Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXE6_LEIMU

TriTrypDb:

LmxM.25.0690

Length:

1057

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.571
CLV_C14_Caspase3-7	259	263	PF00656	0.682
CLV_C14_Caspase3-7	515	519	PF00656	0.669
CLV_C14_Caspase3-7	711	715	PF00656	0.713
CLV_C14_Caspase3-7	748	752	PF00656	0.678
CLV_C14_Caspase3-7	817	821	PF00656	0.631
CLV_MEL_PAP_1	224	230	PF00089	0.623
CLV_NRD_NRD_1	199	201	PF00675	0.598
CLV_NRD_NRD_1	25	27	PF00675	0.635
CLV_NRD_NRD_1	293	295	PF00675	0.643
CLV_NRD_NRD_1	488	490	PF00675	0.545
CLV_NRD_NRD_1	674	676	PF00675	0.571
CLV_NRD_NRD_1	689	691	PF00675	0.553
CLV_NRD_NRD_1	71	73	PF00675	0.665
CLV_NRD_NRD_1	919	921	PF00675	0.621
CLV_PCSK_FUR_1	197	201	PF00082	0.597
CLV_PCSK_FUR_1	291	295	PF00082	0.469
CLV_PCSK_FUR_1	486	490	PF00082	0.680
CLV_PCSK_KEX2_1	199	201	PF00082	0.606
CLV_PCSK_KEX2_1	241	243	PF00082	0.482
CLV_PCSK_KEX2_1	293	295	PF00082	0.643
CLV_PCSK_KEX2_1	488	490	PF00082	0.545
CLV_PCSK_KEX2_1	674	676	PF00082	0.609
CLV_PCSK_KEX2_1	689	691	PF00082	0.599
CLV_PCSK_KEX2_1	71	73	PF00082	0.665
CLV_PCSK_KEX2_1	911	913	PF00082	0.446
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.482
CLV_PCSK_PC1ET2_1	911	913	PF00082	0.446
CLV_PCSK_PC7_1	195	201	PF00082	0.688
CLV_PCSK_SKI1_1	26	30	PF00082	0.645
CLV_PCSK_SKI1_1	304	308	PF00082	0.661
CLV_PCSK_SKI1_1	599	603	PF00082	0.577
CLV_PCSK_SKI1_1	636	640	PF00082	0.458
CLV_PCSK_SKI1_1	890	894	PF00082	0.480
CLV_PCSK_SKI1_1	912	916	PF00082	0.618
CLV_PCSK_SKI1_1	958	962	PF00082	0.471
DEG_APCC_DBOX_1	645	653	PF00400	0.376
DEG_APCC_DBOX_1	889	897	PF00400	0.472
DEG_COP1_1	936	945	PF00400	0.478
DEG_SCF_TRCP1_1	809	815	PF00400	0.721
DEG_SPOP_SBC_1	468	472	PF00917	0.600
DEG_SPOP_SBC_1	705	709	PF00917	0.749
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.452
DOC_MAPK_DCC_7	293	303	PF00069	0.626
DOC_MAPK_DCC_7	435	444	PF00069	0.629
DOC_MAPK_DCC_7	488	498	PF00069	0.546
DOC_MAPK_gen_1	486	493	PF00069	0.664
DOC_MAPK_gen_1	597	604	PF00069	0.433
DOC_MAPK_gen_1	911	919	PF00069	0.393
DOC_MAPK_HePTP_8	432	444	PF00069	0.621
DOC_MAPK_MEF2A_6	167	176	PF00069	0.644
DOC_MAPK_MEF2A_6	294	303	PF00069	0.628
DOC_MAPK_MEF2A_6	435	444	PF00069	0.629
DOC_MAPK_MEF2A_6	489	498	PF00069	0.558
DOC_MAPK_MEF2A_6	575	583	PF00069	0.546
DOC_MAPK_MEF2A_6	607	615	PF00069	0.433
DOC_PP1_RVXF_1	1047	1054	PF00149	0.695
DOC_PP2B_LxvP_1	385	388	PF13499	0.628
DOC_PP2B_LxvP_1	797	800	PF13499	0.637
DOC_PP2B_LxvP_1	896	899	PF13499	0.517
DOC_SPAK_OSR1_1	655	659	PF12202	0.516
DOC_USP7_MATH_1	1003	1007	PF00917	0.697
DOC_USP7_MATH_1	1009	1013	PF00917	0.597
DOC_USP7_MATH_1	102	106	PF00917	0.538
DOC_USP7_MATH_1	306	310	PF00917	0.598
