G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania mexicana

UniProt:

E9AXC2_LEIMU

TriTrypDb:

LmxM.25.0450

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXC2

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	1
GO:0002097	tRNA wobble base modification	7	1
GO:0002098	tRNA wobble uridine modification	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0030488	tRNA methylation	5	1
GO:0032259	methylation	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.542
CLV_MEL_PAP_1	72	78	PF00089	0.411
CLV_NRD_NRD_1	165	167	PF00675	0.507
CLV_NRD_NRD_1	197	199	PF00675	0.487
CLV_NRD_NRD_1	305	307	PF00675	0.234
CLV_NRD_NRD_1	349	351	PF00675	0.363
CLV_NRD_NRD_1	425	427	PF00675	0.572
CLV_NRD_NRD_1	465	467	PF00675	0.505
CLV_PCSK_FUR_1	303	307	PF00082	0.335
CLV_PCSK_KEX2_1	164	166	PF00082	0.508
CLV_PCSK_KEX2_1	188	190	PF00082	0.528
CLV_PCSK_KEX2_1	197	199	PF00082	0.441
CLV_PCSK_KEX2_1	305	307	PF00082	0.234
CLV_PCSK_KEX2_1	349	351	PF00082	0.423
CLV_PCSK_KEX2_1	425	427	PF00082	0.572
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.606
CLV_PCSK_SKI1_1	426	430	PF00082	0.515
CLV_PCSK_SKI1_1	514	518	PF00082	0.336
CLV_Separin_Metazoa	346	350	PF03568	0.493
CLV_Separin_Metazoa	439	443	PF03568	0.346
DEG_APCC_DBOX_1	380	388	PF00400	0.467
DOC_CKS1_1	291	296	PF01111	0.431
DOC_CKS1_1	368	373	PF01111	0.397
DOC_CYCLIN_RxL_1	371	382	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.393
DOC_MAPK_gen_1	73	80	PF00069	0.436
DOC_MAPK_MEF2A_6	354	362	PF00069	0.332
DOC_MAPK_MEF2A_6	67	76	PF00069	0.440
DOC_PP1_RVXF_1	372	379	PF00149	0.385
DOC_PP1_RVXF_1	458	465	PF00149	0.357
DOC_PP2B_LxvP_1	327	330	PF13499	0.303
DOC_PP2B_LxvP_1	387	390	PF13499	0.450
DOC_PP2B_LxvP_1	431	434	PF13499	0.518
DOC_PP2B_LxvP_1	6	9	PF13499	0.417
DOC_PP2B_LxvP_1	83	86	PF13499	0.422
DOC_PP4_FxxP_1	243	246	PF00568	0.498
DOC_PP4_FxxP_1	480	483	PF00568	0.367
DOC_PP4_FxxP_1	520	523	PF00568	0.385
DOC_USP7_MATH_1	223	227	PF00917	0.648
DOC_USP7_UBL2_3	274	278	PF12436	0.456
DOC_WW_Pin1_4	197	202	PF00397	0.447
DOC_WW_Pin1_4	22	27	PF00397	0.414
DOC_WW_Pin1_4	290	295	PF00397	0.431
DOC_WW_Pin1_4	367	372	PF00397	0.417
LIG_14-3-3_CanoR_1	135	139	PF00244	0.387
LIG_14-3-3_CanoR_1	158	162	PF00244	0.542
LIG_14-3-3_CanoR_1	170	175	PF00244	0.522
LIG_14-3-3_CanoR_1	442	446	PF00244	0.466
LIG_14-3-3_CanoR_1	73	79	PF00244	0.408
LIG_APCC_ABBA_1	476	481	PF00400	0.453
LIG_Clathr_ClatBox_1	288	292	PF01394	0.442
