Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXE7_LEIMU

TriTrypDb:

LmxM.25.0700

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.496
CLV_C14_Caspase3-7	31	35	PF00656	0.494
CLV_C14_Caspase3-7	487	491	PF00656	0.485
CLV_NRD_NRD_1	183	185	PF00675	0.525
CLV_NRD_NRD_1	274	276	PF00675	0.535
CLV_NRD_NRD_1	367	369	PF00675	0.606
CLV_NRD_NRD_1	38	40	PF00675	0.735
CLV_NRD_NRD_1	97	99	PF00675	0.418
CLV_PCSK_FUR_1	365	369	PF00082	0.673
CLV_PCSK_FUR_1	506	510	PF00082	0.614
CLV_PCSK_KEX2_1	185	187	PF00082	0.538
CLV_PCSK_KEX2_1	274	276	PF00082	0.530
CLV_PCSK_KEX2_1	367	369	PF00082	0.678
CLV_PCSK_KEX2_1	508	510	PF00082	0.611
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.504
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.611
CLV_PCSK_SKI1_1	14	18	PF00082	0.627
CLV_PCSK_SKI1_1	173	177	PF00082	0.429
CLV_PCSK_SKI1_1	203	207	PF00082	0.576
CLV_PCSK_SKI1_1	249	253	PF00082	0.549
CLV_PCSK_SKI1_1	388	392	PF00082	0.618
CLV_PCSK_SKI1_1	6	10	PF00082	0.575
CLV_PCSK_SKI1_1	78	82	PF00082	0.404
CLV_PCSK_SKI1_1	98	102	PF00082	0.269
DEG_APCC_DBOX_1	172	180	PF00400	0.433
DEG_APCC_DBOX_1	248	256	PF00400	0.525
DEG_SPOP_SBC_1	197	201	PF00917	0.524
DEG_SPOP_SBC_1	262	266	PF00917	0.487
DEG_SPOP_SBC_1	28	32	PF00917	0.503
DEG_SPOP_SBC_1	309	313	PF00917	0.591
DEG_SPOP_SBC_1	65	69	PF00917	0.474
DOC_CDC14_PxL_1	334	342	PF14671	0.469
DOC_CKS1_1	458	463	PF01111	0.593
DOC_MAPK_MEF2A_6	388	395	PF00069	0.552
DOC_USP7_MATH_1	111	115	PF00917	0.473
DOC_USP7_MATH_1	197	201	PF00917	0.634
DOC_USP7_MATH_1	23	27	PF00917	0.577
DOC_USP7_MATH_1	235	239	PF00917	0.532
DOC_USP7_MATH_1	263	267	PF00917	0.580
DOC_USP7_MATH_1	270	274	PF00917	0.546
DOC_USP7_MATH_1	28	32	PF00917	0.537
DOC_USP7_MATH_1	310	314	PF00917	0.602
DOC_USP7_MATH_1	350	354	PF00917	0.555
DOC_USP7_MATH_1	49	53	PF00917	0.526
DOC_USP7_MATH_1	496	500	PF00917	0.606
DOC_USP7_MATH_1	65	69	PF00917	0.570
DOC_USP7_UBL2_3	181	185	PF12436	0.559
DOC_WW_Pin1_4	231	236	PF00397	0.536
DOC_WW_Pin1_4	313	318	PF00397	0.682
DOC_WW_Pin1_4	395	400	PF00397	0.488
DOC_WW_Pin1_4	420	425	PF00397	0.552
DOC_WW_Pin1_4	448	453	PF00397	0.620
DOC_WW_Pin1_4	457	462	PF00397	0.627
DOC_WW_Pin1_4	463	468	PF00397	0.701
DOC_WW_Pin1_4	47	52	PF00397	0.439
LIG_14-3-3_CanoR_1	360	364	PF00244	0.613
LIG_14-3-3_CanoR_1	453	457	PF00244	0.570
LIG_14-3-3_CanoR_1	485	493	PF00244	0.481
LIG_14-3-3_CanoR_1	509	515	PF00244	0.560
LIG_14-3-3_CanoR_1	78	84	PF00244	0.450
LIG_14-3-3_CanoR_1	98	104	PF00244	0.342
