J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXD3_LEIMU

TriTrypDb:

LmxM.25.0560

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AXD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.595
CLV_NRD_NRD_1	158	160	PF00675	0.411
CLV_NRD_NRD_1	31	33	PF00675	0.539
CLV_NRD_NRD_1	57	59	PF00675	0.465
CLV_PCSK_KEX2_1	157	159	PF00082	0.404
CLV_PCSK_KEX2_1	31	33	PF00082	0.539
CLV_PCSK_KEX2_1	57	59	PF00082	0.433
CLV_PCSK_KEX2_1	67	69	PF00082	0.360
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.379
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.388
CLV_PCSK_SKI1_1	18	22	PF00082	0.535
CLV_PCSK_SKI1_1	181	185	PF00082	0.345
CLV_PCSK_SKI1_1	192	196	PF00082	0.625
DEG_APCC_DBOX_1	180	188	PF00400	0.482
DOC_MAPK_gen_1	155	163	PF00069	0.555
DOC_PP1_RVXF_1	145	151	PF00149	0.597
DOC_PP1_RVXF_1	157	164	PF00149	0.544
DOC_PP2B_LxvP_1	83	86	PF13499	0.594
DOC_USP7_MATH_1	138	142	PF00917	0.586
DOC_USP7_MATH_1	24	28	PF00917	0.739
DOC_USP7_MATH_1	86	90	PF00917	0.654
DOC_USP7_UBL2_3	100	104	PF12436	0.670
DOC_WW_Pin1_4	129	134	PF00397	0.558
LIG_14-3-3_CanoR_1	10	20	PF00244	0.632
LIG_14-3-3_CanoR_1	26	34	PF00244	0.663
LIG_14-3-3_CanoR_1	57	65	PF00244	0.691
LIG_14-3-3_CterR_2	192	196	PF00244	0.405
LIG_EH1_1	162	170	PF00400	0.532
LIG_EH1_1	172	180	PF00400	0.418
LIG_FHA_2	73	79	PF00498	0.539
LIG_FHA_2	88	94	PF00498	0.567
LIG_LIR_Gen_1	59	65	PF02991	0.691
LIG_LIR_Nem_3	75	80	PF02991	0.577
LIG_Pex14_2	73	77	PF04695	0.562
LIG_SH2_STAT5	135	138	PF00017	0.613
LIG_SH3_3	127	133	PF00018	0.549
LIG_SH3_3	180	186	PF00018	0.410
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.561
LIG_SUMO_SIM_par_1	78	84	PF11976	0.595
LIG_TRFH_1	150	154	PF08558	0.538
MOD_CK1_1	140	146	PF00069	0.523
MOD_CK1_1	27	33	PF00069	0.689
MOD_CK1_1	87	93	PF00069	0.527
MOD_CK2_1	86	92	PF00069	0.573
MOD_Cter_Amidation	65	68	PF01082	0.501
MOD_GlcNHglycan	13	16	PF01048	0.550
MOD_GlcNHglycan	26	29	PF01048	0.619
MOD_GlcNHglycan	50	53	PF01048	0.607
MOD_GSK3_1	20	27	PF00069	0.653
MOD_GSK3_1	9	16	PF00069	0.581
MOD_N-GLC_1	187	192	PF02516	0.512
MOD_NEK2_1	13	18	PF00069	0.744
MOD_NEK2_1	187	192	PF00069	0.491
MOD_NEK2_1	20	25	PF00069	0.682
MOD_NEK2_1	36	41	PF00069	0.545
MOD_PIKK_1	138	144	PF00454	0.610
MOD_PIKK_1	56	62	PF00454	0.542
MOD_PIKK_1	72	78	PF00454	0.352
MOD_PKA_2	56	62	PF00069	0.619
MOD_PKA_2	9	15	PF00069	0.495
MOD_Plk_1	187	193	PF00069	0.571
MOD_Plk_1	87	93	PF00069	0.570
MOD_ProDKin_1	129	135	PF00069	0.445
TRG_DiLeu_BaEn_2	68	74	PF01217	0.467
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.614
TRG_ENDOCYTIC_2	61	64	PF00928	0.731
TRG_ER_diArg_1	145	148	PF00400	0.513
TRG_ER_diArg_1	158	160	PF00400	0.505
TRG_NLS_MonoExtC_3	156	162	PF00514	0.479
TRG_NLS_MonoExtN_4	154	161	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP6	Leptomonas seymouri	68%	100%
A0A0S4IQD4	Bodo saltans	45%	100%
A0A1X0P4F3	Trypanosomatidae	61%	100%
A0A3S7WYX1	Leishmania donovani	92%	99%
A0A422NX26	Trypanosoma rangeli	68%	100%
A4HEG2	Leishmania braziliensis	82%	100%
A4I197	Leishmania infantum	92%	99%
D0A5I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
Q4QA39	Leishmania major	91%	100%