Putative epsin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative epsin

Gene product:

epsin, putative

Species:

Leishmania mexicana

UniProt:

E9AXE4_LEIMU

TriTrypDb:

LmxM.25.0670

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0030117	membrane coat	3	1
GO:0030118	clathrin coat	4	1
GO:0030120	vesicle coat	4	1
GO:0030125	clathrin vesicle coat	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXE4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0030276	clathrin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.574
CLV_NRD_NRD_1	240	242	PF00675	0.643
CLV_NRD_NRD_1	290	292	PF00675	0.641
CLV_PCSK_FUR_1	288	292	PF00082	0.588
CLV_PCSK_KEX2_1	240	242	PF00082	0.643
CLV_PCSK_KEX2_1	290	292	PF00082	0.641
CLV_PCSK_PC7_1	236	242	PF00082	0.623
CLV_PCSK_SKI1_1	77	81	PF00082	0.354
DEG_Nend_UBRbox_3	1	3	PF02207	0.594
DOC_CKS1_1	545	550	PF01111	0.579
DOC_CYCLIN_RxL_1	73	83	PF00134	0.354
DOC_CYCLIN_yCln2_LP_2	478	484	PF00134	0.591
DOC_MAPK_gen_1	288	296	PF00069	0.652
DOC_MAPK_MEF2A_6	225	234	PF00069	0.599
DOC_PP2B_LxvP_1	309	312	PF13499	0.607
DOC_PP2B_LxvP_1	325	328	PF13499	0.626
DOC_PP4_FxxP_1	326	329	PF00568	0.698
DOC_PP4_FxxP_1	331	334	PF00568	0.691
DOC_PP4_MxPP_1	398	401	PF00568	0.575
DOC_PP4_MxPP_1	405	408	PF00568	0.576
DOC_PP4_MxPP_1	412	415	PF00568	0.573
DOC_PP4_MxPP_1	419	422	PF00568	0.575
DOC_PP4_MxPP_1	426	429	PF00568	0.577
DOC_PP4_MxPP_1	433	436	PF00568	0.578
DOC_PP4_MxPP_1	440	443	PF00568	0.576
DOC_PP4_MxPP_1	447	450	PF00568	0.575
DOC_PP4_MxPP_1	454	457	PF00568	0.577
DOC_PP4_MxPP_1	461	464	PF00568	0.573
DOC_PP4_MxPP_1	468	471	PF00568	0.569
DOC_PP4_MxPP_1	482	485	PF00568	0.568
DOC_PP4_MxPP_1	489	492	PF00568	0.585
DOC_PP4_MxPP_1	496	499	PF00568	0.575
DOC_PP4_MxPP_1	503	506	PF00568	0.574
DOC_PP4_MxPP_1	510	513	PF00568	0.573
DOC_PP4_MxPP_1	517	520	PF00568	0.576
DOC_PP4_MxPP_1	524	527	PF00568	0.577
DOC_PP4_MxPP_1	531	534	PF00568	0.581
DOC_USP7_MATH_1	18	22	PF00917	0.534
DOC_USP7_MATH_1	200	204	PF00917	0.726
DOC_USP7_MATH_1	339	343	PF00917	0.654
DOC_USP7_MATH_1	345	349	PF00917	0.570
DOC_USP7_MATH_1	394	398	PF00917	0.694
DOC_USP7_MATH_1	401	405	PF00917	0.661
DOC_USP7_MATH_1	408	412	PF00917	0.611
DOC_USP7_MATH_1	415	419	PF00917	0.577
DOC_USP7_MATH_1	422	426	PF00917	0.580
DOC_USP7_MATH_1	429	433	PF00917	0.629
DOC_USP7_MATH_1	436	440	PF00917	0.694
DOC_USP7_MATH_1	443	447	PF00917	0.720
DOC_USP7_MATH_1	450	454	PF00917	0.660
DOC_USP7_MATH_1	457	461	PF00917	0.578
DOC_USP7_MATH_1	464	468	PF00917	0.578
DOC_USP7_MATH_1	471	475	PF00917	0.577
DOC_USP7_MATH_1	485	489	PF00917	0.585