LIG_Actin_WH2_2	136	152	PF00022	0.487
LIG_Actin_WH2_2	320	335	PF00022	0.495
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_2	490	494	PF00653	0.467
LIG_BRCT_BRCA1_1	232	236	PF00533	0.569
LIG_BRCT_BRCA1_1	294	298	PF00533	0.616
LIG_BRCT_BRCA1_1	497	501	PF00533	0.588
LIG_FHA_1	158	164	PF00498	0.390
LIG_FHA_1	280	286	PF00498	0.582
LIG_FHA_1	346	352	PF00498	0.562
LIG_FHA_1	379	385	PF00498	0.656
LIG_FHA_1	421	427	PF00498	0.485
LIG_FHA_1	453	459	PF00498	0.594
LIG_FHA_1	509	515	PF00498	0.609
LIG_FHA_2	17	23	PF00498	0.493
LIG_FHA_2	224	230	PF00498	0.503
LIG_FHA_2	263	269	PF00498	0.742
LIG_FHA_2	396	402	PF00498	0.523
LIG_Integrin_isoDGR_2	37	39	PF01839	0.564
LIG_LIR_Gen_1	101	112	PF02991	0.357
LIG_LIR_Gen_1	233	244	PF02991	0.555
LIG_LIR_Gen_1	54	63	PF02991	0.394
LIG_LIR_Nem_3	101	107	PF02991	0.399
LIG_LIR_Nem_3	233	239	PF02991	0.589
LIG_LIR_Nem_3	499	505	PF02991	0.598
LIG_LIR_Nem_3	54	59	PF02991	0.405
LIG_MLH1_MIPbox_1	498	502	PF16413	0.585
LIG_Pex14_2	402	406	PF04695	0.543
LIG_Pex14_2	497	501	PF04695	0.660
LIG_SH2_CRK	431	435	PF00017	0.558
LIG_SH2_NCK_1	431	435	PF00017	0.579
LIG_SH2_SRC	167	170	PF00017	0.385
LIG_SH2_STAT5	104	107	PF00017	0.385
LIG_SH2_STAT5	155	158	PF00017	0.382
LIG_SH2_STAT5	167	170	PF00017	0.463
LIG_SH2_STAT5	357	360	PF00017	0.616
LIG_SH2_STAT5	436	439	PF00017	0.494
LIG_SH2_STAT5	517	520	PF00017	0.676
LIG_SH2_STAT5	532	535	PF00017	0.489
LIG_SH3_3	424	430	PF00018	0.664
LIG_SH3_3	474	480	PF00018	0.668
LIG_TRAF2_1	52	55	PF00917	0.528
MOD_CDK_SPK_2	448	453	PF00069	0.611
MOD_CDK_SPxK_1	47	53	PF00069	0.438
MOD_CK1_1	102	108	PF00069	0.292
MOD_CK1_1	189	195	PF00069	0.579
MOD_CK1_1	264	270	PF00069	0.604
MOD_CK1_1	313	319	PF00069	0.686
MOD_CK1_1	378	384	PF00069	0.662
MOD_CK1_1	451	457	PF00069	0.578
MOD_CK1_1	466	472	PF00069	0.630
MOD_CK1_1	495	501	PF00069	0.606
MOD_CK1_1	513	519	PF00069	0.588
MOD_CK1_1	67	73	PF00069	0.602
MOD_CK1_1	82	88	PF00069	0.335
MOD_CK2_1	16	22	PF00069	0.497
MOD_CK2_1	171	177	PF00069	0.464
MOD_CK2_1	333	339	PF00069	0.451
MOD_CK2_1	395	401	PF00069	0.476
MOD_CK2_1	49	55	PF00069	0.509
MOD_CK2_1	525	531	PF00069	0.541
MOD_Cter_Amidation	37	40	PF01082	0.566
MOD_GlcNHglycan	109	112	PF01048	0.347
MOD_GlcNHglycan	173	176	PF01048	0.348
MOD_GlcNHglycan	193	196	PF01048	0.655
MOD_GlcNHglycan	294	297	PF01048	0.531
MOD_GlcNHglycan	312	315	PF01048	0.654
MOD_GlcNHglycan	353	356	PF01048	0.539
MOD_GlcNHglycan	372	375	PF01048	0.774
MOD_GlcNHglycan	377	380	PF01048	0.543
MOD_GlcNHglycan	494	497	PF01048	0.592
