Scd6-like Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXD1_LEIMU

TriTrypDb:

LmxM.25.0540

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1990124	messenger ribonucleoprotein complex	3	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AXD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXD1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033962	P-body assembly	7	1
GO:0034063	stress granule assembly	7	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.603
CLV_NRD_NRD_1	182	184	PF00675	0.574
CLV_NRD_NRD_1	263	265	PF00675	0.627
CLV_NRD_NRD_1	283	285	PF00675	0.560
CLV_NRD_NRD_1	45	47	PF00675	0.353
CLV_PCSK_KEX2_1	143	145	PF00082	0.603
CLV_PCSK_KEX2_1	182	184	PF00082	0.574
CLV_PCSK_KEX2_1	283	285	PF00082	0.560
CLV_PCSK_SKI1_1	72	76	PF00082	0.314
DEG_Nend_UBRbox_3	1	3	PF02207	0.529
DOC_PP1_RVXF_1	219	226	PF00149	0.353
DOC_USP7_UBL2_3	229	233	PF12436	0.499
DOC_USP7_UBL2_3	237	241	PF12436	0.495
DOC_WW_Pin1_4	79	84	PF00397	0.674
LIG_14-3-3_CanoR_1	123	129	PF00244	0.646
LIG_APCC_ABBA_1	74	79	PF00400	0.489
LIG_BRCT_BRCA1_1	241	245	PF00533	0.500
LIG_FHA_1	30	36	PF00498	0.458
LIG_FHA_1	55	61	PF00498	0.576
LIG_FHA_2	188	194	PF00498	0.550
LIG_LIR_Gen_1	242	251	PF02991	0.499
LIG_LIR_Gen_1	58	66	PF02991	0.458
LIG_LIR_Nem_3	242	248	PF02991	0.488
LIG_LIR_Nem_3	58	64	PF02991	0.487
LIG_MLH1_MIPbox_1	241	245	PF16413	0.500
LIG_PCNA_yPIPBox_3	2	14	PF02747	0.313
LIG_Pex14_2	205	209	PF04695	0.495
LIG_SH2_NCK_1	129	133	PF00017	0.609
LIG_SH2_SRC	129	132	PF00017	0.720
LIG_SH2_STAT3	19	22	PF00017	0.510
LIG_SH3_3	90	96	PF00018	0.669
LIG_SUMO_SIM_par_1	28	36	PF11976	0.465
MOD_CDK_SPxxK_3	79	86	PF00069	0.675
MOD_CK1_1	119	125	PF00069	0.720
MOD_CK1_1	25	31	PF00069	0.530
MOD_CK2_1	10	16	PF00069	0.553
MOD_Cter_Amidation	44	47	PF01082	0.353
MOD_GlcNHglycan	118	121	PF01048	0.616
MOD_GlcNHglycan	172	175	PF01048	0.718
MOD_GlcNHglycan	177	180	PF01048	0.672
MOD_GSK3_1	112	119	PF00069	0.701
MOD_GSK3_1	25	32	PF00069	0.494
MOD_GSK3_1	270	277	PF00069	0.575
MOD_N-GLC_1	160	165	PF02516	0.811
MOD_N-GLC_1	239	244	PF02516	0.401
MOD_N-GLC_1	79	84	PF02516	0.507
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	244	249	PF00069	0.576
MOD_NEK2_1	275	280	PF00069	0.585
MOD_NEK2_2	124	129	PF00069	0.644
MOD_PKA_2	122	128	PF00069	0.648
MOD_PKA_2	66	72	PF00069	0.458
MOD_Plk_1	29	35	PF00069	0.502
MOD_Plk_1	72	78	PF00069	0.471
MOD_Plk_4	72	78	PF00069	0.489
MOD_ProDKin_1	79	85	PF00069	0.674
MOD_SUMO_rev_2	187	197	PF00179	0.611
MOD_SUMO_rev_2	216	223	PF00179	0.494
MOD_SUMO_rev_2	226	234	PF00179	0.554
MOD_SUMO_rev_2	69	74	PF00179	0.514
TRG_ER_diArg_1	181	183	PF00400	0.596
TRG_ER_diArg_1	282	284	PF00400	0.560
TRG_ER_diArg_1	289	292	PF00400	0.585
TRG_ER_diArg_1	97	100	PF00400	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC4	Leptomonas seymouri	71%	100%
A0A1X0P4R0	Trypanosomatidae	46%	100%
A0A3Q8IGG5	Leishmania donovani	85%	99%
A0A3R7KUL5	Trypanosoma rangeli	40%	100%
A4HEG4	Leishmania braziliensis	83%	100%
A4I195	Leishmania infantum	85%	99%
D0A5I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
P45978	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	85%
Q4QA41	Leishmania major	89%	100%
Q9BX40	Homo sapiens	31%	77%
V5BN65	Trypanosoma cruzi	38%	91%