DUF1308 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1308), putative

Species:

Leishmania mexicana

UniProt:

E9AXB2_LEIMU

TriTrypDb:

LmxM.25.0350

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.592
CLV_C14_Caspase3-7	53	57	PF00656	0.531
CLV_NRD_NRD_1	183	185	PF00675	0.412
CLV_NRD_NRD_1	338	340	PF00675	0.472
CLV_NRD_NRD_1	380	382	PF00675	0.649
CLV_NRD_NRD_1	39	41	PF00675	0.547
CLV_NRD_NRD_1	448	450	PF00675	0.411
CLV_NRD_NRD_1	740	742	PF00675	0.502
CLV_NRD_NRD_1	744	746	PF00675	0.524
CLV_PCSK_FUR_1	329	333	PF00082	0.507
CLV_PCSK_FUR_1	737	741	PF00082	0.467
CLV_PCSK_KEX2_1	183	185	PF00082	0.448
CLV_PCSK_KEX2_1	331	333	PF00082	0.581
CLV_PCSK_KEX2_1	338	340	PF00082	0.462
CLV_PCSK_KEX2_1	379	381	PF00082	0.702
CLV_PCSK_KEX2_1	39	41	PF00082	0.547
CLV_PCSK_KEX2_1	739	741	PF00082	0.498
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.581
CLV_PCSK_SKI1_1	240	244	PF00082	0.609
CLV_PCSK_SKI1_1	292	296	PF00082	0.498
CLV_PCSK_SKI1_1	297	301	PF00082	0.490
CLV_PCSK_SKI1_1	393	397	PF00082	0.616
CLV_PCSK_SKI1_1	467	471	PF00082	0.452
CLV_PCSK_SKI1_1	475	479	PF00082	0.546
CLV_PCSK_SKI1_1	483	487	PF00082	0.405
CLV_PCSK_SKI1_1	577	581	PF00082	0.360
CLV_PCSK_SKI1_1	603	607	PF00082	0.403
CLV_PCSK_SKI1_1	689	693	PF00082	0.316
CLV_PCSK_SKI1_1	728	732	PF00082	0.376
CLV_Separin_Metazoa	104	108	PF03568	0.314
DEG_APCC_DBOX_1	474	482	PF00400	0.435
DEG_Nend_UBRbox_2	1	3	PF02207	0.591
DEG_SPOP_SBC_1	285	289	PF00917	0.530
DEG_SPOP_SBC_1	34	38	PF00917	0.593
DEG_SPOP_SBC_1	88	92	PF00917	0.570
DOC_ANK_TNKS_1	182	189	PF00023	0.448
DOC_CKS1_1	666	671	PF01111	0.389
DOC_CYCLIN_RxL_1	297	309	PF00134	0.526
DOC_CYCLIN_RxL_1	617	626	PF00134	0.424
DOC_CYCLIN_yClb3_PxF_3	666	672	PF00134	0.534
DOC_MAPK_gen_1	238	247	PF00069	0.611
DOC_MAPK_gen_1	338	345	PF00069	0.510
DOC_MAPK_gen_1	617	627	PF00069	0.371
DOC_MAPK_gen_1	745	752	PF00069	0.413
DOC_MAPK_MEF2A_6	240	249	PF00069	0.615
DOC_MAPK_MEF2A_6	338	347	PF00069	0.474
DOC_MAPK_MEF2A_6	745	752	PF00069	0.413
DOC_MIT_MIM_1	110	119	PF04212	0.476
DOC_PP1_RVXF_1	270	276	PF00149	0.455
DOC_PP1_RVXF_1	687	693	PF00149	0.294
DOC_PP2B_LxvP_1	207	210	PF13499	0.560
DOC_PP2B_LxvP_1	348	351	PF13499	0.494
DOC_PP2B_LxvP_1	514	517	PF13499	0.499
DOC_PP4_FxxP_1	503	506	PF00568	0.419
DOC_SPAK_OSR1_1	280	284	PF12202	0.395
DOC_USP7_MATH_1	125	129	PF00917	0.626
DOC_USP7_MATH_1	153	157	PF00917	0.559
DOC_USP7_MATH_1	160	164	PF00917	0.423
DOC_USP7_MATH_1	260	264	PF00917	0.611
DOC_USP7_MATH_1	34	38	PF00917	0.619
DOC_USP7_MATH_1	371	375	PF00917	0.526
DOC_USP7_MATH_1	465	469	PF00917	0.441
DOC_USP7_MATH_1	497	501	PF00917	0.657
DOC_USP7_MATH_1	50	54	PF00917	0.707
