Putative transcription factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor IIIb, putative

Species:

Leishmania mexicana

UniProt:

E9AXC1_LEIMU

TriTrypDb:

LmxM.25.0440

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097550	transcription preinitiation complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXC1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0022607	cellular component assembly	4	8
GO:0043933	protein-containing complex organization	4	8
GO:0065003	protein-containing complex assembly	5	8
GO:0065004	protein-DNA complex assembly	6	8
GO:0070897	transcription preinitiation complex assembly	7	8
GO:0071824	protein-DNA complex subunit organization	5	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0008134	transcription factor binding	3	8
GO:0017025	TBP-class protein binding	5	8
GO:0140296	general transcription initiation factor binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.274
CLV_NRD_NRD_1	218	220	PF00675	0.274
CLV_NRD_NRD_1	291	293	PF00675	0.618
CLV_NRD_NRD_1	332	334	PF00675	0.544
CLV_NRD_NRD_1	579	581	PF00675	0.624
CLV_NRD_NRD_1	614	616	PF00675	0.528
CLV_NRD_NRD_1	651	653	PF00675	0.576
CLV_NRD_NRD_1	86	88	PF00675	0.274
CLV_PCSK_FUR_1	577	581	PF00082	0.601
CLV_PCSK_FUR_1	612	616	PF00082	0.522
CLV_PCSK_FUR_1	649	653	PF00082	0.572
CLV_PCSK_KEX2_1	136	138	PF00082	0.274
CLV_PCSK_KEX2_1	218	220	PF00082	0.274
CLV_PCSK_KEX2_1	257	259	PF00082	0.274
CLV_PCSK_KEX2_1	332	334	PF00082	0.544
CLV_PCSK_KEX2_1	383	385	PF00082	0.596
CLV_PCSK_KEX2_1	392	394	PF00082	0.543
CLV_PCSK_KEX2_1	579	581	PF00082	0.610
CLV_PCSK_KEX2_1	614	616	PF00082	0.528
CLV_PCSK_KEX2_1	628	630	PF00082	0.674
CLV_PCSK_KEX2_1	648	650	PF00082	0.573
CLV_PCSK_KEX2_1	651	653	PF00082	0.565
CLV_PCSK_KEX2_1	86	88	PF00082	0.274
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.317
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.596
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.543
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.674
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.573
CLV_PCSK_PC7_1	388	394	PF00082	0.610
CLV_PCSK_PC7_1	645	651	PF00082	0.619
CLV_PCSK_SKI1_1	111	115	PF00082	0.317
CLV_PCSK_SKI1_1	257	261	PF00082	0.348
CLV_PCSK_SKI1_1	380	384	PF00082	0.562
CLV_PCSK_SKI1_1	477	481	PF00082	0.631
CLV_PCSK_SKI1_1	567	571	PF00082	0.589
CLV_PCSK_SKI1_1	580	584	PF00082	0.605
CLV_PCSK_SKI1_1	61	65	PF00082	0.627
CLV_PCSK_SKI1_1	87	91	PF00082	0.317
DEG_APCC_DBOX_1	566	574	PF00400	0.582
DEG_SCF_FBW7_2	344	349	PF00400	0.602
DEG_SCF_FBW7_2	546	553	PF00400	0.638