DOC_USP7_MATH_1	346	350	PF00917	0.650
DOC_USP7_MATH_1	37	41	PF00917	0.599
DOC_USP7_MATH_1	371	375	PF00917	0.632
DOC_USP7_MATH_1	380	384	PF00917	0.582
DOC_USP7_MATH_1	468	472	PF00917	0.617
DOC_USP7_MATH_1	522	526	PF00917	0.672
DOC_USP7_MATH_1	535	539	PF00917	0.465
DOC_USP7_MATH_1	564	568	PF00917	0.683
DOC_USP7_MATH_1	63	67	PF00917	0.681
DOC_USP7_MATH_1	660	664	PF00917	0.497
DOC_USP7_MATH_1	706	710	PF00917	0.755
DOC_USP7_MATH_1	763	767	PF00917	0.723
DOC_USP7_MATH_1	778	782	PF00917	0.686
DOC_USP7_MATH_1	841	845	PF00917	0.677
DOC_USP7_MATH_1	935	939	PF00917	0.551
DOC_USP7_MATH_1	97	101	PF00917	0.651
DOC_USP7_MATH_2	931	937	PF00917	0.479
DOC_WW_Pin1_4	361	366	PF00397	0.803
DOC_WW_Pin1_4	469	474	PF00397	0.674
DOC_WW_Pin1_4	531	536	PF00397	0.626
DOC_WW_Pin1_4	552	557	PF00397	0.533
DOC_WW_Pin1_4	790	795	PF00397	0.761
DOC_WW_Pin1_4	925	930	PF00397	0.683
DOC_WW_Pin1_4	944	949	PF00397	0.650
DOC_WW_Pin1_4	991	996	PF00397	0.756
LIG_14-3-3_CanoR_1	227	235	PF00244	0.508
LIG_14-3-3_CanoR_1	242	250	PF00244	0.514
LIG_14-3-3_CanoR_1	255	261	PF00244	0.723
LIG_14-3-3_CanoR_1	38	44	PF00244	0.531
LIG_14-3-3_CanoR_1	399	404	PF00244	0.609
LIG_14-3-3_CanoR_1	502	507	PF00244	0.581
LIG_14-3-3_CanoR_1	822	830	PF00244	0.648
LIG_14-3-3_CanoR_1	912	919	PF00244	0.612
LIG_14-3-3_CanoR_1	98	106	PF00244	0.613
LIG_Actin_WH2_2	127	143	PF00022	0.658
LIG_Actin_WH2_2	378	393	PF00022	0.631
LIG_APCC_ABBA_1	582	587	PF00400	0.443
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BRCT_BRCA1_1	328	332	PF00533	0.607
LIG_BRCT_BRCA1_1	78	82	PF00533	0.716
LIG_BRCT_BRCA1_1	802	806	PF00533	0.653
LIG_BRCT_BRCA1_1	820	824	PF00533	0.612
LIG_Clathr_ClatBox_1	582	586	PF01394	0.500
LIG_CSL_BTD_1	532	535	PF09270	0.690
LIG_CtBP_PxDLS_1	453	457	PF00389	0.704
LIG_EH1_1	576	584	PF00400	0.531
LIG_eIF4E_1	577	583	PF01652	0.345
LIG_eIF4E_1	887	893	PF01652	0.584
LIG_EVH1_2	794	798	PF00568	0.680
LIG_EVH1_2	859	863	PF00568	0.766
LIG_FHA_1	1025	1031	PF00498	0.530
LIG_FHA_1	1046	1052	PF00498	0.467
LIG_FHA_1	280	286	PF00498	0.515
LIG_FHA_1	308	314	PF00498	0.557
LIG_FHA_1	323	329	PF00498	0.663
LIG_FHA_1	334	340	PF00498	0.519
LIG_FHA_1	40	46	PF00498	0.520
LIG_FHA_1	748	754	PF00498	0.694
LIG_FHA_1	768	774	PF00498	0.710
LIG_FHA_1	84	90	PF00498	0.508
LIG_FHA_2	204	210	PF00498	0.661
LIG_FHA_2	827	833	PF00498	0.733
LIG_FHA_2	91	97	PF00498	0.609
LIG_FHA_2	975	981	PF00498	0.708
LIG_GSK3_LRP6_1	991	996	PF00069	0.490
LIG_LIR_Apic_2	464	468	PF02991	0.507
LIG_LIR_Gen_1	1005	1015	PF02991	0.528
LIG_LIR_Gen_1	247	257	PF02991	0.617
LIG_LIR_Gen_1	322	331	PF02991	0.502
LIG_LIR_Gen_1	608	617	PF02991	0.467
LIG_LIR_Gen_1	740	746	PF02991	0.664
LIG_LIR_Gen_1	963	969	PF02991	0.486
