Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXD7_LEIMU

TriTrypDb:

LmxM.25.0600

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.336
CLV_C14_Caspase3-7	209	213	PF00656	0.308
CLV_C14_Caspase3-7	341	345	PF00656	0.662
CLV_C14_Caspase3-7	401	405	PF00656	0.608
CLV_NRD_NRD_1	320	322	PF00675	0.657
CLV_NRD_NRD_1	332	334	PF00675	0.651
CLV_NRD_NRD_1	4	6	PF00675	0.537
CLV_PCSK_KEX2_1	332	334	PF00082	0.644
CLV_PCSK_KEX2_1	4	6	PF00082	0.537
CLV_PCSK_SKI1_1	115	119	PF00082	0.421
CLV_PCSK_SKI1_1	192	196	PF00082	0.397
CLV_PCSK_SKI1_1	5	9	PF00082	0.563
DEG_APCC_DBOX_1	191	199	PF00400	0.464
DEG_APCC_DBOX_1	4	12	PF00400	0.493
DEG_COP1_1	92	102	PF00400	0.450
DEG_SCF_FBW7_1	99	105	PF00400	0.436
DEG_SPOP_SBC_1	170	174	PF00917	0.479
DOC_ANK_TNKS_1	107	114	PF00023	0.494
DOC_CKS1_1	99	104	PF01111	0.442
DOC_PP1_RVXF_1	113	119	PF00149	0.302
DOC_PP2B_LxvP_1	179	182	PF13499	0.505
DOC_PP4_FxxP_1	70	73	PF00568	0.591
DOC_USP7_MATH_1	53	57	PF00917	0.505
DOC_USP7_MATH_1	63	67	PF00917	0.684
DOC_WW_Pin1_4	232	237	PF00397	0.348
DOC_WW_Pin1_4	291	296	PF00397	0.615
DOC_WW_Pin1_4	98	103	PF00397	0.662
LIG_14-3-3_CanoR_1	271	276	PF00244	0.429
LIG_14-3-3_CanoR_1	4	11	PF00244	0.493
LIG_Actin_WH2_2	20	35	PF00022	0.349
LIG_BIR_III_2	344	348	PF00653	0.540
LIG_BRCT_BRCA1_1	171	175	PF00533	0.417
LIG_BRCT_BRCA1_1	195	199	PF00533	0.463
LIG_Clathr_ClatBox_1	124	128	PF01394	0.266
LIG_FHA_1	176	182	PF00498	0.392
LIG_FHA_1	233	239	PF00498	0.450
LIG_FHA_1	249	255	PF00498	0.496
LIG_FHA_1	26	32	PF00498	0.446
LIG_FHA_1	368	374	PF00498	0.605
LIG_FHA_1	99	105	PF00498	0.724
LIG_FHA_2	213	219	PF00498	0.439
LIG_FHA_2	7	13	PF00498	0.443
LIG_GBD_Chelix_1	145	153	PF00786	0.482
LIG_LIR_Apic_2	394	398	PF02991	0.623
LIG_LIR_Apic_2	67	73	PF02991	0.584
LIG_LIR_Gen_1	128	137	PF02991	0.511
LIG_LIR_Gen_1	173	184	PF02991	0.548
LIG_LIR_Gen_1	251	258	PF02991	0.507
LIG_LIR_Gen_1	370	379	PF02991	0.574
LIG_LIR_Gen_1	38	47	PF02991	0.446
LIG_LIR_Nem_3	128	133	PF02991	0.316
LIG_LIR_Nem_3	173	179	PF02991	0.515
LIG_LIR_Nem_3	251	256	PF02991	0.514
LIG_LIR_Nem_3	370	374	PF02991	0.494
LIG_LIR_Nem_3	38	42	PF02991	0.440
LIG_MLH1_MIPbox_1	172	176	PF16413	0.367
LIG_MYND_1	386	390	PF01753	0.636
LIG_Pex14_2	367	371	PF04695	0.517
LIG_SH2_CRK	130	134	PF00017	0.307
LIG_SH2_PTP2	39	42	PF00017	0.223
LIG_SH2_SRC	239	242	PF00017	0.564
LIG_SH2_SRC	363	366	PF00017	0.565
LIG_SH2_STAP1	130	134	PF00017	0.469
LIG_SH2_STAT5	39	42	PF00017	0.378
LIG_SH3_3	208	214	PF00018	0.409