DOC_CKS1_1	322	327	PF01111	0.516
DOC_CKS1_1	547	552	PF01111	0.724
DOC_MAPK_gen_1	383	391	PF00069	0.542
DOC_MAPK_gen_1	612	622	PF00069	0.588
DOC_MAPK_gen_1	671	680	PF00069	0.528
DOC_MAPK_gen_1	84	92	PF00069	0.517
DOC_MAPK_MEF2A_6	561	570	PF00069	0.541
DOC_MAPK_MEF2A_6	614	622	PF00069	0.592
DOC_PP2B_LxvP_1	365	368	PF13499	0.498
DOC_PP2B_LxvP_1	588	591	PF13499	0.594
DOC_USP7_MATH_1	317	321	PF00917	0.493
DOC_USP7_MATH_1	403	407	PF00917	0.750
DOC_USP7_MATH_1	422	426	PF00917	0.486
DOC_USP7_MATH_1	435	439	PF00917	0.521
DOC_USP7_MATH_1	469	473	PF00917	0.527
DOC_USP7_MATH_1	522	526	PF00917	0.659
DOC_USP7_MATH_1	62	66	PF00917	0.668
DOC_USP7_MATH_1	644	648	PF00917	0.639
DOC_WW_Pin1_4	237	242	PF00397	0.487
DOC_WW_Pin1_4	262	267	PF00397	0.611
DOC_WW_Pin1_4	321	326	PF00397	0.540
DOC_WW_Pin1_4	342	347	PF00397	0.526
DOC_WW_Pin1_4	354	359	PF00397	0.483
DOC_WW_Pin1_4	444	449	PF00397	0.648
DOC_WW_Pin1_4	541	546	PF00397	0.688
LIG_14-3-3_CanoR_1	139	147	PF00244	0.478
LIG_14-3-3_CanoR_1	249	255	PF00244	0.474
LIG_14-3-3_CanoR_1	258	266	PF00244	0.474
LIG_14-3-3_CanoR_1	292	299	PF00244	0.574
LIG_14-3-3_CanoR_1	477	486	PF00244	0.582
LIG_14-3-3_CanoR_1	61	67	PF00244	0.550
LIG_14-3-3_CanoR_1	617	623	PF00244	0.654
LIG_14-3-3_CanoR_1	631	638	PF00244	0.591
LIG_14-3-3_CanoR_1	649	655	PF00244	0.667
LIG_AP2alpha_2	554	556	PF02296	0.664
LIG_APCC_ABBA_1	620	625	PF00400	0.609
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_4	402	406	PF00653	0.661
LIG_BIR_III_4	507	511	PF00653	0.670
LIG_BRCT_BRCA1_1	306	310	PF00533	0.494
LIG_BRCT_BRCA1_1	8	12	PF00533	0.577
LIG_deltaCOP1_diTrp_1	329	334	PF00928	0.457
LIG_FHA_1	138	144	PF00498	0.517
LIG_FHA_1	19	25	PF00498	0.511
LIG_FHA_1	193	199	PF00498	0.474
LIG_FHA_1	265	271	PF00498	0.490
LIG_FHA_1	357	363	PF00498	0.502
LIG_FHA_1	368	374	PF00498	0.514
LIG_FHA_1	482	488	PF00498	0.591
LIG_FHA_1	597	603	PF00498	0.662
LIG_FHA_1	6	12	PF00498	0.555
LIG_FHA_1	675	681	PF00498	0.497
LIG_FHA_1	69	75	PF00498	0.593
LIG_FHA_2	167	173	PF00498	0.405
LIG_FHA_2	293	299	PF00498	0.592
LIG_FHA_2	343	349	PF00498	0.539
LIG_FHA_2	547	553	PF00498	0.794
LIG_FHA_2	632	638	PF00498	0.528
LIG_FHA_2	662	668	PF00498	0.545
LIG_Integrin_isoDGR_2	17	19	PF01839	0.464
LIG_IRF3_LxIS_1	92	99	PF10401	0.517
LIG_LIR_Gen_1	146	155	PF02991	0.628
LIG_LIR_Gen_1	480	491	PF02991	0.584
LIG_LIR_Gen_1	586	593	PF02991	0.572
LIG_LIR_Nem_3	146	150	PF02991	0.560
LIG_LIR_Nem_3	307	313	PF02991	0.446
LIG_LIR_Nem_3	329	334	PF02991	0.457
LIG_LIR_Nem_3	480	486	PF02991	0.523
LIG_LIR_Nem_3	553	559	PF02991	0.685
LIG_LIR_Nem_3	586	590	PF02991	0.572
