

LmxM.25.0770

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.450
CLV_C14_Caspase3-7	169	173	PF00656	0.519
CLV_NRD_NRD_1	115	117	PF00675	0.529
CLV_NRD_NRD_1	244	246	PF00675	0.602
CLV_NRD_NRD_1	269	271	PF00675	0.617
CLV_NRD_NRD_1	28	30	PF00675	0.675
CLV_PCSK_KEX2_1	243	245	PF00082	0.601
CLV_PCSK_KEX2_1	269	271	PF00082	0.611
CLV_PCSK_KEX2_1	28	30	PF00082	0.654
CLV_PCSK_SKI1_1	135	139	PF00082	0.546
CLV_PCSK_SKI1_1	269	273	PF00082	0.469
CLV_PCSK_SKI1_1	94	98	PF00082	0.485
DEG_APCC_DBOX_1	163	171	PF00400	0.492
DEG_APCC_DBOX_1	268	276	PF00400	0.465
DOC_CKS1_1	9	14	PF01111	0.512
DOC_CYCLIN_RxL_1	132	142	PF00134	0.314
DOC_CYCLIN_RxL_1	267	277	PF00134	0.522
DOC_CYCLIN_yClb1_LxF_4	207	213	PF00134	0.378
DOC_MAPK_FxFP_2	211	214	PF00069	0.435
DOC_MAPK_gen_1	116	123	PF00069	0.485
DOC_MAPK_gen_1	269	275	PF00069	0.455
DOC_MAPK_MEF2A_6	32	40	PF00069	0.446
DOC_PP2B_LxvP_1	100	103	PF13499	0.552
DOC_PP2B_LxvP_1	123	126	PF13499	0.492
DOC_PP4_FxxP_1	211	214	PF00568	0.483
DOC_PP4_FxxP_1	49	52	PF00568	0.458
DOC_USP7_MATH_1	127	131	PF00917	0.427
DOC_USP7_MATH_1	146	150	PF00917	0.446
DOC_USP7_MATH_1	178	182	PF00917	0.657
DOC_USP7_MATH_1	185	189	PF00917	0.610
DOC_USP7_MATH_1	22	26	PF00917	0.539
DOC_USP7_MATH_1	235	239	PF00917	0.657
DOC_USP7_MATH_1	253	257	PF00917	0.637
DOC_USP7_MATH_1	404	408	PF00917	0.641
DOC_USP7_MATH_1	5	9	PF00917	0.748
DOC_WW_Pin1_4	176	181	PF00397	0.787
DOC_WW_Pin1_4	32	37	PF00397	0.714
DOC_WW_Pin1_4	60	65	PF00397	0.653
DOC_WW_Pin1_4	8	13	PF00397	0.513
LIG_14-3-3_CanoR_1	107	112	PF00244	0.373
LIG_BIR_III_2	177	181	PF00653	0.487
LIG_FHA_1	182	188	PF00498	0.456
LIG_FHA_1	63	69	PF00498	0.670
LIG_FHA_2	108	114	PF00498	0.383
LIG_LIR_Apic_2	46	52	PF02991	0.459
LIG_NRBOX	133	139	PF00104	0.306
LIG_PTAP_UEV_1	411	416	PF05743	0.612
LIG_PTB_Apo_2	205	212	PF02174	0.447
LIG_PTB_Apo_2	340	347	PF02174	0.501
LIG_PTB_Phospho_1	340	346	PF10480	0.503
LIG_SH2_CRK	362	366	PF00017	0.625
LIG_SH2_GRB2like	354	357	PF00017	0.763
LIG_SH2_GRB2like	369	372	PF00017	0.526
LIG_SH2_GRB2like	383	386	PF00017	0.543
LIG_SH2_NCK_1	355	359	PF00017	0.618
LIG_SH2_SRC	369	372	PF00017	0.516
LIG_SH2_SRC	410	413	PF00017	0.620
LIG_SH2_STAP1	45	49	PF00017	0.429
LIG_SH2_STAT3	345	348	PF00017	0.637
LIG_SH2_STAT3	391	394	PF00017	0.649
LIG_SH2_STAT5	276	279	PF00017	0.437
LIG_SH2_STAT5	410	413	PF00017	0.620
LIG_SH2_STAT5	45	48	PF00017	0.519
LIG_SH3_3	373	379	PF00018	0.628
LIG_SH3_3	409	415	PF00018	0.618
LIG_SH3_3	58	64	PF00018	0.654
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.361
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.639