DOC_USP7_MATH_1	499	503	PF00917	0.583
DOC_USP7_MATH_1	506	510	PF00917	0.586
DOC_USP7_MATH_1	513	517	PF00917	0.579
DOC_USP7_MATH_1	520	524	PF00917	0.579
DOC_USP7_MATH_1	527	531	PF00917	0.586
DOC_USP7_MATH_1	534	538	PF00917	0.580
DOC_USP7_MATH_1	568	572	PF00917	0.665
DOC_USP7_MATH_1	585	589	PF00917	0.584
DOC_WW_Pin1_4	204	209	PF00397	0.722
DOC_WW_Pin1_4	304	309	PF00397	0.746
DOC_WW_Pin1_4	310	315	PF00397	0.773
DOC_WW_Pin1_4	544	549	PF00397	0.577
DOC_WW_Pin1_4	598	603	PF00397	0.567
LIG_14-3-3_CanoR_1	105	113	PF00244	0.354
LIG_14-3-3_CanoR_1	241	249	PF00244	0.557
LIG_AP2alpha_2	344	346	PF02296	0.528
LIG_APCC_Cbox_2	91	97	PF00515	0.375
LIG_BIR_III_4	385	389	PF00653	0.699
LIG_BRCT_BRCA1_1	107	111	PF00533	0.354
LIG_Clathr_ClatBox_1	79	83	PF01394	0.354
LIG_deltaCOP1_diTrp_1	385	393	PF00928	0.641
LIG_deltaCOP1_diTrp_1	620	629	PF00928	0.589
LIG_FHA_1	2	8	PF00498	0.560
LIG_FHA_1	317	323	PF00498	0.690
LIG_FHA_1	605	611	PF00498	0.570
LIG_FHA_2	17	23	PF00498	0.527
LIG_FHA_2	217	223	PF00498	0.549
LIG_FHA_2	268	274	PF00498	0.608
LIG_FHA_2	29	35	PF00498	0.311
LIG_GBD_Chelix_1	132	140	PF00786	0.419
LIG_GBD_Chelix_1	148	156	PF00786	0.414
LIG_LIR_Apic_2	110	116	PF02991	0.419
LIG_LIR_Apic_2	323	329	PF02991	0.664
LIG_LIR_Apic_2	385	390	PF02991	0.708
LIG_LIR_Apic_2	560	564	PF02991	0.596
LIG_LIR_Gen_1	21	30	PF02991	0.358
LIG_LIR_Gen_1	344	354	PF02991	0.566
LIG_LIR_Nem_3	12	16	PF02991	0.502
LIG_LIR_Nem_3	21	26	PF02991	0.315
LIG_LIR_Nem_3	344	349	PF02991	0.543
LIG_LIR_Nem_3	569	575	PF02991	0.741
LIG_LIR_Nem_3	620	626	PF02991	0.638
LIG_MYND_1	328	332	PF01753	0.555
LIG_Pex14_1	72	76	PF04695	0.354
LIG_SH2_CRK	113	117	PF00017	0.419
LIG_SH2_CRK	76	80	PF00017	0.354
LIG_SH2_GRB2like	113	116	PF00017	0.419
LIG_SH2_PTP2	23	26	PF00017	0.354
LIG_SH2_STAP1	253	257	PF00017	0.601
LIG_SH2_STAT5	113	116	PF00017	0.357
LIG_SH2_STAT5	23	26	PF00017	0.354
LIG_SH2_STAT5	84	87	PF00017	0.341
LIG_SH3_1	35	41	PF00018	0.419
LIG_SH3_3	211	217	PF00018	0.665
LIG_SH3_3	291	297	PF00018	0.644
LIG_SH3_3	305	311	PF00018	0.659
LIG_SH3_3	326	332	PF00018	0.697
LIG_SH3_3	333	339	PF00018	0.714
LIG_SH3_3	35	41	PF00018	0.367
LIG_SH3_3	478	484	PF00018	0.634
LIG_SH3_3	489	495	PF00018	0.682
LIG_SUMO_SIM_anti_2	21	29	PF11976	0.332
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.354
LIG_SUMO_SIM_par_1	78	83	PF11976	0.358
LIG_TRAF2_1	219	222	PF00917	0.558
LIG_TRAF2_1	321	324	PF00917	0.636
LIG_WRC_WIRS_1	346	351	PF05994	0.602
MOD_CDK_SPxK_1	304	310	PF00069	0.762
MOD_CK1_1	203	209	PF00069	0.687
MOD_CK1_1	242	248	PF00069	0.617