LIG_OCRL_FandH_1	333	345	PF00620	0.536
LIG_REV1ctd_RIR_1	556	565	PF16727	0.623
LIG_SH2_CRK	483	487	PF00017	0.534
LIG_SH2_NCK_1	311	315	PF00017	0.435
LIG_SH2_SRC	276	279	PF00017	0.538
LIG_SH2_STAP1	483	487	PF00017	0.594
LIG_SH2_STAT5	164	167	PF00017	0.511
LIG_SH2_STAT5	181	184	PF00017	0.517
LIG_SH2_STAT5	233	236	PF00017	0.517
LIG_SH2_STAT5	432	435	PF00017	0.635
LIG_SH2_STAT5	483	486	PF00017	0.595
LIG_SH2_STAT5	604	607	PF00017	0.566
LIG_SH3_2	322	327	PF14604	0.509
LIG_SH3_3	172	178	PF00018	0.474
LIG_SH3_3	319	325	PF00018	0.524
LIG_SH3_3	521	527	PF00018	0.602
LIG_SH3_3	544	550	PF00018	0.695
LIG_SH3_3	657	663	PF00018	0.621
LIG_TRAF2_1	294	297	PF00917	0.605
LIG_TRAF2_1	346	349	PF00917	0.609
LIG_TRAF2_1	374	377	PF00917	0.561
LIG_TRAF2_1	550	553	PF00917	0.642
LIG_TRAF2_1	569	572	PF00917	0.588
LIG_TRAF2_1	634	637	PF00917	0.583
LIG_TRFH_1	34	38	PF08558	0.568
LIG_TYR_ITIM	309	314	PF00017	0.501
LIG_TYR_ITIM	602	607	PF00017	0.631
LIG_UBA3_1	158	163	PF00899	0.459
LIG_UBA3_1	309	318	PF00899	0.511
LIG_UBA3_1	364	371	PF00899	0.513
MOD_CDK_SPxK_1	321	327	PF00069	0.509
MOD_CDK_SPxxK_3	262	269	PF00069	0.634
MOD_CK1_1	2	8	PF00069	0.534
MOD_CK1_1	279	285	PF00069	0.546
MOD_CK1_1	291	297	PF00069	0.611
MOD_CK1_1	438	444	PF00069	0.761
MOD_CK1_1	525	531	PF00069	0.733
MOD_CK1_1	78	84	PF00069	0.563
MOD_CK1_1	99	105	PF00069	0.517
MOD_CK2_1	166	172	PF00069	0.403
MOD_CK2_1	291	297	PF00069	0.611
MOD_CK2_1	299	305	PF00069	0.546
MOD_CK2_1	342	348	PF00069	0.591
MOD_CK2_1	486	492	PF00069	0.577
MOD_CK2_1	546	552	PF00069	0.794
MOD_CK2_1	631	637	PF00069	0.535
MOD_CK2_1	661	667	PF00069	0.608
MOD_Cter_Amidation	216	219	PF01082	0.274
MOD_Cter_Amidation	255	258	PF01082	0.348
MOD_GlcNHglycan	119	122	PF01048	0.274
MOD_GlcNHglycan	305	309	PF01048	0.511
MOD_GlcNHglycan	459	462	PF01048	0.807
MOD_GlcNHglycan	48	51	PF01048	0.644
MOD_GlcNHglycan	514	517	PF01048	0.683
MOD_GlcNHglycan	8	11	PF01048	0.570
MOD_GSK3_1	2	9	PF00069	0.536
MOD_GSK3_1	287	294	PF00069	0.579
MOD_GSK3_1	312	319	PF00069	0.494
MOD_GSK3_1	435	442	PF00069	0.723
MOD_GSK3_1	477	484	PF00069	0.576
MOD_GSK3_1	525	532	PF00069	0.683
MOD_GSK3_1	62	69	PF00069	0.671
MOD_GSK3_1	674	681	PF00069	0.502
MOD_N-GLC_1	287	292	PF02516	0.639
MOD_N-GLC_1	398	403	PF02516	0.618
MOD_N-GLC_1	529	534	PF02516	0.666
MOD_N-GLC_1	678	683	PF02516	0.484
MOD_N-GLC_1	69	74	PF02516	0.607
MOD_N-GLC_1	90	95	PF02516	0.354
MOD_NEK2_1	235	240	PF00069	0.571
MOD_NEK2_1	287	292	PF00069	0.606
MOD_NEK2_1	439	444	PF00069	0.738
MOD_NEK2_1	486	491	PF00069	0.574
MOD_NEK2_1	56	61	PF00069	0.647