DOC_USP7_MATH_1	554	558	PF00917	0.653
DOC_USP7_MATH_1	578	582	PF00917	0.546
DOC_USP7_MATH_1	726	730	PF00917	0.376
DOC_USP7_MATH_2	138	144	PF00917	0.503
DOC_USP7_UBL2_3	166	170	PF12436	0.524
DOC_WW_Pin1_4	134	139	PF00397	0.629
DOC_WW_Pin1_4	192	197	PF00397	0.454
DOC_WW_Pin1_4	200	205	PF00397	0.613
DOC_WW_Pin1_4	314	319	PF00397	0.485
DOC_WW_Pin1_4	402	407	PF00397	0.598
DOC_WW_Pin1_4	46	51	PF00397	0.676
DOC_WW_Pin1_4	665	670	PF00397	0.457
DOC_WW_Pin1_4	91	96	PF00397	0.521
LIG_14-3-3_CanoR_1	159	168	PF00244	0.485
LIG_14-3-3_CanoR_1	272	276	PF00244	0.557
LIG_14-3-3_CanoR_1	393	399	PF00244	0.597
LIG_14-3-3_CanoR_1	40	50	PF00244	0.551
LIG_14-3-3_CanoR_1	577	586	PF00244	0.466
LIG_14-3-3_CanoR_1	623	628	PF00244	0.376
LIG_14-3-3_CanoR_1	728	736	PF00244	0.376
LIG_BIR_III_2	496	500	PF00653	0.618
LIG_BIR_III_4	54	58	PF00653	0.696
LIG_BIR_III_4	63	67	PF00653	0.586
LIG_BRCT_BRCA1_1	499	503	PF00533	0.460
LIG_CSL_BTD_1	397	400	PF09270	0.586
LIG_CSL_BTD_1	664	667	PF09270	0.600
LIG_EVH1_1	665	669	PF00568	0.490
LIG_EVH1_2	210	214	PF00568	0.526
LIG_FHA_1	177	183	PF00498	0.417
LIG_FHA_1	318	324	PF00498	0.467
LIG_FHA_1	394	400	PF00498	0.694
LIG_FHA_1	411	417	PF00498	0.259
LIG_FHA_1	46	52	PF00498	0.678
LIG_FHA_1	557	563	PF00498	0.623
LIG_FHA_1	578	584	PF00498	0.608
LIG_FHA_1	628	634	PF00498	0.485
LIG_FHA_1	666	672	PF00498	0.374
LIG_FHA_1	98	104	PF00498	0.312
LIG_FHA_2	200	206	PF00498	0.595
LIG_FHA_2	232	238	PF00498	0.488
LIG_FHA_2	516	522	PF00498	0.471
LIG_FHA_2	596	602	PF00498	0.356
LIG_FHA_2	651	657	PF00498	0.506
LIG_FHA_2	671	677	PF00498	0.464
LIG_FHA_2	702	708	PF00498	0.365
LIG_GBD_Chelix_1	108	116	PF00786	0.483
LIG_LIR_Apic_2	396	401	PF02991	0.597
LIG_LIR_Apic_2	500	506	PF02991	0.438
LIG_LIR_Apic_2	519	525	PF02991	0.483
LIG_LIR_Gen_1	2	11	PF02991	0.611
LIG_LIR_Gen_1	290	301	PF02991	0.551
LIG_LIR_Gen_1	317	327	PF02991	0.470
LIG_LIR_Gen_1	596	606	PF02991	0.418
LIG_LIR_Gen_1	674	684	PF02991	0.383
LIG_LIR_LC3C_4	205	209	PF02991	0.536
LIG_LIR_Nem_3	162	168	PF02991	0.480
LIG_LIR_Nem_3	227	232	PF02991	0.509
LIG_LIR_Nem_3	243	249	PF02991	0.572
LIG_LIR_Nem_3	250	255	PF02991	0.615
LIG_LIR_Nem_3	290	296	PF02991	0.557
LIG_LIR_Nem_3	570	574	PF02991	0.290
LIG_LIR_Nem_3	596	602	PF02991	0.368
LIG_LIR_Nem_3	674	680	PF02991	0.384
LIG_MYND_1	400	404	PF01753	0.558
LIG_NRBOX	101	107	PF00104	0.519
LIG_NRBOX	115	121	PF00104	0.482
LIG_NRBOX	322	328	PF00104	0.390
LIG_PDZ_Class_2	747	752	PF00595	0.471
LIG_Rb_LxCxE_1	230	250	PF01857	0.528
LIG_SH2_CRK	165	169	PF00017	0.465
LIG_SH2_CRK	229	233	PF00017	0.542
LIG_SH2_CRK	571	575	PF00017	0.284
LIG_SH2_PTP2	246	249	PF00017	0.657
