UBP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania mexicana

UniProt:

E9AXE2_LEIMU

TriTrypDb:

LmxM.25.0650

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.601
CLV_C14_Caspase3-7	334	338	PF00656	0.463
CLV_C14_Caspase3-7	425	429	PF00656	0.537
CLV_NRD_NRD_1	144	146	PF00675	0.566
CLV_NRD_NRD_1	148	150	PF00675	0.600
CLV_NRD_NRD_1	190	192	PF00675	0.471
CLV_NRD_NRD_1	305	307	PF00675	0.653
CLV_NRD_NRD_1	321	323	PF00675	0.505
CLV_NRD_NRD_1	403	405	PF00675	0.571
CLV_PCSK_FUR_1	188	192	PF00082	0.480
CLV_PCSK_KEX2_1	144	146	PF00082	0.557
CLV_PCSK_KEX2_1	148	150	PF00082	0.589
CLV_PCSK_KEX2_1	190	192	PF00082	0.471
CLV_PCSK_KEX2_1	305	307	PF00082	0.586
CLV_PCSK_KEX2_1	403	405	PF00082	0.564
CLV_PCSK_PC7_1	144	150	PF00082	0.472
CLV_PCSK_PC7_1	301	307	PF00082	0.494
CLV_PCSK_SKI1_1	506	510	PF00082	0.484
CLV_PCSK_SKI1_1	564	568	PF00082	0.505
CLV_PCSK_SKI1_1	646	650	PF00082	0.467
DEG_SCF_FBW7_1	457	462	PF00400	0.606
DEG_SCF_FBW7_2	73	80	PF00400	0.599
DEG_SIAH_1	473	481	PF03145	0.543
DEG_SPOP_SBC_1	300	304	PF00917	0.493
DEG_SPOP_SBC_1	369	373	PF00917	0.658
DEG_SPOP_SBC_1	376	380	PF00917	0.599
DEG_SPOP_SBC_1	603	607	PF00917	0.523
DEG_SPOP_SBC_1	67	71	PF00917	0.571
DEG_SPOP_SBC_1	91	95	PF00917	0.486
DOC_CDC14_PxL_1	481	489	PF14671	0.484
DOC_CKS1_1	173	178	PF01111	0.489
DOC_CKS1_1	74	79	PF01111	0.599
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.454
DOC_MAPK_gen_1	144	153	PF00069	0.480
DOC_MAPK_gen_1	188	197	PF00069	0.453
DOC_MAPK_gen_1	305	312	PF00069	0.521
DOC_MAPK_MEF2A_6	190	199	PF00069	0.434
DOC_MAPK_MEF2A_6	305	312	PF00069	0.508
DOC_MAPK_MEF2A_6	506	515	PF00069	0.471
DOC_PP1_RVXF_1	241	248	PF00149	0.514
DOC_PP2B_LxvP_1	170	173	PF13499	0.417
DOC_USP7_MATH_1	293	297	PF00917	0.621
DOC_USP7_MATH_1	299	303	PF00917	0.656
DOC_USP7_MATH_1	365	369	PF00917	0.693
DOC_USP7_MATH_1	370	374	PF00917	0.673
DOC_USP7_MATH_1	375	379	PF00917	0.617
DOC_USP7_MATH_1	474	478	PF00917	0.619
DOC_USP7_MATH_1	486	490	PF00917	0.413
DOC_USP7_MATH_1	51	55	PF00917	0.668
DOC_USP7_MATH_1	603	607	PF00917	0.523
DOC_USP7_MATH_1	66	70	PF00917	0.590
DOC_USP7_MATH_1	91	95	PF00917	0.528
DOC_USP7_UBL2_3	646	650	PF12436	0.462
DOC_WW_Pin1_4	172	177	PF00397	0.487
DOC_WW_Pin1_4	363	368	PF00397	0.460
DOC_WW_Pin1_4	455	460	PF00397	0.602
DOC_WW_Pin1_4	468	473	PF00397	0.543
DOC_WW_Pin1_4	495	500	PF00397	0.549
DOC_WW_Pin1_4	599	604	PF00397	0.536
DOC_WW_Pin1_4	73	78	PF00397	0.613
LIG_14-3-3_CanoR_1	148	154	PF00244	0.635
