Tyrosine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tyrosine phosphatase family, putative

Species:

Leishmania mexicana

UniProt:

E9AXD4_LEIMU

TriTrypDb:

LmxM.25.0570

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXD4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.730
CLV_C14_Caspase3-7	146	150	PF00656	0.572
CLV_C14_Caspase3-7	294	298	PF00656	0.546
CLV_C14_Caspase3-7	313	317	PF00656	0.349
CLV_NRD_NRD_1	271	273	PF00675	0.336
CLV_NRD_NRD_1	287	289	PF00675	0.222
CLV_NRD_NRD_1	318	320	PF00675	0.509
CLV_PCSK_KEX2_1	287	289	PF00082	0.307
CLV_PCSK_KEX2_1	318	320	PF00082	0.509
DEG_Nend_UBRbox_1	1	4	PF02207	0.530
DOC_CYCLIN_yClb5_NLxxxL_5	274	283	PF00134	0.546
DOC_USP7_MATH_1	123	127	PF00917	0.737
DOC_USP7_MATH_1	168	172	PF00917	0.690
DOC_USP7_MATH_1	219	223	PF00917	0.770
DOC_USP7_MATH_1	62	66	PF00917	0.557
DOC_WW_Pin1_4	188	193	PF00397	0.678
LIG_14-3-3_CanoR_1	184	193	PF00244	0.614
LIG_APCC_ABBA_1	302	307	PF00400	0.546
LIG_BRCT_BRCA1_1	186	190	PF00533	0.617
LIG_BRCT_BRCA1_1	212	216	PF00533	0.733
LIG_Clathr_ClatBox_1	309	313	PF01394	0.546
LIG_FHA_1	34	40	PF00498	0.438
LIG_FHA_2	144	150	PF00498	0.560
LIG_FHA_2	230	236	PF00498	0.546
LIG_FHA_2	82	88	PF00498	0.718
LIG_GBD_Chelix_1	237	245	PF00786	0.346
LIG_LIR_Gen_1	299	309	PF02991	0.546
LIG_LIR_Nem_3	187	193	PF02991	0.654
LIG_LIR_Nem_3	247	253	PF02991	0.526
LIG_LIR_Nem_3	284	289	PF02991	0.543
LIG_LIR_Nem_3	299	304	PF02991	0.460
LIG_LIR_Nem_3	58	63	PF02991	0.588
LIG_LYPXL_yS_3	251	254	PF13949	0.546
LIG_NRBOX	241	247	PF00104	0.546
LIG_PDZ_Class_2	321	326	PF00595	0.575
LIG_Pex14_2	301	305	PF04695	0.504
LIG_SH2_CRK	26	30	PF00017	0.466
LIG_SH2_CRK	80	84	PF00017	0.790
LIG_SH2_NCK_1	80	84	PF00017	0.713
LIG_SH2_SRC	134	137	PF00017	0.525
LIG_SH2_STAT5	10	13	PF00017	0.497
LIG_SH2_STAT5	134	137	PF00017	0.595
LIG_SH2_STAT5	200	203	PF00017	0.674
LIG_SH2_STAT5	80	83	PF00017	0.790
LIG_SH3_3	190	196	PF00018	0.680
LIG_SUMO_SIM_par_1	251	256	PF11976	0.546
LIG_SUMO_SIM_par_1	278	285	PF11976	0.546
LIG_SUMO_SIM_par_1	306	313	PF11976	0.619
LIG_TRAF2_1	113	116	PF00917	0.648
MOD_CDC14_SPxK_1	191	194	PF00782	0.490
MOD_CDK_SPxK_1	188	194	PF00069	0.493
MOD_CK1_1	108	114	PF00069	0.663
MOD_CK1_1	188	194	PF00069	0.706
MOD_CK1_1	212	218	PF00069	0.516
MOD_CK1_1	55	61	PF00069	0.580
MOD_CK2_1	141	147	PF00069	0.748
MOD_CK2_1	229	235	PF00069	0.392
MOD_CK2_1	278	284	PF00069	0.546
MOD_Cter_Amidation	316	319	PF01082	0.538
MOD_GlcNHglycan	125	128	PF01048	0.690
MOD_GlcNHglycan	212	215	PF01048	0.805
MOD_GlcNHglycan	263	266	PF01048	0.313
MOD_GlcNHglycan	54	57	PF01048	0.492
MOD_GSK3_1	119	126	PF00069	0.796
MOD_GSK3_1	163	170	PF00069	0.779
MOD_GSK3_1	184	191	PF00069	0.652
MOD_GSK3_1	308	315	PF00069	0.692
MOD_GSK3_1	62	69	PF00069	0.585
MOD_GSK3_1	87	94	PF00069	0.733
MOD_N-GLC_1	105	110	PF02516	0.728
MOD_N-GLC_1	141	146	PF02516	0.772
MOD_N-GLC_1	185	190	PF02516	0.706
MOD_N-GLC_1	291	296	PF02516	0.346
MOD_NEK2_1	118	123	PF00069	0.528
MOD_NEK2_1	253	258	PF00069	0.524
MOD_NEK2_1	28	33	PF00069	0.471
MOD_NEK2_1	52	57	PF00069	0.484
MOD_PIKK_1	64	70	PF00454	0.644
MOD_PKA_1	318	324	PF00069	0.509
MOD_PKA_2	318	324	PF00069	0.509
MOD_Plk_2-3	308	314	PF00069	0.619
MOD_Plk_4	237	243	PF00069	0.546
MOD_Plk_4	278	284	PF00069	0.546
MOD_Plk_4	318	324	PF00069	0.509
MOD_Plk_4	55	61	PF00069	0.532
MOD_Plk_4	78	84	PF00069	0.707
MOD_ProDKin_1	188	194	PF00069	0.678
MOD_SUMO_for_1	113	116	PF00179	0.746
MOD_SUMO_rev_2	222	227	PF00179	0.753
TRG_DiLeu_BaEn_4	307	313	PF01217	0.546
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.546
TRG_ENDOCYTIC_2	228	231	PF00928	0.455
TRG_ENDOCYTIC_2	250	253	PF00928	0.526
TRG_ENDOCYTIC_2	26	29	PF00928	0.458
TRG_ENDOCYTIC_2	286	289	PF00928	0.546
TRG_ENDOCYTIC_2	80	83	PF00928	0.790
TRG_ER_diArg_1	286	288	PF00400	0.546
TRG_ER_diArg_1	318	320	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW7	Leptomonas seymouri	57%	87%
A0A3S7WYV2	Leishmania donovani	90%	96%
A4HEG1	Leishmania braziliensis	78%	100%
A4I198	Leishmania infantum	89%	96%
Q4QA38	Leishmania major	86%	100%