LIG_SH3_3	279	285	PF00018	0.554
LIG_SH3_3	381	387	PF00018	0.646
LIG_SH3_3	96	102	PF00018	0.622
LIG_Sin3_3	221	228	PF02671	0.245
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.402
LIG_SUMO_SIM_par_1	123	128	PF11976	0.399
LIG_SUMO_SIM_par_1	21	26	PF11976	0.396
LIG_TRAF2_1	204	207	PF00917	0.460
LIG_WRC_WIRS_1	250	255	PF05994	0.380
MOD_CK1_1	299	305	PF00069	0.738
MOD_CK1_1	56	62	PF00069	0.508
MOD_CK1_1	6	12	PF00069	0.383
MOD_CK1_1	94	100	PF00069	0.698
MOD_CK2_1	163	169	PF00069	0.571
MOD_CK2_1	6	12	PF00069	0.432
MOD_GlcNHglycan	120	123	PF01048	0.401
MOD_GlcNHglycan	189	192	PF01048	0.519
MOD_GlcNHglycan	195	198	PF01048	0.399
MOD_GlcNHglycan	206	211	PF01048	0.374
MOD_GlcNHglycan	301	304	PF01048	0.707
MOD_GlcNHglycan	5	8	PF01048	0.400
MOD_GlcNHglycan	55	58	PF01048	0.519
MOD_GlcNHglycan	83	86	PF01048	0.703
MOD_GSK3_1	159	166	PF00069	0.566
MOD_GSK3_1	170	177	PF00069	0.422
MOD_GSK3_1	230	237	PF00069	0.531
MOD_GSK3_1	271	278	PF00069	0.473
MOD_GSK3_1	291	298	PF00069	0.539
MOD_GSK3_1	308	315	PF00069	0.537
MOD_GSK3_1	53	60	PF00069	0.579
MOD_GSK3_1	91	98	PF00069	0.689
MOD_NEK2_1	118	123	PF00069	0.384
MOD_NEK2_1	149	154	PF00069	0.418
MOD_NEK2_1	163	168	PF00069	0.512
MOD_NEK2_1	175	180	PF00069	0.481
MOD_NEK2_1	25	30	PF00069	0.289
MOD_NEK2_1	296	301	PF00069	0.600
MOD_NEK2_1	367	372	PF00069	0.568
MOD_NEK2_1	402	407	PF00069	0.540
MOD_NEK2_1	93	98	PF00069	0.590
MOD_NEK2_2	308	313	PF00069	0.672
MOD_PIKK_1	316	322	PF00454	0.580
MOD_PK_1	271	277	PF00069	0.436
MOD_PKA_2	3	9	PF00069	0.416
MOD_PKA_2	312	318	PF00069	0.618
MOD_Plk_1	206	212	PF00069	0.437
MOD_Plk_1	248	254	PF00069	0.509
MOD_Plk_4	171	177	PF00069	0.519
MOD_Plk_4	234	240	PF00069	0.444
MOD_Plk_4	249	255	PF00069	0.385
MOD_ProDKin_1	232	238	PF00069	0.325
MOD_ProDKin_1	291	297	PF00069	0.613
MOD_ProDKin_1	98	104	PF00069	0.660
TRG_DiLeu_BaEn_1	112	117	PF01217	0.244
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.464
TRG_ENDOCYTIC_2	130	133	PF00928	0.309
TRG_ENDOCYTIC_2	39	42	PF00928	0.401
TRG_ER_diArg_1	106	109	PF00400	0.395
TRG_ER_diArg_1	3	5	PF00400	0.554
TRG_ER_diArg_1	337	340	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X9	Leptomonas seymouri	54%	98%
A0A1X0P4Q1	Trypanosomatidae	30%	100%
A0A3S5IS63	Trypanosoma rangeli	31%	100%
A0A3S7WZ17	Leishmania donovani	89%	100%
A4HEF8	Leishmania braziliensis	76%	100%
A4I1A1	Leishmania infantum	89%	100%
D0A5J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QA35	Leishmania major	87%	100%
V5B7R1	Trypanosoma cruzi	29%	100%