SCAMP family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SCAMP family, putative

Species:

Leishmania mexicana

UniProt:

E9AXE8_LEIMU

TriTrypDb:

LmxM.25.0710

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0032588	trans-Golgi network membrane	4	1
GO:0055038	recycling endosome membrane	6	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AXE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXE8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.786
CLV_C14_Caspase3-7	47	51	PF00656	0.768
CLV_NRD_NRD_1	111	113	PF00675	0.567
CLV_NRD_NRD_1	166	168	PF00675	0.311
CLV_NRD_NRD_1	341	343	PF00675	0.344
CLV_NRD_NRD_1	348	350	PF00675	0.361
CLV_NRD_NRD_1	352	354	PF00675	0.360
CLV_PCSK_KEX2_1	348	350	PF00082	0.364
CLV_PCSK_KEX2_1	352	354	PF00082	0.365
CLV_PCSK_PC7_1	348	354	PF00082	0.431
CLV_PCSK_SKI1_1	105	109	PF00082	0.424
CLV_PCSK_SKI1_1	116	120	PF00082	0.419
CLV_PCSK_SKI1_1	167	171	PF00082	0.364
CLV_PCSK_SKI1_1	187	191	PF00082	0.331
CLV_PCSK_SKI1_1	192	196	PF00082	0.326
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_ODPH_VHL_1	161	172	PF01847	0.379
DEG_SCF_TRCP1_1	42	48	PF00400	0.691
DOC_MAPK_DCC_7	308	318	PF00069	0.273
DOC_MAPK_gen_1	348	358	PF00069	0.629
DOC_MAPK_RevD_3	335	349	PF00069	0.541
DOC_PIKK_1	138	145	PF02985	0.663
DOC_PP4_FxxP_1	287	290	PF00568	0.226
DOC_USP7_MATH_1	219	223	PF00917	0.328
DOC_USP7_MATH_1	96	100	PF00917	0.617
DOC_USP7_MATH_2	58	64	PF00917	0.752
DOC_USP7_UBL2_3	93	97	PF12436	0.710
DOC_WW_Pin1_4	54	59	PF00397	0.736
DOC_WW_Pin1_4	82	87	PF00397	0.798
LIG_14-3-3_CanoR_1	112	118	PF00244	0.702
LIG_APCC_ABBA_1	224	229	PF00400	0.368
LIG_BRCT_BRCA1_1	68	72	PF00533	0.612
LIG_FHA_1	154	160	PF00498	0.684
LIG_FHA_1	6	12	PF00498	0.757
LIG_FHA_1	79	85	PF00498	0.716
LIG_FHA_1	99	105	PF00498	0.699
LIG_FHA_2	72	78	PF00498	0.743
LIG_Integrin_isoDGR_2	24	26	PF01839	0.602
LIG_LIR_Apic_2	63	67	PF02991	0.738
LIG_LIR_Gen_1	197	206	PF02991	0.441
LIG_LIR_Gen_1	330	340	PF02991	0.417
LIG_LIR_Nem_3	197	201	PF02991	0.441
LIG_LIR_Nem_3	330	335	PF02991	0.369
LIG_PCNA_yPIPBox_3	291	299	PF02747	0.179
LIG_Pex14_2	165	169	PF04695	0.496
LIG_SH2_NCK_1	64	68	PF00017	0.756
LIG_SH3_2	163	168	PF14604	0.496
LIG_SH3_3	160	166	PF00018	0.496
LIG_SH3_3	309	315	PF00018	0.362
LIG_SH3_3	52	58	PF00018	0.736
LIG_SUMO_SIM_par_1	79	85	PF11976	0.670
LIG_TYR_ITIM	252	257	PF00017	0.354
LIG_WRC_WIRS_1	329	334	PF05994	0.190
MOD_CDK_SPK_2	54	59	PF00069	0.767
MOD_CK1_1	179	185	PF00069	0.541
MOD_CK1_1	48	54	PF00069	0.732
MOD_CK1_1	5	11	PF00069	0.688
MOD_CK2_1	179	185	PF00069	0.524
MOD_CK2_1	54	60	PF00069	0.725
MOD_GlcNHglycan	20	23	PF01048	0.551
MOD_GlcNHglycan	216	219	PF01048	0.546
MOD_GlcNHglycan	221	224	PF01048	0.550
MOD_GlcNHglycan	309	312	PF01048	0.559
MOD_GlcNHglycan	42	45	PF01048	0.612
MOD_GlcNHglycan	47	50	PF01048	0.492
MOD_GlcNHglycan	68	71	PF01048	0.405
MOD_GSK3_1	112	119	PF00069	0.625
MOD_GSK3_1	36	43	PF00069	0.819
MOD_GSK3_1	78	85	PF00069	0.699
MOD_GSK3_1	87	94	PF00069	0.735
MOD_PIKK_1	5	11	PF00454	0.688
MOD_PKA_1	112	118	PF00069	0.662
MOD_PKA_2	111	117	PF00069	0.709
MOD_PKA_2	307	313	PF00069	0.385
MOD_PKA_2	36	42	PF00069	0.663
MOD_Plk_1	76	82	PF00069	0.743
MOD_Plk_2-3	60	66	PF00069	0.754
MOD_Plk_4	246	252	PF00069	0.378
MOD_Plk_4	328	334	PF00069	0.338
MOD_ProDKin_1	54	60	PF00069	0.736
MOD_ProDKin_1	82	88	PF00069	0.796
MOD_SUMO_rev_2	120	125	PF00179	0.686
TRG_ENDOCYTIC_2	254	257	PF00928	0.496
TRG_ER_diArg_1	352	354	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M1	Leptomonas seymouri	51%	98%
A0A1X0P5U6	Trypanosomatidae	41%	95%
A0A3Q8IBN8	Leishmania donovani	91%	100%
A0A3R7KLV8	Trypanosoma rangeli	37%	97%
A4HE02	Leishmania braziliensis	77%	100%
A4I1B2	Leishmania infantum	91%	100%
D0A5K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	90%
Q4QA24	Leishmania major	88%	100%
V5B7L0	Trypanosoma cruzi	39%	97%