MOD_GlcNHglycan	498	501	PF01048	0.529
MOD_GlcNHglycan	69	72	PF01048	0.557
MOD_GlcNHglycan	84	87	PF01048	0.298
MOD_GSK3_1	107	114	PF00069	0.389
MOD_GSK3_1	187	194	PF00069	0.560
MOD_GSK3_1	23	30	PF00069	0.611
MOD_GSK3_1	231	238	PF00069	0.591
MOD_GSK3_1	258	265	PF00069	0.542
MOD_GSK3_1	304	311	PF00069	0.741
MOD_GSK3_1	370	377	PF00069	0.642
MOD_GSK3_1	43	50	PF00069	0.720
MOD_GSK3_1	434	441	PF00069	0.665
MOD_GSK3_1	444	451	PF00069	0.648
MOD_GSK3_1	452	459	PF00069	0.569
MOD_GSK3_1	463	470	PF00069	0.650
MOD_GSK3_1	479	486	PF00069	0.663
MOD_GSK3_1	492	499	PF00069	0.671
MOD_GSK3_1	509	516	PF00069	0.717
MOD_GSK3_1	532	539	PF00069	0.599
MOD_GSK3_1	67	74	PF00069	0.422
MOD_GSK3_1	98	105	PF00069	0.538
MOD_LATS_1	331	337	PF00433	0.479
MOD_N-GLC_1	319	324	PF02516	0.575
MOD_N-GLC_1	370	375	PF02516	0.690
MOD_N-GLC_1	438	443	PF02516	0.493
MOD_N-GLC_1	467	472	PF02516	0.601
MOD_N-GLC_1	520	525	PF02516	0.603
MOD_NEK2_1	107	112	PF00069	0.383
MOD_NEK2_1	230	235	PF00069	0.627
MOD_NEK2_1	280	285	PF00069	0.511
MOD_NEK2_1	332	337	PF00069	0.442
MOD_NEK2_1	79	84	PF00069	0.418
MOD_NEK2_2	244	249	PF00069	0.523
MOD_PIKK_1	280	286	PF00454	0.519
MOD_PIKK_1	93	99	PF00454	0.427
MOD_PK_1	333	339	PF00069	0.451
MOD_PKA_1	508	514	PF00069	0.611
MOD_PKA_1	98	104	PF00069	0.385
MOD_PKA_2	187	193	PF00069	0.530
MOD_PKA_2	292	298	PF00069	0.549
MOD_PKA_2	359	365	PF00069	0.587
MOD_PKA_2	452	458	PF00069	0.590
MOD_PKA_2	484	490	PF00069	0.672
MOD_PKA_2	508	514	PF00069	0.611
MOD_PKA_2	91	97	PF00069	0.463
MOD_PKB_1	184	192	PF00069	0.534
MOD_Plk_1	520	526	PF00069	0.615
MOD_Plk_2-3	359	365	PF00069	0.566
MOD_Plk_4	429	435	PF00069	0.559
MOD_Plk_4	513	519	PF00069	0.627
MOD_Plk_4	71	77	PF00069	0.513
MOD_Plk_4	79	85	PF00069	0.378
MOD_Plk_4	99	105	PF00069	0.398
MOD_ProDKin_1	231	237	PF00069	0.534
MOD_ProDKin_1	313	319	PF00069	0.686
MOD_ProDKin_1	395	401	PF00069	0.486
MOD_ProDKin_1	420	426	PF00069	0.553
MOD_ProDKin_1	448	454	PF00069	0.618
MOD_ProDKin_1	457	463	PF00069	0.632
MOD_ProDKin_1	467	473	PF00069	0.760
MOD_ProDKin_1	47	53	PF00069	0.438
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.370
TRG_ENDOCYTIC_2	104	107	PF00928	0.356
TRG_ENDOCYTIC_2	155	158	PF00928	0.368
TRG_ENDOCYTIC_2	431	434	PF00928	0.563
TRG_ER_diArg_1	4	7	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM3	Leptomonas seymouri	47%	98%
A0A3Q8ID86	Leishmania donovani	90%	100%
A4HE00	Leishmania braziliensis	78%	100%
A4I1B1	Leishmania infantum	90%	100%
Q4QA25	Leishmania major	90%	100%