LIG_SH2_PTP2	252	255	PF00017	0.528
LIG_SH2_SRC	246	249	PF00017	0.625
LIG_SH2_SRC	258	261	PF00017	0.446
LIG_SH2_SRC	425	428	PF00017	0.548
LIG_SH2_STAP1	473	477	PF00017	0.489
LIG_SH2_STAP1	5	9	PF00017	0.439
LIG_SH2_STAT3	72	75	PF00017	0.681
LIG_SH2_STAT5	246	249	PF00017	0.657
LIG_SH2_STAT5	252	255	PF00017	0.528
LIG_SH2_STAT5	258	261	PF00017	0.465
LIG_SH2_STAT5	473	476	PF00017	0.436
LIG_SH2_STAT5	677	680	PF00017	0.376
LIG_SH3_1	741	747	PF00018	0.507
LIG_SH3_3	205	211	PF00018	0.521
LIG_SH3_3	242	248	PF00018	0.556
LIG_SH3_3	250	256	PF00018	0.616
LIG_SH3_3	347	353	PF00018	0.471
LIG_SH3_3	372	378	PF00018	0.646
LIG_SH3_3	388	394	PF00018	0.612
LIG_SH3_3	398	404	PF00018	0.607
LIG_SH3_3	458	464	PF00018	0.435
LIG_SH3_3	658	664	PF00018	0.674
LIG_SH3_3	741	747	PF00018	0.507
LIG_SUMO_SIM_anti_2	282	290	PF11976	0.492
LIG_SUMO_SIM_par_1	320	328	PF11976	0.518
LIG_SUMO_SIM_par_1	412	421	PF11976	0.327
LIG_SUMO_SIM_par_1	457	463	PF11976	0.342
LIG_SUMO_SIM_par_1	623	631	PF11976	0.439
LIG_TRAF2_1	598	601	PF00917	0.418
LIG_TYR_ITIM	569	574	PF00017	0.295
LIG_TYR_ITIM	675	680	PF00017	0.376
LIG_UBA3_1	322	331	PF00899	0.534
LIG_WRC_WIRS_1	98	103	PF05994	0.283
MOD_CK1_1	126	132	PF00069	0.642
MOD_CK1_1	134	140	PF00069	0.669
MOD_CK1_1	200	206	PF00069	0.567
MOD_CK1_1	28	34	PF00069	0.700
MOD_CK1_1	35	41	PF00069	0.670
MOD_CK2_1	111	117	PF00069	0.529
MOD_CK2_1	134	140	PF00069	0.668
MOD_CK2_1	231	237	PF00069	0.519
MOD_CK2_1	271	277	PF00069	0.711
MOD_CK2_1	284	290	PF00069	0.482
MOD_CK2_1	41	47	PF00069	0.646
MOD_CK2_1	420	426	PF00069	0.427
MOD_CK2_1	534	540	PF00069	0.714
MOD_CK2_1	595	601	PF00069	0.357
MOD_CK2_1	670	676	PF00069	0.510
MOD_CK2_1	701	707	PF00069	0.362
MOD_CK2_1	726	732	PF00069	0.390
MOD_GlcNHglycan	12	15	PF01048	0.654
MOD_GlcNHglycan	149	152	PF01048	0.770
MOD_GlcNHglycan	162	165	PF01048	0.628
MOD_GlcNHglycan	189	192	PF01048	0.590
MOD_GlcNHglycan	249	252	PF01048	0.596
MOD_GlcNHglycan	260	263	PF01048	0.609
MOD_GlcNHglycan	31	34	PF01048	0.706
MOD_GlcNHglycan	369	372	PF01048	0.457
MOD_GlcNHglycan	43	46	PF01048	0.765
MOD_GlcNHglycan	499	502	PF01048	0.628
MOD_GlcNHglycan	536	539	PF01048	0.614
MOD_GlcNHglycan	556	559	PF01048	0.444
MOD_GlcNHglycan	570	574	PF01048	0.317
MOD_GlcNHglycan	580	583	PF01048	0.502
MOD_GlcNHglycan	638	641	PF01048	0.553
MOD_GlcNHglycan	680	683	PF01048	0.353
MOD_GSK3_1	192	199	PF00069	0.565
MOD_GSK3_1	25	32	PF00069	0.681
MOD_GSK3_1	260	267	PF00069	0.647
MOD_GSK3_1	35	42	PF00069	0.790
MOD_GSK3_1	367	374	PF00069	0.546
MOD_GSK3_1	389	396	PF00069	0.617
MOD_GSK3_1	411	418	PF00069	0.398
MOD_GSK3_1	46	53	PF00069	0.686
MOD_GSK3_1	467	474	PF00069	0.489
MOD_GSK3_1	543	550	PF00069	0.790
