RNA-binding protein, putative, UPB1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein UBP1, putative

Species:

Leishmania mexicana

UniProt:

E9AXC6_LEIMU

TriTrypDb:

LmxM.25.0490

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AXC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXC6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	15
GO:0005488	binding	1	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	55	61	PF00089	0.351
CLV_PCSK_KEX2_1	105	107	PF00082	0.325
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.325
CLV_PCSK_SKI1_1	105	109	PF00082	0.338
CLV_PCSK_SKI1_1	53	57	PF00082	0.325
DOC_CKS1_1	4	9	PF01111	0.623
DOC_CYCLIN_RxL_1	50	57	PF00134	0.525
DOC_MAPK_gen_1	105	111	PF00069	0.525
DOC_PP4_MxPP_1	5	8	PF00568	0.645
DOC_WW_Pin1_4	3	8	PF00397	0.656
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_FHA_2	43	49	PF00498	0.525
LIG_IBAR_NPY_1	149	151	PF08397	0.613
LIG_LIR_Nem_3	57	62	PF02991	0.525
LIG_LIR_Nem_3	76	82	PF02991	0.525
LIG_SH2_CRK	79	83	PF00017	0.568
LIG_SH2_STAT3	122	125	PF00017	0.622
LIG_SH2_STAT3	163	166	PF00017	0.808
LIG_SH2_STAT5	42	45	PF00017	0.527
LIG_SH3_3	24	30	PF00018	0.699
MOD_CK1_1	86	92	PF00069	0.525
MOD_CK2_1	43	49	PF00069	0.525
MOD_GlcNHglycan	113	116	PF01048	0.694
MOD_GlcNHglycan	85	88	PF01048	0.325
MOD_NEK2_1	111	116	PF00069	0.675
MOD_PKA_2	70	76	PF00069	0.536
MOD_ProDKin_1	3	9	PF00069	0.657
TRG_ENDOCYTIC_2	79	82	PF00928	0.568
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P4G4	Trypanosomatidae	65%	83%
A0A1X0P4M7	Trypanosomatidae	67%	100%
A0A3Q8ID53	Leishmania donovani	99%	100%
A0A3S7WYY4	Leishmania donovani	100%	100%
A0A422NWY7	Trypanosoma rangeli	72%	100%
A4HDZ1	Leishmania braziliensis	90%	100%
A4HDZ2	Leishmania braziliensis	90%	100%
A4I191	Leishmania infantum	99%	100%
E9AH94	Leishmania infantum	99%	75%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4QA45	Leishmania major	99%	100%
Q4QA46	Leishmania major	99%	100%
V5BNA6	Trypanosoma cruzi	70%	100%