Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXB5_LEIMU

TriTrypDb:

LmxM.25.0380

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.508
CLV_NRD_NRD_1	242	244	PF00675	0.429
CLV_NRD_NRD_1	387	389	PF00675	0.562
CLV_NRD_NRD_1	413	415	PF00675	0.469
CLV_NRD_NRD_1	428	430	PF00675	0.434
CLV_NRD_NRD_1	473	475	PF00675	0.381
CLV_NRD_NRD_1	603	605	PF00675	0.569
CLV_NRD_NRD_1	721	723	PF00675	0.517
CLV_NRD_NRD_1	764	766	PF00675	0.334
CLV_PCSK_KEX2_1	387	389	PF00082	0.511
CLV_PCSK_KEX2_1	413	415	PF00082	0.428
CLV_PCSK_KEX2_1	473	475	PF00082	0.415
CLV_PCSK_KEX2_1	487	489	PF00082	0.482
CLV_PCSK_KEX2_1	721	723	PF00082	0.509
CLV_PCSK_KEX2_1	764	766	PF00082	0.464
CLV_PCSK_KEX2_1	774	776	PF00082	0.474
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.476
CLV_PCSK_PC1ET2_1	774	776	PF00082	0.478
CLV_PCSK_SKI1_1	243	247	PF00082	0.535
CLV_PCSK_SKI1_1	313	317	PF00082	0.449
CLV_PCSK_SKI1_1	329	333	PF00082	0.459
CLV_PCSK_SKI1_1	360	364	PF00082	0.510
CLV_PCSK_SKI1_1	379	383	PF00082	0.512
CLV_PCSK_SKI1_1	387	391	PF00082	0.417
CLV_PCSK_SKI1_1	447	451	PF00082	0.430
CLV_PCSK_SKI1_1	466	470	PF00082	0.421
CLV_PCSK_SKI1_1	483	487	PF00082	0.378
CLV_PCSK_SKI1_1	556	560	PF00082	0.524
CLV_PCSK_SKI1_1	584	588	PF00082	0.397
CLV_PCSK_SKI1_1	596	600	PF00082	0.443
CLV_PCSK_SKI1_1	619	623	PF00082	0.473
CLV_PCSK_SKI1_1	714	718	PF00082	0.574
DEG_APCC_KENBOX_2	399	403	PF00400	0.487
DEG_SCF_FBW7_1	19	26	PF00400	0.498
DEG_SPOP_SBC_1	250	254	PF00917	0.515
DEG_SPOP_SBC_1	538	542	PF00917	0.617
DEG_SPOP_SBC_1	657	661	PF00917	0.658
DOC_CKS1_1	20	25	PF01111	0.501
DOC_CKS1_1	531	536	PF01111	0.592
DOC_CKS1_1	788	793	PF01111	0.578
DOC_CYCLIN_RxL_1	241	251	PF00134	0.459
DOC_MAPK_gen_1	616	624	PF00069	0.473
DOC_MAPK_MEF2A_6	441	450	PF00069	0.443
DOC_PP1_RVXF_1	493	500	PF00149	0.465
DOC_PP2B_LxvP_1	114	117	PF13499	0.517
DOC_PP2B_LxvP_1	255	258	PF13499	0.578
DOC_PP2B_LxvP_1	708	711	PF13499	0.485
DOC_USP7_MATH_1	120	124	PF00917	0.714
DOC_USP7_MATH_1	125	129	PF00917	0.626
DOC_USP7_MATH_1	14	18	PF00917	0.734
DOC_USP7_MATH_1	174	178	PF00917	0.608
DOC_USP7_MATH_1	248	252	PF00917	0.619
DOC_USP7_MATH_1	538	542	PF00917	0.545
DOC_USP7_MATH_1	558	562	PF00917	0.598
DOC_USP7_MATH_1	689	693	PF00917	0.624
DOC_USP7_MATH_1	701	705	PF00917	0.660
DOC_USP7_MATH_1	792	796	PF00917	0.573
DOC_USP7_UBL2_3	483	487	PF12436	0.482
DOC_USP7_UBL2_3	770	774	PF12436	0.418
DOC_WW_Pin1_4	101	106	PF00397	0.610
DOC_WW_Pin1_4	112	117	PF00397	0.703
DOC_WW_Pin1_4	130	135	PF00397	0.604
DOC_WW_Pin1_4	157	162	PF00397	0.527
DOC_WW_Pin1_4	185	190	PF00397	0.574