LIG_14-3-3_CanoR_1	158	167	PF00244	0.523
LIG_14-3-3_CanoR_1	188	198	PF00244	0.414
LIG_14-3-3_CanoR_1	301	308	PF00244	0.474
LIG_14-3-3_CanoR_1	506	511	PF00244	0.476
LIG_14-3-3_CanoR_1	601	611	PF00244	0.500
LIG_14-3-3_CanoR_1	637	642	PF00244	0.384
LIG_Actin_WH2_2	233	251	PF00022	0.526
LIG_Actin_WH2_2	308	324	PF00022	0.520
LIG_Actin_WH2_2	387	405	PF00022	0.613
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	488	492	PF00533	0.467
LIG_BRCT_BRCA1_1	53	57	PF00533	0.544
LIG_FHA_1	190	196	PF00498	0.469
LIG_FHA_1	205	211	PF00498	0.421
LIG_FHA_1	219	225	PF00498	0.525
LIG_FHA_1	54	60	PF00498	0.605
LIG_FHA_1	567	573	PF00498	0.473
LIG_FHA_2	160	166	PF00498	0.578
LIG_FHA_2	290	296	PF00498	0.606
LIG_FHA_2	337	343	PF00498	0.585
LIG_FHA_2	403	409	PF00498	0.503
LIG_FHA_2	460	466	PF00498	0.624
LIG_FHA_2	82	88	PF00498	0.651
LIG_LIR_Gen_1	17	26	PF02991	0.475
LIG_LIR_Gen_1	489	497	PF02991	0.480
LIG_LIR_Nem_3	17	23	PF02991	0.484
LIG_LIR_Nem_3	489	493	PF02991	0.459
LIG_LIR_Nem_3	569	573	PF02991	0.383
LIG_NRBOX	351	357	PF00104	0.348
LIG_PAM2_1	470	482	PF00658	0.433
LIG_PTAP_UEV_1	366	371	PF05743	0.541
LIG_PTAP_UEV_1	47	52	PF05743	0.586
LIG_REV1ctd_RIR_1	490	498	PF16727	0.505
LIG_SH2_CRK	361	365	PF00017	0.425
LIG_SH2_STAP1	23	27	PF00017	0.373
LIG_SH2_STAT5	124	127	PF00017	0.508
LIG_SH2_STAT5	222	225	PF00017	0.569
LIG_SH2_STAT5	395	398	PF00017	0.468
LIG_SH3_3	170	176	PF00018	0.497
LIG_SH3_3	178	184	PF00018	0.450
LIG_SH3_3	310	316	PF00018	0.482
LIG_SH3_3	361	367	PF00018	0.485
LIG_SH3_3	45	51	PF00018	0.563
LIG_SH3_3	454	460	PF00018	0.510
LIG_SUMO_SIM_anti_2	192	199	PF11976	0.389
LIG_SUMO_SIM_anti_2	615	620	PF11976	0.396
LIG_SUMO_SIM_par_1	331	337	PF11976	0.474
LIG_SUMO_SIM_par_1	80	87	PF11976	0.604
LIG_TRAF2_1	345	348	PF00917	0.538
LIG_TRAF2_1	77	80	PF00917	0.594
LIG_TYR_ITIM	359	364	PF00017	0.387
LIG_WRC_WIRS_1	487	492	PF05994	0.458
LIG_WRC_WIRS_1	567	572	PF05994	0.407
MOD_CAAXbox	657	660	PF01239	0.539
MOD_CK1_1	189	195	PF00069	0.648
MOD_CK1_1	220	226	PF00069	0.438
MOD_CK1_1	252	258	PF00069	0.506
MOD_CK1_1	271	277	PF00069	0.612
MOD_CK1_1	368	374	PF00069	0.626
MOD_CK1_1	495	501	PF00069	0.427
MOD_CK1_1	579	585	PF00069	0.545
MOD_CK2_1	336	342	PF00069	0.536
MOD_CK2_1	436	442	PF00069	0.649
MOD_CK2_1	81	87	PF00069	0.649
MOD_CMANNOS	273	276	PF00535	0.630
MOD_DYRK1A_RPxSP_1	599	603	PF00069	0.497
MOD_GlcNHglycan	270	273	PF01048	0.552
MOD_GlcNHglycan	278	281	PF01048	0.576