MOD_GSK3_1	578	585	PF00069	0.600
MOD_GSK3_1	623	630	PF00069	0.452
MOD_GSK3_1	650	657	PF00069	0.815
MOD_GSK3_1	678	685	PF00069	0.337
MOD_GSK3_1	724	731	PF00069	0.353
MOD_GSK3_1	87	94	PF00069	0.632
MOD_N-GLC_1	140	145	PF02516	0.688
MOD_N-GLC_1	264	269	PF02516	0.550
MOD_NEK2_1	25	30	PF00069	0.710
MOD_NEK2_1	411	416	PF00069	0.339
MOD_NEK2_1	562	567	PF00069	0.500
MOD_NEK2_1	678	683	PF00069	0.324
MOD_NEK2_1	89	94	PF00069	0.537
MOD_NEK2_2	420	425	PF00069	0.427
MOD_NEK2_2	682	687	PF00069	0.376
MOD_PIKK_1	131	137	PF00454	0.690
MOD_PIKK_1	418	424	PF00454	0.417
MOD_PK_1	123	129	PF00069	0.485
MOD_PK_1	623	629	PF00069	0.446
MOD_PKA_1	39	45	PF00069	0.522
MOD_PKA_2	153	159	PF00069	0.668
MOD_PKA_2	271	277	PF00069	0.674
MOD_PKA_2	39	45	PF00069	0.628
MOD_PKA_2	654	660	PF00069	0.696
MOD_PKA_2	678	684	PF00069	0.371
MOD_PKB_1	157	165	PF00069	0.565
MOD_PKB_1	238	246	PF00069	0.601
MOD_Plk_1	16	22	PF00069	0.693
MOD_Plk_1	371	377	PF00069	0.581
MOD_Plk_1	411	417	PF00069	0.338
MOD_Plk_1	562	568	PF00069	0.471
MOD_Plk_1	595	601	PF00069	0.357
MOD_Plk_1	628	634	PF00069	0.468
MOD_Plk_2-3	16	22	PF00069	0.506
MOD_Plk_4	203	209	PF00069	0.627
MOD_Plk_4	394	400	PF00069	0.642
MOD_Plk_4	563	569	PF00069	0.423
MOD_Plk_4	623	629	PF00069	0.380
MOD_Plk_4	97	103	PF00069	0.287
MOD_ProDKin_1	134	140	PF00069	0.630
MOD_ProDKin_1	192	198	PF00069	0.468
MOD_ProDKin_1	200	206	PF00069	0.610
MOD_ProDKin_1	314	320	PF00069	0.478
MOD_ProDKin_1	402	408	PF00069	0.580
MOD_ProDKin_1	46	52	PF00069	0.678
MOD_ProDKin_1	665	671	PF00069	0.448
MOD_ProDKin_1	91	97	PF00069	0.516
MOD_SUMO_rev_2	596	605	PF00179	0.461
MOD_SUMO_rev_2	727	735	PF00179	0.374
TRG_DiLeu_BaEn_1	564	569	PF01217	0.460
TRG_DiLeu_BaEn_3	600	606	PF01217	0.422
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.369
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.424
TRG_ENDOCYTIC_2	165	168	PF00928	0.534
TRG_ENDOCYTIC_2	229	232	PF00928	0.507
TRG_ENDOCYTIC_2	246	249	PF00928	0.377
TRG_ENDOCYTIC_2	252	255	PF00928	0.618
TRG_ENDOCYTIC_2	5	8	PF00928	0.604
TRG_ENDOCYTIC_2	571	574	PF00928	0.283
TRG_ENDOCYTIC_2	599	602	PF00928	0.419
TRG_ENDOCYTIC_2	677	680	PF00928	0.376
TRG_ER_diArg_1	157	160	PF00400	0.594
TRG_ER_diArg_1	171	174	PF00400	0.474
TRG_ER_diArg_1	182	184	PF00400	0.412
TRG_ER_diArg_1	378	381	PF00400	0.642
TRG_ER_diArg_1	736	739	PF00400	0.507
TRG_NES_CRM1_1	476	491	PF08389	0.526
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW5	Leptomonas seymouri	48%	98%
A0A1X0P4J1	Trypanosomatidae	28%	100%
A0A3Q8IC76	Leishmania donovani	88%	100%
A4H4A7	Leishmania braziliensis	67%	99%
A4I178	Leishmania infantum	88%	100%
Q4QA60	Leishmania major	87%	100%