DOC_WW_Pin1_4	19	24	PF00397	0.569
DOC_WW_Pin1_4	253	258	PF00397	0.509
DOC_WW_Pin1_4	260	265	PF00397	0.626
DOC_WW_Pin1_4	530	535	PF00397	0.599
DOC_WW_Pin1_4	564	569	PF00397	0.667
DOC_WW_Pin1_4	787	792	PF00397	0.567
LIG_14-3-3_CanoR_1	126	134	PF00244	0.711
LIG_14-3-3_CanoR_1	185	189	PF00244	0.528
LIG_14-3-3_CanoR_1	351	358	PF00244	0.565
LIG_14-3-3_CanoR_1	466	472	PF00244	0.317
LIG_14-3-3_CanoR_1	488	497	PF00244	0.293
LIG_14-3-3_CanoR_1	619	625	PF00244	0.506
LIG_14-3-3_CanoR_1	67	76	PF00244	0.495
LIG_14-3-3_CanoR_1	714	723	PF00244	0.578
LIG_14-3-3_CanoR_1	744	749	PF00244	0.495
LIG_14-3-3_CanoR_1	775	781	PF00244	0.475
LIG_14-3-3_CanoR_1	802	807	PF00244	0.485
LIG_Actin_WH2_2	390	408	PF00022	0.485
LIG_Actin_WH2_2	432	449	PF00022	0.431
LIG_Actin_WH2_2	605	621	PF00022	0.476
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_CaM_NSCaTE_8	499	506	PF13499	0.402
LIG_DLG_GKlike_1	802	809	PF00625	0.479
LIG_FHA_1	250	256	PF00498	0.618
LIG_FHA_1	32	38	PF00498	0.652
LIG_FHA_1	330	336	PF00498	0.419
LIG_FHA_1	372	378	PF00498	0.480
LIG_FHA_1	531	537	PF00498	0.598
LIG_FHA_1	574	580	PF00498	0.526
LIG_FHA_1	60	66	PF00498	0.517
LIG_FHA_1	631	637	PF00498	0.498
LIG_FHA_1	70	76	PF00498	0.538
LIG_FHA_1	703	709	PF00498	0.665
LIG_FHA_1	754	760	PF00498	0.491
LIG_FHA_1	826	832	PF00498	0.498
LIG_FHA_2	212	218	PF00498	0.513
LIG_FHA_2	23	29	PF00498	0.796
LIG_FHA_2	351	357	PF00498	0.589
LIG_FHA_2	41	47	PF00498	0.396
LIG_FHA_2	460	466	PF00498	0.438
LIG_FHA_2	518	524	PF00498	0.492
LIG_FHA_2	668	674	PF00498	0.548
LIG_FHA_2	715	721	PF00498	0.552
LIG_FHA_2	745	751	PF00498	0.499
LIG_FHA_2	755	761	PF00498	0.427
LIG_FHA_2	80	86	PF00498	0.474
LIG_FXI_DFP_1	693	697	PF00024	0.506
LIG_Integrin_RGD_1	509	511	PF01839	0.538
LIG_LIR_Gen_1	729	736	PF02991	0.506
LIG_LIR_Gen_1	85	96	PF02991	0.538
LIG_LIR_Nem_3	729	734	PF02991	0.516
LIG_LIR_Nem_3	85	91	PF02991	0.542
LIG_NRBOX	326	332	PF00104	0.451
LIG_NRBOX	805	811	PF00104	0.504
LIG_NRP_CendR_1	829	832	PF00754	0.523
LIG_Pex14_2	589	593	PF04695	0.319
LIG_PTAP_UEV_1	654	659	PF05743	0.489
LIG_Rb_LxCxE_1	43	62	PF01857	0.485
LIG_SH2_CRK	88	92	PF00017	0.544
LIG_SH2_STAP1	33	37	PF00017	0.646
LIG_SH2_STAP1	88	92	PF00017	0.420
LIG_SH2_STAT3	412	415	PF00017	0.495
LIG_SH2_STAT5	33	36	PF00017	0.659
LIG_SH2_STAT5	591	594	PF00017	0.316
LIG_SH3_3	113	119	PF00018	0.763
LIG_SH3_3	17	23	PF00018	0.723
LIG_SH3_3	261	267	PF00018	0.576
LIG_SH3_3	35	41	PF00018	0.570
LIG_SH3_3	528	534	PF00018	0.595
LIG_SH3_3	554	560	PF00018	0.588
LIG_SH3_3	652	658	PF00018	0.611
LIG_SH3_3	785	791	PF00018	0.531
LIG_SUMO_SIM_par_1	467	472	PF11976	0.486