MOD_CK2_1	121	127	PF00069	0.354
MOD_CK2_1	16	22	PF00069	0.411
MOD_CK2_1	216	222	PF00069	0.582
MOD_CK2_1	28	34	PF00069	0.354
MOD_CK2_1	6	12	PF00069	0.536
MOD_GlcNHglycan	167	170	PF01048	0.683
MOD_GlcNHglycan	192	195	PF01048	0.599
MOD_GlcNHglycan	241	244	PF01048	0.635
MOD_GlcNHglycan	341	344	PF01048	0.643
MOD_GlcNHglycan	587	590	PF01048	0.742
MOD_GSK3_1	103	110	PF00069	0.444
MOD_GSK3_1	18	25	PF00069	0.364
MOD_GSK3_1	190	197	PF00069	0.649
MOD_GSK3_1	200	207	PF00069	0.714
MOD_GSK3_1	298	305	PF00069	0.682
MOD_GSK3_1	345	352	PF00069	0.610
MOD_GSK3_1	359	366	PF00069	0.599
MOD_GSK3_1	549	556	PF00069	0.620
MOD_GSK3_1	580	587	PF00069	0.596
MOD_GSK3_1	594	601	PF00069	0.607
MOD_GSK3_1	602	609	PF00069	0.640
MOD_N-GLC_1	1	6	PF02516	0.577
MOD_N-GLC_1	158	163	PF02516	0.622
MOD_N-GLC_1	603	608	PF02516	0.596
MOD_NEK2_1	1	6	PF00069	0.577
MOD_NEK2_1	103	108	PF00069	0.386
MOD_NEK2_1	111	116	PF00069	0.329
MOD_NEK2_1	252	257	PF00069	0.558
MOD_NEK2_1	349	354	PF00069	0.618
MOD_NEK2_1	603	608	PF00069	0.634
MOD_PIKK_1	1	7	PF00454	0.574
MOD_PIKK_1	181	187	PF00454	0.545
MOD_PIKK_1	363	369	PF00454	0.577
MOD_PKA_2	190	196	PF00069	0.651
MOD_PKA_2	239	245	PF00069	0.623
MOD_Plk_1	68	74	PF00069	0.354
MOD_Plk_4	107	113	PF00069	0.505
MOD_Plk_4	22	28	PF00069	0.364
MOD_Plk_4	345	351	PF00069	0.635
MOD_Plk_4	394	400	PF00069	0.572
MOD_Plk_4	401	407	PF00069	0.582
MOD_Plk_4	408	414	PF00069	0.572
MOD_Plk_4	415	421	PF00069	0.580
MOD_Plk_4	422	428	PF00069	0.598
MOD_Plk_4	429	435	PF00069	0.612
MOD_Plk_4	436	442	PF00069	0.612
MOD_Plk_4	443	449	PF00069	0.592
MOD_Plk_4	450	456	PF00069	0.575
MOD_Plk_4	457	463	PF00069	0.571
MOD_Plk_4	464	470	PF00069	0.572
MOD_Plk_4	471	477	PF00069	0.575
MOD_Plk_4	485	491	PF00069	0.573
MOD_Plk_4	499	505	PF00069	0.573
MOD_Plk_4	506	512	PF00069	0.584
MOD_Plk_4	513	519	PF00069	0.578
MOD_Plk_4	520	526	PF00069	0.578
MOD_Plk_4	527	533	PF00069	0.583
MOD_Plk_4	75	81	PF00069	0.400
MOD_ProDKin_1	204	210	PF00069	0.722
MOD_ProDKin_1	304	310	PF00069	0.748
MOD_ProDKin_1	544	550	PF00069	0.578
MOD_ProDKin_1	598	604	PF00069	0.567
TRG_AP2beta_CARGO_1	344	353	PF09066	0.537
TRG_DiLeu_BaEn_1	96	101	PF01217	0.419
TRG_ENDOCYTIC_2	23	26	PF00928	0.354
TRG_ENDOCYTIC_2	76	79	PF00928	0.354
TRG_ER_diArg_1	257	260	PF00400	0.561
TRG_ER_diArg_1	288	291	PF00400	0.606
TRG_ER_diArg_1	61	64	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P4K8	Trypanosomatidae	38%	100%
A0A3Q8IDD0	Leishmania donovani	84%	100%
A4HDZ7	Leishmania braziliensis	63%	100%
A4I1A8	Leishmania infantum	88%	100%
Q4QA28	Leishmania major	68%	92%