Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXE0_LEIMU

TriTrypDb:

LmxM.25.0630

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AXE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.306
CLV_NRD_NRD_1	8	10	PF00675	0.443
CLV_PCSK_FUR_1	231	235	PF00082	0.363
CLV_PCSK_KEX2_1	217	219	PF00082	0.305
CLV_PCSK_KEX2_1	233	235	PF00082	0.368
CLV_PCSK_KEX2_1	8	10	PF00082	0.444
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.329
CLV_PCSK_SKI1_1	256	260	PF00082	0.339
DOC_CYCLIN_RxL_1	253	261	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.662
DOC_MAPK_DCC_7	22	30	PF00069	0.532
DOC_MAPK_gen_1	253	262	PF00069	0.518
DOC_MAPK_gen_1	5	14	PF00069	0.641
DOC_MAPK_MEF2A_6	253	262	PF00069	0.535
DOC_MAPK_MEF2A_6	274	282	PF00069	0.528
DOC_MAPK_MEF2A_6	59	66	PF00069	0.680
DOC_MAPK_MEF2A_6	83	92	PF00069	0.621
DOC_PP4_FxxP_1	45	48	PF00568	0.698
LIG_14-3-3_CanoR_1	157	163	PF00244	0.534
LIG_14-3-3_CanoR_1	217	221	PF00244	0.496
LIG_Actin_WH2_2	39	55	PF00022	0.702
LIG_ActinCP_TwfCPI_2	45	53	PF01115	0.707
LIG_eIF4E_1	23	29	PF01652	0.654
LIG_EVH1_2	62	66	PF00568	0.669
LIG_FHA_1	1	7	PF00498	0.572
LIG_LIR_Gen_1	166	177	PF02991	0.509
LIG_LIR_Nem_3	15	20	PF02991	0.656
LIG_LIR_Nem_3	166	172	PF02991	0.493
LIG_LIR_Nem_3	219	223	PF02991	0.477
LIG_LIR_Nem_3	292	298	PF02991	0.334
LIG_PCNA_yPIPBox_3	233	246	PF02747	0.541
LIG_PTB_Apo_2	241	248	PF02174	0.460
LIG_PTB_Phospho_1	241	247	PF10480	0.456
LIG_SH2_CRK	223	227	PF00017	0.464
LIG_SH2_GRB2like	295	298	PF00017	0.541
LIG_SH2_NCK_1	223	227	PF00017	0.464
LIG_SH2_SRC	223	226	PF00017	0.427
LIG_SH2_STAP1	169	173	PF00017	0.492
LIG_SH2_STAP1	201	205	PF00017	0.471
LIG_SH2_STAT5	195	198	PF00017	0.480
LIG_SH2_STAT5	295	298	PF00017	0.457
LIG_SH3_2	48	53	PF14604	0.650
LIG_SH3_3	174	180	PF00018	0.558
LIG_SH3_3	21	27	PF00018	0.605
LIG_SH3_3	45	51	PF00018	0.640
LIG_SH3_3	57	63	PF00018	0.617
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.654
LIG_SUMO_SIM_par_1	70	76	PF11976	0.654
LIG_TYR_ITIM	221	226	PF00017	0.317
LIG_UBA3_1	226	233	PF00899	0.339
LIG_UBA3_1	242	248	PF00899	0.472
MOD_CK1_1	118	124	PF00069	0.447
MOD_CK1_1	149	155	PF00069	0.457
MOD_Cter_Amidation	231	234	PF01082	0.405
MOD_GlcNHglycan	136	139	PF01048	0.485
MOD_GSK3_1	282	289	PF00069	0.302
MOD_GSK3_1	86	93	PF00069	0.585
MOD_N-GLC_2	281	283	PF02516	0.353
MOD_NEK2_1	173	178	PF00069	0.396
MOD_NEK2_1	18	23	PF00069	0.604
MOD_NEK2_2	158	163	PF00069	0.393
MOD_PIKK_1	90	96	PF00454	0.476
MOD_PKA_2	115	121	PF00069	0.449
MOD_PKA_2	216	222	PF00069	0.359
MOD_Plk_1	173	179	PF00069	0.428
MOD_Plk_4	118	124	PF00069	0.447
MOD_Plk_4	158	164	PF00069	0.427
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.629
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.571
TRG_ENDOCYTIC_2	169	172	PF00928	0.375
TRG_ENDOCYTIC_2	223	226	PF00928	0.308
TRG_ENDOCYTIC_2	275	278	PF00928	0.354
TRG_ENDOCYTIC_2	40	43	PF00928	0.517
TRG_ER_diArg_1	216	218	PF00400	0.338
TRG_ER_diArg_1	7	9	PF00400	0.539
TRG_NES_CRM1_1	70	85	PF08389	0.579
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZB7	Leptomonas seymouri	82%	100%
A0A1X0P4P9	Trypanosomatidae	70%	100%
A0A3S7WYX0	Leishmania donovani	96%	100%
A4HEF5	Leishmania braziliensis	93%	100%
A4I1A4	Leishmania infantum	96%	100%
D0A5J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
Q4QA32	Leishmania major	95%	100%
V5BN61	Trypanosoma cruzi	68%	100%