LIG_TRAF2_1	747	750	PF00917	0.497
LIG_UBA3_1	611	616	PF00899	0.506
MOD_CK1_1	104	110	PF00069	0.656
MOD_CK1_1	177	183	PF00069	0.718
MOD_CK1_1	213	219	PF00069	0.522
MOD_CK1_1	251	257	PF00069	0.570
MOD_CK1_1	307	313	PF00069	0.438
MOD_CK1_1	32	38	PF00069	0.789
MOD_CK1_1	540	546	PF00069	0.598
MOD_CK1_1	562	568	PF00069	0.505
MOD_CK1_1	6	12	PF00069	0.665
MOD_CK1_1	630	636	PF00069	0.480
MOD_CK1_1	79	85	PF00069	0.501
MOD_CK2_1	211	217	PF00069	0.521
MOD_CK2_1	23	29	PF00069	0.772
MOD_CK2_1	330	336	PF00069	0.580
MOD_CK2_1	350	356	PF00069	0.594
MOD_CK2_1	40	46	PF00069	0.469
MOD_CK2_1	416	422	PF00069	0.475
MOD_CK2_1	425	431	PF00069	0.498
MOD_CK2_1	459	465	PF00069	0.440
MOD_CK2_1	517	523	PF00069	0.490
MOD_CK2_1	542	548	PF00069	0.643
MOD_CK2_1	679	685	PF00069	0.647
MOD_CK2_1	714	720	PF00069	0.560
MOD_CK2_1	726	732	PF00069	0.523
MOD_CK2_1	744	750	PF00069	0.404
MOD_CK2_1	754	760	PF00069	0.432
MOD_CK2_1	79	85	PF00069	0.479
MOD_DYRK1A_RPxSP_1	185	189	PF00069	0.458
MOD_GlcNHglycan	127	130	PF01048	0.710
MOD_GlcNHglycan	16	19	PF01048	0.580
MOD_GlcNHglycan	181	184	PF01048	0.533
MOD_GlcNHglycan	222	225	PF01048	0.430
MOD_GlcNHglycan	293	296	PF01048	0.498
MOD_GlcNHglycan	407	410	PF01048	0.471
MOD_GlcNHglycan	504	507	PF01048	0.437
MOD_GlcNHglycan	564	567	PF01048	0.465
MOD_GlcNHglycan	645	648	PF01048	0.658
MOD_GlcNHglycan	667	670	PF01048	0.630
MOD_GlcNHglycan	673	677	PF01048	0.622
MOD_GlcNHglycan	78	81	PF01048	0.562
MOD_GlcNHglycan	9	12	PF01048	0.628
MOD_GSK3_1	100	107	PF00069	0.588
MOD_GSK3_1	120	127	PF00069	0.798
MOD_GSK3_1	14	21	PF00069	0.796
MOD_GSK3_1	156	163	PF00069	0.618
MOD_GSK3_1	175	182	PF00069	0.763
MOD_GSK3_1	184	191	PF00069	0.592
MOD_GSK3_1	209	216	PF00069	0.519
MOD_GSK3_1	249	256	PF00069	0.564
MOD_GSK3_1	29	36	PF00069	0.620
MOD_GSK3_1	3	10	PF00069	0.667
MOD_GSK3_1	371	378	PF00069	0.480
MOD_GSK3_1	513	520	PF00069	0.570
MOD_GSK3_1	537	544	PF00069	0.635
MOD_GSK3_1	558	565	PF00069	0.542
MOD_GSK3_1	649	656	PF00069	0.633
MOD_GSK3_1	659	666	PF00069	0.651
MOD_GSK3_1	667	674	PF00069	0.616
MOD_GSK3_1	710	717	PF00069	0.549
MOD_GSK3_1	75	82	PF00069	0.577
MOD_N-GLC_1	416	421	PF02516	0.413
MOD_N-GLC_1	513	518	PF02516	0.546
MOD_N-GLC_1	775	780	PF02516	0.502
MOD_N-GLC_2	522	524	PF02516	0.494
MOD_NEK2_1	106	111	PF00069	0.702
MOD_NEK2_1	210	215	PF00069	0.510
MOD_NEK2_1	218	223	PF00069	0.479
MOD_NEK2_1	330	335	PF00069	0.528
MOD_NEK2_1	4	9	PF00069	0.464
MOD_NEK2_1	405	410	PF00069	0.415
MOD_NEK2_1	469	474	PF00069	0.488
MOD_NEK2_1	547	552	PF00069	0.465
MOD_NEK2_1	667	672	PF00069	0.607
MOD_NEK2_1	75	80	PF00069	0.708