LIG_SUMO_SIM_par_1	166	172	PF11976	0.539
LIG_SUMO_SIM_par_1	191	198	PF11976	0.623
LIG_SUMO_SIM_par_1	271	277	PF11976	0.401
LIG_TRAF2_1	110	113	PF00917	0.500
LIG_TRAF2_1	7	10	PF00917	0.655
MOD_CK1_1	144	150	PF00069	0.544
MOD_CK1_1	153	159	PF00069	0.471
MOD_CK1_1	181	187	PF00069	0.678
MOD_CK1_1	188	194	PF00069	0.532
MOD_CK1_1	202	208	PF00069	0.361
MOD_CK1_1	256	262	PF00069	0.495
MOD_CK1_1	4	10	PF00069	0.654
MOD_CK2_1	107	113	PF00069	0.377
MOD_CK2_1	4	10	PF00069	0.694
MOD_DYRK1A_RPxSP_1	32	36	PF00069	0.614
MOD_GlcNHglycan	144	147	PF01048	0.561
MOD_GlcNHglycan	152	155	PF01048	0.539
MOD_GlcNHglycan	20	23	PF01048	0.598
MOD_GlcNHglycan	200	204	PF01048	0.366
MOD_GlcNHglycan	3	6	PF01048	0.621
MOD_GlcNHglycan	356	359	PF01048	0.641
MOD_GlcNHglycan	400	403	PF01048	0.597
MOD_GlcNHglycan	406	409	PF01048	0.629
MOD_GlcNHglycan	412	415	PF01048	0.558
MOD_GlcNHglycan	53	56	PF01048	0.717
MOD_GlcNHglycan	69	72	PF01048	0.627
MOD_GlcNHglycan	74	77	PF01048	0.551
MOD_GlcNHglycan	87	91	PF01048	0.357
MOD_GSK3_1	1	8	PF00069	0.820
MOD_GSK3_1	112	119	PF00069	0.513
MOD_GSK3_1	142	149	PF00069	0.515
MOD_GSK3_1	18	25	PF00069	0.529
MOD_GSK3_1	181	188	PF00069	0.541
MOD_GSK3_1	195	202	PF00069	0.510
MOD_GSK3_1	235	242	PF00069	0.545
MOD_GSK3_1	39	46	PF00069	0.569
MOD_GSK3_1	406	413	PF00069	0.628
MOD_GSK3_1	60	67	PF00069	0.616
MOD_N-GLC_1	127	132	PF02516	0.427
MOD_N-GLC_1	22	27	PF02516	0.513
MOD_N-GLC_1	72	77	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.647
MOD_NEK2_1	139	144	PF00069	0.484
MOD_NEK2_1	18	23	PF00069	0.626
MOD_NEK2_1	199	204	PF00069	0.374
MOD_NEK2_1	43	48	PF00069	0.560
MOD_NEK2_1	86	91	PF00069	0.400
MOD_NMyristoyl	1	7	PF02799	0.631
MOD_PIKK_1	5	11	PF00454	0.789
MOD_PK_1	116	122	PF00069	0.361
MOD_PKA_1	116	122	PF00069	0.494
MOD_Plk_1	127	133	PF00069	0.432
MOD_Plk_1	199	205	PF00069	0.424
MOD_Plk_1	86	92	PF00069	0.444
MOD_Plk_4	116	122	PF00069	0.447
MOD_Plk_4	153	159	PF00069	0.384
MOD_Plk_4	188	194	PF00069	0.671
MOD_Plk_4	235	241	PF00069	0.606
MOD_Plk_4	39	45	PF00069	0.553
MOD_Plk_4	406	412	PF00069	0.630
MOD_ProDKin_1	176	182	PF00069	0.788
MOD_ProDKin_1	32	38	PF00069	0.707
MOD_ProDKin_1	60	66	PF00069	0.653
MOD_ProDKin_1	8	14	PF00069	0.512
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.466
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.452
TRG_ER_diArg_1	243	245	PF00400	0.607
TRG_NES_CRM1_1	92	106	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V9	Leptomonas seymouri	33%	100%
A0A3Q8ICF2	Leishmania donovani	85%	100%
A4HE12	Leishmania braziliensis	55%	99%
A4I1B9	Leishmania infantum	85%	100%
Q4QA17	Leishmania major	83%	100%