SUI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania mexicana

UniProt:

E9AXB8_LEIMU

TriTrypDb:

LmxM.25.0410

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXB8

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	1
GO:0002183	cytoplasmic translational initiation	4	1
GO:0002188	translation reinitiation	5	1
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.560
CLV_NRD_NRD_1	173	175	PF00675	0.472
CLV_NRD_NRD_1	176	178	PF00675	0.501
CLV_NRD_NRD_1	212	214	PF00675	0.286
CLV_NRD_NRD_1	235	237	PF00675	0.348
CLV_NRD_NRD_1	94	96	PF00675	0.733
CLV_PCSK_FUR_1	174	178	PF00082	0.490
CLV_PCSK_FUR_1	3	7	PF00082	0.688
CLV_PCSK_KEX2_1	175	177	PF00082	0.499
CLV_PCSK_KEX2_1	208	210	PF00082	0.357
CLV_PCSK_KEX2_1	212	214	PF00082	0.338
CLV_PCSK_KEX2_1	237	239	PF00082	0.348
CLV_PCSK_KEX2_1	5	7	PF00082	0.718
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.477
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.357
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.348
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.718
CLV_PCSK_PC7_1	172	178	PF00082	0.485
CLV_PCSK_PC7_1	233	239	PF00082	0.336
CLV_PCSK_SKI1_1	176	180	PF00082	0.503
CLV_PCSK_SKI1_1	192	196	PF00082	0.575
CLV_PCSK_SKI1_1	213	217	PF00082	0.314
DEG_SPOP_SBC_1	28	32	PF00917	0.648
DOC_MAPK_gen_1	195	203	PF00069	0.483
DOC_MAPK_gen_1	276	284	PF00069	0.574
DOC_MAPK_gen_1	84	93	PF00069	0.606
DOC_USP7_MATH_1	278	282	PF00917	0.538
DOC_USP7_UBL2_3	77	81	PF12436	0.687
DOC_USP7_UBL2_3	97	101	PF12436	0.601
LIG_14-3-3_CanoR_1	176	185	PF00244	0.488
LIG_14-3-3_CanoR_1	212	221	PF00244	0.473
LIG_14-3-3_CanoR_1	236	245	PF00244	0.556
LIG_14-3-3_CanoR_1	6	15	PF00244	0.594
LIG_Actin_RPEL_3	185	204	PF02755	0.521
LIG_Actin_WH2_2	214	231	PF00022	0.543
LIG_BIR_III_2	26	30	PF00653	0.508
LIG_deltaCOP1_diTrp_1	234	239	PF00928	0.458
LIG_FHA_1	28	34	PF00498	0.585
LIG_FHA_2	178	184	PF00498	0.485
LIG_GBD_Chelix_1	263	271	PF00786	0.258
LIG_LIR_Apic_2	273	278	PF02991	0.472
LIG_LIR_LC3C_4	120	125	PF02991	0.494
LIG_LIR_Nem_3	132	138	PF02991	0.427
LIG_Pex14_1	235	239	PF04695	0.458
LIG_SH2_CRK	135	139	PF00017	0.406
LIG_SH2_CRK	275	279	PF00017	0.458
LIG_SH2_STAT5	135	138	PF00017	0.396
LIG_SH2_STAT5	283	286	PF00017	0.461
LIG_SH3_3	288	294	PF00018	0.580
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.302
LIG_SUMO_SIM_par_1	119	126	PF11976	0.648
LIG_SUMO_SIM_par_1	199	205	PF11976	0.321
LIG_TRAF2_1	118	121	PF00917	0.691
LIG_TRAF2_1	17	20	PF00917	0.637
LIG_TRAF2_1	247	250	PF00917	0.458
LIG_TYR_ITIM	133	138	PF00017	0.421
MOD_CK1_1	7	13	PF00069	0.726
MOD_CK2_1	14	20	PF00069	0.693
MOD_Cter_Amidation	172	175	PF01082	0.476
MOD_Cter_Amidation	210	213	PF01082	0.272
MOD_Cter_Amidation	286	289	PF01082	0.602
MOD_GlcNHglycan	147	151	PF01048	0.445
MOD_GlcNHglycan	41	47	PF01048	0.773
MOD_GlcNHglycan	60	63	PF01048	0.708
MOD_GSK3_1	58	65	PF00069	0.732
MOD_NEK2_1	123	128	PF00069	0.581
MOD_NEK2_1	214	219	PF00069	0.486
MOD_NEK2_1	270	275	PF00069	0.548
MOD_NEK2_2	278	283	PF00069	0.533
MOD_PKA_1	237	243	PF00069	0.548
MOD_PKA_2	237	243	PF00069	0.556
MOD_PKA_2	62	68	PF00069	0.732
MOD_Plk_2-3	66	72	PF00069	0.590
MOD_Plk_4	214	220	PF00069	0.548
MOD_Plk_4	278	284	PF00069	0.529
MOD_SUMO_rev_2	105	109	PF00179	0.706
TRG_DiLeu_BaEn_1	280	285	PF01217	0.564
TRG_ENDOCYTIC_2	135	138	PF00928	0.424
TRG_ER_diArg_1	174	177	PF00400	0.492
TRG_ER_diArg_1	212	214	PF00400	0.543
TRG_ER_diArg_1	235	238	PF00400	0.548
TRG_NLS_Bipartite_1	79	101	PF00514	0.687
TRG_NLS_MonoCore_2	173	178	PF00514	0.463
TRG_NLS_MonoCore_2	94	99	PF00514	0.688
TRG_NLS_MonoExtC_3	287	292	PF00514	0.550
TRG_NLS_MonoExtC_3	94	99	PF00514	0.600
TRG_NLS_MonoExtN_4	172	179	PF00514	0.463
TRG_NLS_MonoExtN_4	233	240	PF00514	0.548
TRG_NLS_MonoExtN_4	3	9	PF00514	0.617
TRG_NLS_MonoExtN_4	95	102	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD2	Leptomonas seymouri	60%	100%
A0A1X0P4H3	Trypanosomatidae	57%	100%
A0A3Q8ICD2	Leishmania donovani	90%	100%
A0A3R7KWX6	Trypanosoma rangeli	54%	100%
A4HDY3	Leishmania braziliensis	80%	100%
A4I184	Leishmania infantum	90%	100%
D0A5G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4QA54	Leishmania major	90%	100%
V5BN78	Trypanosoma cruzi	50%	100%