Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXF4_LEIMU

TriTrypDb:

LmxM.25.0760

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXF4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.447
CLV_C14_Caspase3-7	38	42	PF00656	0.529
CLV_NRD_NRD_1	15	17	PF00675	0.552
CLV_NRD_NRD_1	273	275	PF00675	0.420
CLV_PCSK_KEX2_1	15	17	PF00082	0.552
CLV_PCSK_KEX2_1	272	274	PF00082	0.427
CLV_PCSK_SKI1_1	136	140	PF00082	0.502
CLV_PCSK_SKI1_1	249	253	PF00082	0.523
CLV_PCSK_SKI1_1	90	94	PF00082	0.537
DEG_SPOP_SBC_1	36	40	PF00917	0.480
DEG_SPOP_SBC_1	61	65	PF00917	0.540
DOC_AGCK_PIF_2	149	154	PF00069	0.342
DOC_CKS1_1	332	337	PF01111	0.371
DOC_CYCLIN_RxL_1	181	190	PF00134	0.532
DOC_CYCLIN_RxL_1	87	95	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.415
DOC_MAPK_HePTP_8	119	131	PF00069	0.434
DOC_MAPK_MEF2A_6	122	131	PF00069	0.670
DOC_MAPK_MEF2A_6	288	296	PF00069	0.339
DOC_PP1_RVXF_1	182	189	PF00149	0.536
DOC_PP2B_LxvP_1	289	292	PF13499	0.385
DOC_USP7_MATH_1	120	124	PF00917	0.568
DOC_USP7_MATH_1	29	33	PF00917	0.577
DOC_USP7_MATH_1	5	9	PF00917	0.580
DOC_USP7_MATH_1	60	64	PF00917	0.598
DOC_WW_Pin1_4	122	127	PF00397	0.713
DOC_WW_Pin1_4	165	170	PF00397	0.678
DOC_WW_Pin1_4	331	336	PF00397	0.481
DOC_WW_Pin1_4	66	71	PF00397	0.607
LIG_14-3-3_CanoR_1	122	126	PF00244	0.458
LIG_14-3-3_CanoR_1	177	183	PF00244	0.578
LIG_14-3-3_CanoR_1	249	254	PF00244	0.519
LIG_Actin_WH2_2	202	220	PF00022	0.531
LIG_APCC_ABBA_1	142	147	PF00400	0.340
LIG_BRCT_BRCA1_1	167	171	PF00533	0.547
LIG_CaM_NSCaTE_8	225	232	PF13499	0.437
LIG_Clathr_ClatBox_1	206	210	PF01394	0.405
LIG_Clathr_ClatBox_1	306	310	PF01394	0.431
LIG_eIF4E_1	201	207	PF01652	0.383
LIG_eIF4E_1	44	50	PF01652	0.493
LIG_FHA_1	252	258	PF00498	0.525
LIG_FHA_1	291	297	PF00498	0.439
LIG_FHA_1	43	49	PF00498	0.591
LIG_FHA_2	36	42	PF00498	0.472
LIG_HCF-1_HBM_1	198	201	PF13415	0.388
LIG_LIR_Gen_1	137	146	PF02991	0.392
LIG_LIR_Gen_1	147	154	PF02991	0.452
LIG_LIR_Nem_3	137	142	PF02991	0.394
LIG_LIR_Nem_3	147	152	PF02991	0.444
LIG_LIR_Nem_3	195	200	PF02991	0.536
LIG_LIR_Nem_3	343	348	PF02991	0.507
LIG_MYND_1	346	350	PF01753	0.506
LIG_MYND_3	235	239	PF01753	0.406
LIG_NRBOX	202	208	PF00104	0.420
LIG_NRBOX	88	94	PF00104	0.462
LIG_Pex14_1	197	201	PF04695	0.326
LIG_SH2_CRK	75	79	PF00017	0.518
LIG_SH2_SRC	145	148	PF00017	0.384
LIG_SH2_STAP1	154	158	PF00017	0.532
LIG_SH2_STAP1	44	48	PF00017	0.562
LIG_SH2_STAT3	80	83	PF00017	0.512
LIG_SH2_STAT5	145	148	PF00017	0.448
LIG_SH2_STAT5	154	157	PF00017	0.572
LIG_SH2_STAT5	201	204	PF00017	0.379
LIG_SH2_STAT5	44	47	PF00017	0.530
LIG_SH2_STAT5	80	83	PF00017	0.512
LIG_SH3_3	124	130	PF00018	0.467
LIG_SH3_3	329	335	PF00018	0.450
LIG_SH3_3	49	55	PF00018	0.511
LIG_SUMO_SIM_par_1	304	311	PF11976	0.420
MOD_CDK_SPxxK_3	331	338	PF00069	0.409
MOD_CK1_1	325	331	PF00069	0.500
MOD_CK1_1	40	46	PF00069	0.669
MOD_CK1_1	64	70	PF00069	0.581
MOD_CK2_1	192	198	PF00069	0.360
MOD_DYRK1A_RPxSP_1	122	126	PF00069	0.458
MOD_GlcNHglycan	114	117	PF01048	0.664
MOD_GlcNHglycan	156	159	PF01048	0.693
MOD_GlcNHglycan	174	177	PF01048	0.532
MOD_GlcNHglycan	325	328	PF01048	0.584
MOD_GlcNHglycan	64	67	PF01048	0.679
MOD_GSK3_1	152	159	PF00069	0.557
MOD_GSK3_1	209	216	PF00069	0.508
MOD_GSK3_1	23	30	PF00069	0.663
MOD_GSK3_1	257	264	PF00069	0.295
MOD_GSK3_1	318	325	PF00069	0.475
MOD_GSK3_1	35	42	PF00069	0.660
MOD_GSK3_1	60	67	PF00069	0.695
MOD_NEK2_1	121	126	PF00069	0.506
MOD_NEK2_1	152	157	PF00069	0.715
MOD_NEK2_1	171	176	PF00069	0.471
MOD_NEK2_1	209	214	PF00069	0.464
MOD_NEK2_1	23	28	PF00069	0.579
MOD_NEK2_1	297	302	PF00069	0.377
MOD_PIKK_1	209	215	PF00454	0.449
MOD_PIKK_1	23	29	PF00454	0.678
MOD_PIKK_1	239	245	PF00454	0.655
MOD_PIKK_1	257	263	PF00454	0.290
MOD_PKA_2	121	127	PF00069	0.450
MOD_PKB_1	272	280	PF00069	0.445
MOD_Plk_1	209	215	PF00069	0.499
MOD_Plk_1	40	46	PF00069	0.628
MOD_Plk_4	5	11	PF00069	0.498
MOD_ProDKin_1	122	128	PF00069	0.708
MOD_ProDKin_1	165	171	PF00069	0.677
MOD_ProDKin_1	331	337	PF00069	0.414
MOD_ProDKin_1	66	72	PF00069	0.599
TRG_DiLeu_BaEn_1	6	11	PF01217	0.450
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.378
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.431
TRG_ENDOCYTIC_2	200	203	PF00928	0.467
TRG_ER_diArg_1	14	16	PF00400	0.540
TRG_ER_diArg_1	272	274	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T2	Leptomonas seymouri	34%	99%
A0A3Q8IF78	Leishmania donovani	85%	99%
A0A3R7K7C7	Trypanosoma rangeli	31%	100%
A4HE11	Leishmania braziliensis	71%	99%
A4I1B8	Leishmania infantum	87%	100%
D0A5L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QA18	Leishmania major	88%	99%