Small integral membrane protein 29

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXC3_LEIMU

TriTrypDb:

LmxM.25.0460

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AXC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.506
CLV_PCSK_KEX2_1	109	111	PF00082	0.686
CLV_PCSK_KEX2_1	131	133	PF00082	0.670
CLV_PCSK_KEX2_1	6	8	PF00082	0.506
CLV_PCSK_KEX2_1	70	72	PF00082	0.485
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.686
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.670
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.506
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.485
CLV_PCSK_SKI1_1	79	83	PF00082	0.411
DEG_APCC_DBOX_1	78	86	PF00400	0.546
DOC_CKS1_1	54	59	PF01111	0.697
DOC_MAPK_gen_1	6	14	PF00069	0.704
DOC_MAPK_HePTP_8	4	16	PF00069	0.704
DOC_MAPK_MEF2A_6	7	16	PF00069	0.704
DOC_MAPK_MEF2A_6	79	87	PF00069	0.375
DOC_MAPK_NFAT4_5	79	87	PF00069	0.222
DOC_WW_Pin1_4	25	30	PF00397	0.694
DOC_WW_Pin1_4	53	58	PF00397	0.749
LIG_14-3-3_CanoR_1	17	23	PF00244	0.581
LIG_eIF4E_1	80	86	PF01652	0.338
LIG_FHA_1	86	92	PF00498	0.513
LIG_FHA_2	26	32	PF00498	0.711
LIG_FHA_2	37	43	PF00498	0.688
LIG_FHA_2	99	105	PF00498	0.451
LIG_LIR_Apic_2	64	69	PF02991	0.571
LIG_LIR_Gen_1	78	87	PF02991	0.546
LIG_LIR_Nem_3	78	83	PF02991	0.428
LIG_NRBOX	86	92	PF00104	0.455
LIG_SH2_CRK	72	76	PF00017	0.656
LIG_SH2_PTP2	80	83	PF00017	0.246
LIG_SH2_STAT5	80	83	PF00017	0.411
LIG_SH3_3	30	36	PF00018	0.734
LIG_SH3_3	51	57	PF00018	0.745
LIG_SUMO_SIM_par_1	26	35	PF11976	0.703
LIG_SUMO_SIM_par_1	82	88	PF11976	0.364
LIG_TRAF2_1	38	41	PF00917	0.700
MOD_CK1_1	52	58	PF00069	0.813
MOD_CK2_1	36	42	PF00069	0.723
MOD_CK2_1	44	50	PF00069	0.654
MOD_CK2_1	98	104	PF00069	0.462
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.748
MOD_GSK3_1	49	56	PF00069	0.740
MOD_NEK2_1	118	123	PF00069	0.470
MOD_NEK2_1	49	54	PF00069	0.770
MOD_NEK2_1	85	90	PF00069	0.369
MOD_NEK2_1	92	97	PF00069	0.349
MOD_PK_1	8	14	PF00069	0.720
MOD_PKA_2	52	58	PF00069	0.813
MOD_Plk_1	8	14	PF00069	0.687
MOD_Plk_2-3	100	106	PF00069	0.477
MOD_Plk_4	85	91	PF00069	0.424
MOD_ProDKin_1	25	31	PF00069	0.695
MOD_ProDKin_1	53	59	PF00069	0.750
MOD_SUMO_rev_2	104	111	PF00179	0.445
MOD_SUMO_rev_2	95	103	PF00179	0.617
TRG_DiLeu_BaEn_1	78	83	PF01217	0.619
TRG_ENDOCYTIC_2	72	75	PF00928	0.659
TRG_ENDOCYTIC_2	80	83	PF00928	0.411
TRG_ER_diLys_1	129	133	PF00400	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C5	Leptomonas seymouri	50%	100%
A0A3S7WYV4	Leishmania donovani	88%	100%
A4HDY8	Leishmania braziliensis	67%	100%
A4I189	Leishmania infantum	88%	100%
Q4QA49	Leishmania major	87%	100%