LIG_LIR_Gen_1	979	988	PF02991	0.530
LIG_LIR_Nem_3	1005	1010	PF02991	0.546
LIG_LIR_Nem_3	1012	1017	PF02991	0.507
LIG_LIR_Nem_3	104	109	PF02991	0.598
LIG_LIR_Nem_3	183	188	PF02991	0.521
LIG_LIR_Nem_3	322	326	PF02991	0.530
LIG_LIR_Nem_3	410	416	PF02991	0.510
LIG_LIR_Nem_3	608	613	PF02991	0.427
LIG_LIR_Nem_3	740	745	PF02991	0.665
LIG_LIR_Nem_3	963	967	PF02991	0.486
LIG_LIR_Nem_3	979	985	PF02991	0.535
LIG_LYPXL_SIV_4	1013	1021	PF13949	0.558
LIG_LYPXL_yS_3	413	416	PF13949	0.496
LIG_MYND_1	388	392	PF01753	0.647
LIG_MYND_1	795	799	PF01753	0.687
LIG_NRBOX	8	14	PF00104	0.517
LIG_NRBOX	921	927	PF00104	0.569
LIG_Pex14_2	275	279	PF04695	0.520
LIG_Rb_LxCxE_1	335	355	PF01857	0.625
LIG_RPA_C_Fungi	779	791	PF08784	0.596
LIG_SH2_CRK	185	189	PF00017	0.539
LIG_SH2_CRK	323	327	PF00017	0.493
LIG_SH2_GRB2like	173	176	PF00017	0.619
LIG_SH2_NCK_1	731	735	PF00017	0.627
LIG_SH2_NCK_1	988	992	PF00017	0.671
LIG_SH2_SRC	704	707	PF00017	0.748
LIG_SH2_SRC	883	886	PF00017	0.609
LIG_SH2_STAP1	725	729	PF00017	0.729
LIG_SH2_STAP1	731	735	PF00017	0.651
LIG_SH2_STAT5	1014	1017	PF00017	0.496
LIG_SH2_STAT5	1052	1055	PF00017	0.693
LIG_SH2_STAT5	109	112	PF00017	0.585
LIG_SH2_STAT5	16	19	PF00017	0.601
LIG_SH2_STAT5	173	176	PF00017	0.619
LIG_SH2_STAT5	217	220	PF00017	0.557
LIG_SH2_STAT5	277	280	PF00017	0.644
LIG_SH2_STAT5	742	745	PF00017	0.592
LIG_SH2_STAT5	946	949	PF00017	0.648
LIG_SH2_STAT5	988	991	PF00017	0.657
LIG_SH3_1	853	859	PF00018	0.654
LIG_SH3_3	124	130	PF00018	0.618
LIG_SH3_3	437	443	PF00018	0.569
LIG_SH3_3	488	494	PF00018	0.544
LIG_SH3_3	521	527	PF00018	0.657
LIG_SH3_3	529	535	PF00018	0.539
LIG_SH3_3	853	859	PF00018	0.675
LIG_SH3_3	86	92	PF00018	0.713
LIG_SH3_3	989	995	PF00018	0.472
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.617
LIG_SUMO_SIM_anti_2	580	587	PF11976	0.513
LIG_SUMO_SIM_par_1	121	126	PF11976	0.510
LIG_SUMO_SIM_par_1	324	330	PF11976	0.468
LIG_SUMO_SIM_par_1	39	46	PF11976	0.584
LIG_SUMO_SIM_par_1	451	458	PF11976	0.709
LIG_SUMO_SIM_par_1	580	587	PF11976	0.513
LIG_SUMO_SIM_par_1	636	642	PF11976	0.462
LIG_TRAF2_1	877	880	PF00917	0.471
LIG_TRAF2_1	93	96	PF00917	0.488
LIG_TYR_ITIM	962	967	PF00017	0.548
LIG_WRC_WIRS_1	103	108	PF05994	0.600
LIG_WRC_WIRS_1	400	405	PF05994	0.536
MOD_CK1_1	1043	1049	PF00069	0.670
MOD_CK1_1	246	252	PF00069	0.519
MOD_CK1_1	327	333	PF00069	0.652
MOD_CK1_1	361	367	PF00069	0.789
MOD_CK1_1	39	45	PF00069	0.626
MOD_CK1_1	402	408	PF00069	0.553
MOD_CK1_1	455	461	PF00069	0.709
MOD_CK1_1	469	475	PF00069	0.721
MOD_CK1_1	552	558	PF00069	0.667
MOD_CK1_1	66	72	PF00069	0.585
MOD_CK1_1	708	714	PF00069	0.760
MOD_CK1_1	766	772	PF00069	0.715
MOD_CK1_1	793	799	PF00069	0.626
