PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXB6_LEIMU

TriTrypDb:

LmxM.25.0390

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AXB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.474
CLV_NRD_NRD_1	50	52	PF00675	0.556
CLV_PCSK_KEX2_1	50	52	PF00082	0.464
CLV_PCSK_SKI1_1	140	144	PF00082	0.486
CLV_PCSK_SKI1_1	69	73	PF00082	0.464
CLV_PCSK_SKI1_1	87	91	PF00082	0.532
DEG_APCC_DBOX_1	139	147	PF00400	0.567
DOC_CYCLIN_RxL_1	66	75	PF00134	0.535
DOC_PP1_RVXF_1	67	74	PF00149	0.532
DOC_USP7_MATH_1	25	29	PF00917	0.476
DOC_USP7_MATH_1	31	35	PF00917	0.457
DOC_USP7_MATH_1	59	63	PF00917	0.605
DOC_WW_Pin1_4	112	117	PF00397	0.608
LIG_14-3-3_CanoR_1	163	168	PF00244	0.570
LIG_BIR_II_1	1	5	PF00653	0.351
LIG_BRCT_BRCA1_1	33	37	PF00533	0.536
LIG_FHA_1	133	139	PF00498	0.528
LIG_FHA_1	62	68	PF00498	0.475
LIG_FHA_2	16	22	PF00498	0.557
LIG_FHA_2	73	79	PF00498	0.497
LIG_FHA_2	96	102	PF00498	0.234
LIG_LIR_Gen_1	104	113	PF02991	0.518
LIG_LIR_Gen_1	72	81	PF02991	0.556
LIG_LIR_Nem_3	104	108	PF02991	0.531
LIG_LIR_Nem_3	122	126	PF02991	0.321
LIG_LIR_Nem_3	72	76	PF02991	0.494
LIG_MLH1_MIPbox_1	33	37	PF16413	0.536
LIG_NRBOX	66	72	PF00104	0.528
LIG_SH2_CRK	38	42	PF00017	0.389
LIG_SH2_SRC	190	193	PF00017	0.441
LIG_SH2_STAT5	9	12	PF00017	0.493
LIG_SUMO_SIM_anti_2	61	69	PF11976	0.545
LIG_SUMO_SIM_anti_2	98	104	PF11976	0.229
LIG_SUMO_SIM_par_1	75	80	PF11976	0.382
LIG_TYR_ITIM	121	126	PF00017	0.454
LIG_WRC_WIRS_1	102	107	PF05994	0.516
LIG_WRC_WIRS_1	70	75	PF05994	0.461
MOD_CK1_1	104	110	PF00069	0.414
MOD_CK1_1	166	172	PF00069	0.562
MOD_CK1_1	2	8	PF00069	0.307
MOD_CK2_1	95	101	PF00069	0.338
MOD_GlcNHglycan	27	30	PF01048	0.529
MOD_GlcNHglycan	4	7	PF01048	0.353
MOD_GlcNHglycan	42	45	PF01048	0.428
MOD_GSK3_1	134	141	PF00069	0.484
MOD_GSK3_1	40	47	PF00069	0.462
MOD_N-GLC_1	52	57	PF02516	0.508
MOD_NEK2_1	119	124	PF00069	0.261
MOD_NEK2_1	37	42	PF00069	0.281
MOD_NEK2_2	31	36	PF00069	0.547
MOD_PIKK_1	107	113	PF00454	0.447
MOD_Plk_1	31	37	PF00069	0.544
MOD_Plk_1	52	58	PF00069	0.500
MOD_Plk_4	101	107	PF00069	0.400
MOD_Plk_4	31	37	PF00069	0.559
MOD_Plk_4	44	50	PF00069	0.292
MOD_Plk_4	72	78	PF00069	0.391
MOD_ProDKin_1	112	118	PF00069	0.598
TRG_DiLeu_BaEn_2	100	106	PF01217	0.222
TRG_ENDOCYTIC_2	123	126	PF00928	0.475
TRG_ENDOCYTIC_2	38	41	PF00928	0.393
TRG_ER_diArg_1	49	51	PF00400	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8M2	Leptomonas seymouri	47%	85%
A0A3Q8IF59	Leishmania donovani	90%	100%
A0A3R7KB37	Trypanosoma rangeli	23%	96%
A4H4A3	Leishmania braziliensis	80%	100%
A4I182	Leishmania infantum	90%	100%
D0A5G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	99%
Q4QA56	Leishmania major	89%	100%