LIG_FHA_1	124	130	PF00498	0.446
LIG_FHA_1	150	156	PF00498	0.630
LIG_FHA_1	250	256	PF00498	0.455
LIG_FHA_1	275	281	PF00498	0.453
LIG_FHA_1	284	290	PF00498	0.443
LIG_FHA_1	291	297	PF00498	0.479
LIG_FHA_1	299	305	PF00498	0.491
LIG_FHA_1	343	349	PF00498	0.552
LIG_FHA_1	392	398	PF00498	0.470
LIG_FHA_1	469	475	PF00498	0.400
LIG_FHA_2	198	204	PF00498	0.426
LIG_FHA_2	280	286	PF00498	0.535
LIG_FHA_2	361	367	PF00498	0.344
LIG_FHA_2	380	386	PF00498	0.368
LIG_FHA_2	442	448	PF00498	0.433
LIG_FHA_2	463	469	PF00498	0.379
LIG_FHA_2	502	508	PF00498	0.511
LIG_Integrin_isoDGR_2	18	20	PF01839	0.429
LIG_LIR_Apic_2	477	483	PF02991	0.355
LIG_LIR_Gen_1	118	129	PF02991	0.406
LIG_LIR_Gen_1	444	453	PF02991	0.493
LIG_LIR_LC3C_4	323	326	PF02991	0.499
LIG_LIR_Nem_3	118	124	PF02991	0.419
LIG_LIR_Nem_3	136	141	PF02991	0.629
LIG_LIR_Nem_3	196	202	PF02991	0.435
LIG_LIR_Nem_3	203	209	PF02991	0.441
LIG_LIR_Nem_3	25	30	PF02991	0.410
LIG_LIR_Nem_3	444	448	PF02991	0.475
LIG_LIR_Nem_3	488	493	PF02991	0.360
LIG_LIR_Nem_3	511	516	PF02991	0.282
LIG_Pex14_2	513	517	PF04695	0.413
LIG_REV1ctd_RIR_1	477	482	PF16727	0.349
LIG_SH2_CRK	148	152	PF00017	0.397
LIG_SH2_CRK	316	320	PF00017	0.535
LIG_SH2_CRK	415	419	PF00017	0.360
LIG_SH2_NCK_1	199	203	PF00017	0.420
LIG_SH2_NCK_1	415	419	PF00017	0.360
LIG_SH2_SRC	121	124	PF00017	0.413
LIG_SH2_STAP1	316	320	PF00017	0.535
LIG_SH2_STAT5	101	104	PF00017	0.378
LIG_SH2_STAT5	199	202	PF00017	0.413
LIG_SH2_STAT5	377	380	PF00017	0.391
LIG_SH3_3	227	233	PF00018	0.497
LIG_SH3_3	365	371	PF00018	0.388
LIG_SUMO_SIM_anti_2	285	293	PF11976	0.458
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.452
LIG_SUMO_SIM_par_1	170	177	PF11976	0.616
LIG_SUMO_SIM_par_1	285	293	PF11976	0.445
LIG_SUMO_SIM_par_1	403	410	PF11976	0.340
LIG_SUMO_SIM_par_1	85	90	PF11976	0.397
LIG_TRAF2_1	201	204	PF00917	0.421
LIG_WRC_WIRS_1	486	491	PF05994	0.357
MOD_CDK_SPK_2	367	372	PF00069	0.373
MOD_CDK_SPxxK_3	367	374	PF00069	0.400
MOD_CK1_1	100	106	PF00069	0.392
MOD_CK1_1	160	166	PF00069	0.494
MOD_CK1_1	173	179	PF00069	0.488
MOD_CK1_1	226	232	PF00069	0.566
MOD_CK1_1	469	475	PF00069	0.372
MOD_CK2_1	197	203	PF00069	0.419
MOD_CK2_1	379	385	PF00069	0.390
MOD_CK2_1	441	447	PF00069	0.473
MOD_CK2_1	462	468	PF00069	0.467
MOD_CK2_1	49	55	PF00069	0.460
MOD_CK2_1	501	507	PF00069	0.547
MOD_GlcNHglycan	103	106	PF01048	0.367
MOD_GlcNHglycan	220	223	PF01048	0.644
MOD_GlcNHglycan	309	312	PF01048	0.269
MOD_GlcNHglycan	402	405	PF01048	0.477