MOD_CK1_1	810	816	PF00069	0.756
MOD_CK1_1	818	824	PF00069	0.680
MOD_CK1_1	825	831	PF00069	0.532
MOD_CK2_1	147	153	PF00069	0.647
MOD_CK2_1	157	163	PF00069	0.692
MOD_CK2_1	587	593	PF00069	0.566
MOD_CK2_1	811	817	PF00069	0.664
MOD_CK2_1	90	96	PF00069	0.677
MOD_CK2_1	974	980	PF00069	0.719
MOD_CK2_1	991	997	PF00069	0.689
MOD_Cter_Amidation	909	912	PF01082	0.468
MOD_GlcNHglycan	1011	1014	PF01048	0.511
MOD_GlcNHglycan	1035	1039	PF01048	0.746
MOD_GlcNHglycan	1045	1048	PF01048	0.611
MOD_GlcNHglycan	17	20	PF01048	0.547
MOD_GlcNHglycan	2	5	PF01048	0.563
MOD_GlcNHglycan	206	209	PF01048	0.710
MOD_GlcNHglycan	228	231	PF01048	0.643
MOD_GlcNHglycan	258	261	PF01048	0.606
MOD_GlcNHglycan	33	36	PF01048	0.475
MOD_GlcNHglycan	360	363	PF01048	0.800
MOD_GlcNHglycan	404	407	PF01048	0.561
MOD_GlcNHglycan	510	513	PF01048	0.615
MOD_GlcNHglycan	523	527	PF01048	0.525
MOD_GlcNHglycan	551	554	PF01048	0.709
MOD_GlcNHglycan	568	571	PF01048	0.600
MOD_GlcNHglycan	641	644	PF01048	0.474
MOD_GlcNHglycan	66	69	PF01048	0.485
MOD_GlcNHglycan	662	665	PF01048	0.607
MOD_GlcNHglycan	680	683	PF01048	0.469
MOD_GlcNHglycan	710	713	PF01048	0.761
MOD_GlcNHglycan	760	763	PF01048	0.678
MOD_GlcNHglycan	784	787	PF01048	0.514
MOD_GlcNHglycan	808	812	PF01048	0.717
MOD_GlcNHglycan	825	828	PF01048	0.817
MOD_GlcNHglycan	908	911	PF01048	0.622
MOD_GlcNHglycan	935	938	PF01048	0.715
MOD_GSK3_1	143	150	PF00069	0.653
MOD_GSK3_1	322	329	PF00069	0.579
MOD_GSK3_1	342	349	PF00069	0.650
MOD_GSK3_1	361	368	PF00069	0.738
MOD_GSK3_1	414	421	PF00069	0.462
MOD_GSK3_1	494	501	PF00069	0.575
MOD_GSK3_1	508	515	PF00069	0.607
MOD_GSK3_1	527	534	PF00069	0.712
MOD_GSK3_1	544	551	PF00069	0.509
MOD_GSK3_1	587	594	PF00069	0.375
MOD_GSK3_1	626	633	PF00069	0.510
MOD_GSK3_1	63	70	PF00069	0.488
MOD_GSK3_1	704	711	PF00069	0.669
MOD_GSK3_1	763	770	PF00069	0.667
MOD_GSK3_1	778	785	PF00069	0.606
MOD_GSK3_1	789	796	PF00069	0.550
MOD_GSK3_1	807	814	PF00069	0.720
MOD_GSK3_1	816	823	PF00069	0.631
MOD_GSK3_1	826	833	PF00069	0.607
MOD_GSK3_1	83	90	PF00069	0.551
MOD_GSK3_1	921	928	PF00069	0.657
MOD_GSK3_1	97	104	PF00069	0.691
MOD_GSK3_1	974	981	PF00069	0.687
MOD_GSK3_1	986	993	PF00069	0.709
MOD_LATS_1	805	811	PF00433	0.717
MOD_N-GLC_1	143	148	PF02516	0.762
MOD_N-GLC_1	243	248	PF02516	0.466
MOD_N-GLC_1	358	363	PF02516	0.613
MOD_N-GLC_1	660	665	PF02516	0.592
MOD_N-GLC_1	758	763	PF02516	0.709
MOD_N-GLC_2	932	934	PF02516	0.479
MOD_NEK2_1	1024	1029	PF00069	0.534
MOD_NEK2_1	123	128	PF00069	0.564
MOD_NEK2_1	253	258	PF00069	0.465
MOD_NEK2_1	307	312	PF00069	0.602
MOD_NEK2_1	461	466	PF00069	0.635
MOD_NEK2_1	549	554	PF00069	0.622
MOD_NEK2_1	56	61	PF00069	0.611
MOD_NEK2_1	639	644	PF00069	0.475
