Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXD5_LEIMU

TriTrypDb:

LmxM.25.0580

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.516
CLV_NRD_NRD_1	178	180	PF00675	0.655
CLV_NRD_NRD_1	18	20	PF00675	0.397
CLV_NRD_NRD_1	2	4	PF00675	0.570
CLV_NRD_NRD_1	43	45	PF00675	0.550
CLV_PCSK_FUR_1	153	157	PF00082	0.426
CLV_PCSK_KEX2_1	155	157	PF00082	0.471
CLV_PCSK_KEX2_1	18	20	PF00082	0.397
CLV_PCSK_KEX2_1	2	4	PF00082	0.570
CLV_PCSK_KEX2_1	43	45	PF00082	0.550
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.450
CLV_PCSK_PC7_1	151	157	PF00082	0.411
CLV_PCSK_SKI1_1	112	116	PF00082	0.550
CLV_PCSK_SKI1_1	2	6	PF00082	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DEG_SCF_FBW7_1	54	60	PF00400	0.528
DOC_CKS1_1	5	10	PF01111	0.544
DOC_CKS1_1	54	59	PF01111	0.538
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.403
DOC_MAPK_gen_1	131	140	PF00069	0.392
DOC_MAPK_gen_1	2	13	PF00069	0.646
DOC_MAPK_MEF2A_6	133	142	PF00069	0.376
DOC_MAPK_MEF2A_6	6	15	PF00069	0.426
DOC_MAPK_RevD_3	140	156	PF00069	0.374
DOC_USP7_MATH_1	171	175	PF00917	0.563
DOC_USP7_MATH_1	33	37	PF00917	0.574
DOC_USP7_UBL2_3	127	131	PF12436	0.437
DOC_USP7_UBL2_3	133	137	PF12436	0.424
DOC_USP7_UBL2_3	176	180	PF12436	0.638
DOC_WW_Pin1_4	4	9	PF00397	0.673
DOC_WW_Pin1_4	53	58	PF00397	0.434
LIG_FHA_1	113	119	PF00498	0.505
LIG_FHA_1	93	99	PF00498	0.511
LIG_FHA_2	91	97	PF00498	0.507
LIG_LIR_Gen_1	170	177	PF02991	0.563
LIG_LIR_Nem_3	147	152	PF02991	0.349
LIG_LIR_Nem_3	94	100	PF02991	0.521
LIG_SH2_GRB2like	97	100	PF00017	0.506
LIG_SH2_PTP2	149	152	PF00017	0.312
LIG_SH2_STAT3	100	103	PF00017	0.538
LIG_SH2_STAT5	149	152	PF00017	0.419
LIG_SH2_STAT5	172	175	PF00017	0.514
LIG_SH2_STAT5	97	100	PF00017	0.454
LIG_SUMO_SIM_par_1	12	17	PF11976	0.406
LIG_SxIP_EBH_1	18	28	PF03271	0.606
LIG_TYR_ITIM	70	75	PF00017	0.405
MOD_CDK_SPxK_1	4	10	PF00069	0.675
MOD_CDK_SPxK_1	53	59	PF00069	0.545
MOD_CK2_1	90	96	PF00069	0.442
MOD_GSK3_1	171	178	PF00069	0.603
MOD_GSK3_1	53	60	PF00069	0.406
MOD_N-GLC_1	33	38	PF02516	0.607
MOD_NEK2_1	138	143	PF00069	0.382
MOD_NEK2_1	14	19	PF00069	0.602
MOD_NEK2_1	158	163	PF00069	0.429
MOD_NEK2_1	175	180	PF00069	0.547
MOD_NEK2_1	48	53	PF00069	0.501
MOD_NEK2_2	171	176	PF00069	0.612
MOD_PIKK_1	158	164	PF00454	0.481
MOD_PIKK_1	182	188	PF00454	0.652
MOD_PKA_2	17	23	PF00069	0.621
MOD_Plk_2-3	90	96	PF00069	0.453
MOD_Plk_4	145	151	PF00069	0.487
MOD_ProDKin_1	4	10	PF00069	0.676
MOD_ProDKin_1	53	59	PF00069	0.434
MOD_SUMO_rev_2	130	139	PF00179	0.416
TRG_ENDOCYTIC_2	149	152	PF00928	0.357
TRG_ENDOCYTIC_2	172	175	PF00928	0.500
TRG_ENDOCYTIC_2	71	74	PF00928	0.368
TRG_ER_diArg_1	1	3	PF00400	0.583
TRG_ER_diArg_1	150	153	PF00400	0.495
TRG_ER_diArg_1	42	44	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM8	Leptomonas seymouri	79%	100%
A0A0S4IKU3	Bodo saltans	51%	100%
A0A1X0P4E1	Trypanosomatidae	60%	93%
A0A3Q8IC88	Leishmania donovani	92%	100%
A0A422NWZ6	Trypanosoma rangeli	62%	100%
A4HEG0	Leishmania braziliensis	90%	100%
A4I199	Leishmania infantum	92%	100%
D0A5J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	95%
Q4QA37	Leishmania major	93%	100%