MOD_NEK2_1	810	815	PF00069	0.486
MOD_PIKK_1	211	217	PF00454	0.494
MOD_PIKK_1	218	224	PF00454	0.526
MOD_PIKK_1	297	303	PF00454	0.625
MOD_PIKK_1	504	510	PF00454	0.552
MOD_PIKK_1	622	628	PF00454	0.487
MOD_PIKK_1	702	708	PF00454	0.512
MOD_PKA_2	125	131	PF00069	0.527
MOD_PKA_2	144	150	PF00069	0.565
MOD_PKA_2	184	190	PF00069	0.510
MOD_PKA_2	280	286	PF00069	0.588
MOD_PKA_2	350	356	PF00069	0.594
MOD_PKA_2	375	381	PF00069	0.473
MOD_PKA_2	663	669	PF00069	0.702
MOD_PKA_2	671	677	PF00069	0.584
MOD_PKA_2	743	749	PF00069	0.524
MOD_PKB_1	289	297	PF00069	0.515
MOD_Plk_1	107	113	PF00069	0.551
MOD_Plk_1	513	519	PF00069	0.648
MOD_Plk_1	547	553	PF00069	0.551
MOD_Plk_1	630	636	PF00069	0.508
MOD_Plk_1	70	76	PF00069	0.378
MOD_Plk_1	775	781	PF00069	0.505
MOD_Plk_2-3	695	701	PF00069	0.601
MOD_Plk_4	33	39	PF00069	0.741
MOD_Plk_4	532	538	PF00069	0.479
MOD_Plk_4	754	760	PF00069	0.615
MOD_ProDKin_1	101	107	PF00069	0.614
MOD_ProDKin_1	112	118	PF00069	0.699
MOD_ProDKin_1	130	136	PF00069	0.603
MOD_ProDKin_1	157	163	PF00069	0.525
MOD_ProDKin_1	185	191	PF00069	0.566
MOD_ProDKin_1	19	25	PF00069	0.569
MOD_ProDKin_1	253	259	PF00069	0.514
MOD_ProDKin_1	260	266	PF00069	0.616
MOD_ProDKin_1	530	536	PF00069	0.602
MOD_ProDKin_1	564	570	PF00069	0.512
MOD_ProDKin_1	787	793	PF00069	0.570
MOD_SUMO_for_1	389	392	PF00179	0.500
MOD_SUMO_for_1	769	772	PF00179	0.454
MOD_SUMO_for_1	816	819	PF00179	0.496
MOD_SUMO_rev_2	121	125	PF00179	0.528
MOD_SUMO_rev_2	401	408	PF00179	0.478
MOD_SUMO_rev_2	583	592	PF00179	0.429
TRG_DiLeu_BaEn_1	607	612	PF01217	0.654
TRG_DiLeu_BaEn_1	631	636	PF01217	0.508
TRG_DiLeu_BaEn_1	638	643	PF01217	0.453
TRG_DiLeu_BaEn_1	71	76	PF01217	0.426
TRG_DiLeu_BaEn_1	737	742	PF01217	0.436
TRG_DiLeu_BaEn_4	192	198	PF01217	0.511
TRG_DiLeu_BaEn_4	431	437	PF01217	0.439
TRG_DiLeu_BaEn_4	750	756	PF01217	0.500
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.450
TRG_DiLeu_LyEn_5	631	636	PF01217	0.508
TRG_DiLeu_LyEn_5	638	643	PF01217	0.453
TRG_ENDOCYTIC_2	88	91	PF00928	0.545
TRG_ER_diArg_1	197	200	PF00400	0.524
TRG_ER_diArg_1	412	414	PF00400	0.435
TRG_ER_diArg_1	445	448	PF00400	0.449
TRG_ER_diArg_1	473	476	PF00400	0.416
TRG_ER_diArg_1	721	723	PF00400	0.513
TRG_NES_CRM1_1	238	249	PF08389	0.357
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	714	718	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y9	Leptomonas seymouri	47%	93%
A0A3S7WYS7	Leishmania donovani	84%	98%
A4H4A4	Leishmania braziliensis	65%	100%
A4I181	Leishmania infantum	84%	98%
Q4QA57	Leishmania major	82%	100%
V5B7N4	Trypanosoma cruzi	25%	100%