MOD_GlcNHglycan	468	471	PF01048	0.404
MOD_GSK3_1	107	114	PF00069	0.400
MOD_GSK3_1	123	130	PF00069	0.414
MOD_GSK3_1	156	163	PF00069	0.547
MOD_GSK3_1	250	257	PF00069	0.456
MOD_GSK3_1	270	277	PF00069	0.345
MOD_GSK3_1	279	286	PF00069	0.409
MOD_GSK3_1	36	43	PF00069	0.493
MOD_GSK3_1	379	386	PF00069	0.376
MOD_GSK3_1	391	398	PF00069	0.379
MOD_GSK3_1	462	469	PF00069	0.398
MOD_GSK3_1	97	104	PF00069	0.399
MOD_N-GLC_1	48	53	PF02516	0.545
MOD_NEK2_1	149	154	PF00069	0.472
MOD_NEK2_1	218	223	PF00069	0.665
MOD_NEK2_1	254	259	PF00069	0.452
MOD_NEK2_1	441	446	PF00069	0.422
MOD_NEK2_1	462	467	PF00069	0.498
MOD_NEK2_1	74	79	PF00069	0.420
MOD_NEK2_1	89	94	PF00069	0.395
MOD_NEK2_2	279	284	PF00069	0.431
MOD_NEK2_2	485	490	PF00069	0.344
MOD_PIKK_1	283	289	PF00454	0.431
MOD_PIKK_1	298	304	PF00454	0.431
MOD_PK_1	170	176	PF00069	0.485
MOD_PKA_1	466	472	PF00069	0.393
MOD_PKA_2	134	140	PF00069	0.384
MOD_PKA_2	157	163	PF00069	0.580
MOD_PKA_2	298	304	PF00069	0.500
MOD_PKA_2	441	447	PF00069	0.374
MOD_PKA_2	74	80	PF00069	0.527
MOD_Plk_1	395	401	PF00069	0.382
MOD_Plk_4	170	176	PF00069	0.485
MOD_Plk_4	250	256	PF00069	0.448
MOD_Plk_4	360	366	PF00069	0.480
MOD_Plk_4	441	447	PF00069	0.473
MOD_Plk_4	97	103	PF00069	0.377
MOD_ProDKin_1	197	203	PF00069	0.448
MOD_ProDKin_1	22	28	PF00069	0.412
MOD_ProDKin_1	290	296	PF00069	0.431
MOD_ProDKin_1	367	373	PF00069	0.413
MOD_SUMO_rev_2	337	343	PF00179	0.370
TRG_DiLeu_BaEn_2	510	516	PF01217	0.298
TRG_ENDOCYTIC_2	121	124	PF00928	0.413
TRG_ENDOCYTIC_2	148	151	PF00928	0.403
TRG_ENDOCYTIC_2	199	202	PF00928	0.413
TRG_ENDOCYTIC_2	316	319	PF00928	0.535
TRG_ENDOCYTIC_2	377	380	PF00928	0.391
TRG_ENDOCYTIC_2	490	493	PF00928	0.356
TRG_ER_diArg_1	164	166	PF00400	0.512
TRG_ER_diArg_1	197	199	PF00400	0.477
TRG_ER_diArg_1	303	306	PF00400	0.535
TRG_ER_diArg_1	348	350	PF00400	0.502
TRG_ER_diArg_1	371	374	PF00400	0.423
TRG_ER_diArg_1	424	426	PF00400	0.570
TRG_ER_diArg_1	457	460	PF00400	0.362
TRG_ER_diArg_1	72	75	PF00400	0.443
TRG_NES_CRM1_1	355	366	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER9	Leptomonas seymouri	82%	100%
A0A0S4IU66	Bodo saltans	50%	100%
A0A1X0P4I4	Trypanosomatidae	64%	100%
A0A3R7NZ49	Trypanosoma rangeli	66%	100%
A0A3S5H7E2	Leishmania donovani	98%	100%
A4HDY7	Leishmania braziliensis	91%	100%
A4I188	Leishmania infantum	97%	100%
D0A5H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
Q4QA50	Leishmania major	92%	100%
V5B7N0	Trypanosoma cruzi	65%	100%