MOD_NEK2_1	82	87	PF00069	0.506
MOD_NEK2_1	830	835	PF00069	0.593
MOD_NEK2_1	978	983	PF00069	0.691
MOD_NEK2_2	130	135	PF00069	0.645
MOD_NEK2_2	371	376	PF00069	0.634
MOD_NEK2_2	800	805	PF00069	0.615
MOD_PIKK_1	1040	1046	PF00454	0.731
MOD_PIKK_1	407	413	PF00454	0.723
MOD_PIKK_1	544	550	PF00454	0.685
MOD_PIKK_1	76	82	PF00454	0.649
MOD_PIKK_1	778	784	PF00454	0.676
MOD_PKA_2	226	232	PF00069	0.633
MOD_PKA_2	307	313	PF00069	0.622
MOD_PKA_2	37	43	PF00069	0.548
MOD_PKA_2	767	773	PF00069	0.609
MOD_PKA_2	90	96	PF00069	0.677
MOD_PKA_2	97	103	PF00069	0.549
MOD_Plk_1	152	158	PF00069	0.602
MOD_Plk_1	246	252	PF00069	0.689
MOD_Plk_1	627	633	PF00069	0.507
MOD_Plk_1	978	984	PF00069	0.662
MOD_Plk_2-3	587	593	PF00069	0.532
MOD_Plk_2-3	974	980	PF00069	0.672
MOD_Plk_4	1003	1009	PF00069	0.555
MOD_Plk_4	102	108	PF00069	0.600
MOD_Plk_4	1024	1030	PF00069	0.638
MOD_Plk_4	333	339	PF00069	0.615
MOD_Plk_4	371	377	PF00069	0.631
MOD_Plk_4	461	467	PF00069	0.571
MOD_Plk_4	512	518	PF00069	0.514
MOD_Plk_4	56	62	PF00069	0.673
MOD_Plk_4	793	799	PF00069	0.640
MOD_Plk_4	864	870	PF00069	0.675
MOD_Plk_4	921	927	PF00069	0.618
MOD_ProDKin_1	361	367	PF00069	0.793
MOD_ProDKin_1	469	475	PF00069	0.675
MOD_ProDKin_1	531	537	PF00069	0.622
MOD_ProDKin_1	552	558	PF00069	0.532
MOD_ProDKin_1	790	796	PF00069	0.758
MOD_ProDKin_1	925	931	PF00069	0.689
MOD_ProDKin_1	944	950	PF00069	0.645
MOD_ProDKin_1	991	997	PF00069	0.760
MOD_SUMO_rev_2	20	29	PF00179	0.632
TRG_DiLeu_BaEn_1	183	188	PF01217	0.604
TRG_DiLeu_BaEn_2	739	745	PF01217	0.552
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.630
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.579
TRG_DiLeu_BaLyEn_6	887	892	PF01217	0.470
TRG_DiLeu_LyEn_5	183	188	PF01217	0.604
TRG_ENDOCYTIC_2	1014	1017	PF00928	0.496
TRG_ENDOCYTIC_2	173	176	PF00928	0.615
TRG_ENDOCYTIC_2	185	188	PF00928	0.474
TRG_ENDOCYTIC_2	277	280	PF00928	0.586
TRG_ENDOCYTIC_2	323	326	PF00928	0.533
TRG_ENDOCYTIC_2	413	416	PF00928	0.496
TRG_ENDOCYTIC_2	742	745	PF00928	0.662
TRG_ENDOCYTIC_2	964	967	PF00928	0.482
TRG_ER_diArg_1	290	293	PF00400	0.640
TRG_ER_diArg_1	301	304	PF00400	0.653
TRG_ER_diArg_1	486	489	PF00400	0.581
TRG_ER_diArg_1	673	675	PF00400	0.634
TRG_ER_diArg_1	71	73	PF00400	0.658
TRG_NES_CRM1_1	593	608	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	675	680	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	890	895	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	976	980	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX0	Leptomonas seymouri	36%	97%
A0A3S7WYX4	Leishmania donovani	90%	100%
A4HDZ9	Leishmania braziliensis	73%	100%
A4I1B0	Leishmania infantum	90%	100%
Q4QA26	Leishmania major	90%	100%