MOD_NEK2_1	73	78	PF00069	0.681
MOD_NEK2_1	90	95	PF00069	0.423
MOD_PIKK_1	157	163	PF00454	0.464
MOD_PIKK_1	317	323	PF00454	0.558
MOD_PIKK_1	356	362	PF00454	0.371
MOD_PIKK_1	469	475	PF00454	0.450
MOD_PIKK_1	525	531	PF00454	0.669
MOD_PIKK_1	535	541	PF00454	0.622
MOD_PIKK_1	678	684	PF00454	0.521
MOD_PK_1	650	656	PF00069	0.627
MOD_PKA_1	257	263	PF00069	0.548
MOD_PKA_1	292	298	PF00069	0.607
MOD_PKA_1	650	656	PF00069	0.627
MOD_PKA_2	122	128	PF00069	0.521
MOD_PKA_2	138	144	PF00069	0.490
MOD_PKA_2	18	24	PF00069	0.512
MOD_PKA_2	248	254	PF00069	0.489
MOD_PKA_2	257	263	PF00069	0.488
MOD_PKA_2	291	297	PF00069	0.611
MOD_PKA_2	644	650	PF00069	0.608
MOD_PKA_2	78	84	PF00069	0.503
MOD_PKB_1	629	637	PF00069	0.621
MOD_Plk_1	304	310	PF00069	0.506
MOD_Plk_1	393	399	PF00069	0.679
MOD_Plk_1	435	441	PF00069	0.712
MOD_Plk_1	481	487	PF00069	0.592
MOD_Plk_1	529	535	PF00069	0.643
MOD_Plk_1	678	684	PF00069	0.485
MOD_Plk_1	69	75	PF00069	0.608
MOD_Plk_1	99	105	PF00069	0.525
MOD_Plk_4	122	128	PF00069	0.517
MOD_Plk_4	154	160	PF00069	0.478
MOD_Plk_4	618	624	PF00069	0.574
MOD_Plk_4	69	75	PF00069	0.521
MOD_ProDKin_1	237	243	PF00069	0.487
MOD_ProDKin_1	262	268	PF00069	0.614
MOD_ProDKin_1	321	327	PF00069	0.529
MOD_ProDKin_1	342	348	PF00069	0.531
MOD_ProDKin_1	354	360	PF00069	0.483
MOD_ProDKin_1	444	450	PF00069	0.650
MOD_ProDKin_1	541	547	PF00069	0.685
MOD_SUMO_for_1	382	385	PF00179	0.497
MOD_SUMO_for_1	391	394	PF00179	0.512
MOD_SUMO_rev_2	312	320	PF00179	0.463
MOD_SUMO_rev_2	348	356	PF00179	0.649
TRG_DiLeu_BaEn_1	385	390	PF01217	0.558
TRG_DiLeu_BaEn_1	482	487	PF01217	0.590
TRG_DiLeu_BaEn_4	348	354	PF01217	0.605
TRG_DiLeu_BaEn_4	636	642	PF01217	0.579
TRG_DiLeu_LyEn_5	385	390	PF01217	0.600
TRG_DiLeu_LyEn_5	482	487	PF01217	0.590
TRG_ENDOCYTIC_2	311	314	PF00928	0.451
TRG_ENDOCYTIC_2	483	486	PF00928	0.537
TRG_ENDOCYTIC_2	604	607	PF00928	0.566
TRG_ER_diArg_1	218	220	PF00400	0.474
TRG_ER_diArg_1	331	333	PF00400	0.523
TRG_ER_diArg_1	612	615	PF00400	0.520
TRG_ER_diArg_1	649	652	PF00400	0.576
TRG_ER_diArg_1	670	673	PF00400	0.553
TRG_NES_CRM1_1	88	101	PF08389	0.517
TRG_NLS_Bipartite_1	614	632	PF00514	0.651
TRG_NLS_MonoCore_2	647	652	PF00514	0.565
TRG_NLS_MonoExtC_3	647	652	PF00514	0.565
TRG_NLS_MonoExtN_4	626	632	PF00514	0.670
TRG_NLS_MonoExtN_4	645	652	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM92	Leptomonas seymouri	71%	100%
A0A3S7WYT5	Leishmania donovani	96%	100%
A4HDY6	Leishmania braziliensis	86%	99%
A4I187	Leishmania infantum	96%	100%
D0A5H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QA51	Leishmania major	95%	100%