MOD_GlcNHglycan	295	298	PF01048	0.650
MOD_GlcNHglycan	367	370	PF01048	0.650
MOD_GlcNHglycan	379	382	PF01048	0.522
MOD_GlcNHglycan	438	441	PF01048	0.682
MOD_GlcNHglycan	502	505	PF01048	0.672
MOD_GlcNHglycan	576	579	PF01048	0.645
MOD_GlcNHglycan	582	585	PF01048	0.583
MOD_GlcNHglycan	596	599	PF01048	0.347
MOD_GlcNHglycan	70	73	PF01048	0.615
MOD_GlcNHglycan	94	97	PF01048	0.629
MOD_GSK3_1	200	207	PF00069	0.460
MOD_GSK3_1	267	274	PF00069	0.649
MOD_GSK3_1	276	283	PF00069	0.524
MOD_GSK3_1	289	296	PF00069	0.529
MOD_GSK3_1	365	372	PF00069	0.651
MOD_GSK3_1	402	409	PF00069	0.521
MOD_GSK3_1	455	462	PF00069	0.597
MOD_GSK3_1	470	477	PF00069	0.476
MOD_GSK3_1	576	583	PF00069	0.554
MOD_GSK3_1	599	606	PF00069	0.532
MOD_N-GLC_1	468	473	PF02516	0.595
MOD_NEK2_1	268	273	PF00069	0.534
MOD_NEK2_1	402	407	PF00069	0.577
MOD_NEK2_1	492	497	PF00069	0.510
MOD_NEK2_1	68	73	PF00069	0.606
MOD_NEK2_1	92	97	PF00069	0.547
MOD_NEK2_2	280	285	PF00069	0.554
MOD_NEK2_2	35	40	PF00069	0.489
MOD_OFUCOSY	33	39	PF10250	0.486
MOD_PIKK_1	406	412	PF00454	0.459
MOD_PIKK_1	426	432	PF00454	0.624
MOD_PK_1	249	255	PF00069	0.430
MOD_PKA_2	189	195	PF00069	0.537
MOD_PKA_2	300	306	PF00069	0.510
MOD_PKA_2	402	408	PF00069	0.543
MOD_PKA_2	426	432	PF00069	0.591
MOD_PKB_1	599	607	PF00069	0.504
MOD_Plk_1	217	223	PF00069	0.523
MOD_Plk_1	233	239	PF00069	0.455
MOD_Plk_1	249	255	PF00069	0.529
MOD_Plk_1	410	416	PF00069	0.547
MOD_Plk_4	106	112	PF00069	0.537
MOD_Plk_4	225	231	PF00069	0.406
MOD_Plk_4	280	286	PF00069	0.510
MOD_Plk_4	308	314	PF00069	0.529
MOD_Plk_4	459	465	PF00069	0.582
MOD_Plk_4	474	480	PF00069	0.481
MOD_ProDKin_1	172	178	PF00069	0.491
MOD_ProDKin_1	363	369	PF00069	0.464
MOD_ProDKin_1	455	461	PF00069	0.603
MOD_ProDKin_1	468	474	PF00069	0.542
MOD_ProDKin_1	495	501	PF00069	0.548
MOD_ProDKin_1	599	605	PF00069	0.534
MOD_ProDKin_1	73	79	PF00069	0.612
MOD_SUMO_for_1	256	259	PF00179	0.488
MOD_SUMO_for_1	631	634	PF00179	0.488
TRG_DiLeu_BaEn_1	442	447	PF01217	0.519
TRG_DiLeu_BaEn_4	347	353	PF01217	0.512
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.348
TRG_ENDOCYTIC_2	361	364	PF00928	0.415
TRG_ER_diArg_1	187	190	PF00400	0.481
TRG_ER_diArg_1	305	307	PF00400	0.661
TRG_ER_diArg_1	402	404	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP2	Leptomonas seymouri	45%	100%
A0A3S7WYX9	Leishmania donovani	84%	99%
A4HEF3	Leishmania braziliensis	68%	100%
A4I1A6	Leishmania infantum	85%	99%
Q4QA30	Leishmania major	83%	100%