Protein CASC1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein CASC1

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXE9_LEIMU

TriTrypDb:

LmxM.25.0715

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.436
CLV_NRD_NRD_1	209	211	PF00675	0.503
CLV_NRD_NRD_1	217	219	PF00675	0.636
CLV_PCSK_KEX2_1	209	211	PF00082	0.503
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.503
CLV_PCSK_SKI1_1	261	265	PF00082	0.706
CLV_PCSK_SKI1_1	273	277	PF00082	0.649
DOC_ANK_TNKS_1	181	188	PF00023	0.621
DOC_CKS1_1	143	148	PF01111	0.573
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.592
DOC_MAPK_MEF2A_6	157	166	PF00069	0.500
DOC_PP2B_LxvP_1	166	169	PF13499	0.475
DOC_USP7_MATH_1	221	225	PF00917	0.586
DOC_USP7_MATH_1	255	259	PF00917	0.459
DOC_USP7_UBL2_3	232	236	PF12436	0.502
DOC_USP7_UBL2_3	261	265	PF12436	0.634
DOC_USP7_UBL2_3	270	274	PF12436	0.682
DOC_WW_Pin1_4	142	147	PF00397	0.666
LIG_14-3-3_CanoR_1	256	260	PF00244	0.714
LIG_BRCT_BRCA1_1	13	17	PF00533	0.489
LIG_FHA_1	196	202	PF00498	0.621
LIG_FHA_2	150	156	PF00498	0.722
LIG_FHA_2	202	208	PF00498	0.567
LIG_LIR_Apic_2	224	228	PF02991	0.664
LIG_LIR_Gen_1	110	119	PF02991	0.480
LIG_LIR_Gen_1	14	25	PF02991	0.649
LIG_LIR_Gen_1	186	194	PF02991	0.556
LIG_LIR_Gen_1	73	83	PF02991	0.523
LIG_LIR_Nem_3	110	115	PF02991	0.476
LIG_LIR_Nem_3	186	192	PF02991	0.530
LIG_LIR_Nem_3	73	79	PF02991	0.515
LIG_PTB_Apo_2	188	195	PF02174	0.650
LIG_PTB_Phospho_1	188	194	PF10480	0.647
LIG_SH2_CRK	189	193	PF00017	0.522
LIG_SH2_CRK	225	229	PF00017	0.605
LIG_SH2_CRK	76	80	PF00017	0.538
LIG_SH2_GRB2like	189	192	PF00017	0.543
LIG_SH2_PTP2	159	162	PF00017	0.613
LIG_SH2_SRC	159	162	PF00017	0.613
LIG_SH2_STAT5	118	121	PF00017	0.468
LIG_SH2_STAT5	159	162	PF00017	0.613
LIG_SH2_STAT5	229	232	PF00017	0.573
LIG_SH3_1	159	165	PF00018	0.612
LIG_SH3_2	146	151	PF14604	0.573
LIG_SH3_3	143	149	PF00018	0.665
LIG_SH3_3	159	165	PF00018	0.425
LIG_SH3_3	197	203	PF00018	0.460
LIG_SH3_3	227	233	PF00018	0.594
LIG_SH3_3	23	29	PF00018	0.545
LIG_SH3_3	249	255	PF00018	0.642
LIG_SH3_4	232	239	PF00018	0.493
LIG_SH3_4	261	268	PF00018	0.690
LIG_TRAF2_1	152	155	PF00917	0.644
LIG_TRAF2_1	19	22	PF00917	0.726
LIG_TRAF2_1	39	42	PF00917	0.760
LIG_WW_3	148	152	PF00397	0.559
MOD_CK1_1	110	116	PF00069	0.568
MOD_CK1_1	117	123	PF00069	0.522
MOD_CK1_1	84	90	PF00069	0.446
MOD_CK2_1	149	155	PF00069	0.614
MOD_CK2_1	245	251	PF00069	0.648
MOD_CK2_1	43	49	PF00069	0.712
MOD_GlcNHglycan	170	173	PF01048	0.633
MOD_GlcNHglycan	204	207	PF01048	0.626
MOD_GlcNHglycan	33	36	PF01048	0.692
MOD_GlcNHglycan	83	86	PF01048	0.580
MOD_GSK3_1	110	117	PF00069	0.527
MOD_N-GLC_1	120	125	PF02516	0.443
MOD_NEK2_1	107	112	PF00069	0.564
MOD_PIKK_1	195	201	PF00454	0.704
MOD_PIKK_1	268	274	PF00454	0.607
MOD_PKA_2	255	261	PF00069	0.595
MOD_Plk_1	107	113	PF00069	0.579
MOD_Plk_1	120	126	PF00069	0.465
MOD_Plk_4	107	113	PF00069	0.539
MOD_Plk_4	114	120	PF00069	0.509
MOD_Plk_4	75	81	PF00069	0.543
MOD_ProDKin_1	142	148	PF00069	0.659
MOD_SUMO_for_1	175	178	PF00179	0.527
MOD_SUMO_for_1	263	266	PF00179	0.653
TRG_ENDOCYTIC_2	189	192	PF00928	0.473
TRG_ENDOCYTIC_2	76	79	PF00928	0.539
TRG_NLS_MonoExtC_3	208	214	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P685	Leptomonas seymouri	57%	94%
A0A1X0P5H5	Trypanosomatidae	33%	100%
A0A3Q8IC96	Leishmania donovani	88%	100%
A0A422NX50	Trypanosoma rangeli	35%	100%
A4HE03	Leishmania braziliensis	69%	98%
A4I1B3	Leishmania infantum	88%	100%
D0A5K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4QA23	Leishmania major	87%	100%
V5BN56	Trypanosoma cruzi	31%	100%